Heparin and low-molecular-weight heparin.

Abstract:

:Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been shown to be at least as effective and safe as unfractionated heparin and have replaced the latter in many indications. In this article the chemistry, mechanisms of action, measurement of anticoagulant activities, and clinical status of heparin and LMWH are reviewed.

journal_name

Thromb Haemost

authors

Gray E,Mulloy B,Barrowcliffe TW

doi

10.1160/TH08-01-0032

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

807-18

issue

5

eissn

0340-6245

issn

2567-689X

pii

08050807

journal_volume

99

pub_type

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