Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis.

abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

journal_title：Thrombosis and haemostasis

authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:Osteoprotegerin (OPG) regulates bone metabolism by reducing the activation of osteoclasts, but may also be involved in blood vessel calcification and atherosclerosis. Within endothelial cells OPG is stored in Weibel-Palade bodies (WPBs). Blood kinetics of OPG are essentially unknown. We aimed to assess these using two...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Kovacevic KD,Brostjan C,Schwameis M,Hayden H,Derhaschnig U,Firbas C,Jilma B,Schoergenhofer C

更新日期：2020-07-01 00:00:00

abstract：:Lysyl oxidase (LOX) is an extracellular matrix-modifying enzyme that seems to play a critical role in vascular remodelling. However, the lack of viable LOX-deficient animal models has been an obstacle to deep in LOX biology. In this study we have developed a transgenic mouse model that over-expresses LOX in vascular s...

journal_title：Thrombosis and haemostasis

authors： Orriols M,Guadall A,Galán M,Martí-Pàmies I,Varona S,Rodríguez-Calvo R,Briones AM,Navarro MA,de Diego A,Osada J,Martínez-González J,Rodríguez C

更新日期：2014-10-01 00:00:00

abstract：:In the AMPLIFY clinical trial, apixaban was non-inferior to warfarin plus subcutaneous enoxaparin bridge therapy in the treatment of acute venous thromboembolism (VTE) and was associated with significantly less bleeding. This study evaluated their comparative effectiveness and safety in routine clinical practice. A ma...

journal_title：Thrombosis and haemostasis

authors： Weycker D,Li X,Wygant GD,Lee T,Hamilton M,Luo X,Vo L,Mardekian J,Pan X,Burns L,Atwood M,Hanau A,Cohen AT

更新日期：2018-11-01 00:00:00

abstract：:Fibrinogen degradation products formed by the action of purified haemolymph and saliva of a Saturnidae caterpillar of the Lonomia genus were studies by immunoelectrophoresis and polyacrylamide/SDS gel electrophoresis. The pattern of degradation differ form the one described for plasmin, trypsin, brinase, and ochrase. ...

journal_title：Thrombosis and haemostasis

authors： Arocha-Piñango CL,Perales J,Carvajal Z

更新日期：1981-06-30 00:00:00

abstract：:A possible role of the plasminogen/plasmin or fibrinolytic system in several biological processes has been implied from correlations between fibrinolytic activity and (patho)physiological phenomena. However, such indirect evidence does not allow to definitively establish the biological relevance of this system. Two re...

journal_title：Thrombosis and haemostasis

authors： Carmeliet P,Collen D

更新日期：1995-07-01 00:00:00

abstract：:Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the rel...

journal_title：Thrombosis and haemostasis

authors： Reddel CJ,Pennings GJ,Curnow JL,Chen VM,Kritharides L

更新日期：2018-04-01 00:00:00

abstract：:Constitutive expression of tissue factor (TF) by acute promyelocytic leukemia (APL) cells may contribute to thrombotic complications. In this study we examined the transcriptional mechanisms of all-trans retinoic acid (ATRA)-induced down-regulation of TF in the APL cell line NB4, by analysis of stable clones expressin...

journal_title：Thrombosis and haemostasis

authors： Tenno T,Oberg F,Mackman N,Nilsson K,Siegbahn A

更新日期：2003-11-01 00:00:00

abstract：:Imaging methods based on time-lapse microscopy are important tools for studying the dynamic events that shape thrombus formation upon vascular injury. However, there is a lack of methods to translate the vast amount of visual data generated in such experiments into quantitative variables describing platelet movements ...

journal_title：Thrombosis and haemostasis

authors： Tunströmer K,Faxälv L,Boknäs N,Lindahl TL

更新日期：2018-09-01 00:00:00

abstract：:The stimulated release of von Willebrand factor (vWF) from endothelial cells by secretagogues such as thrombin is associated with the translocation of Weibel-Palade bodies to the cell membrane and the surface expression of P-selectin (also known as GMP 140, PADGEM and CD 62). P-selectin, which is stored in Weibel-Pala...

