Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins.

abstract：:It is now recognised that acute myocardial infarction results from the rupture of atherosclerotic plaques. Lymphocytes and macrophages, which infiltrate rupture sites, contribute to plaque degradation by expressing urokinase (u-PA) bound to cell membrane by urokinase receptor (u-PAR) and by secreting metalloproteinase...

journal_title：Thrombosis and haemostasis

authors： Ganné F,Vasse M,Beaudeux JL,Peynet J,François A,Mishal Z,Chartier A,Tobelem G,Vannier JP,Soria J,Soria C

更新日期：2000-10-01 00:00:00

abstract：:Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is requ...

journal_title：Thrombosis and haemostasis

authors： Mühle C,Schulz-Drost S,Khrenov AV,Saenko EL,Klinge J,Schneider H

更新日期：2004-03-01 00:00:00

abstract：:Tissue thromboplastin apoprotein was partially purified from human brain. The apoprotein was recombined with mixed phospholipids to yield active thromboplastin. The recombined thromboplastin induced proteolytic activation of isolated human factor IX in the presence of factor VII and Ca2+. The clotting times of various...

journal_title：Thrombosis and haemostasis

authors： van den Besselaar AM,Ram IE,Alderkamp GH,Bertina RM

更新日期：1982-08-24 00:00:00

abstract：:There are conflicting views on the effects of age, gene source and familial severity on levels of factor VIII in carriers of haemophilia. Different workers have found that factor VIII increases with age, is higher in paternal carriers, and is higher in carriers from families with more severe haemophilia. Other workers...

journal_title：Thrombosis and haemostasis

authors： Duncan BM,Tunbridge LJ,Lloyd JV

更新日期：1983-10-31 00:00:00

abstract：:There is increasing recognition of the importance of vulnerable plaque and acute plaque rupture leading to thrombosis, in the pathogenesis of acute coronary syndromes. This is fueling a number of developments, including novel imaging modalities and potential plaque stabilization therapies. However, to date, no animal ...

journal_title：Thrombosis and haemostasis

authors： Lowe HC,Jang IK,Khachigian LM

更新日期：2003-11-01 00:00:00

abstract：:Edoxaban is an oral, direct, once-daily, factor Xa inhibitor developed for stroke prevention in patients with atrial fibrillation and for the treatment and secondary prevention of recurrent thromboembolism in patients with acute symptomatic venous thromboembolism. Among elderly patients who require anticoagulation the...

journal_title：Thrombosis and haemostasis

authors： Parasrampuria DA,Marbury T,Matsushima N,Chen S,Wickremasingha PK,He L,Dishy V,Brown KS

更新日期：2015-04-01 00:00:00

abstract：:Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphism...

journal_title：Thrombosis and haemostasis

authors： Pomp ER,Doggen CJ,Vos HL,Reitsma PH,Rosendaal FR

更新日期：2009-01-01 00:00:00

abstract：:Haemophilia A and B are X-linked disorders which are due to a reduced activity of coagulation factor VIII or IX, respectively. Female carriers have a wide range of plasma concentration of factor VIII or factor IX, and may in rare cases have an affected phenotype. In order to investigate if this variation is related to...

journal_title：Thrombosis and haemostasis

authors： Orstavik KH,Scheibel E,Ingerslev J,Schwartz M

更新日期：2000-03-01 00:00:00

abstract：:An abnormal fibrinogen was discovered in the plasma of a clinically asymptomatic woman. This fibrinogen variant was analyzed by high resolution two-dimensional gel electrophoresis and its molecular abnormality established consisting in a slight decrease in molecular mass of the B beta-chains. Analysis of fibrin reveal...

journal_title：Thrombosis and haemostasis

authors： Meyer M,Schellenberg I,Vogel G,Bischoff I

更新日期：1988-04-08 00:00:00

abstract：:Undoubtedly, platelets are key elements in the regulation of thrombosis and haemostasis. Along with their primary task to prevent blood loss from injured vessels, platelets have emerged as regulators of a variety of processes in the vasculature. Multiple challenges, from the contact and adhesion to subendothelial matr...

journal_title：Thrombosis and haemostasis

authors： von Hundelshausen P,Petersen F,Brandt E

更新日期：2007-05-01 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Botney MJ,Swanson AL,Shuman MN

