Plasma glycoprotein V levels in the general population: normal distribution, associated parameters and implications for clinical studies.

abstract：:Bleeding and thrombotic disorders are major complications affecting patients with chronic kidney disease (CKD). Exposure of circulating platelets to uraemic toxins and contact with artificial surfaces during dialysis induce platelet abnormalities and alter the platelet proteome. We hypothesised that these changes may ...

journal_title：Thrombosis and haemostasis

authors： Plé H,Maltais M,Corduan A,Rousseau G,Madore F,Provost P

更新日期：2012-10-01 00:00:00

abstract：:Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

journal_title：Thrombosis and haemostasis

authors： Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

更新日期：2003-03-01 00:00:00

abstract：:We report here on a patient whose abnormal fibrin clot was detected via the measurement of clot rigidity with a simple buoyant inner cylinder elastometer. The patient's clinical coagulation studies were all within normal limits except for prolonged thrombin and reptilase clotting times and high level of fibrin split p...

journal_title：Thrombosis and haemostasis

authors： Carr ME Jr,Blatt PM,Roberts HR,Brooker JZ,Hermans J

更新日期：1979-10-31 00:00:00

abstract：:We previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain. As the peptides represent ...

journal_title：Thrombosis and haemostasis

authors： Vanhoorelbeke K,van der Plas RM,Vandecasteele G,Vauterin S,Huizinga EG,Sixma JJ,Deckmyn H

更新日期：2000-10-01 00:00:00

abstract：:Duplex ultrasound is the first-line diagnostic test for detecting lower limb deep-vein thrombosis (DVT) but it is time consuming, requires patient transport, and cannot be interpreted by most physicians. The accuracy of emergency physician-performed ultrasound (EPPU) for the diagnosis of DVT, when performed at the bed...

journal_title：Thrombosis and haemostasis

authors： Pomero F,Dentali F,Borretta V,Bonzini M,Melchio R,Douketis JD,Fenoglio LM

更新日期：2013-01-01 00:00:00

abstract：:Bleeding time and platelet function tests were performed on 31 patients with progressive chronic renal failure (CRF) due to non-immunological (urological) causes, and compared with 22 healthy controls. Patients were classified as mild (plasma creatinine less than 300 mumol/l), moderate (300-600 mumol/l) or severe rena...

journal_title：Thrombosis and haemostasis

authors： Gordge MP,Faint RW,Rylance PB,Neild GH

更新日期：1988-08-30 00:00:00

abstract：:Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involv...

journal_title：Thrombosis and haemostasis

authors： Lethagen S,Isaksson C,Schaedel C,Holmberg L

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Preliminary evidence suggests that use of antipsychotic drugs is associated with an increased risk of venous thromboembolism. OBJECTIVE:To evaluate the relationship between antipsychotic or antidepressant drug use and venous thromboembolism among adults aged 65 years and older. DESIGN:Retrospective cohort ...

journal_title：Thrombosis and haemostasis

authors： Ray JG,Mamdani MM,Yeo EL

更新日期：2002-08-01 00:00:00

abstract：:Tissue factor (TF), the main initiator of blood coagulation, contributes to the manifestation of disseminated intravascular coagulation following septic shock in meningococcal infection. Since a direct relationship between disease severity and lipopolysaccharide (LPS) concentration in the circulation has been shown, w...

journal_title：Thrombosis and haemostasis

authors： Henriksson CE,Klingenberg O,Ovstebø R,Joø GB,Westvik AB,Kierulf P

更新日期：2005-12-01 00:00:00

abstract：:Tissue factor (TF) plays a critical role in tumour growth and metastasis, and its enhanced release into plasma in association with cellular microparticles (MPs) has recently been associated with pathological cancer progression. We have previously demonstrated significantly elevated levels of plasma TF antigen as well ...

journal_title：Thrombosis and haemostasis

authors： Haubold K,Rink M,Spath B,Friedrich M,Chun FK,Marx G,Amirkhosravi A,Francis JL,Bokemeyer C,Eifrig B,Langer F

更新日期：2009-06-01 00:00:00

abstract：:Accurate and precise measurement of plasma D-dimer levels is important in the diagnosis and management of venous thromboembolism. Considerable variability in D-dimer results obtained using different methods has, however, been reported in multicentre studies. This study explored in two separate multicentre exercises th...

journal_title：Thrombosis and haemostasis

authors： Jennings I,Woods TA,Kitchen DP,Kitchen S,Walker ID

更新日期：2007-11-01 00:00:00

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

journal_title：Thrombosis and haemostasis

authors： Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

更新日期：2004-12-01 00:00:00

abstract：:An assay of human antiplasmins has been developed utilizing radial diffusion of plasma from wells cut in plasmin-enriched, fibrinogen-agarose plates. After diffusion the fibrinogen is clotted. Zones of fibrin protected from background fibrinolysis develop as the result of plasma antiplasmin activity. A pooled plasma s...

journal_title：Thrombosis and haemostasis

authors： Andes WA

更新日期：1978-04-30 00:00:00

abstract：:We have devised an improved high pressure liquid chromatographic technique whereby serotonin, nucleosides, cyclic nucleotides, namely cAMP and cGMP, and 5'mono-, 5'di-, and 5'tri-nucleotides can be analyzed. The cyclic nucleotides have been measured in picomolar quantities. All nucleotides can be quantitated in a sing...

