Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford.

abstract：:Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the if vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topic...

journal_title：Thrombosis and haemostasis

authors： Mussoni L,Sironi L,Tedeschi L,Calvio AM,Colli S,Tremoli E

更新日期：2001-11-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

journal_title：Thrombosis and haemostasis

authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

更新日期：2017-12-01 00:00:00

abstract：:Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is an endothelial protein that is secreted to the c...

journal_title：Thrombosis and haemostasis

authors： de Jong A,Dirven RJ,Boender J,Atiq F,Anvar SY,Leebeek FWG,van Vlijmen BJM,Eikenboom J

更新日期：2020-11-01 00:00:00

abstract：:Recurrent joint bleeding is the most common manifestation of haemophilia resulting in haemophilic arthropathy (HA). The exact pathophysiology is unknown, but it is suggested that arthropathy is stimulated by liberation of fibrinolytic activators from the synovium during haemarthrosis. The aim of this study was to test...

journal_title：Thrombosis and haemostasis

authors： Nieuwenhuizen L,Roosendaal G,Coeleveld K,Lubberts E,Biesma DH,Lafeber FP,Schutgens RE

更新日期：2013-07-01 00:00:00

abstract：:The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003...

journal_title：Thrombosis and haemostasis

authors： Kenet G,Waldman D,Lubetsky A,Kornbrut N,Khalil A,Koren A,Wolach B,Fattal A,Kapelushnik J,Tamary H,Yacobovitch J,Raveh E,Revel-Vilk S,Toren A,Brenner B

更新日期：2004-10-01 00:00:00

abstract：:Interactions between proteins and heparin(-like) structures involve electrostatic forces and structural features. Based on charge distributions in the linear sequence of protein C inhibitor (PCI), two positively charged regions of PCI were proposed as possible candidates for this interaction. The first region, the A+ ...

journal_title：Thrombosis and haemostasis

authors： Elisen MG,Maseland MH,Church FC,Bouma BN,Meijers JC

更新日期：1996-05-01 00:00:00

abstract：:Samples of blood for estimation of beta-thromboglobulin (B.T.G.) in normal subjects have been obtained both from blood donors at the end of their donation and from other volunteers by standard venepuncture. The former was a satisfactory method in males only. By standard venepuncture females have on average lower value...

journal_title：Thrombosis and haemostasis

authors： Dewar HA,Marshall T,Weightman D,Prakash V,Boon PJ

更新日期：1979-12-21 00:00:00

abstract：:The functional activity and active site of plasmin in full-term newborns have been studied and compared to those in adults in order to investigate the nature of the abnormality found in newborn plasminogen described in a previous paper. The functional activity of newborn plasminogen measured on chromogenic substrate w...

journal_title：Thrombosis and haemostasis

authors： Benavent A,Estellés A,Aznar J,Martinez-Sales V,Gilabert J,Fornas E

更新日期：1984-02-28 00:00:00

abstract：:The 50 laboratories of the Netherlands Federation of Thrombosis Services, covering a population of 9 million and responsible for the laboratory control of approximately 150,000 patients under oral anticoagulation, have participated since 1974 in a voluntary external and internal quality control program. The external p...

journal_title：Thrombosis and haemostasis

authors： van Dijk-Wierda CA,Hermans J,Loeliger EA,Roos J

更新日期：1977-06-30 00:00:00

abstract：:Cysteinyl leukotrienes (i.e. LTC4, LTD4), produced by activated leukocytes or by transcellular metabolism may act at different levels on vascular smooth muscle cells (VSMC) during inflammatory process or atherosclerosis. We studied the effect of LTC4, LTD4, and LTE4 on the in vitro proliferation of rat VSMC, measured ...

journal_title：Thrombosis and haemostasis

authors： Porreca E,Di Febbo C,Di Sciullo A,Angelucci D,Nasuti M,Vitullo P,Reale M,Conti P,Cuccurullo F,Poggi A