更新日期：1979-07-01 00:00:00

abstract：:To determine a possible relation of changes in plasma levels of plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA) to the development of coronary restenosis after successful coronary angioplasty (PTCA), we followed 104 patients with a low grade residual stenosis after PTCA (less than 30%...

journal_title：Thrombosis and haemostasis

authors： Huber K,Jörg M,Probst P,Schuster E,Lang I,Kaindl F,Binder BR

更新日期：1992-02-03 00:00:00

abstract：:Patients with both chronic kidney disease (CKD) and diabetes mellitus (DM) are at increased risk for thrombotic events compared to those with one abnormality alone. Whether this can be attributed to changes in platelet reactivity among those with both CKD and DM is unknown. We prospectively studied 438 clopidogrel-naï...

journal_title：Thrombosis and haemostasis

authors： Baber U,Bander J,Karajgikar R,Yadav K,Hadi A,Theodoropolous K,Gukathasan N,Roy S,Sayeneni S,Scott SA,Kovacic JC,Yu J,Sartori S,Mehran R,Uribarri J,Badimon JJ,Muntner P,Moreno P,Kini AS,Sharma SK

更新日期：2013-07-01 00:00:00

abstract：:Inherited thrombophilic states are associated with an increased risk for deep vein thrombosis (DVT), but whether they are also risk factors for superficial vein thrombosis (SVT) is uncertain. We assessed the risk conferred by inherited thrombophilic states in patients with a first episode of SVT in whom the coexistenc...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Taioli E,De Stefano V,Chiusolo P,Mannucci PM

更新日期：1999-10-01 00:00:00

abstract：:There is increasing concern that some anticoagulants can paradoxically increase thrombogenesis under certain circumstances. Previously, we demonstrated that at certain doses a direct thrombin inhibitor, melagatran, worsens the coagulation status induced by tissue factor (TF) injection in a rat model. We utilised an i...

journal_title：Thrombosis and haemostasis

authors： Furugohri T,Sugiyama N,Morishima Y,Shibano T

更新日期：2011-12-01 00:00:00

abstract：:Epidemiological studies suggest that hormone replacement therapy (HRT) decreases the risk of cardiovascular disease in postmenopausal women via several mechanisms, including modifications in the fibrinolytic system and lipoprotein(a) [Lp(a)] levels. The aim of this study was to examine the influence of the levels and ...

journal_title：Thrombosis and haemostasis

authors： Estellés A,Cano A,Falcó C,España F,Gilabert J,Grancha S,Aznar J

更新日期：1999-01-01 00:00:00

abstract：:We have identified two novel minor deletions (case 1; -TA or -AT at nucleotide 9831-3 in exon 5 and case 2; -A at nucleotide 7640-1 in exon 4), one novel nonsense mutation (case 3; TAT to TAA at nucleotide 7491 in exon 4), and one recurrent nonsense mutation (case 4; CGA to TGA at nucleotide 5381 in exon 3A) in Japane...

journal_title：Thrombosis and haemostasis

authors： Nakahara Y,Tsuji H,Nakagawa K,Masuda H,Kitamura H,Nishimura H,Kasahara T,Sugano T,Sawada S,Nakagawa M

更新日期：1997-04-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a multifactorial disease. Major provoking factors (e. g. surgery, cancer, major trauma, and immobilisation) are identified in 50-60 % of patients, while the remaining cases are classified as unprovoked. However, minor predisposing conditions may be detectable in these patients, possibly...

journal_title：Thrombosis and haemostasis

authors： Riva N,Donadini MP,Ageno W

更新日期：2015-06-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and paraoxonase 1 (PON1) are directly involved in the pathogenesis of atherosclerosis by modulation of oxidative stress and/or NO bioavailability. We aimed to assess whether endurance exercise which is known to be cardioprotective could beneficially affect thes...

journal_title：Thrombosis and haemostasis

authors： Richter B,Niessner A,Penka M,Grdić M,Steiner S,Strasser B,Ziegler S,Zorn G,Maurer G,Simeon-Rudolf V,Wojta J,Huber K

