Comparison of the inhibitory effects of the TXA2 receptor antagonist, vapiprost, and other antiplatelet drugs on arterial thrombosis in rats: possible role of TXA2.

abstract：:Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced "FVa activity augmentation" as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (r...

journal_title：Thrombosis and haemostasis

authors： Bhat V,von Drygalski A,Gale AJ,Griffin JH,Mosnier LO

更新日期：2016-03-01 00:00:00

abstract：:Angiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties. In this r...

journal_title：Thrombosis and haemostasis

authors： Degani H,Chetrit-Dadiani M,Bogin L,Furman-Haran E

更新日期：2003-01-01 00:00:00

abstract：:Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

journal_title：Thrombosis and haemostasis

authors： Furlan M,Rupp C,Beck EA,Svendsen L

更新日期：1982-04-30 00:00:00

abstract：:Washed human platelets have been labeled with either 32Pi or glycerol-1-14C and the distribution of the label in the phospholipids determined. 32Pi was introduced primarily into polyphosphoinositides, i.e. di- and triphosphoinositide, whereas the label from glycerol which indicates de novo synthesis of lipid molecules...

journal_title：Thrombosis and haemostasis

authors： Kaulen HD,Gross R

更新日期：1976-04-30 00:00:00

abstract：:Haemorrhagic metalloproteinases from Bothrops jararaca and other venoms degrade vessel-wall and plasma proteins involved in platelet plug and fibrin clot formation. These enzymes also cause proteolytic digestion of fibrinogen which has been suggested to cause defective platelet function. Fibrinogen degradation by jara...

journal_title：Thrombosis and haemostasis

authors： Kamiguti AS,Slupsky JR,Zuzel M,Hay CR

更新日期：1994-08-01 00:00:00

abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

journal_title：Thrombosis and haemostasis

authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

更新日期：2003-08-01 00:00:00

abstract：:Interaction of proteases with cell surface receptors may modulate cell adhesion, migration, invasion, and matrix degradation. Since the plasminogen activator system has been hypothesized to play a role in intimal thickening after various types of vascular injury, we first studied the expression of urokinase receptor (...

journal_title：Thrombosis and haemostasis

authors： Okada SS,Golden MA,Raghunath PN,Tomaszewski JE,David ML,Kuo A,Kariko K,Barnathan ES

更新日期：1998-07-01 00:00:00

abstract：:It was the study objective to evaluate whether chewing a 180 mg loading dose of ticagrelor versus an equal dose of traditional oral administration, enhances inhibition of platelet aggregation 1 hour (h) after administering a ticagrelor loading dose in non-ST elevation myocardial infarction (NSTEMI) patients. Dual anti...

journal_title：Thrombosis and haemostasis

authors： Asher E,Frydman S,Katz M,Regev E,Sabbag A,Mazin I,Abu-Much A,Kukuy A,Mazo A,Erez A,Berkovitch A,Narodistky M,Barbash I,Segev A,Beigel R,Matetzky S

更新日期：2017-04-03 00:00:00

abstract：:The walls of rabbit mesenteric arterioles and venules (diameter 20 to 40 microns) were punctured with glass micropipets (tip diameter 6 to 8 microns). Thromboembolic reactions resulting from this standardized, small mechanical vessel wall injury could be quantified in vivo with the use of intravital video-microscopy. ...

journal_title：Thrombosis and haemostasis

authors： oude Egbrink MG,Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1988-02-25 00:00:00

abstract：:Molsidomine and its active metabolite SIN-1 were examined in humans and animals for platelet suppressant and fibrinolytic activities. Following oral administration of molsidomine at doses of 6 or 15 mg/kg to rabbits, their blood platelets in PRP ex vivo required higher threshold concentrations of ADP, AA and thrombin ...

journal_title：Thrombosis and haemostasis

authors： Basista M,Grodzińska L,Swies J

更新日期：1985-12-17 00:00:00

abstract：:Hematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. ...

