Low Affinity Platelet Factor 4 and High Affinity Platelet Factor 4 - Two Antiheparin Factors Secreted by Human Platelets.

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:Anticoagulant control facilities are being overwhelmed by requests for monitoring and large numbers of patients are not therefore receiving treatment. Procedures designed for point-of-care testing have therefore been developed, the most popular being the CoaguChek. The need for external quality assessment (EQA) of mon...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Poller L,van den Besselaar AM,van der Meer FJ,Palareti G,Tripodi A,Shiach C,Keown M,Ibrahim S

更新日期：2010-05-01 00:00:00

abstract：INTRODUCTION:Rivaroxaban (RXA) is a direct oral factor Xa (Xa) antagonist with a short half-life and a fast onset and offset of effect. Before elective surgery, discontinuation is recommended with an interval of at least > 24 hours. In clinical practice, this is, however, not always sufficient to achieve a residual RXA...

journal_title：Thrombosis and haemostasis

authors： Kaserer A,Schedler A,Jetter A,Seifert B,Spahn DR,Stein P,Studt JD

更新日期：2018-05-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs that negatively regulate posttranscriptional gene expression. Several microRNAs have been described to regulate the process of angiogenesis. Previously, we have shown that bone morphogenetic protein 4 (BMP4) increased the pro-angiogenic activity of endothelial cells. In this project...

journal_title：Thrombosis and haemostasis

authors： Esser JS,Saretzki E,Pankratz F,Engert B,Grundmann S,Bode C,Moser M,Zhou Q

更新日期：2017-04-03 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and plays a central role in angiogenesis and vasculogenesis. Therefore, VEGF and its receptors VEGFR-1 and VEGFR-2 are prime targets for anti-angiogenic intervention which is thought to be one of the most promising approaches in cancer...

journal_title：Thrombosis and haemostasis

authors： Piossek C,Thierauch KH,Schneider-Mergener J,Volkmer-Engert R,Bachmann MF,Korff T,Augustin HG,Germeroth L

更新日期：2003-09-01 00:00:00

abstract：:Many of the agonists that cause platelet activation are thought to do so by interacting with G protein-coupled receptors on the platelet surface. By activating heterotrimeric G proteins, these receptors evoke shape change, granule secretion and platelet aggregation. This review provides a brief overview of these event...

journal_title：Thrombosis and haemostasis

authors： Brass LF,Manning DR,Cichowski K,Abrams CS

更新日期：1997-07-01 00:00:00

abstract：:Protein Z-dependent protease inhibitor (ZPI) is plasma proteinase inhibitor in the serpin superfamily that produces rapid inhibition of factor Xa in the presence of phospholipids, Ca++ and protein Z (PZ). Mouse ZPI cDNA was isolated and cloned from mouse liver RNA using RT-PCR. The cDNA contains 100 nucleotides 5' of ...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Broze GJ Jr

更新日期：2001-05-01 00:00:00

abstract：:Heparin and low molecular weight heparins stimulate two to three fold the accumulation of an antithrombotic heparan sulfate secreted by endothelial cells in culture. This led us to search for the minimum structural requirements of the heparin molecule able to elicit the enhancement of the heparan sulfate. Fragments we...

journal_title：Thrombosis and haemostasis

authors： Pinhal MA,Santos IA,Silva IF,Dietrich CP,Nader HB

更新日期：1995-10-01 00:00:00

abstract：:The increased risk for deep vein thrombosis (DVT) after orthopaedic surgery has been well documented as well as hypercoagulable state during both total hip arthroplasty (THA) and total knee replacement (TKR). To investigate the influence of the surgical procedure [posterolateral (PL) or lateral (L) approach for THA, u...

journal_title：Thrombosis and haemostasis

authors： Fedi S,Gori AM,Falciani M,Cellai AP,Aglietti P,Baldini A,Vena LM,Prisco D,Abbate R,Gensini GF

更新日期：1999-06-01 00:00:00

abstract：:Monospecific antisera against the purified protein component of tissue thromboplastin (apoprotein-III) from human brain have been raised in goats and rabbits. The antisera neutralized tissue thromboplastin prepared from brain, thyroid gland and pulmonary tissue, indicating that apoproteins in the various preparations ...

