Relation between ADAMTS13 activity and ADAMTS13 antigen levels in healthy donors and patients with thrombotic microangiopathies (TMA).

abstract：:In a prospective study, coagulation test results were compared in 137 patients with colorectal cancer (CRC) and 39 subjects with benign colorectal diseases. Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and soluble fibrin (SF) were measured in plasma before and after surgery. CRC patients prese...

journal_title：Thrombosis and haemostasis

authors： Iversen LH,Thorlacius-Ussing O

更新日期：2002-03-01 00:00:00

abstract：:The prevalence of coagulation disorders in patients with upper extremity deep-vein thrombosis (UE-DVT) is unknown due to only a few observational studies of limited size reporting varying results. Therefore, we aimed to evaluate the prevalence of thrombophilia in patients with UE-DVT compared to patients with lower ex...

journal_title：Thrombosis and haemostasis

authors： Linnemann B,Meister F,Schwonberg J,Schindewolf M,Zgouras D,Lindhoff-Last E,MAISTHRO registry.

更新日期：2008-09-01 00:00:00

abstract：:Parameters of the fibrinolytic system were studied in a primate model where the generation of thrombin was promoted in vivo. The procoagulant stimulus used was a combination of human factor Xa in combination with phosphatidylcholine/phosphatidylserine lipid vesicles (PCPS) as the source of coagulant active phospholipi...

journal_title：Thrombosis and haemostasis

authors： Giles AR,Nesheim ME,Herring SW,Hoogendoorn H,Stump DC,Heldebrant CM

更新日期：1990-06-28 00:00:00

abstract：:ADP or thrombin caused a transient change in creatine phosphate (CP) content of rat platelets. At 25 degrees C the CP content decreased most 30 sec after the addition of ADP or thrombin and recovered thereafter. ATP or AMP was without effect. The rat platelets aggregated at 25 degrees C by ADP or thrombin, but the cha...

journal_title：Thrombosis and haemostasis

authors： Shibata S

更新日期：1979-08-31 00:00:00

abstract：:Haemophilia A and B are X-linked disorders which are due to a reduced activity of coagulation factor VIII or IX, respectively. Female carriers have a wide range of plasma concentration of factor VIII or factor IX, and may in rare cases have an affected phenotype. In order to investigate if this variation is related to...

journal_title：Thrombosis and haemostasis

authors： Orstavik KH,Scheibel E,Ingerslev J,Schwartz M

更新日期：2000-03-01 00:00:00

abstract：:In the last decade, several studies revealed inter-patient response variability to antiplatelet agents: patients who display negligible or no responses to these drugs are considered poor responders, or "resistant" to treatment. In order to identify poor responders to an antiplatelet drug, laboratory tests of platelet ...

journal_title：Thrombosis and haemostasis

authors： Cattaneo M

更新日期：2013-05-01 00:00:00

abstract：:Tamoxifen is a known anti-cancer drug and established estrogen receptor modulator. Few clinical studies have earlier implicated the drug in thrombotic complications attributable to lower anti-thrombin and protein S levels in plasma. However, action of tamoxifen on platelet signalling machinery has not been elucidated ...

journal_title：Thrombosis and haemostasis

authors： Nayak MK,Singh SK,Roy A,Prakash V,Kumar A,Dash D

更新日期：2011-10-01 00:00:00

abstract：:Antithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early a...

journal_title：Thrombosis and haemostasis

authors： Johnson EJ,Prentice CR,Parapia LA

更新日期：1990-02-19 00:00:00

abstract：:Thirty-one non-hemophilic patients with acquired antibodies to factor VIII were entered into a prospective, randomized, multi-institutional trial to determine the safety and efficacy of prednisone (P), cyclophosphamide (C), or the combination in the treatment of this disorder. Patients were eligible if they had antibo...

journal_title：Thrombosis and haemostasis

authors： Green D,Rademaker AW,Briët E

更新日期：1993-11-15 00:00:00

abstract：:Graduated elastic compression stockings (GECS) are commonly used in the primary prevention of deep vein thrombosis (DVT); however, their role in preventing recurrent DVT and also post-thrombotic syndrome is less well established. The aim of this review was to investigate the effect of GECS after DVT. A literature sear...

