当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure. Substudy of the RE-LY trial.

Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure. Substudy of the RE-LY trial.

Abstract：

:In patients with atrial fibrillation (AF) who require interruption of dabigatran or warfarin for an elective surgery/procedure, the risks and benefits of perioperative bridging anticoagulation is uncertain.We accessed the database from RE-LY, a randomised trial comparing dabigatran with warfarin for stroke prevention in AF, to assess the potential benefits and risks of bridging. In patients who had a first interruption of dabigatran or warfarin for an elective surgery/procedure, we compared the risk for major bleeding (MB), stroke or systemic embolism (SSE) and any thromboembolism (TE) in patients who were bridged or not bridged during the period of seven days before until 30 days after surgery/procedure. We used multivariable Cox regression to adjust for potential confounders.Bridging was used more during warfarin interruption than dabigatran interruption (27.5 % vs 15.4 %; p< 0.001). With dabigatran interruption, bridged patients had more MB (6.5 % vs 1.8 %, p< 0.001) than those not bridged but bridged and not bridged groups did not differ for any TE (1.2 % vs 0.6 %, p=0.16) and SSE (0.5 % vs 0.3 %, p=0.46). With warfarin interruption, bridged patients had more MB (6.8 % vs 1.6 %, p< 0.001) and any TE (1.8 % vs 0.3 %, p=0.007) than those not bridged but bridged and not bridged groups did not differ for SSE (0.5 % vs 0.2 %, p=0.321). In conclusion, in patients who interrupted dabigatran or warfarin for a surgery/ procedure in the RE-LY trial, use of bridging anticoagulation appeared to increase the risk for major bleeding irrespective of dabigatran or warfarin interruption.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Douketis JD,Healey JS,Brueckmann M,Eikelboom JW,Ezekowitz MD,Fraessdorf M,Noack H,Oldgren J,Reilly P,Spyropoulos AC,Wallentin L,Connolly SJ

doi

10.1160/TH14-04-0305

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

625-32

issue

3

eissn

0340-6245

issn

2567-689X

pii

14-04-0305

journal_volume

113

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • A plasma clot lysis assay based on the release of fibrin degradation products: application to the diagnosis of hypofibrinolytic states.

    abstract：:Using a monoclonal antibody-based assay, we measured the fibrin degradation product release in the supernatant of plasma clots obtained before and after venous occlusion (VO) in 30 patients with definite or suspected vascular thrombosis (19 definite and 2 suspected deep vein thrombosis, 6 recurrent superficial thrombo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Gaussem P,Gandrille S,Molho-Sabatier P,Capron L,Fiessinger JN,Aiach M

    更新日期：1990-02-19 00:00:00

  • Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.

    abstract：:Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits potent cytoprotective a...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH12-10-0760

    authors： Ding Q,Yang L,Hassanian SM,Rezaie AR

    更新日期：2013-04-01 00:00:00

  • Perioperative management of oral antiplatelet therapy and clinical outcomes in coronary stent patients undergoing surgery. Results of a multicentre registry.

    abstract：:The aim was to investigate the perioperative risk of ischaemic and bleeding events in patients with coronary stents undergoing cardiac and non-cardiac surgery and how these outcomes are affected by the perioperative use of oral antiplatelet therapy. This was a multicentre, retrospective, observational study conducted ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：10.1160/TH14-05-0436

    authors： Rossini R,Musumeci G,Capodanno D,Lettieri C,Limbruno U,Tarantini G,Russo N,Calabria P,Romano M,Inashvili A,Sirbu V,Guagliumi G,Valsecchi O,Senni M,Gavazzi A,Angiolillo DJ

    更新日期：2015-02-01 00:00:00

  • Increased prevalence of hypertension in haemophilia patients.

    abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：10.1160/TH12-05-0313

    authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

    更新日期：2012-10-01 00:00:00

  • Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury.

    abstract：:The transforming growth factor-beta (TGFbeta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGFbeta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH04-05-0324

    authors： Brunner G,Blakytny R

    更新日期：2004-08-01 00:00:00

  • Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala.

