Thrombin-Induced and Collagen-Induced Platelet Aggregation.

abstract：:Enhanced adhesion of sickle erythrocytes to the vascular endothelium and subendothelial matrix is fundamental to the development of vascular occlusion in sickle cell disease. Erythrocyte membrane sulfatide is implicated in the pathogenesis of vasoocclusive crises in sickle cell disease (SCD) patients. Because previous...

journal_title：Thrombosis and haemostasis

authors： Zhou Z,Thiagarajan P,Udden M,Lòpez JA,Guchhait P

更新日期：2011-06-01 00:00:00

abstract：:Thrombin-activated human platelets release substance(s) of a proteic nature which induce an increase in the intracellular calcium concentration in polymorphonuclear leukocytes (PMN). Aim of this study was to characterize the platelet released product(s) responsible for PMN stimulation. PMN-stimulating activity was iso...

journal_title：Thrombosis and haemostasis

authors： Piccardoni P,Evangelista V,Piccoli A,de Gaetano G,Walz A,Cerletti C

更新日期：1996-11-01 00:00:00

abstract：:In the last decade, several studies revealed inter-patient response variability to antiplatelet agents: patients who display negligible or no responses to these drugs are considered poor responders, or "resistant" to treatment. In order to identify poor responders to an antiplatelet drug, laboratory tests of platelet ...

journal_title：Thrombosis and haemostasis

authors： Cattaneo M

更新日期：2013-05-01 00:00:00

abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

journal_title：Thrombosis and haemostasis

authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

更新日期：2019-03-01 00:00:00

abstract：:The effect of the ADP receptor antagonists ATP and adenosine 5'-(beta, gamma-methylene)triphosphate (AMP-PCP), and the ADP-utilizing enzyme systems creatine phosphokinase/creatine phosphate (CPK/CP) and pyruvate kinase/phosphoenol pyruvate (PK/PEP) on platelet deposition onto type I collagen was examined. An in vitro ...

journal_title：Thrombosis and haemostasis

authors： Wagner WR,Hubbell JA

更新日期：1992-04-02 00:00:00

abstract：:Adhesion to collagen was investigated as a function of platelet age in rat platelets. Platelet adherence was measured using EDTA-containing platelet- rich plasma which was added to preparations of collagen fibers clamped between magnetic stirrers by recording changes in light transmission. The plot of light transmissi...

journal_title：Thrombosis and haemostasis

authors： Castellan RM,Steiner M

更新日期：1976-11-30 00:00:00

abstract：:Megakaryocyte (MK)-derived miRNAs have been detected in platelets. Here, we analysed the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that might be altered with their target mRNAs in type 2 diabetes mellitus (DM2). MiRNAs were isolated from leukocyte-depleted platelets and plasma sample...

journal_title：Thrombosis and haemostasis

authors： Fejes Z,Póliska S,Czimmerer Z,Káplár M,Penyige A,Gál Szabó G,Beke Debreceni I,Kunapuli SP,Kappelmayer J,Nagy B Jr

更新日期：2017-02-28 00:00:00

abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

journal_title：Thrombosis and haemostasis

authors： Hooper WC,Phillips DJ,Evatt BL

更新日期：1997-05-01 00:00:00

abstract：:Thrombotic complications are frequently associated with atherosclerosis. Lysophosphatidylcholine (LPC), a component accumulated in oxidatively modified LDL (ox-LDL), is known to play a crucial role in the initiation and progression of atherosclerotic vascular lesions. Since a vascular anticoagulant, tissue factor path...

journal_title：Thrombosis and haemostasis

authors： Sato N,Kokame K,Miyata T,Kato H

更新日期：1998-01-01 00:00:00

abstract：:Plaque rupture followed by thrombosis is the underlying cause of the majority of acute coronary syndromes. Circulating microparticles (cMPs), membrane blebs released into blood by activated cells, have been associated to vascular diseases. Specifically, high levels of platelet-derived microparticles (pMPs) have been f...

