Platelet adhesion to native collagens involves proteoglycans and may be a two-step process.

abstract：:Advanced glycation end-products (AGEs) interact with their receptor RAGE, leading to an inflammatory state. We investigated the role of RAGE in postischaemic leukocyte adhesion after myocardial infarction and its effect on postischaemic myocardial function. Wildtype (WT), ICAM-1-/-, RAGE-/- or ICAM-1/RAGE-/- mice unde...

journal_title：Thrombosis and haemostasis

authors： Ziegler T,Horstkotte M,Lange P,Ng J,Bongiovanni D,Hinkel R,Laugwitz KL,Sperandio M,Horstkotte J,Kupatt C

更新日期：2016-08-01 00:00:00

abstract：:The alphaII(b)beta3 integrin and FcgammaRII receptors mediate, respectively, platelet adhesion and spreading on fibrinogen and immunoglobulin (IgG) coated surfaces. Platelet adhesion to fibrinogen resulted in a partial conversion of the faster to the slower migrating (phosphorylated) form of Ca(+2)-sensitive cytosolic...

journal_title：Thrombosis and haemostasis

authors： Haimovich B,Ji P,Ginalis E,Kramer R,Greco R

更新日期：1999-04-01 00:00:00

abstract：:We have developed a sensitive and quantitative RT-PCR assay for the determination of tissue factor (TF) mRNA levels in human cells. An in vitro synthesized internal standard RNA was used to correct for differences in reverse transcription or amplification of various RNA samples. The PCR products were quantitated by hy...

journal_title：Thrombosis and haemostasis

authors： Pötgens AJ,Lubsen NH,van Altena G,Schoenmakers JG,Ruiter DJ,de Waal RM

更新日期：1994-02-01 00:00:00

abstract：:Warfarin induction is accomplished by titrating dosage to coagulation test results. Algorithms can guide this process but not identify the starting dose. We hypothesized that an initial warfarin dose approximating the maintenance value would safely enhance rapidity of induction. In a randomized trial we compared a fix...

journal_title：Thrombosis and haemostasis

authors： Shine D,Patel J,Kumar J,Malik A,Jaeger J,Maida M,Ord L,Burrows G

更新日期：2003-02-01 00:00:00

abstract：:We evaluated the effect of d-alpha-tocopherol (vitamin E) on the production of prostacyclin (PGI2) by cultured bovine aortic endothelial cells. Vitamin E at physiological doses significantly enhanced the production of PGI2 by aortic endothelial cells when added to the culture simultaneously with histamine, the Ca2+ io...

journal_title：Thrombosis and haemostasis

authors： Kunisaki M,Umeda F,Inoguchi T,Nawata H

更新日期：1992-12-07 00:00:00

abstract：:Thrombomodulin (TM), a marker of endothelial cell damage, has been localized to the placental syncytiotrophoblast. A prospective cohort study of twenty-five pregnant women who were admitted with a clinical diagnosis of placental abruption was undertaken. Abruption was confirmed after delivery in eight cases (Group 1)....

journal_title：Thrombosis and haemostasis

authors： Magriples U,Chan DW,Bruzek D,Copel JA,Hsu CD

更新日期：1999-01-01 00:00:00

abstract：:The molecular basis of Factor V deficiency has been defined in few patients only. We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. This substitution results in the replacement of an arginine (R) by a histidine (H) in amino acid position 2074, lo...

journal_title：Thrombosis and haemostasis

authors： Schrijver I,Houissa-Kastally R,Jones CD,Garcia KC,Zehnder JL

更新日期：2002-02-01 00:00:00

abstract：:This study assessed the abundance and activity of thrombin in human thrombi. removed at autopsy or during surgery. Arterial and venous thrombus sections showed thrombin activity by in situ zymography, based on conversion of fibrinogen to fibrin. Hirudin or antibodies to thrombin abolished the activity. Thrombin activi...