    abstract：:We have identified a patient with a dysfunctional prothrombin that we have designated Prothrombin Frankfurt. The proband was characterized by a prothrombin activity level of 13% and 20% compared to normal controls using two different assays with a normal prothrombin antigen level of 91% of normal controls. The genetic...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Degen SJ,McDowell SA,Sparks LM,Scharrer I

    更新日期：1995-02-01 00:00:00

  • ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb.

    abstract：:Among the nine ellagitannins, rugosin E was the most potent platelet aggregating agent with an EC50 of 1.5 +/- 0.1 microM in rabbit platelets and 3.2 +/- 0.1 microM in human platelets. The aggregations caused by rugosin E and ADP were inhibited by EGTA, PGE1, mepacrine, sodium nitroprusside and neomycin, but not by in...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Teng CM,Kang YF,Chang YL,Ko FN,Yang SC,Hsu FL

    更新日期：1997-03-01 00:00:00

  • Animal models of vulnerable plaque. Clinical context and current status.

    abstract：:There is increasing recognition of the importance of vulnerable plaque and acute plaque rupture leading to thrombosis, in the pathogenesis of acute coronary syndromes. This is fueling a number of developments, including novel imaging modalities and potential plaque stabilization therapies. However, to date, no animal ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH03-06-0374

    authors： Lowe HC,Jang IK,Khachigian LM

    更新日期：2003-11-01 00:00:00

  • DDAVP reduces bleeding during continued hirudin administration in the rabbit.

    abstract：:Hirudin is a potent thrombin inhibitor derived from the leech Hirudo medicinalis salivary gland which has considerable potential for therapeutic use in thrombotic disease. The major risk attendant its use is hemorrhage. This study investigates the hypothesis that the prohemostatic effects of DDAVP infusion can curtail...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Bove CM,Casey B,Marder VJ

    更新日期：1996-03-01 00:00:00

  • The increased sensitivity of platelets to prostacyclin in marathon runners.

    abstract：:Platelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners' platelets were much more sensitive to inhibition by prost...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Dix CJ,Hassall DG,Bruckdorfer KR

    更新日期：1984-07-29 00:00:00

  • Recent investigations of the first bleeder family in Aland (Finland) described by von Willebrand.

    abstract：:The still living members of the original bleeder family on the Aland Islands described by von Willebrand in 1926 have been reinvestigated by using modern laboratory techniques for the measurement of the Factor VIII complex and with regard to platelet aggregation. The low level of F VIII : C activity demonstrated in 19...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Nyman D,Eriksson AW,Blombäck M,Frants RR,Wahlberg P

    更新日期：1981-02-23 00:00:00

  • Improvement of walking distance by defibrotide in patients with intermittent claudication--results of a randomized, placebo-controlled study (the DICLIS study). Defibrotide Intermittent CLaudication Italian Study.

    abstract：:Defibrotide is an antithrombotic drug which enhances prostacyclin production and activates fibrinolytic system. The aim of this study was to investigate the improvement of walking distance in patients with intermittent claudication treated with defibrotide. DICLIS was a double blind, placebo-controlled study which inc...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Violi F,Marubini E,Coccheri S,Nenci GG

    更新日期：2000-05-01 00:00:00

  • Residual venous obstruction in patients with a single episode of deep vein thrombosis and in patients with recurrent deep vein thrombosis.

    abstract：:Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a p...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-12-0817

    authors： Galli M,Ageno W,Squizzato A,Dentali F,Manfredi E,Steidl L,Venco A

    更新日期：2005-07-01 00:00:00

  • The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity.

    abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kumar R,Béguin S,Hemker HC

    更新日期：1995-09-01 00:00:00

  • Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor.

    abstract：:Tissue factor-factor VIIa catalysed activation of factor IX is inhibited by the complex of tissue factor pathway inhibitor (TFPI) and factor Xa. At present, no information is available as to what extent the kinetics of complex formation between TFPI and factor Xa during factor X activation contribute to the overall ra...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Lindhout T,Franssen J,Willems G

