Abstract：
:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy volunteers were infused with saline for 30 min followed by aVP for 1 hour and blood samples taken every 30 min for measurement of aVP, ECLT, tissue-type plasminogen activator (t-PA), t-PA inhibition (tPA-I), plasminogen activator inhibitor 1 (PAI-1 Ag), activated partial thromboplastin time (APTT), fibrinopeptide A (FPA), fibrinopeptide B 15-42 (FPB beta 15-42) and cross-linked fibrin breakdown products (XL-FDP). Plasma aVP rose to a median of 75 pg/ml after 90 min and fell to 13.8 pg/ml 30 min later. The APTT fell from 43.5 to 35 sec (p less than 0.01) but there was no change in plasma FPA or in XL-FDP. Plasminogen activator activity (10(6)/ECLT2) increased from 25 to 736 units (p less than 0.01) and t-PA from 200 to 1012 mIU/ml (p less than 0.01). tPA-I fell from 8.0 to 2.7 IU/ml at 90 min (p less than 0.05) but PAI-1 Ag remained unchanged. Plasma FPB beta 15-42 was 2.4 and 1.2 pmol/ml before infusion with aVP and showed a small rise to 3.5 pmol/ml after 60 min (p less than 0.05). The results show the effects of aVP on fibrinolysis are mediated by an increase in t-PA. In the absence of thrombin generation the rise in t-PA was not accompanied by changes in XL-FDP.
journal_name
Thromb Haemostjournal_title
Thrombosis and haemostasisauthors
Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CRsubject
Has Abstractpub_date
1989-04-25 00:00:00pages
298-300issue
2eissn
0340-6245issn
2567-689Xjournal_volume
61pub_type
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journal_title：Thrombosis and haemostasis
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doi：10.1160/TH16-01-0051
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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更新日期：1983-04-28 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1989-02-28 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1979-06-30 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1984-10-31 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Thrombosis and haemostasis
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doi：
更新日期：2007-05-01 00:00:00
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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更新日期：2001-01-01 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1987-02-03 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
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更新日期：1982-10-29 00:00:00
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journal_title：Thrombosis and haemostasis
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