journal_title：Thrombosis and haemostasis

authors： D'Souza L,Glueck HI

更新日期：1977-12-15 00:00:00

abstract：:The molecular basis of Factor V deficiency has been defined in few patients only. We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. This substitution results in the replacement of an arginine (R) by a histidine (H) in amino acid position 2074, lo...

journal_title：Thrombosis and haemostasis

authors： Schrijver I,Houissa-Kastally R,Jones CD,Garcia KC,Zehnder JL

更新日期：2002-02-01 00:00:00

abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

journal_title：Thrombosis and haemostasis

authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

更新日期：2013-04-01 00:00:00

abstract：:Platelet-rich clots are inefficiently lysed by current fibrinolytic agents. Platelets contain a great deal of plasminogen activator inhibitor 1 (PAI-1), the principal endogenous inhibitor of tissue-type plasminogen activator (t-PA). We have tested whether PAI-1 resistant t-PAs would be more effective thrombolytic agen...

journal_title：Thrombosis and haemostasis

authors： Shohet RV,Spitzer S,Madison EL,Bassel-Duby R,Gething MJ,Sambrook JF

更新日期：1994-01-01 00:00:00

abstract：:Paired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1...

journal_title：Thrombosis and haemostasis

authors： Jones CR,McCabe R,Hamilton CA,Reid JL

更新日期：1985-02-18 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:Adhesion to collagen was investigated as a function of platelet age in rat platelets. Platelet adherence was measured using EDTA-containing platelet- rich plasma which was added to preparations of collagen fibers clamped between magnetic stirrers by recording changes in light transmission. The plot of light transmissi...

journal_title：Thrombosis and haemostasis

authors： Castellan RM,Steiner M

更新日期：1976-11-30 00:00:00

abstract：:Severe inflammatory complications are a potential consequence in patients with predetermined conditions of infections, pulmonary diseases, or cardiovascular disorders. Notably, the amplitude of the inflammatory response towards these complications can dictate the disease progression and outcome. During the recent year...

journal_title：Thrombosis and haemostasis

authors： Preissner KT,Herwald H

更新日期：2017-06-27 00:00:00

abstract：:This study was undertaken to appraise the application of those reagents most widely used in the UK for the detection and confirmation of lupus anticoagulant (LA) on an Amelung KC4A and a Sysmex CA-6000 coagulometer. Five sets of dilute Russell's viper venom time (DRVVT) reagents were assessed as well as the Textarin-P...

journal_title：Thrombosis and haemostasis

authors： Lawrie AS,Mackie IJ,Purdy G,Machin SJ

更新日期：1999-05-01 00:00:00

abstract：:Compelling evidence suggests that the risk of pulmonary embolism (PE) and deep-vein thrombosis (DVT) persists after hospital discharge in acutely-ill medical patients. However, no studies consistently supported the routine use of extended-duration thromboprophylaxis (ET) in this setting. We performed a meta-analysis t...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Mumoli N,Prisco D,Fontanella A,Di Minno MN

更新日期：2017-02-28 00:00:00

abstract：:The availability of mice with tissue-specific expression of recombinase Cre is the limiting step for a successful gene targeting by the Cre-LoxP methodology. This work aimed at generating transgenic mice with restricted expression of recombinase Cre in megakaryocytes and platelets, driven by the promoter of the αIIb g...

journal_title：Thrombosis and haemostasis

authors： Nowakowski A,Alonso-Martín S,Arias-Salgado EG,Fernández D,Vilar M,Ayuso MS,Parrilla R

更新日期：2011-01-01 00:00:00

abstract：:We studied a murine monoclonal antibody (211 A6) to von Willebrand factor (vWF) with a view to investigating structure-relationship of plasma vWF. The specificity of this antibody has been substantiated by ELISA tests and indirect immunofluorescence. It reacts with purified vWF, normal plasma but not with plasma or pl...

journal_title：Thrombosis and haemostasis

authors： Jorieux S,de Romeuf C,Samor B,Goudemand M,Mazurier C

更新日期：1987-06-03 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00

abstract：:Acid-treated human plasma is a competitive inhibitor of the hydrolysis of D-Val-Leu-Lys-Nan (S-2251) by plasmin. The rate of hydrolysis is decreased to 50% by 750 fold diluted acidified normal plasma and by 60 fold diluted acidified alpha 2-antiplasmin depleted plasma (alpha 2-antiplasmin concentration less than 2%). ...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maes M,Castel M,Samama M,Collen D

更新日期：1982-12-27 00:00:00

abstract：:We have developed a simple assay that measures the circulating activated protein C (APC) in plasma. The assay requires collection of duplicate blood samples, one in citrate plus heparin and the other in citrate plus inhibitors of the enzyme. In the heparin tube, APC reacts completely and irreversibly with its major pl...

journal_title：Thrombosis and haemostasis

authors： Espana F,Zuazu I,Vicente V,Estellés A,Marco P,Aznar J

更新日期：1996-01-01 00:00:00

abstract：:A recent report indicated that an arrow poison used by the native Indians of Rondonia, Brazil, to kill small animals was associated with profuse bleeding. The arrow poison was prepared from the bark of a tree, known locally as Tike-Uba. We have obtained bark and sap specimens from this tree and have characterized a po...

journal_title：Thrombosis and haemostasis

authors： Jacobs JW,Petroski C,Friedman PA,Simpson E

更新日期：1990-02-19 00:00:00