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Prognostic importance of anaemia in patients with acute pulmonary embolism.

Abstract：

:Although associated with adverse outcomes in other cardiopulmonary diseases, limited evidence exists on the prognostic value of anaemia in patients with acute pulmonary embolism (PE). We sought to examine the associations between anaemia and mortality and length of hospital stay in patients with PE. We evaluated 14,276 patients with a primary diagnosis of PE from 186 hospitals in Pennsylvania, USA. We used random-intercept logistic regression to assess the association between anaemia at the time of presentation and 30-day mortality and discrete-time logistic hazard models to assess the association between anaemia and time to hospital discharge, adjusting for patient (age, gender, race, insurance type, clinical and laboratory variables) and hospital (region, size, teaching status) factors. Anaemia was present in 38.7% of patients at admission. Patients with anaemia had a higher 30-day mortality (13.7% vs. 6.3%; p <0.001) and a longer length of stay (geometric mean, 6.9 vs. 6.6 days; p <0.001) compared to patients without anaemia. In multivariable analyses, anaemia remained associated with an increased odds of death (OR 1.82, 95% CI: 1.60-2.06) and a decreased odds of discharge (OR 0.85, 95% CI: 0.82-0.89). Anaemia is very common in patients presenting with PE and is independently associated with an increased short-term mortality and length of stay.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Donzé J,Labarère J,Méan M,Jiménez D,Aujesky D

doi

10.1160/TH11-04-0208

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

289-95

issue

2

eissn

0340-6245

issn

2567-689X

pii

11-04-0208

journal_volume

106

pub_type

杂志文章,多中心研究

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