当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Efficacy and safety of extended thromboprophylaxis for medically ill patients. A meta-analysis of randomised controlled trials.

Efficacy and safety of extended thromboprophylaxis for medically ill patients. A meta-analysis of randomised controlled trials.

Abstract：

:Compelling evidence suggests that the risk of pulmonary embolism (PE) and deep-vein thrombosis (DVT) persists after hospital discharge in acutely-ill medical patients. However, no studies consistently supported the routine use of extended-duration thromboprophylaxis (ET) in this setting. We performed a meta-analysis to assess efficacy and safety of ET in acutely-ill medical patients. Efficacy outcome was defined by the prevention of symptomatic DVT, PE, venous thromboembolism (VTE) and VTE-related mortality. Safety outcome was the occurrence of major bleeding (MB) and fatal bleeding (FB). Pooled odds ratios (ORs) and 95 % confidence intervals (95 %CI) were calculated for each outcome using a random effects model. Four RCTs for a total of 28,105 acutely-ill medical patients were included. ET was associated with a significantly lower risk of DVT (0.3 % vs 0.6 %, OR 0.504, 95 %CI: 0.287-0.885) and VTE (0.5 % vs 1.0 %, OR: 0.544, 95 %CI: 0.297-0.997); a non-significantly lower risk of PE (0.3 % vs 0.4 %, OR 0.633, 95 %CI: 0.388-1.034) and of VTE-related mortality (0.2 % vs 0.3 %, OR 0.687, 95 %CI: 0.445-1.059) and with a significantly higher risk of MB (0.8 % vs 0.4 %, OR 2.095, 95 %CI: 1.333-3.295). No difference in FB was found (0.06 % vs 0.03 %, OR 1.79, 95 %CI: 0.384-8.325). The risk benefit analysis showed that the NNT for DVT was 339, for VTE was 239, and the NNH for MB was 247. Results of our meta-analyses focused on clinical important outcomes did not support a general use of antithrombotic prophylaxis beyond the period of hospitalization in acutely-ill medical patients.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Dentali F,Mumoli N,Prisco D,Fontanella A,Di Minno MN

doi

10.1160/TH16-08-0595

subject

Has Abstract

pub_date

2017-02-28 00:00:00

pages

606-617

issue

3

eissn

0340-6245

issn

2567-689X

pii

16-08-0595

journal_volume

117

pub_type

杂志文章,meta分析

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.

    abstract：:Emicizumab, a humanised bispecific antibody recognising factors (F) IX/IXa and X/Xa, can accelerate FIXa-catalysed FX activation by bridging FIXa and FX in a manner similar to FVIIIa. However, details of the emicizumab-antigen interactions have not been reported so far. In this study, we first showed by surface plasmo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-01-0030

    authors： Kitazawa T,Esaki K,Tachibana T,Ishii S,Soeda T,Muto A,Kawabe Y,Igawa T,Tsunoda H,Nogami K,Shima M,Hattori K

    更新日期：2017-06-28 00:00:00

  • Growth hormone deficiency impairs blood clotting and reduces factor VII coagulant activity in rat.

    abstract：:To investigate pituitary effects on the vitamin K-dependent coagulation factors, female rats were hypophysectomized (hypox) and treated with growth hormone (GH), cortisone, thyroxine, vitamin K, or saline. After 11 days of treatment, the prothrombin time, platelet count, and factors II, VII, IX, and X were determined....

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Sävendahl LS,Grankvist K,Engström KG

    更新日期：1995-04-01 00:00:00

  • Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells.

    abstract：:The cellular phospholipid, lysophosphatidic acid (LPA), released by activated platelets and fibroblasts or, at high levels, from ovarian and cervical carcinomas is a powerful serum mitogen that may modulate several signaling pathways in endothelial cells (EC). Hence, LPA could function in a paracrine manner during EC-...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Palmetshofer A,Robson SC,Nehls V

    更新日期：1999-11-01 00:00:00

  • Association between anti-apolipoprotein A-1 antibodies and cardiovascular disease in the general population. Results from the CoLaus study.

