当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin.

Extending the pharmacokinetic half-life of coagulation factors by fusion to recombinant albumin.

Abstract：

:The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa), respectively. The extension of the half-lives of rFIX and rFVIIa could allow for longer intervals between infusions and could thereby improve adherence and clinical outcomes and may improve quality of life. Albumin fusion is one of a number of different techniques currently being examined to prolong the half-life of rFIX and rFVIIa. Results from a phase I clinical trial demonstrated that the recombinant fusion protein linking FIX to albumin (rIX-FP) has a five-times longer half-life than rFIX, and preclinical studies with the recombinant fusion protein linking FVIIa to albumin (rVIIa-FP) suggest that rVIIa-FP possesses a significantly extended half-life versus rFVIIa. In this review, we describe albumin fusion technology and examine the recent progress in the development of rIX-FP and rVIIa-FP.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Metzner HJ,Pipe SW,Weimer T,Schulte S

doi

10.1160/TH13-03-0213

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

931-9

issue

5

eissn

0340-6245

issn

2567-689X

pii

13-03-0213

journal_volume

110

pub_type

杂志文章,评审

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.

    abstract：:We studied the HR2 haplotype of the factor V gene in a case-control study for venous thrombosis including 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched healthy controls (Leiden Thrombophilia Study, LETS). We investigated both the original His1299Arg (A4070G) polymorphism and the Met385Thr...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： de Visser MC,Guasch JF,Kamphuisen PW,Vos HL,Rosendaal FR,Bertina RM

    更新日期：2000-04-01 00:00:00

  • Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.

    abstract：:Emicizumab, a humanised bispecific antibody recognising factors (F) IX/IXa and X/Xa, can accelerate FIXa-catalysed FX activation by bridging FIXa and FX in a manner similar to FVIIIa. However, details of the emicizumab-antigen interactions have not been reported so far. In this study, we first showed by surface plasmo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-01-0030

    authors： Kitazawa T,Esaki K,Tachibana T,Ishii S,Soeda T,Muto A,Kawabe Y,Igawa T,Tsunoda H,Nogami K,Shima M,Hattori K

    更新日期：2017-06-28 00:00:00

  • The reliability of activated partial thromboplastin time methods and the relationship to lipid composition and ultrastructure.

    abstract：:Wide variations in procoagulant properties, lipid composition and ultrastructure of five commonly used APTT methods have been demonstrated. Performance of the methods with a range of coagulation abnormalities has been ranked. Most of the reagents obtained a high score with one or more defects, but a low score with oth...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Stevenson KJ,Easton AC,Curry A,Thomson JM,Poller L

    更新日期：1986-04-30 00:00:00

  • New coagulation factor V gene polymorphisms define a single and infrequent haplotype underlying the factor V Leiden mutation in Mediterranean populations and Indians.

    abstract：:Two novel polymorphisms were identified in the factor V gene by direct sequencing of intronic areas. One of them, located in intron 9, is the marker closest to the Leiden mutation ever described, whereas the other, in intron 16, displays a rare allele invariantly associated to the mutation. Allele-specific amplificati...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Castoldi E,Lunghi B,Mingozzi F,Ioannou P,Marchetti G,Bernardi F

    更新日期：1997-09-01 00:00:00

  • Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.

    abstract：:Activated protein C (APC)-mediated inactivation of factor VIII (FVIII) correlates with cleavage at either Arg336 and/or Arg562. To elucidate the APC cleavage requirements for inactivation of FVIII, APC cleavage site mutants in FVIII (R336I, R562K and R336I/R562K) were made by site-directed mutagenesis. Analysis of the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Amano K,Michnick DA,Moussalli M,Kaufman RJ

    更新日期：1998-03-01 00:00:00

  • Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice.

    abstract：:Deep-vein thrombosis (DVT) is a common condition that often leads to pulmonary thromboembolism (VTE) and death. The role of prostaglandin-endoperoxide synthase (PTGS)2 in arterial thrombosis has been well established, whereas its impact in venous thrombosis remains unclear. Here, we showed that PTGS2 deletion predispo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-12-0968

    authors： Amadio P,Tarantino E,Sandrini L,Tremoli E,Barbieri SS

    更新日期：2017-07-26 00:00:00

  • High-Content Immunophenotyping and Hierarchical Clustering Reveal Sources of Heterogeneity and New Surface Markers of Human Blood Monocyte Subsets.

    abstract：OBJECTIVE: Blood monocyte subsets are emerging as biomarkers of cardiovascular inflammation. However, our understanding of human monocyte heterogeneity and their immunophenotypic features under healthy and inflammatory conditions is still evolving. RATIONALE: In this study, we sought to investigate the immunophenome o...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0039-1700871

    authors： Hoffmann J,Fišer K,Liebetrau C,Staubach N,Kost D,Voss S,Heiden AZ,Dörr O,Lipps C,Nef HM,Möllmann H,Hamm CW,Keller T,Troidl C