journal_title：Thrombosis and haemostasis

authors： Mutch NJ,Robbie LA,Booth NA

更新日期：2001-10-01 00:00:00

abstract：:Early treatment of disseminated intravascular coagulation (DIC) is recommended but global coagulation tests used in authorized DIC criteria are not sensitive for diagnosis of early-phase DIC. We examined the plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC) and D-dimer in p...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Wada H,Okamoto K,Iba T,Uchiyama T,Eguchi Y,Kawasugi K,Koga S,Mayumi T,Koike K,Gando S

更新日期：2006-02-01 00:00:00

abstract：:The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates fo...

journal_title：Thrombosis and haemostasis

authors： Leissinger C,Josephson CD,Granger S,Konkle BA,Kruse-Jarres R,Ragni MV,Journeycake JM,Valentino L,Key NS,Gill JC,McCrae KR,Neufeld EJ,Manno C,Raffini L,Saxena K,Torres M,Marder V,Bennett CM,Assmann SF

更新日期：2014-09-02 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:Previous studies have shown an association between serum C-reactive protein (CRP) and cardiovascular disease (CVD) risk. The roles of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) are less well established. The aim of the present study was to analyze the associations of CRP, IL-6 and TNFalpha with in...

journal_title：Thrombosis and haemostasis

authors： Tuomisto K,Jousilahti P,Sundvall J,Pajunen P,Salomaa V

更新日期：2006-03-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs that negatively regulate posttranscriptional gene expression. Several microRNAs have been described to regulate the process of angiogenesis. Previously, we have shown that bone morphogenetic protein 4 (BMP4) increased the pro-angiogenic activity of endothelial cells. In this project...

journal_title：Thrombosis and haemostasis

authors： Esser JS,Saretzki E,Pankratz F,Engert B,Grundmann S,Bode C,Moser M,Zhou Q

更新日期：2017-04-03 00:00:00

abstract：:Cellular adhesion molecules also known as selectins promote recruitment of inflammatory cells into the arterial wall where they interact with lipid particles leading subsequently to plaque formation. The intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leuk...

journal_title：Thrombosis and haemostasis

authors： Hoke M,Winter MP,Wagner O,Exner M,Schillinger M,Arnold Z,Mlekusch W,Maurer G,Koppensteiner R,Minar E,Goliasch G

更新日期：2015-08-31 00:00:00

abstract：:Activated protein C (APC)-mediated inactivation of factor VIII (FVIII) correlates with cleavage at either Arg336 and/or Arg562. To elucidate the APC cleavage requirements for inactivation of FVIII, APC cleavage site mutants in FVIII (R336I, R562K and R336I/R562K) were made by site-directed mutagenesis. Analysis of the...

journal_title：Thrombosis and haemostasis

authors： Amano K,Michnick DA,Moussalli M,Kaufman RJ

更新日期：1998-03-01 00:00:00

abstract：:Thrombin and other agonists that induce secretion and aggregation in human platelets also activate phospholipase D (PLD), but the signaling cascade leading to activation of PLD in human platelets is not yet clear. We have determined that apyrase, which scavenges ADP secreted during platelet activation, is able to bloc...

journal_title：Thrombosis and haemostasis

authors： Martinson EA,Scheible S,Marx-Grunwitz A,Presek P

更新日期：1998-12-01 00:00:00

abstract：:In patients with von Willebrand disease (VWD) replacement therapy with factor VIII/von Willebrand (VWF) concentrates is increasingly applied as prophylactic regimen. Since 2000, 82 consecutively enrolled patients with clinically relevant bleeding episodes (spontaneous, peri- or postoperative) were diagnosed with VWD [...

journal_title：Thrombosis and haemostasis

authors： Halimeh S,Krümpel A,Rott H,Bogdanova N,Budde U,Manner D,Faeser B,Mesters R,Nowak-Göttl U

更新日期：2011-04-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00

abstract：:Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases,...

journal_title：Thrombosis and haemostasis

authors： Sakai H,Goto S,Kim JY,Aoki N,Abe S,Ichikawa N,Yoshida M,Nagaoka Y,Handa S

更新日期：2000-08-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a persistent inflammatory state, which can be secondary to chronic pulmonary infection and may affect vascular endothelium. We measured circulating levels of von Willebrand factor (vWF), tissue-plasminogen activator (t-PA), and P-selectin in 20 CF patients and 20 healthy subjec...