journal_title：Thrombosis and haemostasis

authors： Suades R,Padró T,Vilahur G,Badimon L

更新日期：2012-12-01 00:00:00

abstract：:The Ig-ITIM superfamily member, PECAM-1 acts as a negative regulator of ITAM-signalling pathways in platelets involving GPVI/FcR gamma chain and Fc?RIIa. This negative feedback loop involves regulation of collagen and GPVI-dependent aggregation events, platelet-thrombus-growth on immobilised collagen under flow and Fc...

journal_title：Thrombosis and haemostasis

authors： Sardjono CT,Harbour SN,Yip JC,Paddock C,Tridandapani S,Newman PJ,Jackson DE

更新日期：2006-12-01 00:00:00

abstract：:The vitamin K-dependent carboxylation of specific glutamyl residues to gamma-carboxyglutamyl residues occurs during the endoplasmic reticulum processing of a limited number of proteins. The fate of the under-gamma-carboxylated proteins during protein processing was studied. When human hepatoma (HepG2) cells were grown...

journal_title：Thrombosis and haemostasis

authors： Wu W,Bancroft JD,Suttie JW

更新日期：1996-07-01 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:Platelets are critically involved in atherosclerosis and acute thrombosis. The platelet phenotype shows a wide variability documented by the inherited difference of platelet reactivity, platelet volume and count and function of platelet surface receptors. Several candidate genes have been put into focus and investigat...

journal_title：Thrombosis and haemostasis

authors： Geisler T,Schaeffeler E,Gawaz M,Schwab M

更新日期：2013-11-01 00:00:00

abstract：:The aim of the study was to compare the efficacy and safety of once-daily subcutaneous injection of dalteparin, a low molecular weight heparin, with that of intravenous unfractionated heparin in the treatment of deep venous thrombosis (DVT). Patients were included if they had deep venous thrombosis distal to inguinal ...

journal_title：Thrombosis and haemostasis

authors： Fiessinger JN,Lopez-Fernandez M,Gatterer E,Granqvist S,Kher A,Olsson CG,Söderberg K

更新日期：1996-08-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been associated with thrombosis and pregnancy losses in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. It has been proposed that aPL may affect endothelia...

journal_title：Thrombosis and haemostasis

authors： Pierangeli SS,Liu X,Espinola R,Olee T,Zhu M,Harris NE,Chen PP

更新日期：2000-09-01 00:00:00

abstract：:The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

journal_title：Thrombosis and haemostasis

authors： Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:Unstimulated human platelets from normal volunteers adhere to sulfatides (galactosylceramide-I3-sulfate) as single cells but do not adhere appreciably to other lipids including gangliosides, neutral glycolipids, phospholipids or cholesterol-3-SO4. Platelet adhesion to sulfatide is saturable and dose-dependent, reaches...

journal_title：Thrombosis and haemostasis

authors： Data RE,Williams SB,Roberts DD,Gralnick HR

更新日期：1991-05-06 00:00:00

abstract：:Calibration of local standards for ristocetin cofactor activity of von Willebrand's factor (vWF:Rcof) against reference preparations is required to achieve a better standardization of this measurement. We have observed that in calibration assays (multiple line parallel bioassay) for vWF:Rcof, measured aggregometricall...

journal_title：Thrombosis and haemostasis

authors： Rodeghiero F,Castaman G

更新日期：1987-12-18 00:00:00

abstract：:Adhesion of rat blood platelets to native rat tail collagen fibrils was studied in the electron microscope under conditions that preserved collagen-associated proteoglycans (CAPG). The CAPG molecules were aligned in chain-like configurations that encircled the fibrils with a 65 nm period; they appeared to coat the fib...

journal_title：Thrombosis and haemostasis

authors： Behnke O

更新日期：1987-08-04 00:00:00

abstract：:Venous thromboembolism (VTE) is a central concern in the intensive care unit (ICU). However, little is known about both current practices for VTE prevention in the ICU and the risk for VTE in persons with severe sepsis and septic shock. XPRESS was a randomized, double-blind, placebo-controlled trial of prophylactic he...

journal_title：Thrombosis and haemostasis

authors： Shorr AF,Williams MD

更新日期：2009-01-01 00:00:00

abstract：:Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, ge...

