Gene targeting and gene transfer studies of the biological role of the plasminogen/plasmin system.

abstract：:Low molecular weight heparin (LMWH) is used increasingly for prophylaxis and treatment of venous thromboembolism during pregnancy. However, the prophylactic dose for patients at moderate risk varies between centers, and the recommended LMWH dose for the non pregnant patient is frequently used in pregnant women. The ai...

journal_title：Thrombosis and haemostasis

authors： Norris LA,Bonnar J,Smith MP,Steer PJ,Savidge G

更新日期：2004-10-01 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:Although there is evidence that altitude increases the platelet count, its effect on the platelet precursor stimulating factor, thrombopoietin (TPO), is unclear. Unlike erythropoietin, TPO appears largely unresponsive to exogenous signals. In a study in 16 healthy volunteers, we report the effects of altitude exposure...

journal_title：Thrombosis and haemostasis

authors： Hartmann S,Krafft A,Huch R,Breymann C

更新日期：2005-01-01 00:00:00

abstract：:Primary prevention of cardiovascular events with aspirin in patients with elevated cardiovascular risk, including diabetics, is currently under intense discussion. Data from meta-analyses suggests that the efficacy of aspirin in these patients is low, whereas there is a significantly increased bleeding tendency. Howev...

journal_title：Thrombosis and haemostasis

authors： Schrör K,Kristensen SD,Storey RF,Verheugt FWA

更新日期：2019-10-01 00:00:00

abstract：:Several members of a family from Scranton, Pennsylvania were identified to have normal levels of prothrombin antigen while their prothrombin clotting activity was approximately 50% of normal. There has been no previous history of bleeding or other clinical manifestations in this family. The genomic DNA from the proban...

journal_title：Thrombosis and haemostasis

authors： Sun WY,Smirnow D,Jenkins ML,Degen SJ

更新日期：2001-04-01 00:00:00

abstract：:The endothelial barrier of the vasculature is of utmost importance for separating the blood stream from underlying tissues. This barrier is formed by tight and adherens junctions (TJ and AJ) that form intercellular endothelial contacts. TJ and AJ are integral membrane structures that are connected to the actin cytoske...

journal_title：Thrombosis and haemostasis

authors： García-Ponce A,Citalán-Madrid AF,Velázquez-Avila M,Vargas-Robles H,Schnoor M

更新日期：2015-01-01 00:00:00

abstract：:A new immunoadsorbent-amidolytic assay (IAA) for the specific differential detection of two-chain urokinase-type plasminogen activator (tcu-PA) and its single-chain precursor (scu-PA) in cell culture supernatants has been developed. The assay combines the selectivity of immunoassays with the specificity of enzyme acti...

journal_title：Thrombosis and haemostasis

authors： Corti A,Nolli ML,Cassani G

更新日期：1986-12-15 00:00:00

abstract：:Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the pathophysiology of ischaemic heart disease. Clopidogrel and the novel intravenous antithrombotic agent AR-C69931MX act at the level of the platelet P2Y12 receptor, which is known to amplify platelet activatio...

journal_title：Thrombosis and haemostasis

authors： Storey RF,Judge HM,Wilcox RG,Heptinstall S

更新日期：2002-09-01 00:00:00

abstract：:Hyperinsulinemia predicts future cardiovascular events, but may also contribute to atherosclerosis. We therefore studied the consequences of prolonged insulin treatment of human umbilical vein endothelial cells (HUVEC) on the phosphatidylinositol-3'-kinase(PI3K)/Akt/nitric oxide(NO)-dependent insulin signaling, togeth...

journal_title：Thrombosis and haemostasis

authors： Madonna R,De Caterina R

更新日期：2009-02-01 00:00:00

abstract：:Myocardial infarction in the young provides a unique model for the investigation of potential interactions between atherosclerotic and prothrombotic risk factors. Because myocardial infarction reflects atherothrombotic disease, it is important to take into account factors related to atherosclerosis when examining prot...

journal_title：Thrombosis and haemostasis

authors： Siscovick DS,Schwartz SM,Rosendaal FR,Psaty BM

更新日期：1997-07-01 00:00:00

abstract：:Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism. NOMAC/E2 is a new monophasic OC that combines nomegestrol acetate (NOMAC), a highly selective progestogen, with 17β-estradiol (E2). The study objective was to co...