journal_title：Thrombosis and haemostasis

authors： Ruan C,Wu Y,Okada T,Motoi S,Kondo T,Jiang M,Xin X,Peng L,Ichihara K,Ikeda Y

更新日期：2002-07-01 00:00:00

abstract：:The plasma protein beta2-glycoprotein I (beta2-GPI) is a major target of autoantibodies in patients with the antiphospholipid syndrome. To understand the physiological function of beta2-GPI and its potential role in the pathophysiology of the antiphospholipid syndrome, the binding of beta2-GPI to phospholipid membrane...

journal_title：Thrombosis and haemostasis

authors： Harper MF,Hayes PM,Lentz BR,Roubey RA

更新日期：1998-10-01 00:00:00

abstract：:Severe type I plasminogen deficiency is the underlying cause of ligneous conjunctivitis, a rare disease characterized by wood-like pseudomembranes developing on the ocular and extraocular mucosa. Two unrelated female patients with ligneous conjunctivitis and moderate hypoplasminogenemia are described. Being of fertile...

journal_title：Thrombosis and haemostasis

authors： Teresa Sartori M,Saggiorato G,Pellati D,Casonato A,Spiezia L,Pontara E,Gavasso S,Girolami A

更新日期：2003-07-01 00:00:00

abstract：:In consecutive patients with suspected venous thromboembolism the interobserver variability of the SimpliRED D-dimer test was evaluated by two observers who independently scored one plate, the between assay variation was performed simultaneously by a third independent observer, who assessed a second plate. The biologi...

journal_title：Thrombosis and haemostasis

authors： Turkstra F,van Beek EJ,Büller HR

更新日期：1998-01-01 00:00:00

abstract：:Restenosis following successful percutaneous coronary revascularization continues to represent a major problem limiting the clinical efficacy of this procedure. The underlying mechanisms of restenosis are comprised of a combination of effects from vessel recoil, negative vascular remodeling, thrombus formation and neo...

journal_title：Thrombosis and haemostasis

authors： Rosanio S,Tocchi M,Patterson C,Runge MS

更新日期：1999-09-01 00:00:00

abstract：:In the last decades, substantial progress has been made in understanding the relationship between lipid disorders and prevention of cardiac ischemic disease. Statins competitively inhibit 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme crucial to cholesterol biosynthesis. Statins have long been t...

journal_title：Thrombosis and haemostasis

authors： Mach F

更新日期：2003-10-01 00:00:00

abstract：:The amino acid sequence of the subunit of human platelet factor 4 has been determined. Human platelet factor 4 consists of identical subunits containing 70 amino acids, each with a molecular weight of 7,756. The molecule contains no methionine, phenylalanine or tryptophan. The proposed amino acid sequence of PF4 is: G...

journal_title：Thrombosis and haemostasis

authors： Morgan FJ,Begg GS,Chesterman CN

更新日期：1980-02-29 00:00:00

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:The effect of negatively-charged polymers, used in some artificial devices, on plasma clotting and kinin systems was studied in vitro using polyelectrolyte complexes. Contact activation was observed as an immediate, transient and surface-dependent phenomenon. After incubation of the plasma with the polymer a small dec...

journal_title：Thrombosis and haemostasis

authors： Boffa MC,Dreyer B,Pusineri C

更新日期：1984-02-28 00:00:00

abstract：:We performed a case-controlled study to investigate whether the FV Leiden mutation and the C > T677 polymorphism of the 5, 10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers w...

journal_title：Thrombosis and haemostasis

authors： Grandone E,Margaglione M,Colaizzo D,Cappucci G,Paladini D,Martinelli P,Montanaro S,Pavone G,Di Minno G

更新日期：1997-06-01 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00

abstract：:Noninvasive diagnosis of deep vein thrombosis (DVT) is based on ultrasound examination of the leg veins, usually restricted to only compression of the proximal veins (CUS). Patients with negative CUS findings require a second examination or a combination with other tests, which impairs clinical efficiency. In this pro...