journal_title：Thrombosis and haemostasis

authors： Kakkos SK,Daskalopoulou SS,Daskalopoulos ME,Nicolaides AN,Geroulakos G

更新日期：2006-10-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein however the mechanisms by which Lp(a) promote the atherosclerotic process are not clear. The apolipoprotein(a) portion of Lp(a) shares partial homology with plasminogen, a finding that has stimulated numerous studies. Lp(a) binds to fibrin and the affinity between f...

journal_title：Thrombosis and haemostasis

authors： Harpel PC,Hermann A,Zhang X,Ostfeld I,Borth W

更新日期：1995-07-01 00:00:00

abstract：:There is increasing recognition of the importance of vulnerable plaque and acute plaque rupture leading to thrombosis, in the pathogenesis of acute coronary syndromes. This is fueling a number of developments, including novel imaging modalities and potential plaque stabilization therapies. However, to date, no animal ...

journal_title：Thrombosis and haemostasis

authors： Lowe HC,Jang IK,Khachigian LM

更新日期：2003-11-01 00:00:00

abstract：:CD36, also known as GPIIIb or GPIV, is a main protein of the platelet membrane. Accumulating evidence implicates CD36 in the pathogenesis of atherosclerosis. CD36 binds to cholesteryl-hemisuccinate coupled to agarose. This binding may be of physiologic relevance since CD36 has a long extracellular hydrophobic region a...

journal_title：Thrombosis and haemostasis

authors： Kronenberg A,Grahl H,Kehrel B

更新日期：1998-05-01 00:00:00

abstract：:A native fucosylated glycosaminoglycan from sea cucumber Holothuria fuscopunctata (nHG), mainly branched with Fuc3S4S, exhibited potent anticoagulant activity by intrinsic tenase iXase (FIXa-FVIIIa complex) and antithrombin-dependent factor IIa (FIIa) inhibition, but also had the effects of FXII activation and platele...

journal_title：Thrombosis and haemostasis

authors： Zhou L,Gao N,Sun H,Xiao C,Yang L,Lin L,Yin R,Li Z,Zhang H,Ji X,Zhao J

更新日期：2020-04-01 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:The Bernard-Soulier syndrome (BSS) is characterized by thrombocytopenia with giant platelets, a prolonged bleeding time with defective platelet adhesion to the subendothelium related to a defect in platelet membrane glycoprotein Ib (GPIb) and a decreased prothrombin consumption. The mechanism of the latter abnormality...

journal_title：Thrombosis and haemostasis

authors： Bellucci S,Girma JP,Lozano M,Meyer D,Caen JP

更新日期：1997-02-01 00:00:00

abstract：:Severe type I plasminogen deficiency is the underlying cause of ligneous conjunctivitis, a rare disease characterized by wood-like pseudomembranes developing on the ocular and extraocular mucosa. Two unrelated female patients with ligneous conjunctivitis and moderate hypoplasminogenemia are described. Being of fertile...

journal_title：Thrombosis and haemostasis

authors： Teresa Sartori M,Saggiorato G,Pellati D,Casonato A,Spiezia L,Pontara E,Gavasso S,Girolami A

更新日期：2003-07-01 00:00:00

abstract：:Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is requ...

journal_title：Thrombosis and haemostasis

authors： Mühle C,Schulz-Drost S,Khrenov AV,Saenko EL,Klinge J,Schneider H

更新日期：2004-03-01 00:00:00

abstract：:Previous studies on recombinant human soluble thrombomodulin (rsTM) from Chinese hamster ovary cells revealed that rsTM was expressed as two proteins that differed functionally in vitro due to the presence (rsTM beta) or absence (rsTM alpha) of chondroitin-4-sulfate. The current study evaluates the in vivo behavior of...

journal_title：Thrombosis and haemostasis

authors： Nawa K,Itani T,Ono M,Sakano K,Marumoto Y,Iwamoto M

更新日期：1992-03-02 00:00:00

abstract：:Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

journal_title：Thrombosis and haemostasis

authors： Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Paravalvular aortic regurgitation (PVAR) remains a frequent postprocedural concern following transcatheter aortic valve replacement (TAVR). Persistence of flow turbulence results in the cleavage of high-molecular-weight von Willebrand multimers, primary haemostasis dysfunction and may favour bleedings. Recen...