    更新日期：2020-01-01 00:00:00

  • Pathophysiological considerations to thrombophilia in the treatment of multiple myeloma with thalidomide and derivates.

    abstract：:Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma. Although the substance has a better effect/side-effect profile, especially with regard to teratogenicity and neurotoxicity, the rate of therapy-induced thrombosis seems comparable to thali...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH08-01-0009

    authors： Gieseler F

    更新日期：2008-06-01 00:00:00

  • Homozygous variant of antithrombin III that lacks affinity for heparin, AT III Kumamoto.

    abstract：:Abnormal antithrombin III (AT III) was found in the plasma of a 31-year-old female who suffered from recurrent thrombotic episodes. Heparin cofactor activity was 28% of normal and undetectable when measured by inhibition of thrombin and factor Xa (F.Xa), while both progressive antithrombin and antifactor Xa activities...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Okajima K,Ueyama H,Hashimoto Y,Sasaki Y,Matsumoto K,Okabe H,Inoue M,Araki S,Takatsuki K

    更新日期：1989-02-28 00:00:00

  • The fast inhibitor of tissue plasminogen activator in plasma during pregnancy.

    abstract：:The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In hea...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Wiman B,Csemiczky G,Marsk L,Robbe H

    更新日期：1984-10-31 00:00:00

  • Angiogenesis: molecular mechanisms and functional interactions--2nd Kloster Seeon Meeting of the German Priority Research Grant "Angiogenesis".

    abstract：:The German Priority Research Program "Angiogenesis" (www.angiogenese.de) hosts a biannual meeting in the Kloster Seeon in Southern Germany. The 2nd Kloster Seeon Meeting "Angiogenesis: Molecular Mechanisms and Functional Interactions" was held in September 2002. It included sessions on hypoxia, the biology of endothel...

    journal_title：Thrombosis and haemostasis

    pub_type：

    doi：

    authors： Augustin HG,Breier G

    更新日期：2003-01-01 00:00:00

  • The effects of age, gene source and familial severity on Factor VIII in normals and haemophilia carriers: analysis by multiple regression.

    abstract：:There are conflicting views on the effects of age, gene source and familial severity on levels of factor VIII in carriers of haemophilia. Different workers have found that factor VIII increases with age, is higher in paternal carriers, and is higher in carriers from families with more severe haemophilia. Other workers...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Duncan BM,Tunbridge LJ,Lloyd JV

    更新日期：1983-10-31 00:00:00

  • Factors associated with failure to correct the international normalised ratio following fresh frozen plasma administration among patients treated for warfarin-related major bleeding. An analysis of electronic health records.

    abstract：:This study assessed the frequency and factors associated with failure to correct international normalised ratio (INR) in patients administered fresh frozen plasma (FFP) for warfarin-related major bleeding. This retrospective database analysis used electronic health records from an integrated health system. Patients wh...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH11-09-0646

    authors： Menzin J,White LA,Friedman M,Nichols C,Menzin J,Hoesche J,Bergman GE,Jones C

    更新日期：2012-04-01 00:00:00

  • Characteristics of abdominal vein thrombosis in children and adults.

    abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：10.1160/TH12-08-0568

    authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

    更新日期：2013-04-01 00:00:00

  • Radiolabeled r-hirudin as a measure of thrombin activity at, or within, the rabbit aorta wall in vitro and in vivo.

    abstract：:The behavior of 125I-labeled recombinant hirudin towards the uninjured and de-endothelialized rabbit aorta wall has been studied in vitro and in vivo to determine its usefulness as an indicator of thrombin activity associated with the aorta wall. Thrombin adsorbed to either sulfopropyl-Sephadex or heparin-Sepharose bo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Hatton MW,Ross-Ouellet B

    更新日期：1994-04-01 00:00:00

  • Long Noncoding RNAs of the Arterial Wall as Therapeutic Agents and Targets in Atherosclerosis.

    abstract：:Long noncoding ribonucleic acids (lncRNAs) have been defined as transcripts which are > 200 ribonucleotides in size and are not translated into protein. Recent work has shown that many lncRNAs do have specific molecular functions and biological effects, and are involved in a growing number of diseases, including ather...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1055/s-0039-1692680

    authors： Holdt LM,Kohlmaier A,Teupser D

    更新日期：2019-08-01 00:00:00

  • Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets.

    abstract：:Thrombin and other agonists that induce secretion and aggregation in human platelets also activate phospholipase D (PLD), but the signaling cascade leading to activation of PLD in human platelets is not yet clear. We have determined that apyrase, which scavenges ADP secreted during platelet activation, is able to bloc...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Martinson EA,Scheible S,Marx-Grunwitz A,Presek P

    更新日期：1998-12-01 00:00:00

  • Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford.

    abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

    更新日期：1999-09-01 00:00:00

  • Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism.