journal_title：Thrombosis and haemostasis

authors： Gaussem P,Alhenc-Gelas M,Thomas JL,Bachelot-Loza C,Remones V,Ali FD,Aiach M,Scarabin PY

更新日期：2011-03-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) evolution is unpredictable, and there is no therapy except surgery for patients with an aortic size> 5 cm (large AAA). We aimed to identify new potential biomarkers that could facilitate prognosis and treatment of patients with AAA. A differential quantitative proteomic analysis of plas...

journal_title：Thrombosis and haemostasis

authors： Burillo E,Lindholt JS,Molina-Sánchez P,Jorge I,Martinez-Pinna R,Blanco-Colio LM,Tarin C,Torres-Fonseca MM,Esteban M,Laustsen J,Ramos-Mozo P,Calvo E,Lopez JA,Vega de Ceniga M,Michel JB,Egido J,Andrés V,Vazquéz J,Meilha

更新日期：2015-06-01 00:00:00

abstract：:Expression of isolated beta integrin cytoplasmic domains in cultured endothelial cells was reported to induce cell detachment and death. To test whether cell death was the cause or the consequence of cell detachment, we expressed isolated integrin beta1 cytoplasmic and transmembrane domains (CH1) in cultured human umb...

journal_title：Thrombosis and haemostasis

authors： Hasmim M,Vassalli G,Alghisi GC,Bamat J,Ponsonnet L,Bieler G,Bonnard C,Paroz C,Oguey D,Rüegg C

更新日期：2005-11-01 00:00:00

abstract：:Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, sugg...

journal_title：Thrombosis and haemostasis

authors： Mao G,Jin J,Kunapuli SP,Rao AK

更新日期：2016-10-28 00:00:00

abstract：:Monoclonal antibodies to human fibrin have been prepared from stable hybridomas, obtained by fusion of a mouse myeloma cell line (NS-1) and spleen cells of Balb/c mice immunized with a suspension of human fibrin. One cell line, DG1, producing a monoclonal antibody of the IgG1, kappa subclass, reacted specifically with...

journal_title：Thrombosis and haemostasis

authors： Gargan PE,Ploplis VA,Scheu JD

更新日期：1988-06-16 00:00:00

abstract：BACKGROUND: Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the r...

journal_title：Thrombosis and haemostasis

authors： Crombag GAJC,Spronk HM,Nelemans P,Schreuder FHBM,Truijman MTB,van Dijk AC,de Rotte AAJ,Liem MI,Daemen MJAP,van der Steen AFW,Mess WH,Nederkoorn PJ,Hendrikse J,van der Lugt A,Wildberger JE,Ten Cate H,van Oostenbrugge RJ,

更新日期：2018-08-01 00:00:00

abstract：:Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced "FVa activity augmentation" as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (r...

journal_title：Thrombosis and haemostasis

authors： Bhat V,von Drygalski A,Gale AJ,Griffin JH,Mosnier LO

更新日期：2016-03-01 00:00:00

abstract：:Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examined how changes in platelet function relate to changes in platelet coun...

journal_title：Thrombosis and haemostasis

authors： Zwifelhofer NMJ,Bercovitz RS,Cole R,Yan K,Simpson PM,Moroi A,Newman PJ,Niebler RA,Scott JP,Stuth EAD,Woods RK,Benson DW,Newman DK

更新日期：2020-01-01 00:00:00

abstract：:We investigated plasma activated factor VII (FVIIa) levels in uremic patients (nondialysis group: n = 38; dialysis group: n = 36) and healthy controls (n = 32). We also measured the plasma levels of thrombomodulin (an indicator of endothelial cell injury) and tissue factor. Plasma FVIIa showed a marked increase in the...

journal_title：Thrombosis and haemostasis

authors： Kario K,Matsuo T,Matsuo M,Koide M,Yamada T,Nakamura S,Sakata T,Kato H,Miyata T

更新日期：1995-05-01 00:00:00

abstract：:The introduction of venography into patient care was a major advance because it was the first accurate method for the diagnosis of DVT. Compression ultrasound has since become the preferred test for patients with suspected DVT because, unlike venography, it is simple, non-invasive and widely available. Venography has ...