    更新日期：1995-09-01 00:00:00

  • Is prolonged immobilization a risk factor for symptomatic venous thromboembolism in elderly bedridden patients? Results of a historical-cohort study.

    abstract：:Prolonged immobilization and advanced age are considered to be important risk factors for venous thromboembolism (VTE). Nevertheless, the need for VTE prophylaxis in long-term bedridden patients is not known. To assess whether very prolonged immobilization (i.e. over three months) carries an increased risk for clinica...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-07-0481

    authors： Gatt ME,Paltiel O,Bursztyn M

    更新日期：2004-03-01 00:00:00

  • Lupus anticoagulant testing in Europe: an analysis of results from the first European Concerted Action on Thrombophilia (ECAT) survey using plasmas spiked with monoclonal antibodies against human beta2-glycoprotein I.

    abstract：:Lupus anticoagulants (LA) are immunoglobulins directed to either prothrombin or Beta-2-glycoprotein 1(beta1GPI) bound to phospholipids. Most patients with LA have both beta2GPI- and prothrombin-dependent antibodies. Several recent reports have shown that LA is more strongly associated with thrombosis than anticardioli...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Arnout J,Meijer P,Vermylen J

    更新日期：1999-06-01 00:00:00

  • Bernard-Soulier syndrome with severe bleeding: absent platelet glycoprotein Ib alpha due to a homozygous one-base deletion.

    abstract：:Bernard-Soulier syndrome is a rare congenital platelet disorder that affects a surface membrane adhesion receptor, glycoprotein (GP) Ib-V-IX. Both the genetic defects and the bleeding diatheses associated with the syndrome are heterogeneous due, in part, to the complexity of the involved receptor which consists of fou...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Li C,Pasquale DN,Roth GJ

    更新日期：1996-11-01 00:00:00

  • C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study.

    abstract：:Previous studies have shown an association between serum C-reactive protein (CRP) and cardiovascular disease (CVD) risk. The roles of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) are less well established. The aim of the present study was to analyze the associations of CRP, IL-6 and TNFalpha with in...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH05-08-0571

    authors： Tuomisto K,Jousilahti P,Sundvall J,Pajunen P,Salomaa V

    更新日期：2006-03-01 00:00:00

  • Effect of fibrinogen substitution in afibrinogenemia on hemorheology and platelet function.

    abstract：:Fibrinogen substitution can correct bleeding in afibrinogenemia. We assessed the effect of fibrinogen substitution in a patient lacking immunoreactive fibrinogen. Fibrinogen and thrombin time were not measurable before, but became detectable within 30 min after substitution, parallelled by an increase in ADP-induced p...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Reininger AJ,Reininger CB,Spannagl M,Mellinghoff A,Porr A,Heinzmann U,Wurzinger LJ

    更新日期：1995-09-01 00:00:00

  • The effect of monthly ibandronate on bone mineral density and bone turnover markers in patients with haemophilia A and B and increased risk for fracture.

    abstract：:Haemophilia A and B have been associated with increased prevalence of low bone mineral density (BMD). However, no study has so far evaluated the effects of anti-osteoporotic therapy on BMD in haemophilia.The primary endpoint of this prospective study was to estimate the effect of 12-month therapy of oral ibandronate 1...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章

    doi：10.1160/TH13-01-0030

    authors： Anagnostis P,Vyzantiadis TA,Charizopoulou M,Adamidou F,Karras S,Goulis DG,Karagiannis A,Garipidou V,Vakalopoulou S

    更新日期：2013-08-01 00:00:00

  • Importance of protease inhibition in studies on purified factor VIII (antihaemophilic factor).

    abstract：:According to some authors factor VIII procoagulant activity may be dissociable from carrier protein (MW approximately 2 X 10(6) by agarose gel filtration, e.g. at high ionic strength. We were able to reproduce this phenomenon. However, addition of protease inhibitor (Trasylol) prevented the appearance of low molecular...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Beck EA,Bachmann P,Barbier P,Furlan M