    abstract：BACKGROUND:Preliminary evidence suggests that use of antipsychotic drugs is associated with an increased risk of venous thromboembolism. OBJECTIVE:To evaluate the relationship between antipsychotic or antidepressant drug use and venous thromboembolism among adults aged 65 years and older. DESIGN:Retrospective cohort ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Ray JG,Mamdani MM,Yeo EL

    更新日期：2002-08-01 00:00:00

  • Increased prevalence of hypertension in haemophilia patients.

    abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：10.1160/TH12-05-0313

    authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

    更新日期：2012-10-01 00:00:00

  • Collagen induced thrombus formation at the apex of eccentric stenoses--a time course study with non-anticoagulated human blood.

    abstract：:Atherosclerotic plaque rupture may trigger the formation of mural thrombus. This thrombus formation is apparently affected by very high and complex shear conditions introduced by the luminal narrowing (stenosis) of the atheroma. To study the impact of such blood flow behaviour on thrombus formation we employed a model...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Barstad RM,Kierulf P,Sakariassen KS

    更新日期：1996-04-01 00:00:00

  • Persistent hyperfibrinogenemia in acute ischemic stroke / transient ischemic attack (TIA).

    abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH07-08-0484

    authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

    更新日期：2008-01-01 00:00:00

  • The basement membrane underlying the vascular endothelium is not thrombogenic: in vivo and in vitro studies with rabbit and human tissue.

    abstract：:Studies examining the interaction of platelets with exposed subendothelium in vivo have reported conflicting results. To examine possible explanations for the apparently discrepant findings, we measured the platelet reactivity of subendothelium prepared by a number of methods both in vivo and in vitro. In addition, we...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Buchanan MR,Richardson M,Haas TA,Hirsh J,Madri JA

    更新日期：1987-08-04 00:00:00

  • Sequential treatment of arterial occlusions with porcine plasmin and low dose streptokinase.

    abstract：:Sequential treatment of arterial occlusions of the leg with porcine plasmin and low dose streptokinase results in a strong systemic proteolysis as already seen in deep leg vein thrombosis. In 31 of 45 patients the blood flow through major arterial segments could be restored. Thrombolytic success is possible within the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Marbet GA,Eichlisberger R,Duckert F,da Silva MA,Biland L,Widmer LK,Ritz R,Schmitt HE

    更新日期：1982-10-29 00:00:00

  • The vascular biology of macrophage migration inhibitory factor (MIF). Expression and effects in inflammation, atherogenesis and angiogenesis.

    abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer developme...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH12-11-0831

    authors： Asare Y,Schmitt M,Bernhagen J

    更新日期：2013-03-01 00:00:00

  • Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin.

    abstract：:The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and functional factor X during warfarin co-administration were established to provide means to interpret INRs during argatroban/warfarin co-therapy. Twenty-four subjects rec...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Sheth SB,DiCicco RA,Hursting MJ,Montague T,Jorkasky DK

    更新日期：2001-03-01 00:00:00

  • Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass.

    abstract：:The haemostatic system and the use of heparin during cardiopulmonary bypass (CPB) have been studied extensively in adults but not in children. Results from adult trials cannot be extrapolated to children because of age-dependent physiologic differences in haemostasis. We studied 22 consecutive paediatric patients who ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Chan AK,Leaker M,Burrows FA,Williams WG,Gruenwald CE,Whyte L,Adams M,Brooker LA,Adams H,Mitchell L,Andrew M

    更新日期：1997-02-01 00:00:00

  • Extracellular nucleic acids in immunity and cardiovascular responses: between alert and disease.

    abstract：:Severe inflammatory complications are a potential consequence in patients with predetermined conditions of infections, pulmonary diseases, or cardiovascular disorders. Notably, the amplitude of the inflammatory response towards these complications can dictate the disease progression and outcome. During the recent year...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH-16-11-0858

    authors： Preissner KT,Herwald H

    更新日期：2017-06-27 00:00:00

  • Morphine Analgesia Pre-PPCI Is Associated with Prothrombotic State, Reduced Spontaneous Reperfusion and Greater Infarct Size.

    abstract：:The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, which may delay gastric transit and reduce DAPT absorption. We sought to assess the effect of mo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1629896

    authors： Farag M,Spinthakis N,Srinivasan M,Sullivan K,Wellsted D,Gorog DA

    更新日期：2018-03-01 00:00:00

  • A cross sectional study of antiphospholipid-protein antibodies in patients with venous thromboembolism.

    abstract：OBJECTIVE:To look for an association between venous thromboembolism (VTE) and antiphospholipid antibodies (aPL) in patients without Systemic Lupus Erythematosus (SLE) when implementing, beside conventional assays, new tests for aPL screening directed towards purified proteic targets. METHODS:We conducted a cross-secti...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Pasquier E,Amiral J,de Saint Martin L,Mottier D

    更新日期：2001-08-01 00:00:00