journal_title：Thrombosis and haemostasis

authors： Hirsh J,Ginsberg JS,Chan N,Guyatt G,Eikelboom JW

更新日期：2014-01-01 00:00:00

abstract：:Activated blood coagulation factor XIII has an important role in the final stage of the clotting cascade by the covalent crosslinking of alpha- and gamma-fibrin chains. We have recently shown that a functional polymorphism in exon 2. codon 34 of the FXIII A-subunit gene is protective against myocardial infarction. To ...

journal_title：Thrombosis and haemostasis

authors： Kohler HP,Futers TS,Grant PJ

更新日期：1999-04-01 00:00:00

abstract：:The redistribution of platelet glycoproteins (GP) Ib, IIb and IIIa in response to stimulation with human platelet specific alloantibodies, autoantibodies and a quinidine-dependent antibody was investigated using immunofluorescence and a quantitative radioimmunoassay. The platelet GPs carrying the corresponding epitope...

journal_title：Thrombosis and haemostasis

authors： Santoso S,Kiefel V,Mueller-Eckhardt C

更新日期：1987-10-28 00:00:00

abstract：:Nipah virus (NiV) is a highly pathogenic paramyxovirus that was first isolated in 1999 during an outbreak in Malaysia. In contrast to other paramyxoviruses NiV infects many mammalian species. Because of its zoonotic potential, the high pathogenicity and the lack of therapeutic treatment, NiV was classified as a biosaf...

journal_title：Thrombosis and haemostasis

authors： Maisner A,Neufeld J,Weingartl H

更新日期：2009-12-01 00:00:00

abstract：:This study examines the relationship between plasma Plasminogen Activator Inhibitor-1 (PAI-1) activity and the PAI-1 4G/5G polymorphism, and their association with the risk of myocardial infarction (MI). Furthermore, this study explores whether a high level of PAI-1 or whether the PAI-1 4G/5G polymorphism synergistica...

journal_title：Thrombosis and haemostasis

authors： Leander K,Wiman B,Hallqvist J,Sten-Linder M,de Faire U,Stockholm Heart Epidemiology Program.

更新日期：2003-06-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:A study was made of the influence of thrombin on the platelet-aggregating activity of human factor VIII with Ristocetin as cofactor. Purified factor VIII and different amounts of a thrombin-Sepharose 2B complex were mixed and incubated for various periods of time. The factor VIII-related platelet-aggregating activitie...

journal_title：Thrombosis and haemostasis

authors： Vukovich T,Koller E,Doleschel W

更新日期：1979-10-31 00:00:00

abstract：:A technique has been developed to monitor the development of thrombin in freshly collected whole blood in the absence of anticoagulants. It is based on the centrifugal separation of the cellular components from subsamples of blood drawn from non-anticoagulated clotting whole blood which are diluted in buffer containin...

journal_title：Thrombosis and haemostasis

authors： Kessels H,Béguin S,Andree H,Hemker HC

更新日期：1994-07-01 00:00:00

abstract：:Two candidate ECAA reference preparations have been calibrated in a multicentre exercise at 14 representative national laboratories to provide reference thromboplastin for a large field study in 16 European countries. Two preparations were required because of the established differences in ISI arising from the two mai...

journal_title：Thrombosis and haemostasis

authors： Poller L,Barrowcliffe TW,van den Besselaar AM,Jespersen J,Tripodi A,Houghton D

更新日期：1996-12-01 00:00:00

abstract：:The effect of a basic synthetic peptide, representing the C-terminal region of tissue factor pathway inhibitor (TFPI - Lys254 - Met276), as well as that of the whole protein, on the activity of lipoprotein lipase (LPL) is described. The activity of bovine LPL was measured by chromogenic assay using a water-soluble chr...

journal_title：Thrombosis and haemostasis

authors： Mukherjee M,Kakkar VV

更新日期：1999-12-01 00:00:00

abstract：:The vitamin K-dependent carboxylation of specific glutamyl residues to gamma-carboxyglutamyl residues occurs during the endoplasmic reticulum processing of a limited number of proteins. The fate of the under-gamma-carboxylated proteins during protein processing was studied. When human hepatoma (HepG2) cells were grown...

journal_title：Thrombosis and haemostasis

authors： Wu W,Bancroft JD,Suttie JW

更新日期：1996-07-01 00:00:00