当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Influence of long term oral anticoagulants upon prothrombin fragment 1 + 2, thrombin-antithrombin III complex and D-Dimer levels in patients affected by proximal deep vein thrombosis.

Influence of long term oral anticoagulants upon prothrombin fragment 1 + 2, thrombin-antithrombin III complex and D-Dimer levels in patients affected by proximal deep vein thrombosis.

Abstract：

:We have investigated the influence of long term oral anticoagulants (OAC) upon the plasma levels of prothrombin fragment 1 + 2 (F1 + 2), of thrombin-antithrombin III complexes (TAT) and of D-Dimer in 20 patients affected by a proximal deep vein thrombosis (DVT) diagnosed by ultrasonic duplex scanning. Patients (63 +/- 17 years, mean +/- SD) were sampled at the beginning of the OAC treatment (day 1), which was started 1 to 6 days after diagnosis confirmation and full heparinization, and then 8, 35 and 92 days after. The results were compared to those obtained in a blood donor population (39 +/- 10 years) and to an age-matched healthy population (63 +/- 19 years). The mean INR determined on days 8, 35 and 92 were almost identical (2.8 +/- 0.7, 2.9 +/- 0.9 and 2.8 +/- 0.6 respectively). In contrast, highly significant variations of the three markers were recorded during the observation period. Eight days after the beginning of OAC, increased levels of TAT complexes were associated with subnormal levels of F1 + 2 suggesting persistence of a hypercoagulable state. On the further sampling times, TAT complexes were in the normal range while F1 + 2 were far below the normal range. Between day 1 and day 92, the levels of D-Dimer continuously decreased reflecting a long-term fibrinolytic process. This study clearly indicates that high INR are not systematically associated with very low F1 + 2 levels, particularly in the acute phase of thrombosis.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Elias A,Bonfils S,Daoud-Elias M,Gauthier B,Sié P,Boccalon H,Boneu B

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

302-5

issue

4

eissn

0340-6245

issn

2567-689X

journal_volume

69

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • A critical investigation into the existence of circulating platelet aggregates.

    abstract：:By a method of counting single platelets in diluted whole blood, platelet aggregates were quantified ex-vivo. Four groups: 20 thrombotic patients, 10 non-thrombotic patients, 10 healthy old controls and 10 healthy young controls were included in the study. Using a 19 gauge needle, with and without tubing, venous blood...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Saniabadi AR,Lowe GD,Madhok R,Spowart K,Shaw B,Barbenel JC,Forbes CD

    更新日期：1986-08-20 00:00:00

  • Antithrombotic effect of MCI-9042, a new antiplatelet agent on experimental thrombosis models.

    abstract：:The antithrombotic effect of MCI-9042, (+-)-2-(dimethyl-amino)-1-((o-(m- methoxyphenethyl)phenoxyl]methyl]ethyl hydrogen succinate hydrochloride was investigated in three different experimental thrombosis models in animals. Simultaneous injection of serotonin and collagen into the tail vein in mice induced acute pulmo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Hara H,Kitajima A,Shimada H,Tamao Y

    更新日期：1991-10-01 00:00:00

  • Influence of variability of interpretation of contrast venography for screening of postoperative deep venous thrombosis on the results of a thromboprophylactic study.

    abstract：:To assess interobserver variability of venography for screening for postoperative deep venous thrombosis (DVT), we used 185 bilateral ascending contrast venograms (366 lower limbs) which were performed using the long-leg film technique, in the frame of a trial of the efficacy of two low-molecular-weight-heparin fracti...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章

    doi：

    authors： Couson F,Bounameaux C,Didier D,Geiser D,Meyerovitz MF,Schmitt HE,Schneider PA,Bounameaux H

    更新日期：1993-10-18 00:00:00

  • Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: a methodological comparison.

    abstract：:Mature circulating endothelial cells (CECs) are novel cellular markers of endothelial damage/dysfunction. The two main techniques of CEC enumeration are flow cytometry (FC) and immunomagnetic bead (IB) isolation. Both quantify CECs accurately, but a direct comparison of both methods has not been reported. We sought to...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH06-04-0185

    authors： Goon PK,Boos CJ,Stonelake PS,Blann AD,Lip GY

    更新日期：2006-07-01 00:00:00

  • Prognostic relevance of circulating endothelial progenitor cells in patients with chronic heart failure.

    abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-01-0051

    authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

    更新日期：2016-08-01 00:00:00

  • Haemophilia B: impact on patients and economic burden of disease.

    abstract：:Worldwide, haemophilia is the most common hereditary bleeding disorder. The incidence of haemophilia B, however, is considerably less than haemophilia A and consequently appears to have received less attention in the research literature. This article aims to summarise the available evidence documenting the patient and...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH11-03-0193

    authors： Gater A,Thomson TA,Strandberg-Larsen M

    更新日期：2011-09-01 00:00:00

  • Serial determinations of platelet counts in mice by flow cytometry.