更新日期：2005-12-01 00:00:00

abstract：:Following exposure of rats to graded doses of fresh cigarette smoke, the aortic endothelium examined by scanning electron microscopy regularly showed alterations. These essentially consisted of areas of blebbing and microvillus-like projections from the luminal surface, and the presence in the majority of cases, of mi...

journal_title：Thrombosis and haemostasis

authors： Pittilo RM,Mackie IJ,Rowles PM,Machin SJ,Woolf N

更新日期：1982-10-29 00:00:00

abstract：:We investigated the molecular basis for factor VII (FVII) deficiency in Israel and found that 13 patients were homozygous and 10 heterozygous for a C to T substitution at nucleotide 10648 of the FVII gene. This predicted an Ala244Val change and was associated with decreased FVII activity and antigen level. Of the 36 A...

journal_title：Thrombosis and haemostasis

authors： Tamary H,Fromovich Y,Shalmon L,Reich Z,Dym O,Lanir N,Brenner B,Paz M,Luder AS,Blau O,Korostishevsky M,Zaizov R,Seligsohn U

更新日期：1996-09-01 00:00:00

abstract：:The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years w...

journal_title：Thrombosis and haemostasis

authors： Baranyai Z,Krzystanek M,Jósa V,Dede K,Agoston E,Szász AM,Sinkó D,Szarvas V,Salamon F,Eklund AC,Szállási Z,Jakab F

更新日期：2014-03-03 00:00:00

abstract：:In the last decades, substantial progress has been made in understanding the relationship between lipid disorders and prevention of cardiac ischemic disease. Statins competitively inhibit 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme crucial to cholesterol biosynthesis. Statins have long been t...

journal_title：Thrombosis and haemostasis

authors： Mach F

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND: There have been no prior nationwide reports on the prevalence of hypertrophic cardiomyopathy (HCM) among patients suffering from atrial fibrillation (AF). It is also unclear how much stroke risk is attributable to HCM compared with other stroke risks in patients with AF. This study assessed the prevalence o...

journal_title：Thrombosis and haemostasis

authors： Jung H,Yang PS,Sung JH,Jang E,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Lip GYH,Joung B

更新日期：2019-02-01 00:00:00

abstract：:We previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain. As the peptides represent ...

journal_title：Thrombosis and haemostasis

authors： Vanhoorelbeke K,van der Plas RM,Vandecasteele G,Vauterin S,Huizinga EG,Sixma JJ,Deckmyn H

更新日期：2000-10-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:Activated protein C (APC) is a serine proteinase that regulates blood coagulation. In plasma it is inhibited mainly by the protein C inhibitor (PCI). The plasma concentrations of APC-PCI complex is increased in hypercoagulative states such as deep venous thrombosis. Formation of the APC-PCI complex induces a drastic c...

journal_title：Thrombosis and haemostasis

authors： Strandberg K,Kjellberg M,Knebel R,Lilja H,Stenflo J

更新日期：2001-08-01 00:00:00

abstract：:Lysyl oxidase (LOX) is an extracellular matrix-modifying enzyme that seems to play a critical role in vascular remodelling. However, the lack of viable LOX-deficient animal models has been an obstacle to deep in LOX biology. In this study we have developed a transgenic mouse model that over-expresses LOX in vascular s...

journal_title：Thrombosis and haemostasis

authors： Orriols M,Guadall A,Galán M,Martí-Pàmies I,Varona S,Rodríguez-Calvo R,Briones AM,Navarro MA,de Diego A,Osada J,Martínez-González J,Rodríguez C

更新日期：2014-10-01 00:00:00

abstract：:Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the...

journal_title：Thrombosis and haemostasis

authors： Bochkov VN

更新日期：2007-03-01 00:00:00

abstract：:D-Dimer measurements are being increasingly used for negative prediction of deep vein thrombosis (DVT). At our institution, clinical score, D-Dimer assay, plethysmography and, if necessary, Doppler ultrasound are used to secure the diagnosis. We collected the data from 100 consecutive patients proven to have DVT. We e...

journal_title：Thrombosis and haemostasis

authors： Rege KP,Jones S,Day J,Hoggarth CE

更新日期：2004-06-01 00:00:00