journal_title：Thrombosis and haemostasis

authors： Bjorklid E,Storm-Mathisen J,Storm E,Prydz H

更新日期：1977-02-28 00:00:00

abstract：:Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

journal_title：Thrombosis and haemostasis

authors： Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

更新日期：2001-01-01 00:00:00

abstract：:We have identified two novel minor deletions (case 1; -TA or -AT at nucleotide 9831-3 in exon 5 and case 2; -A at nucleotide 7640-1 in exon 4), one novel nonsense mutation (case 3; TAT to TAA at nucleotide 7491 in exon 4), and one recurrent nonsense mutation (case 4; CGA to TGA at nucleotide 5381 in exon 3A) in Japane...

journal_title：Thrombosis and haemostasis

authors： Nakahara Y,Tsuji H,Nakagawa K,Masuda H,Kitamura H,Nishimura H,Kasahara T,Sugano T,Sawada S,Nakagawa M

更新日期：1997-04-01 00:00:00

abstract：:Despite reports that Tris [tris (hydroxymethyl)aminomethane] affects platelets, it is often used to buffer suspending media. Human or rabbit platelets were washed and resuspended in Tyrode solution containing apyrase and 0.35% albumin. Addition of 15 mM Tris partially inhibited primary aggregation induced by 10 microM...

journal_title：Thrombosis and haemostasis

authors： Packham MA,Guccione MA,Nina M,Kinlough-Rathbone RL,Mustard JF

更新日期：1984-04-30 00:00:00

abstract：:We previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain. As the peptides represent ...

journal_title：Thrombosis and haemostasis

authors： Vanhoorelbeke K,van der Plas RM,Vandecasteele G,Vauterin S,Huizinga EG,Sixma JJ,Deckmyn H

更新日期：2000-10-01 00:00:00

abstract：:Few data are available on thrombophilic risk factors and progression of atherosclerotic peripheral arterial disease (PAD). Thrombophilic alterations can be an aggravating factor when arterial stenoses are present. In a cross-sectional study, we evaluated the presence of the thrombophilic factors fibrinogen, homocystei...

journal_title：Thrombosis and haemostasis

authors： Sartori M,Favaretto E,Legnani C,Cini M,Conti E,Amato A,Palareti G

更新日期：2010-07-01 00:00:00

abstract：:Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a p...

journal_title：Thrombosis and haemostasis

authors： Galli M,Ageno W,Squizzato A,Dentali F,Manfredi E,Steidl L,Venco A

更新日期：2005-07-01 00:00:00

abstract：:We measured and compared the levels of plasma soluble (s) P-selectin, sCD40L, platelet-derived microparticles (PDMP), monocyte-derived microparticles (MDMP), and anti-oxidized LDL antibody, to obtain a better understanding of their potential contribution to vascular complications in acute coronary syndrome (ACS). The ...

journal_title：Thrombosis and haemostasis

authors： Matsumoto N,Nomura S,Kamihata H,Kimura Y,Iwasaka T

更新日期：2004-01-01 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：:A possible role of the plasminogen/plasmin or fibrinolytic system in several biological processes has been implied from correlations between fibrinolytic activity and (patho)physiological phenomena. However, such indirect evidence does not allow to definitively establish the biological relevance of this system. Two re...

journal_title：Thrombosis and haemostasis

authors： Carmeliet P,Collen D

更新日期：1995-07-01 00:00:00

abstract：:The mechanisms or host factors involved in septic thrombus or vegetation formation in Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental endocarditis rat model, here we demonstrated that S. aureus HG001-induced vegetation was composed of bacterial floes encased in aggregated p...

journal_title：Thrombosis and haemostasis

authors： Hsu CC,Hsu RB,Ohniwa RL,Chen JW,Yuan CT,Chia JS,Jung CJ

更新日期：2019-05-01 00:00:00

abstract：:The effect of supernatant from phorbol myristate acetate (PMA) stimulated human polymorphonuclear granulocytes (PMN) on human factor VII was studied in vitro. The supernatant caused a rapid loss in factor VII coagulant activity by the action of human leukocyte elastase (HLE) and cathepsin G in the supernatant, as demo...

journal_title：Thrombosis and haemostasis

authors： Anderssen T,Halvorsen H,Bajaj SP,Osterud B

更新日期：1993-09-01 00:00:00

abstract：:In two randomized double-blind studies perioperative bleeding complications and thromboembolic events were assessed in 189 patients (pts) undergoing elective visceral surgery after subcutaneous administration of a low molecular weight (LMW) heparin fragment (KABI fragment 2165) or unfractionated (UF) heparin. The firs...