journal_title：Thrombosis and haemostasis

authors： Schellong SM,Schwarz T,Halbritter K,Beyer J,Siegert G,Oettler W,Schmidt B,Schroeder HE

更新日期：2003-02-01 00:00:00

abstract：:Sixteen Danish unrelated thrombophilic families with plasma protein S deficiency of type 1 (or III) are currently under investigation in our laboratory for defects in the protein S alpha gene. The present paper describes a part of this work, which deals with the identification and phenotypical presentation of two uniq...

journal_title：Thrombosis and haemostasis

authors： Andersen BD,Lind B,Philips M,Hansen AB,Ingerslev J,Thorsen S

更新日期：1996-08-01 00:00:00

abstract：:Cysteinyl leukotrienes (i.e. LTC4, LTD4), produced by activated leukocytes or by transcellular metabolism may act at different levels on vascular smooth muscle cells (VSMC) during inflammatory process or atherosclerosis. We studied the effect of LTC4, LTD4, and LTE4 on the in vitro proliferation of rat VSMC, measured ...

journal_title：Thrombosis and haemostasis

authors： Porreca E,Di Febbo C,Di Sciullo A,Angelucci D,Nasuti M,Vitullo P,Reale M,Conti P,Cuccurullo F,Poggi A

更新日期：1996-07-01 00:00:00

abstract：:The A4070G polymorphism in exon 13 of the factor V (FV) gene, which replaces His by Arg at position 1299 of the B domain, was recently shown to influence circulating FV levels and to contribute to the activated protein C (APC) resistance phenotype. We examined the impact of this polymorphism in a population of unselec...

journal_title：Thrombosis and haemostasis

authors： Alhenc-Gelas M,Nicaud V,Gandrille S,van Dreden P,Amiral J,Aubry ML,Fiessinger JN,Emmerich J,Aiach M

更新日期：1999-02-01 00:00:00

abstract：:In a placebo-controlled trial healthy volunteers and patients with hyperlipoproteinemias types II and IV received orally vitamin E at doses of 300 mg and 600 mg daily for 2 weeks. Serum tocopherol levels increased two-fold, but serum concentrations of total lipids, cholesterol, triglycerides, ceruloplasmin and transfe...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A,Gryglewski RJ,Domagala B,Dworski R,Basista M

更新日期：1985-08-30 00:00:00

abstract：:It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptoma...

journal_title：Thrombosis and haemostasis

authors： Cosmi B,Legnani C,Pengo V,Ghirarduzzi A,Testa S,Poli D,Prisco D,Tripodi A,Palareti G,PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics).

更新日期：2013-03-01 00:00:00

abstract：:Tissue plasminogen activator labeled with radioactive iodine (125I-tPA) was immobilized on vascular prostheses chemically modified with a thin coating of water-insoluble surfactant, tridodecylmethylammonium chloride (TDMAC). Surfactant-treated Dacron, polytetrafluoroethylene (PTFE), silastic, polyethylene and polyuret...

journal_title：Thrombosis and haemostasis

authors： Harvey RA,Kim HC,Pincus J,Trooskin SZ,Wilcox JN,Greco RS

更新日期：1989-02-28 00:00:00

abstract：:We examined the ability of unfractionated heparin to modulate the procoagulant activities of stimulated endothelial cells (EC). Confluent human venous umbilical EC were incubated with heparin before or after stimulation, then rinsed extensively to eliminate any heparin in the solution. EC, stimulated for 4 h with endo...

journal_title：Thrombosis and haemostasis

authors： Cadroy Y,Gaspin D,Dupouy D,Lormeau JC,Boneu B,Sié P

更新日期：1996-01-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa; NovoSeven®) is a heterogeneously glycosylated serine protease used for treatment of haemophiliacs with inhibitors. The drug substance contains a subpopulation consisting of ~20% of rFVIIa molecules which are unsialylated and consists of carbohydrate moieties with terminally ex...

journal_title：Thrombosis and haemostasis

authors： Seested T,Nielsen HM,Christensen EI,Appa RS

更新日期：2010-12-01 00:00:00