journal_title：Thrombosis and haemostasis

authors： Kibler M,Marchandot B,Messas N,Caspar T,Vincent F,Von Hunolstein JJ,Grunebaum L,Reydel A,Rauch A,Crimizade U,Kindo M,Hoang Minh T,Trinh A,Petit-Eisenmann H,De Poli F,Leddet P,Jesel L,Ohlmann P,Susen S,Van Belle E,

更新日期：2018-05-01 00:00:00

abstract：:We studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3,000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprote...

journal_title：Thrombosis and haemostasis

authors： Bolibar I,von Eckardstein A,Assmann G,Thompson S,ECAT Angina Pectoris Study Group. European Concerted Action on Thrombosis and Disabilities.

更新日期：2000-12-01 00:00:00

abstract：:The effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were ...

journal_title：Thrombosis and haemostasis

authors： Davies T,Fieldhouse G,McNicol GP

更新日期：1976-04-30 00:00:00

abstract：:Human protein S (HPS) has three potential N-linked glycosylation sites at Asn458, 468, 489. To study the role of glycosylation at these sites, PCR mutagenesis was used to abolish the consensus sequence of each N-linked glycosylation site (Asn458-->Gln, Ser460-->Gly; Asn468-->Gln, Thr470-->Gly; Asn489-->Gln, Thr491-->G...

journal_title：Thrombosis and haemostasis

authors： Lu D,Xie RL,Rydzewski A,Long GL

更新日期：1997-06-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an acquired thrombophilia with an uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess the association of APS with the clinical phenotype of CTEPH. We retrospectively reviewed data of CTEPH patients referred to our center. Cli...

journal_title：Thrombosis and haemostasis

authors： Jiang X,Du Y,Cheng CY,Denas G,Zhou YP,Wu T,Zhang YX,Han ZY,Pengo V,Jing ZC

更新日期：2019-09-01 00:00:00

abstract：:Prothrombin complex concentrates (PCCs) and fresh-frozen plasma (FFP) have been clinically used for acute warfarin reversal. The recovery of prothrombin time (PT) or international normalised ratio (INR) is often reported as an endpoint, but haemostatic efficacies of PCCs and FFP may not be fully reflected in static cl...

journal_title：Thrombosis and haemostasis

authors： Ogawa S,Szlam F,Ohnishi T,Molinaro RJ,Hosokawa K,Tanaka KA

更新日期：2011-12-01 00:00:00

abstract：:The fibrin-specificity and procoagulant effects of recombinant staphylokinase (Sak42D) were compared with those of recombinant tissue-type plasminogen activator (rt-PA) in patients with acute myocardial infarction. Plasma samples were obtained at baseline and at 25 and 90 min, from 24 patients who were randomly assign...

journal_title：Thrombosis and haemostasis

authors： Okada K,Lijnen HR,Moreau H,Vanderschueren S,Collen D

更新日期：1996-12-01 00:00:00

abstract：:In high-risk and complicated coronary intervention, the risk of acute closure is unpredictable. Thrombus and platelet deposition at the intervention site may also have further effects on subsequent restenosis. In vivo infusion of activated protein C has previously been shown to achieve potent anticoagulation without a...

journal_title：Thrombosis and haemostasis

authors： Foo RS,Gershlick AH,Hogrefe K,Baron JH,Johnston TW,Hussey AJ,Garner I,de Bono DP

更新日期：2000-03-01 00:00:00

abstract：:D-Dimer measurements are being increasingly used for negative prediction of deep vein thrombosis (DVT). At our institution, clinical score, D-Dimer assay, plethysmography and, if necessary, Doppler ultrasound are used to secure the diagnosis. We collected the data from 100 consecutive patients proven to have DVT. We e...

journal_title：Thrombosis and haemostasis

authors： Rege KP,Jones S,Day J,Hoggarth CE

更新日期：2004-06-01 00:00:00

abstract：:Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type...

journal_title：Thrombosis and haemostasis

authors： Hardy AT,Palma-Barqueros V,Watson SK,Malcor JD,Eble JA,Gardiner EE,Blanco JE,Guijarro-Campillo R,Delgado JL,Lozano ML,Teruel-Montoya R,Vicente V,Watson SP,Rivera J,Ferrer-Marín F

更新日期：2018-06-01 00:00:00