    abstract：:Elucidation of the pathophysiological basis of platelet disorders in murine models requires a reliable method for the frequent determinations of platelet counts in individual mice. Here, we present a rapid, reproducible and accurate flow cytometric method for enumeration of platelets that involves fluorescent staining...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Alugupalli KR,Michelson AD,Barnard MR,Leong JM

    更新日期：2001-08-01 00:00:00

  • Peptides inhibiting heparanase procoagulant activity significantly reduce tumour growth and vascularisation in a mouse model.

    abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-02-0119

    authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

    更新日期：2016-09-27 00:00:00

  • Treatments for stroke prevention in atrial fibrillation: a network meta-analysis and indirect comparisons versus dabigatran etexilate.

    abstract：:Patients with atrial fibrillation at moderate to high risk of stroke are not always anticoagulated despite a lack of contraindications to vitamin K antagonists (VKAs) like warfarin. These patients are treated with aspirin, aspirin-clopidogrel combination therapy or even receive no thromboprophylaxis. The oral direct t...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,meta分析

    doi：10.1160/TH10-10-0642

    authors： Roskell NS,Lip GY,Noack H,Clemens A,Plumb JM

    更新日期：2010-12-01 00:00:00

  • Magnetic resonance imaging of tumor vasculature.

    abstract：:Angiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties. In this r...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Degani H,Chetrit-Dadiani M,Bogin L,Furman-Haran E

    更新日期：2003-01-01 00:00:00

  • von Willebrand factor release and P-selectin expression is stimulated by thrombin and trypsin but not IL-1 in cultured human endothelial cells.

    abstract：:The stimulated release of von Willebrand factor (vWF) from endothelial cells by secretagogues such as thrombin is associated with the translocation of Weibel-Palade bodies to the cell membrane and the surface expression of P-selectin (also known as GMP 140, PADGEM and CD 62). P-selectin, which is stored in Weibel-Pala...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Collins PW,Macey MG,Cahill MR,Newland AC

    更新日期：1993-08-02 00:00:00

  • Adsorption of vitamin K-dependent proteins to live cell membranes measured under flow conditions.

    abstract：:Mechanisms mediating initial adsorption of coagulation proteins to live cells were investigated. Adsorption kinetics were examined under varying flow conditions using tracer-dilution techniques in perfused spherical monolayers of cells expressing tissue factor. At biologically relevant time and concentration ranges, r...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： McGee MP,Teuschler H

    更新日期：1999-07-01 00:00:00

  • Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin.

    abstract：:The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH13-03-0213

    authors： Metzner HJ,Pipe SW,Weimer T,Schulte S

    更新日期：2013-11-01 00:00:00

  • Effect of a moderate fish intake on haemostatic parameters in healthy males.

    abstract：:This article describes the results of a dietary intervention study performed in three different centers. In the study the effect of a diet enriched with fish on the coagulation tendency of blood was investigated. Two groups of 40 volunteers were given a dietary supplement consisting of 135 g of canned mackerel or meat...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Muller AD,van Houwelingen AC,van Dam-Mieras MC,Bas BM,Hornstra G

    更新日期：1989-06-30 00:00:00

  • Tissue kallikreins: new players in normal and abnormal cell growth?

    abstract：:Serine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Yousef GM,Diamandis EP

    更新日期：2003-07-01 00:00:00

  • Comparative study of inhibitory antibody derivatives towards thrombin activatable fibrinolysis inhibitor.

    abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH08-09-0834

    authors： Develter J,Dewilde M,Gils A,Declerck PJ

    更新日期：2009-07-01 00:00:00

  • Endothelial cell protein S synthesis is upregulated by the complex of IL-6 and soluble IL-6 receptor.

    abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Hooper WC,Phillips DJ,Evatt BL

    更新日期：1997-05-01 00:00:00

  • Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).

    abstract：:Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Agarwal KC,Russo FX,Parks RE Jr

    更新日期：1982-10-29 00:00:00

  • Factor IX Denver, ASN 346-->ASP mutation resulting in a dysfunctional protein with defective factor VIIIa interaction.

    abstract：:Hemophilia B is a sex-linked recessive bleeding disorder characterized by the presence of either a decreased amount of normal factor IX (FIX) or the presence of a dysfunctional FIX. We have identified a unique mutation in a family with mild hemophilia B. DNA analysis of family members revealed a single base transition...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Lefkowitz JB,Nuss R,Haver T,Jacobson L,Thompson AR,Manco-Johnson M

    更新日期：2001-09-01 00:00:00

  • Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.

    abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-06-0433

    authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

    更新日期：2017-12-01 00:00:00

  • Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia.

    abstract：:Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH11-06-0438

    authors： Schouten M,van 't Veer C,Roelofs JJ,Gerlitz B,Grinnell BW,Levi M,van der Poll T

    更新日期：2011-12-01 00:00:00

  • Randomised, double blind, multicentre, placebo controlled study of sulodexide in the treatment of venous leg ulcers.

    abstract：:Sulodexide, a highly purified glycosaminoglycan, was investigated for treatment of venous leg ulcers. Patients (n = 235) undergoing local treatment including wound care and compression bandaging, were randomised to receive either sulodexide or matching placebo for three months. Primary study endpoint was complete ulce...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Coccheri S,Scondotto G,Agnelli G,Aloisi D,Palazzini E,Zamboni V,Venous arm of the SUAVIS (Sulodexide Arterial Venous Italian Study) Group.