    abstract：:We aimed to determine the association between autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) and prevalent cardiovascular (CV) disease (CVD) as well as markers of CV risk in the general population. Cross-sectional data were obtained from 6649 subjects (age 52.6 ± 10.7 years, 47.4 % male) of the population...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-03-0248

    authors： Antiochos P,Marques-Vidal P,Virzi J,Pagano S,Satta N,Bastardot F,Hartley O,Montecucco F,Mach F,Waeber G,Vollenweider P,Vuilleumier N

    更新日期：2016-09-27 00:00:00

  • A comparative study of prothrombin complex concentrates and fresh-frozen plasma for warfarin reversal under static and flow conditions.

    abstract：:Prothrombin complex concentrates (PCCs) and fresh-frozen plasma (FFP) have been clinically used for acute warfarin reversal. The recovery of prothrombin time (PT) or international normalised ratio (INR) is often reported as an endpoint, but haemostatic efficacies of PCCs and FFP may not be fully reflected in static cl...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH11-04-0240

    authors： Ogawa S,Szlam F,Ohnishi T,Molinaro RJ,Hosokawa K,Tanaka KA

    更新日期：2011-12-01 00:00:00

  • The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer.

    abstract：:The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years w...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH13-08-0632

    authors： Baranyai Z,Krzystanek M,Jósa V,Dede K,Agoston E,Szász AM,Sinkó D,Szarvas V,Salamon F,Eklund AC,Szállási Z,Jakab F

    更新日期：2014-03-03 00:00:00

  • Fibrinogen Milano II: a congenital dysfibrinogenaemia associated with juvenile arterial and venous thrombosis.

    abstract：:A congenitally abnormal fibrinogen was isolated from blood of a young man with deep-vein thrombosis. Two other affected members of his family had three episodes of severe arterial thrombosis. The fibrinogen showed a delayed clotting by thrombin, but a normal clotting by Arvin, Reptilase, and prothrombin-staphylocoagul...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Haverkate F,Koopman J,Kluft C,D'Angelo A,Cattaneo M,Mannucci PM

    更新日期：1986-02-28 00:00:00

  • Reduced Plasma Magnesium Levels in Type-1 Diabetes Associate with Prothrombotic Changes in Fibrin Clotting and Fibrinolysis.

    abstract：:Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0039-3402808

    authors： Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

    更新日期：2020-02-01 00:00:00

  • Platelet survival in patients with dilated cardiomyopathy.

    abstract：:Dilated cardiomyopathy is associated with thromboembolic complications, which correlate poorly, however, with a visible left ventricular thrombus. Therefore, this study was performed to assess whether an abnormality of platelet function in vivo can be detected in patients with dilated cardiomyopathy. Platelet survival...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Weidinger F,Glogar D,Sochor H,Sinzinger H

    更新日期：1991-10-01 00:00:00

  • Transcriptional and posttranscriptional regulation of the plasminogen activator system.

    abstract：:The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH04-12-0814

    authors： Nagamine Y,Medcalf RL,Muñoz-Cánoves P

    更新日期：2005-04-01 00:00:00

  • Purification of a fibrinolysis inhibitor in serum from post-traumatic patients.

    abstract：:A fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also foun...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Bagge L,Björk I,Saldeen T,Wallin R

    更新日期：1978-02-28 00:00:00

  • Localization of tissue thromboplastin in the human brain.

    abstract：:Monospecific antisera against the purified protein component of tissue thromboplastin (apoprotein-III) from human brain have been raised in goats and rabbits. The antisera neutralized tissue thromboplastin prepared from brain, thyroid gland and pulmonary tissue, indicating that apoproteins in the various preparations ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Bjorklid E,Storm-Mathisen J,Storm E,Prydz H

    更新日期：1977-02-28 00:00:00

  • The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity.

    abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kumar R,Béguin S,Hemker HC

    更新日期：1995-09-01 00:00:00

  • Regulation of the tissue factor gene.