journal_title：Thrombosis and haemostasis

authors： Romano M,Collura M,Lapichino L,Pardo F,Falco A,Chiesa PL,Caimi G,Davì G

更新日期：2001-12-01 00:00:00

abstract：:The aim of this study was to evaluate the existence of an additive effect between standard heparin and dDAVP in the enhancement of endogenous fibrinolysis. Eight healthy volunteers were studied in a randomized double blind placebo controlled cross-over trial. The volunteers were treated i.v. with dDAVP, 0.4 micrograms...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Levi M,Cosmi B,ten Cate JW,Nenci GG

更新日期：1989-06-30 00:00:00

abstract：:The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

journal_title：Thrombosis and haemostasis

authors： Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

更新日期：1991-09-02 00:00:00

abstract：BACKGROUND: Factor XI (FXI) deficiency is a rare autosomal bleeding disorder. The rarity of spontaneous bleeding and absence of optimal tools to predict the bleeding risk in FXI-deficient patients hamper the standardization of prophylactic treatment enabling them to undergo major surgeries without blood products. OBJE...

journal_title：Thrombosis and haemostasis

authors： Salomon O,Budnik I,Avishai E,Tamarin I,Bashari D,Dardik R,Livnat T

更新日期：2019-12-01 00:00:00

abstract：:The measurement of platelet deposition in human thrombi is essential for the evaluation of platelet-inhibitory drugs and prosthetic materials for use in patients. The rate of 111Indium-labelled platelet accumulation on Dacron arterial grafts was measured in 27 patients randomised to take either aspirin and dipyridamol...

journal_title：Thrombosis and haemostasis

authors： Norcott HC,Goldman M,Hawker RJ,Rafiqi EI,Drolc Z,McCollum CN

更新日期：1982-12-27 00:00:00

abstract：:To assess interobserver variability of venography for screening for postoperative deep venous thrombosis (DVT), we used 185 bilateral ascending contrast venograms (366 lower limbs) which were performed using the long-leg film technique, in the frame of a trial of the efficacy of two low-molecular-weight-heparin fracti...

journal_title：Thrombosis and haemostasis

authors： Couson F,Bounameaux C,Didier D,Geiser D,Meyerovitz MF,Schmitt HE,Schneider PA,Bounameaux H

更新日期：1993-10-18 00:00:00

abstract：:We compared the Ivy bleeding time method and two alternatives of the Simplate II method (incisions in horizontal and vertical direction) with each other, with regard to the sensitivity, the specificity, the costs and the burden for the patient. In the aspirin study an aspirin-induced bleeding defect was used. Seventy-...

journal_title：Thrombosis and haemostasis

authors： Srámek R,Srámek A,Koster T,Briët E,Rosendaal FR

更新日期：1992-05-04 00:00:00

abstract：:The antithrombotic effect of the thromboxane A2 receptor antagonist, vapiprost, was compared with those of other antiplatelet drugs using an arterial thrombosis model which utilized photochemical reaction in the rat femoral artery. Vapiprost prolonged the time required to occlude the artery with thrombus and inhibited...

journal_title：Thrombosis and haemostasis

authors： Takiguchi Y,Wada K,Nakashima M

更新日期：1992-10-05 00:00:00

abstract：:Activation of coagulation was studied during the peri-operative period in patients undergoing cardiopulmonary bypass (CPB) surgery using activation markers which have recently become available: prothrombin fragment F1 + 2 (F1 + 2), which is a measure of total thrombin generation, and thrombin-antithrombin complex, whi...

journal_title：Thrombosis and haemostasis

authors： Boisclair MD,Lane DA,Philippou H,Sheikh S,Hunt B

更新日期：1993-08-02 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00

abstract：:Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type...

journal_title：Thrombosis and haemostasis

authors： Hardy AT,Palma-Barqueros V,Watson SK,Malcor JD,Eble JA,Gardiner EE,Blanco JE,Guijarro-Campillo R,Delgado JL,Lozano ML,Teruel-Montoya R,Vicente V,Watson SP,Rivera J,Ferrer-Marín F

更新日期：2018-06-01 00:00:00