Platelets from bleeding Simmental cattle have a long delay in both ADP-activated expression of GpIIB-IIIA receptors and fibrinogen-dependent platelet aggregation.

abstract：STUDY OBJECTIVE:Cytokines increase endothelial tissue factor (TF) and tissue plasminogen activator inhibitor type-1 (PAI-1) expression in vitro. Tissue factor interacts with factor VII to facilitate thrombosis and PAI-1 inhibits fibrinolysis by endogenous plasminogen activators. Because cytokine release is increased in...

journal_title：Thrombosis and haemostasis

authors： Green J,Doughty L,Kaplan SS,Sasser H,Carcillo JA

更新日期：2002-02-01 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:The turnover of recombinant pro-urokinase (Rec-pro-UK), recombinant urokinase (Rec-UK) and natural urinary urokinase (Nat-UK) was studied in rabbits and in squirrel monkeys (Saimiri sciureus). Following intravenous injection, urokinase activity disappeared rapidly from the blood. The initial disappearance rate could b...

journal_title：Thrombosis and haemostasis

authors： Collen D,De Cock F,Lijnen HR

更新日期：1984-08-31 00:00:00

abstract：:Thrombolytic therapy has become the mainstay of treatment for acute transmural myocardial infarction. Present fibrinolytic regimens have a number of shortcomings, including the failure to induce early and sustained reperfusion in as many as 40-50% of the patients, and to prevent reocclusion in another 10-20% of the pa...

journal_title：Thrombosis and haemostasis

authors： Pislaru SV,Van de Werf F

更新日期：1999-09-01 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00

abstract：:Neuroserpin is a member of the serine proteinase inhibitor (serpin) gene family that reacts preferentially with tissue-type plasminogen activator (tPA) and is primarily localized to neurons in regions of the brain where tPA is also found. Outside of the central nervous system (CNS) tPA is predominantly found in the bl...

journal_title：Thrombosis and haemostasis

authors： Yepes M,Lawrence DA

更新日期：2004-03-01 00:00:00

abstract：:A recent report indicated that an arrow poison used by the native Indians of Rondonia, Brazil, to kill small animals was associated with profuse bleeding. The arrow poison was prepared from the bark of a tree, known locally as Tike-Uba. We have obtained bark and sap specimens from this tree and have characterized a po...

journal_title：Thrombosis and haemostasis

authors： Jacobs JW,Petroski C,Friedman PA,Simpson E

更新日期：1990-02-19 00:00:00

abstract：:Human antithrombin III was purified from fresh human plasma by affinity chromatography on heparin-Sepharose, affinity chromatography on concanavalin A Sepharose, gel filtration on Ultrogel AcA 34, ion exchange chromatography on DEAE A-50 Sephadex and preparative agarose gel electrophoresis. The hydrolytic activity of ...

journal_title：Thrombosis and haemostasis

authors： Clemmensen I

更新日期：1978-06-30 00:00:00

abstract：:Thrombus formation at an artificial surface in contact with blood is a complex process that encompasses accretion of platelets from flowing blood and fibrin deposition. Platelet adhesion and fibrin formation are intimately intertwined reactions that are triggered by different sets of surface adsorbed plasma proteins. ...

journal_title：Thrombosis and haemostasis

authors： Keuren JF,Wielders SJ,Willems GM,Morra M,Lindhout T

更新日期：2002-04-01 00:00:00

abstract：:Calibration of local standards for ristocetin cofactor activity of von Willebrand's factor (vWF:Rcof) against reference preparations is required to achieve a better standardization of this measurement. We have observed that in calibration assays (multiple line parallel bioassay) for vWF:Rcof, measured aggregometricall...

journal_title：Thrombosis and haemostasis

authors： Rodeghiero F,Castaman G

更新日期：1987-12-18 00:00:00

abstract：:Growing evidence indicates that rheumatoid arthritis (RA) is associated with an increased risk for thromboembolic cardiovascular events. We investigated thrombin generation profiles in RA patients and their dependence on plasma factor/inhibitor composition. Plasma factor (F) compositions (II, V, VII, VIII, IX, X), ant...

journal_title：Thrombosis and haemostasis

authors： Undas A,Gissel M,Kwasny-Krochin B,Gluszko P,Mann KG,Brummel-Ziedins KE

更新日期：2010-08-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an acquired thrombophilia with an uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess the association of APS with the clinical phenotype of CTEPH. We retrospectively reviewed data of CTEPH patients referred to our center. Cli...

journal_title：Thrombosis and haemostasis

authors： Jiang X,Du Y,Cheng CY,Denas G,Zhou YP,Wu T,Zhang YX,Han ZY,Pengo V,Jing ZC

更新日期：2019-09-01 00:00:00

abstract：:Integrins are cell surface adhesion receptors that participate in a variety of important processes throughout the vasculature. Here we summarize some recent findings on the regulation of integrin mediated cellular adhesion. Particular emphasis is placed on the regulation of integrin affinity for ligand (activation), a...

journal_title：Thrombosis and haemostasis

authors： Woodside DG,Liu S,Ginsberg MH

更新日期：2001-07-01 00:00:00

abstract：:Hirudin is a potent thrombin inhibitor derived from the leech Hirudo medicinalis salivary gland which has considerable potential for therapeutic use in thrombotic disease. The major risk attendant its use is hemorrhage. This study investigates the hypothesis that the prohemostatic effects of DDAVP infusion can curtail...

journal_title：Thrombosis and haemostasis

authors： Bove CM,Casey B,Marder VJ

更新日期：1996-03-01 00:00:00

abstract：:Factor V Leiden is a procoagulant mutation associated with venous and arterial thrombosis and pregnancy complications. Its high prevalence of 5% in Caucasians suggests that there are evolutionary benefits as well. Carriers are indeed reported to have various advantageous phenotypes related to haemostasis, inflammation...