journal_title：Thrombosis and haemostasis

authors： Collins PW,Macey MG,Cahill MR,Newland AC

更新日期：1993-08-02 00:00:00

abstract：:Hematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. ...

journal_title：Thrombosis and haemostasis

authors： Ruan C,Wu Y,Okada T,Motoi S,Kondo T,Jiang M,Xin X,Peng L,Ichihara K,Ikeda Y

更新日期：2002-07-01 00:00:00

abstract：:Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objec...

journal_title：Thrombosis and haemostasis

authors： Burchall GF,Piva TJ,Ranasinha S,Teede HJ

更新日期：2017-11-01 00:00:00

abstract：:There is much debate over the appropriateness of prescribing prolonged anticoagulation to heterozygous carriers of factor V Leiden suffering a first episode of deep vein thrombosis (DVT). We, thus used meta-analysis to estimate from six eligible studies the summary odds-ratio of recurrent DVT in carriers of factor V L...

journal_title：Thrombosis and haemostasis

authors： Marchetti M,Pistorio A,Barosi G

更新日期：2000-11-01 00:00:00

abstract：:We have previously reported that platelets from bleeding Simmental cattle do not aggregate in vitro in response to ADP, collagen and calcium ionophore A23187, though calcium mobilization and myosin light chain phosphorylation do occur. The aggregation abnormality, measured by aggregometry, was ascribed to abnormal cyt...

journal_title：Thrombosis and haemostasis

authors： Frojmovic MM,Wong T,Searcy GP

更新日期：1996-12-01 00:00:00

abstract：:Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems. It can be supposed that PMPs can contribute to the development o...

journal_title：Thrombosis and haemostasis

authors： Sinauridze EI,Kireev DA,Popenko NY,Pichugin AV,Panteleev MA,Krymskaya OV,Ataullakhanov FI

更新日期：2007-03-01 00:00:00

abstract：:We have established a new, enzyme-linked immunosorbent assay (ELISA) for the detection of ADAMTS13 antigen using purified polyclonal rabbit anti-human ADAMTS13 IgG. Normal plasma ADAMTS13 antigen levels span a concentration of 740-1420 ng/ml (median 1080 ng/ml) resulting in an ADAMTS13 activity to antigen ratio of 0.4...

journal_title：Thrombosis and haemostasis

authors： Rieger M,Ferrari S,Kremer Hovinga JA,Konetschny C,Herzog A,Koller L,Weber A,Remuzzi G,Dockal M,Plaimauer B,Scheiflinger F

更新日期：2006-02-01 00:00:00

abstract：:According to some authors factor VIII procoagulant activity may be dissociable from carrier protein (MW approximately 2 X 10(6) by agarose gel filtration, e.g. at high ionic strength. We were able to reproduce this phenomenon. However, addition of protease inhibitor (Trasylol) prevented the appearance of low molecular...

journal_title：Thrombosis and haemostasis

authors： Beck EA,Bachmann P,Barbier P,Furlan M

更新日期：1976-02-29 00:00:00

abstract：:Apixaban does not require monitoring nor frequent dose adjustment. However, searching for the optimal dose for the individual patient may be useful in some situations. Moreover, there is a need for clinicians to know whether coagulation assays are influenced by apixaban use. The aim of this study was to determine whic...

journal_title：Thrombosis and haemostasis

authors： Douxfils J,Chatelain C,Chatelain B,Dogné JM,Mullier F

更新日期：2013-08-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) is used increasingly for prophylaxis and treatment of venous thromboembolism during pregnancy. However, the prophylactic dose for patients at moderate risk varies between centers, and the recommended LMWH dose for the non pregnant patient is frequently used in pregnant women. The ai...

journal_title：Thrombosis and haemostasis

authors： Norris LA,Bonnar J,Smith MP,Steer PJ,Savidge G

更新日期：2004-10-01 00:00:00

abstract：:The development of venous thromboembolism (VTE), which includes deep-vein thrombosis and pulmonary embolism, may be associated with inherited or acquired risk factors that can be measured in plasma or DNA testing. The main inherited thrombophilias include the plasma deficiencies of the natural anticoagulants antithrom...