更新日期：1996-07-01 00:00:00

abstract：:Heparin and low-molecular-weight heparin (LMWH) are commonly monitored by determination of activated clotting times or chromogenic assays. Despite their wide use, these assays determine the biological activity and not the concentration of the anticoagulants. They may be inaccurate in some circumstances such as certain...

journal_title：Thrombosis and haemostasis

authors： Szelke H,Harenberg J,Krämer R

更新日期：2009-11-01 00:00:00

abstract：:The behavior of 125I-labeled recombinant hirudin towards the uninjured and de-endothelialized rabbit aorta wall has been studied in vitro and in vivo to determine its usefulness as an indicator of thrombin activity associated with the aorta wall. Thrombin adsorbed to either sulfopropyl-Sephadex or heparin-Sepharose bo...

journal_title：Thrombosis and haemostasis

authors： Hatton MW,Ross-Ouellet B

更新日期：1994-04-01 00:00:00

abstract：:A new immunoadsorbent-amidolytic assay (IAA) for the specific differential detection of two-chain urokinase-type plasminogen activator (tcu-PA) and its single-chain precursor (scu-PA) in cell culture supernatants has been developed. The assay combines the selectivity of immunoassays with the specificity of enzyme acti...

journal_title：Thrombosis and haemostasis

authors： Corti A,Nolli ML,Cassani G

更新日期：1986-12-15 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:The difficulties in cardiovascular drug development have been exposed by recent clinical trials, which have uncovered various limitations of promising drug candidates. Yet, the imperative to improve medical treatment of atherosclerosis in aging populations afflicted by metabolic disease remains unbroken. Herein altern...

journal_title：Thrombosis and haemostasis

authors： Weber C

更新日期：2010-07-01 00:00:00

abstract：:The effects of mental stress (a colour word conflict test, CWT) and adrenaline infusions (0.1 and 0.4 nmol kg-1 min-1) on t-PA activity, t-PA antigen, PAI-1 activity and PAI-1 antigen were studied in 18 healthy male volunteers. Furthermore, the effects of metoprolol (200 mg/day during 1 week) or placebo (double-blind ...

journal_title：Thrombosis and haemostasis

authors： Larsson PT,Wiman B,Olsson G,Angelin B,Hjemdahl P

更新日期：1990-06-28 00:00:00

abstract：:The vast majority of thrombin (>95%) is generated after clotting is completed, suggesting that thrombin formation serves purposes beyond coagulation, such as tissue repair after vessel injury. Two types of vascular thrombin binding sites exist: protease-activated receptors (PARs) and thrombomodulin (TM). Their express...

journal_title：Thrombosis and haemostasis

authors： Schrör K,Bretschneider E,Fischer K,Fischer JW,Pape R,Rauch BH,Rosenkranz AC,Weber AA

更新日期：2010-05-01 00:00:00

abstract：:Vascular cell adhesion molecule 1 (VCAM-1, CD106) is expressed as a type I transmembrane integrin counter-receptor on activated endothelium and mediates white blood cell attachment. The alternatively spliced 7-domain (7d) form of VCAM-1 contains a potential thrombin cleavage site. Thrombin proteolysis of 7d-VCAM-1 may...

journal_title：Thrombosis and haemostasis

authors： Barthel SR,Johansson MW,Annis DS,Mosher DF

更新日期：2006-05-01 00:00:00

abstract：:To identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two dinucleotide repeat polymorphisms were studied. In 519 Caucasian diabetic subject...

journal_title：Thrombosis and haemostasis

authors： Mansfield MW,Stickland MH,Carter AM,Grant PJ

更新日期：1994-06-01 00:00:00

abstract：:There is no patient-reported medication adherence measure that has been validated in Singapore. This study aimed to validate the 8-item Morisky Medication Adherence Scale (MMAS) in patients taking warfarin in Singapore. A cross-sectional survey was conducted in a convenience sample of 151 patients taking warfarin at a...

