Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Although associated with adverse outcomes in other cardiopulmonary diseases, limited evidence exists on the prognostic value of anaemia in patients with acute pulmonary embolism (PE). We sought to examine the associations between anaemia and mortality and length of hospital stay in patients with PE. We evaluated 14,27...

journal_title：Thrombosis and haemostasis

authors： Donzé J,Labarère J,Méan M,Jiménez D,Aujesky D

更新日期：2011-08-01 00:00:00

abstract：:Vascular injury in acute coronary syndromes (ACS) involves a complex cross-talk between inflammatory mediators, platelets and thrombosis, where the interaction between platelets and coagulation factors (e. g. thrombin) is a central link between thrombosis and inflammation. In ACS, aspirin at antiplatelet doses exhibit...

journal_title：Thrombosis and haemostasis

authors： Hohlfeld T,Schrör K

更新日期：2015-08-31 00:00:00

abstract：:The incidence of newly diagnosed malignancy is increased in patients with unexplained venous thromboembolism during the first year after a thromboembolic event in comparison to controls (odds ratio, 3.9-36). Extensive screening with computed tomography, endoscopy and tumor markers can identify most of these undetected...

journal_title：Thrombosis and haemostasis

authors： Prins MH,Hettiarachchi RJ,Lensing AW,Hirsh J

更新日期：1997-07-01 00:00:00

abstract：:In trauma patients, resuscitation treatment of intravascular volume may cause haemodilution including blood cell- and plasma-dilution. After plasma-dilution, fibrinogen is the first factor that decreases to critically low concentrations. Fibrin formed in lowered levels is susceptible to fibrinolysis, a natural forerun...

journal_title：Thrombosis and haemostasis

authors： He S,Johnsson H,Zabczyk M,Hultenby K,Wallén H,Blombäck M

更新日期：2014-03-03 00:00:00

abstract：:The aim of the present study was to evaluate the relative performance of five screening methods for APC resistance caused by the factor V:Q506 mutation: the original method Coatest APC Resistance Chromogenix, a modified method using the same reagents but a predilution 1+4 of the plasma in a factor V deficient plasma f...

journal_title：Thrombosis and haemostasis

authors： Freyburger G,Javorschi S,Labrouche S,Bernard P

更新日期：1997-11-01 00:00:00

abstract：:Intraoperative high-dose aprotinin administration has been shown to reduce the intra-and postoperative blood loss in cardiac surgery. The haemostatic effect has been attributed to platelet preserving properties and to inhibition of contact activation reducing thrombotic and fibrinolytic activity during and after cardi...

journal_title：Thrombosis and haemostasis

authors： Spannagl M,Dooijewaard G,Dietrich W,Kluft C

更新日期：1995-05-01 00:00:00

abstract：:One hundred patients were included in a randomized open trial to assess the systemic factor Xa (FXa) and thrombin inhibitory effect as well as the safety profile of low molecular weight heparin (LMWH) given subcutaneously in conjunction with streptokinase (SK) in patients with acute myocardial infarction (MI). The tre...

journal_title：Thrombosis and haemostasis

authors： Nilsen DW,Gøransson L,Larsen AI,Hetland O,Kierulf P

更新日期：1997-01-01 00:00:00

abstract：:We investigated the prevalence of the new recently reported mutation in the prothrombin gene (20210 A) in a sample of 116 unrelated patients with venous thromboembolism. We found 20 heterozygous carriers (17.2%, CI 95% 10.4-21.1). In comparison, we observed 13 carriers among 201 healthy unmatched controls (6.5%, CI 3....

journal_title：Thrombosis and haemostasis

authors： Souto JC,Coll I,Llobet D,del Río E,Oliver A,Mateo J,Borrell M,Fontcuberta J

更新日期：1998-09-01 00:00:00

abstract：:The acidic mucopolysaccharide extracted from sea cucumber (Stichopus japonicus Selenka) (SJAMP) has been shown to cause platelets to aggregate. Using citrated platelet-rich plasma (PRP), washed platelets and formaldehyde-fixed platelets from humans, we investigated the effects of platelet inhibitors and various plasma...

journal_title：Thrombosis and haemostasis

authors： Li JZ,Lian EC

更新日期：1988-06-16 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Niewiarowski S,Rucinski B,Budzynski AZ

更新日期：1979-07-01 00:00:00

abstract：:In patients with atrial fibrillation (AF) who require interruption of dabigatran or warfarin for an elective surgery/procedure, the risks and benefits of perioperative bridging anticoagulation is uncertain.We accessed the database from RE-LY, a randomised trial comparing dabigatran with warfarin for stroke prevention ...

journal_title：Thrombosis and haemostasis

authors： Douketis JD,Healey JS,Brueckmann M,Eikelboom JW,Ezekowitz MD,Fraessdorf M,Noack H,Oldgren J,Reilly P,Spyropoulos AC,Wallentin L,Connolly SJ

更新日期：2015-03-01 00:00:00

abstract：:von Willebrand disease (VWD) is a quantitative or qualitative defect in von Willebrand factor (VWF) resulting in mucocutaneous bleeding symptoms and hemorrhage following hemostatic challenges, such as trauma or surgery. VWD-specific therapy, DDAVP (1-desamino-8-D-arginine vasopressin) and VWF concentrates, is necessar...

journal_title：Thrombosis and haemostasis

authors： Seaman CD,Ragni MV

更新日期：2020-08-01 00:00:00

abstract：:The effect of chronic administration of ethanol to rats in a controlled regimen upon the activities of the coagulation factors II, VII, VIII, IX and X has been studied. No significant differences were found for factor II, IX and X between the ethanol-treated rats and the control group given an isocaloric diet with car...