    abstract：:Tissue factor is a cellular receptor that initiates blood coagulation. The TF gene is constitutively expressed in some extravascular cell types and is inducibly expressed in several vascular cell types, including monocytes, vascular endothelial cells and vascular smooth muscle cells. Functional studies indicate that S...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Mackman N

    更新日期：1997-07-01 00:00:00

  • A sensitive immunochemical assay for measuring the concentration of the activated protein C-protein C inhibitor complex in plasma: use of a catcher antibody specific for the complexed/cleaved form of the inhibitor.

    abstract：:Activated protein C (APC) is a serine proteinase that regulates blood coagulation. In plasma it is inhibited mainly by the protein C inhibitor (PCI). The plasma concentrations of APC-PCI complex is increased in hypercoagulative states such as deep venous thrombosis. Formation of the APC-PCI complex induces a drastic c...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Strandberg K,Kjellberg M,Knebel R,Lilja H,Stenflo J

    更新日期：2001-08-01 00:00:00

  • The platelet adhesion capacity to subendothelial matrix and collagen in a flow model during storage of platelet concentrates for 7 days.

    abstract：:The influence of storage of platelet concentrates (PC) on the adhesion capacity of platelets was studied. Twenty-four PC, 12 prepared by the buffy coat (BC) method and 12 by the platelet-rich plasma (PRP) method, were stored for 7 days at room temperature. On days 1, 3 and 7 of storage, the platelet adhesion capacity ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Boomgaard MN,Gouwerok CW,Homburg CH,de Groot G,IJsseldijk MJ,de Korte D

    更新日期：1994-10-01 00:00:00

  • Multicenter comparison of von Willebrand factor multimer sizing techniques. Report of the Factor VIII and von Willebrand Factor Subcommittee.

    abstract：:A multicenter study of various types of von Willebrand's disease (vWD) was conducted in order to compare the different electrophoretic techniques used to evaluate von Willebrand factor multimers in plasma. Seven laboratories participated in the blind study of eight plasma samples from two healthy subjects and six vWD ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Mannucci PM,Abildgaard CF,Gralnick HR,Hill FG,Hoyer LW,Lombardi R,Nilsson IM,Tuddenham E,Meyer D

    更新日期：1985-12-17 00:00:00

  • Risk stratification and heparin prophylaxis to prevent venous thromboembolism in pregnant women.

    abstract：:Women with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk of thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because of limited trial data. A strategy of risk assessment and heparin prophylaxis was evaluated in pregn...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1160/th07-05-0329

    authors： Bauersachs RM,Dudenhausen J,Faridi A,Fischer T,Fung S,Geisen U,Harenberg J,Herchenhan E,Keller F,Kemkes-Matthes B,Schinzel H,Spannagl M,Thaler CJ,EThIG Investigators.

    更新日期：2007-12-01 00:00:00

  • Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study.

    abstract：:Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17β-estradiol (E2). The study objective was to co...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,随机对照试验

    doi：10.1160/TH10-05-0327

    authors： Gaussem P,Alhenc-Gelas M,Thomas JL,Bachelot-Loza C,Remones V,Ali FD,Aiach M,Scarabin PY

    更新日期：2011-03-01 00:00:00

  • CT-ADP Point-of-Care Assay Predicts 30-Day Paravalvular Aortic Regurgitation and Bleeding Events following Transcatheter Aortic Valve Replacement.

    abstract：BACKGROUND:Paravalvular aortic regurgitation (PVAR) remains a frequent postprocedural concern following transcatheter aortic valve replacement (TAVR). Persistence of flow turbulence results in the cleavage of high-molecular-weight von Willebrand multimers, primary haemostasis dysfunction and may favour bleedings. Recen...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1639352

    authors： Kibler M,Marchandot B,Messas N,Caspar T,Vincent F,Von Hunolstein JJ,Grunebaum L,Reydel A,Rauch A,Crimizade U,Kindo M,Hoang Minh T,Trinh A,Petit-Eisenmann H,De Poli F,Leddet P,Jesel L,Ohlmann P,Susen S,Van Belle E,