    更新日期：1976-02-29 00:00:00

  • Recommendations for the nomenclature of mutant fibrinolytic genes and their proteins. Report of the SSC Fibrinolysis Subcommittee 1990.

    abstract：:1. Some of the guidelines on the nomenclature for the genotype of bacterial strains can be applied for recommendations on the nomenclature for the description of recombinant mutant fibrinolytic constructs. 2. In view of the usually different size of genomic DNA and corresponding cDNA, it is recommended to employ a dis...

    journal_title：Thrombosis and haemostasis

    pub_type： 指南,杂志文章

    doi：

    authors： Pannekoek H,Lijnen HR,Loskutoff DJ

    更新日期：1990-12-28 00:00:00

  • The APTT monitoring of heparin--the ISTH/ICSH collaborative study.

    abstract：:In an international collaborative study three candidate reference and the local APTT reagent have been tested with lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients to determine whether it was possible to standardize APTT heparin monitoring. The APTT responses of patient...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Van der Velde EA,Poller L

    更新日期：1995-01-01 00:00:00

  • Reliability of a single beta-thromboglobulin measurement in a diabetic population: importance of PGE1 in anticoagulant mixture. Damad Study Group.

    abstract：:During the collection of samples for plasma beta-thromboglobulin (beta-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single beta-TG measurement, blood samples were collected simultaneously from both arms on two separate...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Scarabin PY,Strain L,Ludlam CA,Jones J,Kohner EM

    更新日期：1987-04-07 00:00:00

  • Effects of a snake venom metalloproteinase, triflamp, on platelet aggregation, platelet-neutrophil and neutrophil-neutrophil interactions: involvement of platelet GPIbalpha and neutrophil PSGL-1.

    abstract：:The biologically active components from Viperidae venoms specifically affect cell-matrix interactions, and have been utilized for developing anti-adhesive therapy as anti-thrombotic and anti-angiogenic agents. Utilizing platelet aggregometry coupled with flow cytometry, we found that a metalloproteinase isolated from ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-07-0426

    authors： Tseng YL,Lee CJ,Huang TF

    更新日期：2004-02-01 00:00:00

  • Heparin induced thrombocytopenia: a prospective study.

    abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

    更新日期：1980-02-29 00:00:00

  • On the role of C1-inhibitor as inhibitor of tissue-type plasminogen activator in human plasma.

    abstract：:An enzyme immuno assay was developed to measure complexes of tissue-type plasminogen activator (t-PA) with C1-inhibitor in order to study the role of C1-inhibitor as an inhibitor of t-PA in plasma. In vitro experiments with melanoma and recombinant t-PA learned that purified C1-inhibitor reacts with both single chain ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Huisman LG,van Griensven JM,Kluft C

    更新日期：1995-03-01 00:00:00

  • Increased plasma thrombin-antithrombin III complex levels in non-insulin dependent diabetic patients with albuminuria are reduced by ethyl icosapentatenoate.

    abstract：:Hypercoagulability may increase the risk of cardiovascular disease (CVD) in diabetic patients with albuminuria. Plasma thrombin-anti-thrombin III complex (TAT) levels, representing a functional state of clotting system, were studied in one hundred and fifteen non-insulin-dependent diabetic (NIDDM) patients. The patien...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Shimizu H,Ohtani K,Tanaka Y,Fukatsu A,Uehara Y,Sato N,Mori M

    更新日期：1995-11-01 00:00:00

  • Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets.

    abstract：:Thrombin and other agonists that induce secretion and aggregation in human platelets also activate phospholipase D (PLD), but the signaling cascade leading to activation of PLD in human platelets is not yet clear. We have determined that apyrase, which scavenges ADP secreted during platelet activation, is able to bloc...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Martinson EA,Scheible S,Marx-Grunwitz A,Presek P

    更新日期：1998-12-01 00:00:00