journal_title：Thrombosis and haemostasis

authors： van Mens TE,Levi M,Middeldorp S

更新日期：2013-07-01 00:00:00

abstract：:Platelet aggregation and thromboxane A2 have been implicated in the pathogenesis of several forms of vascular disease. The aim of this study was to determine the effect of a wide range of adrenoceptor antagonists on platelet aggregation, and thromboxane A2 production, from normal human platelet rich plasma in vitro. L...

journal_title：Thrombosis and haemostasis

authors： Greer IA,Walker JJ,McLaren M,Calder AA,Forbes CD

更新日期：1985-08-30 00:00:00

abstract：:Microvascular endothelial damage underlies the pathological changes in haemorrhagic colitis and the haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). Shiga toxins (Stxs) are presently the best characterised EHEC virulence factors that can cause the microvascular endothelium injury...

journal_title：Thrombosis and haemostasis

authors： Bielaszewska M,Karch H

更新日期：2005-08-01 00:00:00

abstract：:Vascular cell adhesion molecule 1 (VCAM-1, CD106) is expressed as a type I transmembrane integrin counter-receptor on activated endothelium and mediates white blood cell attachment. The alternatively spliced 7-domain (7d) form of VCAM-1 contains a potential thrombin cleavage site. Thrombin proteolysis of 7d-VCAM-1 may...

journal_title：Thrombosis and haemostasis

authors： Barthel SR,Johansson MW,Annis DS,Mosher DF

更新日期：2006-05-01 00:00:00

abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

journal_title：Thrombosis and haemostasis

authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

更新日期：2016-09-27 00:00:00

abstract：:Recent progress in the understanding of thrombus formation has suggested an important role of glycoprotein (GP)VI. In contrast to its pivotal role in collagen-induced platelet activation, it has been suggested that its blockade does not induce massive bleeding tendency. To demonstrate the dissociation between inhibito...

journal_title：Thrombosis and haemostasis

authors： Matsumoto Y,Takizawa H,Nakama K,Gong X,Yamada Y,Tandon NN,Kambayashi J

更新日期：2006-08-01 00:00:00

abstract：:Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing medical education (CME) on eAlerts and on thromboproph...

journal_title：Thrombosis and haemostasis

authors： Beeler PE,Kucher N,Blaser J

更新日期：2011-10-01 00:00:00

abstract：:The simultaneous additon of suboptimal concentrations of factor VIII and intact or plasmin-lysed fibrinogen into mixtures of the vitamin K dependent factors, phospholipids, adsorbed bovine serum (supplier to factor V) and calcium, increased the amount of thrombin which was generated three to twenty times over the sum ...

journal_title：Thrombosis and haemostasis

authors： Triantaphyllopoulos DC,Ryan LT

更新日期：1976-04-30 00:00:00

abstract：:A suggestive locus on chromosome 8 could be shown to be associated with familial high factor VIII (FVIII) levels in venous thromboembolism. The ADAMDEC 1 gene is a candidate expressing an ectodomain sheddase. However, the ectodomain of the clearance receptor for FVIII, the low-density lipoprotein receptor-related prot...

journal_title：Thrombosis and haemostasis

authors： Berger M,Moscatelli H,Kulle B,Luxembourg B,Blouin K,Spannagl M,Lindhoff-Last E,Schambeck CM

更新日期：2008-05-01 00:00:00

abstract：:Congenital afibrinogenemia and severe hypofibrinogenemia are severe bleeding disorders characterized by either undetectable or very low levels of fibrinogen in patients' plasma and platelets. A majority of the reported cases are caused by mutations in the fibrinogen Aalpha chain. In this study, we identified a genetic...

journal_title：Thrombosis and haemostasis

authors： Xu X,Wu J,Zhai Z,Zhou R,Wang X,Wang H,Ding K,Sun Z,Ni H

更新日期：2006-06-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:Hemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children (< 3 years), is mainly related to Shiga toxins (Stx)-producing Escherichia coli (STEC) infections. STEC are confined to the gut resulting in hemorrhagic colitis, whereas Stx are delivered in blood to target kidney and brain, with unc...

journal_title：Thrombosis and haemostasis

authors： Brigotti M,He X,Carnicelli D,Arfilli V,Porcellini E,Galassi E,Tazzari PL,Ricci F,Patfield SA,Testa S,Paglialonga F,Picicco D,Caprioli A,Scavia G,Morabito S,Ardissino G

更新日期：2020-01-01 00:00:00

abstract：:Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

journal_title：Thrombosis and haemostasis

authors： Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

更新日期：2012-11-01 00:00:00

abstract：:There is increasing concern that some anticoagulants can paradoxically increase thrombogenesis under certain circumstances. Previously, we demonstrated that at certain doses a direct thrombin inhibitor, melagatran, worsens the coagulation status induced by tissue factor (TF) injection in a rat model. We utilised an i...

journal_title：Thrombosis and haemostasis

authors： Furugohri T,Sugiyama N,Morishima Y,Shibano T

更新日期：2011-12-01 00:00:00

abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

journal_title：Thrombosis and haemostasis

authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

更新日期：2013-04-01 00:00:00

abstract：:The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a thrombin receptor agonist/activating peptide (TRAP). In this study, Northern blot analysis showed that cultured human vascular smooth muscle cells (HVSMC) expr...

journal_title：Thrombosis and haemostasis

authors： Kanthou C,Benzakour O,Patel G,Deadman J,Kakkar VV,Lupu F

更新日期：1995-11-01 00:00:00