journal_title：Thrombosis and haemostasis

authors： Morland J,Holm T,Prydz H

更新日期：1976-12-31 00:00:00

abstract：:Injection of human alpha 2-antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin-induced intravascular coagulation. The amount of alpha 2-antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiol...

journal_title：Thrombosis and haemostasis

authors： Carlin G,Einarsson M,Saldeen T

更新日期：1981-12-23 00:00:00

abstract：:The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis and haemostasis

authors： Metzner HJ,Pipe SW,Weimer T,Schulte S

更新日期：2013-11-01 00:00:00

abstract：:It is known that lupus anticoagulants (LA) are antibodies which interfere with phospholipid-dependent coagulation tests, but due to the heterogeneity of LA and the differences in sensitivity of reagents and tests, the diagnosis of LA remains difficult. Recently, Triplett et al. (26) have proposed a new test based on t...

journal_title：Thrombosis and haemostasis

authors： Forastiero RR,Cerrato GS,Carreras LO

更新日期：1994-11-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) is used increasingly for prophylaxis and treatment of venous thromboembolism during pregnancy. However, the prophylactic dose for patients at moderate risk varies between centers, and the recommended LMWH dose for the non pregnant patient is frequently used in pregnant women. The ai...

journal_title：Thrombosis and haemostasis

authors： Norris LA,Bonnar J,Smith MP,Steer PJ,Savidge G

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND: This study assessed changes in anticoagulation therapy over time in patients with atrial fibrillation (AF). METHODS: Analyses were performed on a claims-based dataset of 4 million health-insured individuals. The study population consisted of patients newly initiating a non-vitamin-K oral anticoagulants (NO...

journal_title：Thrombosis and haemostasis

authors： Hohnloser SH,Basic E,Nabauer M

更新日期：2019-06-01 00:00:00

abstract：:Shiga toxin (Stx)-mediated injury to vascular endothelial cells in the kidneys, brain and other organs underlies the pathogenesis of haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). We present a direct and comprehensive comparison of cellular injury induced by the two major Stx t...

journal_title：Thrombosis and haemostasis

authors： Bauwens A,Bielaszewska M,Kemper B,Langehanenberg P,von Bally G,Reichelt R,Mulac D,Humpf HU,Friedrich AW,Kim KS,Karch H,Müthing J

更新日期：2011-03-01 00:00:00

abstract：:Soluble glycoprotein V (sGPV) is a new plasma marker of thrombosis released from the platelet surface by thrombin. sGPV levels are increased in patients with atherothrombotic diseases, but the determinants of sGPV levels are unknown in the general population. Identification of these potential confounding factors is ne...

journal_title：Thrombosis and haemostasis

authors： Aleil B,Meyer N,Wolff V,Kientz D,Wiesel ML,Gachet C,Cazenave JP,Lanza F

更新日期：2006-10-01 00:00:00

abstract：:Binding of the coagulation protease factor VIIa to its receptor Tissue Factor (TF) induces intracellular signals in several cell types including HaCaT keratinocytes. TF belongs to the cytokine receptor family, but is most likely not alone in transferring the complete TF/FVIIa signal over the plasma membrane. The prote...

journal_title：Thrombosis and haemostasis

authors： Wiiger MT,Prydz H

更新日期：2004-07-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute systemic vasculitis causing coronary arterial aneurysms and myocardial infarction in young children. Prominent thrombocytosis with increased megakaryocytes develops during the convalescent period. To clarify the mechanisms of thrombocytosis, we studied serum levels of thrombopoietin (...

journal_title：Thrombosis and haemostasis

authors： Ishiguro A,Ishikita T,Shimbo T,Matsubara K,Baba K,Hayashi Y,Naritaka S,Nakahata T

更新日期：1998-06-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation occurs in vascular obstructive events such as atherosclerosis and restenosis. We previously showed that Notch receptors are induced in smooth muscle cells during vascular remodeling. Our goal was to determine the mechanisms employed by Notch signaling to regulate prolif...

journal_title：Thrombosis and haemostasis

authors： Havrda MC,Johnson MJ,O'Neill CF,Liaw L

更新日期：2006-09-01 00:00:00

abstract：:We compared the Ivy bleeding time method and two alternatives of the Simplate II method (incisions in horizontal and vertical direction) with each other, with regard to the sensitivity, the specificity, the costs and the burden for the patient. In the aspirin study an aspirin-induced bleeding defect was used. Seventy-...

journal_title：Thrombosis and haemostasis

authors： Srámek R,Srámek A,Koster T,Briët E,Rosendaal FR

更新日期：1992-05-04 00:00:00

abstract：:A new method to determine the concentration of free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assa...

journal_title：Thrombosis and haemostasis

authors： Giri TK,Hillarp A,Härdig Y,Zöller B,Dahlbäck B

更新日期：1998-04-01 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The fu...

journal_title：Thrombosis and haemostasis

authors： Dangelmaier C,Manne BK,Liverani E,Jin J,Bray P,Kunapuli SP

更新日期：2014-03-03 00:00:00

abstract：:It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptoma...

journal_title：Thrombosis and haemostasis

authors： Cosmi B,Legnani C,Pengo V,Ghirarduzzi A,Testa S,Poli D,Prisco D,Tripodi A,Palareti G,PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics).

更新日期：2013-03-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a multifactorial disease. Major provoking factors (e. g. surgery, cancer, major trauma, and immobilisation) are identified in 50-60 % of patients, while the remaining cases are classified as unprovoked. However, minor predisposing conditions may be detectable in these patients, possibly...

journal_title：Thrombosis and haemostasis

authors： Riva N,Donadini MP,Ageno W

更新日期：2015-06-01 00:00:00