journal_title：Thrombosis and haemostasis

authors： Koller M,Schoch U,Buchmann P,Largiadèr F,von Felten A,Frick PG

更新日期：1986-12-15 00:00:00

abstract：:The effect of shear rate and fibrinogen concentration on adenosine diphosphate-induced aggregation of suspensions of washed human platelets in Poiseuille flow at 23 degrees C was studied using a previously described double infusion technique and resistive particle counter size analysis. Using suspensions of multiple-c...

journal_title：Thrombosis and haemostasis

authors： Goldsmith HL,Frojmovic MM,Braovac S,McIntosh F,Wong T

更新日期：1994-01-01 00:00:00

abstract：:We have investigated the influence of long term oral anticoagulants (OAC) upon the plasma levels of prothrombin fragment 1 + 2 (F1 + 2), of thrombin-antithrombin III complexes (TAT) and of D-Dimer in 20 patients affected by a proximal deep vein thrombosis (DVT) diagnosed by ultrasonic duplex scanning. Patients (63 +/-...

journal_title：Thrombosis and haemostasis

authors： Elias A,Bonfils S,Daoud-Elias M,Gauthier B,Sié P,Boccalon H,Boneu B

更新日期：1993-04-01 00:00:00

abstract：:Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the rel...

journal_title：Thrombosis and haemostasis

authors： Reddel CJ,Pennings GJ,Curnow JL,Chen VM,Kritharides L

更新日期：2018-04-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) decreases apoptosis, inflammation and oxidative stress. The aim of the study was to investigate the effects of intracoronary infusion of allogenic bone marrow cells (BMC) overexpressing HO-1 in the porcine model of myocardial infarction (MI). MI was produced by balloon occlusion of a coronary a...

journal_title：Thrombosis and haemostasis

authors： Wojakowski W,Tendera M,Cybulski W,Zuba-Surma EK,Szade K,Florczyk U,Kozakowska M,Szymula A,Krzych L,Paslawska U,Paslawski R,Milewski K,Buszman PP,Nabialek E,Kuczmik W,Janiszewski A,Dziegiel P,Buszman PE,Józkowicz A,D

更新日期：2012-09-01 00:00:00

abstract：:Coagulation factor III (tissue factor) is required for significant activation of factor X in the presence of factor VIIa. Factor III is a membrane protein which requires bound phospholipids for activity, and removal of lipids during purification of factor III abolishes its activity. The activity can be recovered if li...

journal_title：Thrombosis and haemostasis

authors： Carson SD,Konigsberg WH

更新日期：1980-08-29 00:00:00

abstract：:Megakaryocyte (MK)-derived miRNAs have been detected in platelets. Here, we analysed the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that might be altered with their target mRNAs in type 2 diabetes mellitus (DM2). MiRNAs were isolated from leukocyte-depleted platelets and plasma sample...

journal_title：Thrombosis and haemostasis

authors： Fejes Z,Póliska S,Czimmerer Z,Káplár M,Penyige A,Gál Szabó G,Beke Debreceni I,Kunapuli SP,Kappelmayer J,Nagy B Jr

更新日期：2017-02-28 00:00:00

abstract：:Deep vein thrombosis (DVT) in children occurs primarily in the upper body venous system. This prospective diagnostic study compared bilateral venography and ultrasound for detection of DVT in the upper venous system in 66 children with acute lymphoblastic leukemia. Results were interpreted by central blinded adjudicat...

journal_title：Thrombosis and haemostasis

authors： Male C,Chait P,Ginsberg JS,Hanna K,Andrew M,Halton J,Anderson R,McCusker P,Wu J,Abshire T,Cherrick I,Mahoney D,Mitchell L

更新日期：2002-04-01 00:00:00

abstract：:The use of exogenous oestrogen in women with otherwise unprovoked venous thromboembolism (VTE) could be considered sufficient explanation to classify VTE as provoked if the risk of recurrent VTE after 3-6 months of anticoagulant treatment is similar to the risk of recurrent VTE observed after a surgery or prolonged im...

journal_title：Thrombosis and haemostasis

authors： Le Gal G,Kovacs MJ,Carrier M,Do K,Kahn SR,Wells PS,Anderson DA,Chagnon I,Solymoss S,Crowther M,Righini M,Lacut K,White RH,Vickars L,Rodger M

更新日期：2010-09-01 00:00:00