    更新日期：2018-05-01 00:00:00

  • Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis.

    abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1676794

    authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

    更新日期：2019-03-01 00:00:00

  • Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms. Relationship to clinical risk factors.

    abstract：:Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH12-05-0339

    authors： Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

    更新日期：2012-11-01 00:00:00

  • Thrombospondin levels in patients with malignancy.

    abstract：:Thrombospondin (TSP), a large glycoprotein present in platelets, and various normal and tumor tissues, has recently been shown to promote cell adhesion and platelet aggregation. Most importantly because TSP has been shown to promote metastasis of melanoma tumor cells to the lung in a murine model (1) and since thrombo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Tuszynski GP,Smith M,Rothman VL,Capuzzi DM,Joseph RR,Katz J,Besa EC,Treat J,Switalska HI

    更新日期：1992-06-01 00:00:00

  • Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford.

    abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

    更新日期：1999-09-01 00:00:00

  • Thrombophilic risk factors and peripheral arterial disease severity.

    abstract：:Few data are available on thrombophilic risk factors and progression of atherosclerotic peripheral arterial disease (PAD). Thrombophilic alterations can be an aggravating factor when arterial stenoses are present. In a cross-sectional study, we evaluated the presence of the thrombophilic factors fibrinogen, homocystei...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-11-0772

    authors： Sartori M,Favaretto E,Legnani C,Cini M,Conti E,Amato A,Palareti G

    更新日期：2010-07-01 00:00:00

  • Immunoelectrophoretic analysis of membrane glycoproteins in cultured human endothelial cells.

    abstract：:Human endothelial cells isolated from umbilical cords were solubilized in Triton X-100 and examined by crossed immunoelectrophoresis using rabbit antiserum against endothelial cells. Endogenous labelling of the endothelial cell proteins with 14C-mannose followed by crossed immunoelectrophoresis and autoradiography rev...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Børsum T

    更新日期：1990-04-12 00:00:00

  • Studies of alpha-granule proteins in cultured human megakaryocytes.

    abstract：:alpha-Granule protein storage is important for producing platelets with normal haemostatic function. The low to undetectable levels of several megakaryocyte-synthesized alpha-granule proteins in normal plasma suggest megakaryocytes are important to sequester these proteins in vivo. alpha-Granule protein storage in vit...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-02-0125

    authors： Veljkovic DK,Cramer EM,Alimardani G,Fichelson S,Massé JM,Hayward CP

    更新日期：2003-11-01 00:00:00

  • Obstacles and options in the quest for drug candidates against vascular disease.

    abstract：:The difficulties in cardiovascular drug development have been exposed by recent clinical trials, which have uncovered various limitations of promising drug candidates. Yet, the imperative to improve medical treatment of atherosclerosis in aging populations afflicted by metabolic disease remains unbroken. Herein altern...

    journal_title：Thrombosis and haemostasis

    pub_type： 社论

    doi：10.1160/TH10-04-0256

    authors： Weber C

    更新日期：2010-07-01 00:00:00

  • Response variability to aspirin as assessed by the platelet function analyzer (PFA)-100. A systematic review.

    abstract：:It was the aim of the present study to perform a systematic review of the published studies that estimated the prevalence of non-responders to aspirin, as assessed by the closure time of PFA-100, a point-of-care device, and to analyse: 1) some major clinical and methodological factors that can influence it and 2) its ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH07-08-0530

    authors： Crescente M,Di Castelnuovo A,Iacoviello L,Vermylen J,Cerletti C,de Gaetano G

    更新日期：2008-01-01 00:00:00

  • Mediators of induction of augmented expression of plasminogen activator inhibitor type-1 in Hep G2 cells by platelets.

    abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is a physiologic modulator of the fibrinolytic system. We have shown previously that PAI-1 biosynthesis in cultured cells depends on several factors in serum. Because platelets are richly endowed with specific growth factors and because the release reaction is an integral...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Hopkins WE,Westerhausen DR,Fujii S,Billadello JJ,Sobel BE

    更新日期：1991-08-01 00:00:00