journal_title：Thrombosis and haemostasis

authors： Kelly LA,O'Leary JJ,Seidlova-Wuttke D,Wuttke W,Norris LA

更新日期：2010-12-01 00:00:00

abstract：:When adenosine diphosphate (ADP) is added to hirudinized platelet-rich plasma (PRP) in which the level of platelet cAMP has been pharmacologically elevated, there is an initial rapid fall in the level of cAMP brought about by inhibition of adenylate cyclase. This may be followed by a subsequent activation of adenylate...

journal_title：Thrombosis and haemostasis

authors： Glenn JR,Heptinstall S

更新日期：1998-08-01 00:00:00

abstract：:Circulating endotoxin is elevated in sepsis and plays a role in endothelial dysfunction whereas antithrombin is decreased by virtue of its consumption during complex formation with clotting factors and by proteolytic degradation by granulocyte elastase. Dysfunction of endothelium results in enhanced leukocyte rolling ...

journal_title：Thrombosis and haemostasis

authors： Kaneider NC,Förster E,Mosheimer B,Sturn DH,Wiedermann CJ

更新日期：2003-12-01 00:00:00

abstract：:We performed a case-controlled study to investigate whether the FV Leiden mutation and the C > T677 polymorphism of the 5, 10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers w...

journal_title：Thrombosis and haemostasis

authors： Grandone E,Margaglione M,Colaizzo D,Cappucci G,Paladini D,Martinelli P,Montanaro S,Pavone G,Di Minno G

更新日期：1997-06-01 00:00:00

abstract：:Knowledge on the natural history of mesenteric vein thrombosis (MVT) and of the efficacy and safety of long-term oral anticoagulant therapy (OAT) in this setting is based on small uncontrolled series of patients with a limited follow-up. It was the aim of the study to assess the natural history of MVT in a cohort of p...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Ageno W,Witt D,Malato A,Clark N,Garcia D,McCool K,Siragusa S,Dyke S,Crowther M,WARPED consortium.

更新日期：2009-09-01 00:00:00

abstract：:There is little information on the clinical outcome of patients with venous thromboembolism and renal insufficiency. RIETE is an ongoing, prospective registry of consecutive patients with acute, objectively confirmed, symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE). In this analysis we analyzed the t...

journal_title：Thrombosis and haemostasis

authors： Falgá C,Capdevila JA,Soler S,Rabuñal R,Sánchez Muñoz-Torrero JF,Gallego P,Monreal M,RIETE Investigators.

更新日期：2007-10-01 00:00:00

abstract：:Current thrombolytic strategies have a number of important shortcomings including resistance to recanalization and development of acute reocclusion. The purpose of this study was to investigate whether the lysis of venous thrombi by streptokinase could be enhanced by SR 46349, a novel 5-HT2 receptor antagonist, or clo...

journal_title：Thrombosis and haemostasis

authors： Herbert JM,Bernat A,Sainte-Marie M,Dol F,Rinaldi M

更新日期：1993-03-01 00:00:00

abstract：:Biosynthesis of the adhesive glycoprotein von Willebrand factor (vWf) by endothelial cells results in constitutive secretion of small multimers and storage of the largest multimers in rod-shaped granules called Weibel-Palade bodies. This pattern is reproduced by expression of pro-vWf in heterologous cells with a regul...

journal_title：Thrombosis and haemostasis

authors： Journet AM,Saffaripour S,Wagner DD

更新日期：1993-12-20 00:00:00

abstract：:Alteplase is standard therapy for patients with acute, massive pulmonary embolism. The novel plasminogen activator desmoteplase displays high fibrin specificity and selectivity for fibrinbound plasminogen. In a preclinical model desmoteplase was twice as potent with a shorter lysis time and lower reocclusion rate. We ...

journal_title：Thrombosis and haemostasis

authors： Tebbe U,Bramlage P,Graf A,Lechleitner P,Bode C,Riess FC,Clemens N,Al-Rawi Y,Konstantinides S,Goldhaber SZ

更新日期：2009-03-01 00:00:00