journal_title：Thrombosis and haemostasis

authors： Wang Y,Kong MC,Ko Y

更新日期：2012-10-01 00:00:00

abstract：:Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, t...

journal_title：Thrombosis and haemostasis

authors： Nurden AT

更新日期：2011-05-01 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:Although there is considerable evidence that platelet activation is associated with polymerization of actin, it is not known whether there is some pre-existing F-actin even before activation. We have examined the state of actin polymerization in nonactivated platelets by deoxyribonuclease assay of G-actin and total ac...

journal_title：Thrombosis and haemostasis

authors： Davies GE,Palek J

更新日期：1982-10-29 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and paraoxonase 1 (PON1) are directly involved in the pathogenesis of atherosclerosis by modulation of oxidative stress and/or NO bioavailability. We aimed to assess whether endurance exercise which is known to be cardioprotective could beneficially affect thes...

journal_title：Thrombosis and haemostasis

authors： Richter B,Niessner A,Penka M,Grdić M,Steiner S,Strasser B,Ziegler S,Zorn G,Maurer G,Simeon-Rudolf V,Wojta J,Huber K

更新日期：2005-12-01 00:00:00

abstract：:The effect of supernatant from phorbol myristate acetate (PMA) stimulated human polymorphonuclear granulocytes (PMN) on human factor VII was studied in vitro. The supernatant caused a rapid loss in factor VII coagulant activity by the action of human leukocyte elastase (HLE) and cathepsin G in the supernatant, as demo...

journal_title：Thrombosis and haemostasis

authors： Anderssen T,Halvorsen H,Bajaj SP,Osterud B

更新日期：1993-09-01 00:00:00

abstract：:ADAMTS13 dysfunction has been involved in the pathogenesis of Thrombotic Thrombocytopenic Purpura. This disorder occurs more frequently in women and, in 13% of them, is associated with pregnancy. However, there is little information on the protease behaviour in normal pregnancy. We studied von Willebrand factor and AD...

journal_title：Thrombosis and haemostasis

authors： Sánchez-Luceros A,Farías CE,Amaral MM,Kempfer AC,Votta R,Marchese C,Salviú MJ,Woods AI,Meschengieser SS,Lazzari MA

更新日期：2004-12-01 00:00:00

abstract：:We investigated the protective effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against two kinds of experimental disseminated intravascular coagulation (DIC) in rats. Endotoxin-induced experimental DIC was induced by a 4-h sustained infusion of endotoxin at a dose of 100 m...

journal_title：Thrombosis and haemostasis

authors： Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T

更新日期：1994-09-01 00:00:00

abstract：:We have investigated the effect of a new Leu196Pro mutation, identified in the MIDAS-like domain of the beta3 integrin subunit in a patient with type II Glanzmann thrombasthenia, on beta3 integrin receptor function. Expression of the mutant beta3Pro196 subunit in CHO cells, either associated with recombinant human alp...

journal_title：Thrombosis and haemostasis

authors： Morel-Kopp MC,Melchior C,Chen P,Ammerlaan W,Lecompte T,Kaplan C,Kieffer N

更新日期：2001-12-01 00:00:00

abstract：:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy v...

journal_title：Thrombosis and haemostasis

authors： Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CR

更新日期：1989-04-25 00:00:00

abstract：:Using gain-of-function factor IX (FIX) for replacement therapy for haemophilia B (HB) is an attractive strategy. We previously reported a high-activity FIX, FIX-Triple (FIX-V86A/E277A/R338A) as a good substitute for FIX-WT (wild-type) in protein replacement therapy, gene therapy, and cell therapy. Here we generated a ...

journal_title：Thrombosis and haemostasis

authors： Kao CY,Yang SJ,Tao MH,Jeng YM,Yu IS,Lin SW

更新日期：2013-08-01 00:00:00