journal_title：Thrombosis and haemostasis

authors： Franchini M,Martinelli I,Mannucci PM

更新日期：2016-01-01 00:00:00

abstract：:Deep vein thrombosis (DVT) in children occurs primarily in the upper body venous system. This prospective diagnostic study compared bilateral venography and ultrasound for detection of DVT in the upper venous system in 66 children with acute lymphoblastic leukemia. Results were interpreted by central blinded adjudicat...

journal_title：Thrombosis and haemostasis

authors： Male C,Chait P,Ginsberg JS,Hanna K,Andrew M,Halton J,Anderson R,McCusker P,Wu J,Abshire T,Cherrick I,Mahoney D,Mitchell L

更新日期：2002-04-01 00:00:00

abstract：:Patients with haemophilia A have seriously impaired thrombin generation due to an inherited deficiency of factor (F)VIII, making them form unstable fibrin clots that are unable to maintain haemostasis. Data on fibrin structure in haemophilia patients remain limited. Fibrin permeability, assessed by a flow measurement ...

journal_title：Thrombosis and haemostasis

authors： Antovic A,Mikovic D,Elezovic I,Zabczyk M,Hutenby K,Antovic JP

更新日期：2014-04-01 00:00:00

abstract：:The effects on platelet function of a 5-day course of Ticlopidine (Tcl) have been studied in two groups of volunteers receiving different dosage schedules. Tcl had a relatively greater inhibitory effect on aggregation induced by ADP than by other agonists, and a greater effect, in contrast to that of an ADP receptor a...

journal_title：Thrombosis and haemostasis

authors： Hardisty RM,Powling MJ,Nokes TJ

更新日期：1990-08-13 00:00:00

abstract：OBJECTIVE:To look for an association between venous thromboembolism (VTE) and antiphospholipid antibodies (aPL) in patients without Systemic Lupus Erythematosus (SLE) when implementing, beside conventional assays, new tests for aPL screening directed towards purified proteic targets. METHODS:We conducted a cross-secti...

journal_title：Thrombosis and haemostasis

authors： Pasquier E,Amiral J,de Saint Martin L,Mottier D

更新日期：2001-08-01 00:00:00

abstract：:Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been show...

journal_title：Thrombosis and haemostasis

authors： Gray E,Mulloy B,Barrowcliffe TW

更新日期：2008-05-01 00:00:00

abstract：:Dilated cardiomyopathy is associated with thromboembolic complications, which correlate poorly, however, with a visible left ventricular thrombus. Therefore, this study was performed to assess whether an abnormality of platelet function in vivo can be detected in patients with dilated cardiomyopathy. Platelet survival...

journal_title：Thrombosis and haemostasis

authors： Weidinger F,Glogar D,Sochor H,Sinzinger H

更新日期：1991-10-01 00:00:00

abstract：:Despite reports that Tris [tris (hydroxymethyl)aminomethane] affects platelets, it is often used to buffer suspending media. Human or rabbit platelets were washed and resuspended in Tyrode solution containing apyrase and 0.35% albumin. Addition of 15 mM Tris partially inhibited primary aggregation induced by 10 microM...

journal_title：Thrombosis and haemostasis

authors： Packham MA,Guccione MA,Nina M,Kinlough-Rathbone RL,Mustard JF

更新日期：1984-04-30 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is one of the main regulators of the tissue factor (TF) pathway of coagulation. To tether human TFPI to the cell surface, full length or truncated TFPI lacking the third Kunitz domain were fused with domains three and four and the carboxy-terminal sequence of human CD4. Construct...

journal_title：Thrombosis and haemostasis

authors： Riesbeck K,Dorling A,Kemball-Cook G,McVey JH,Jones M,Tuddenham EG,Lechler RI

更新日期：1997-12-01 00:00:00

abstract：:Atherosclerosis and its clinical manifestations (i.e. myocardial infarction, stroke) are major causes of mortality and morbidity in Western countries. Endothelial dysfunction is considered the first step in the cascade leading up to coronary events. Increasing evidence suggests that direct inhibition of thromboxane A2...

journal_title：Thrombosis and haemostasis

authors： Giannarelli C,Zafar MU,Badimon JJ

更新日期：2010-11-01 00:00:00