    更新日期：2002-06-01 00:00:00

  • Platelet survival in patients with dilated cardiomyopathy.

    abstract：:Dilated cardiomyopathy is associated with thromboembolic complications, which correlate poorly, however, with a visible left ventricular thrombus. Therefore, this study was performed to assess whether an abnormality of platelet function in vivo can be detected in patients with dilated cardiomyopathy. Platelet survival...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Weidinger F,Glogar D,Sochor H,Sinzinger H

    更新日期：1991-10-01 00:00:00

  • Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2).

    abstract：:Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, sugg...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH15-09-0749

    authors： Mao G,Jin J,Kunapuli SP,Rao AK

    更新日期：2016-10-28 00:00:00

  • A standard nomenclature for von Willebrand factor gene mutations and polymorphisms. On behalf of the ISTH SSC Subcommittee on von Willebrand factor.

    abstract：:Examination of the entire von Willebrand factor (VWF) gene for mutations, particularly in types 1 and 3 von Willebrand disease (VWD) is becoming more widely practised. The sequence of the entire VWF gene will soon be compiled as a single sequence. For these reasons, a clearly defined nomenclature to use for numbering ...

    journal_title：Thrombosis and haemostasis

    pub_type： 指南,杂志文章

    doi：

    authors： Goodeve AC,Eikenboom JC,Ginsburg D,Hilbert L,Mazurier C,Peake IR,Sadler JE,Rodeghiero F,ISTH SSC Subcommittee on von Willebrand factor.

    更新日期：2001-05-01 00:00:00

  • A decrease in plasminogen activator inhibitor-1 activity after successful percutaneous transluminal coronary angioplasty is associated with a significantly reduced risk for coronary restenosis.

    abstract：:To determine a possible relation of changes in plasma levels of plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA) to the development of coronary restenosis after successful coronary angioplasty (PTCA), we followed 104 patients with a low grade residual stenosis after PTCA (less than 30%...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Huber K,Jörg M,Probst P,Schuster E,Lang I,Kaindl F,Binder BR

    更新日期：1992-02-03 00:00:00

  • Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2.

    abstract：:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and plays a central role in angiogenesis and vasculogenesis. Therefore, VEGF and its receptors VEGFR-1 and VEGFR-2 are prime targets for anti-angiogenic intervention which is thought to be one of the most promising approaches in cancer...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-02-0106

    authors： Piossek C,Thierauch KH,Schneider-Mergener J,Volkmer-Engert R,Bachmann MF,Korff T,Augustin HG,Germeroth L

    更新日期：2003-09-01 00:00:00

  • Antimigratory and antimetastatic effect of heparin-derived 4-18 unit oligosaccharides in a preclinical human melanoma metastasis model.

    abstract：:Heparin and its derivatives have been shown to inhibit angiogenesis and metastasis formation. Accordingly, we investigated the effect of heparin fragments containing 4 to 22 monomers on human melanoma cell proliferation, migration and invasion in vitro as well as on the in vivo metastatic potential in a SCID mouse mod...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-01-0059

    authors： Kenessey I,Simon E,Futosi K,Bereczky B,Kiss A,Erdödi F,Gallagher JT,Tímár J,Tóvári J

    更新日期：2009-12-01 00:00:00

  • Impaired fibrinolysis in obstructive jaundice--evidence from clinical and experimental studies.

    abstract：:Microvascular thrombosis is considered an important pathogenetic factor in renal failure associated with obstructive jaundice but the mechanisms leading to fibrin deposition are still unknown. The plasma levels of plasminogen activator inhibitor (PAI) in 29 patients with obstructive jaundice were found significantly i...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Colucci M,Altomare DF,Chetta G,Triggiani R,Cavallo LG,Semeraro N

    更新日期：1988-08-30 00:00:00

  • Fibrinogen fragments X, Y, D and E increase levels of plasma fibrinogen and liver mRNAs coding for fibrinogen polypeptides in rats.

    abstract：:Previously, we demonstrated that in vivo regulation of liver fibrinogen synthesis occurs via the fibrinogen mRNA level. However, the molecular regulatory mechanism of fibrinogen synthesis is still not well understood. Fibrinogen or fibrin degradation products might play an important role in regulating fibrinogen synth...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Princen HM,Moshage HJ,Emeis JJ,de Haard HJ,Nieuwenhuizen W,Yap SH

    更新日期：1985-04-22 00:00:00