Short-term prognostic value of lipid measurements in patients with angina pectoris. The ECAT Angina Pectoris Study Group: European Concerted Action on Thrombosis and Disabilities.

abstract：:Patients with haemophilia A have seriously impaired thrombin generation due to an inherited deficiency of factor (F)VIII, making them form unstable fibrin clots that are unable to maintain haemostasis. Data on fibrin structure in haemophilia patients remain limited. Fibrin permeability, assessed by a flow measurement ...

journal_title：Thrombosis and haemostasis

authors： Antovic A,Mikovic D,Elezovic I,Zabczyk M,Hutenby K,Antovic JP

更新日期：2014-04-01 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:In trauma patients, resuscitation treatment of intravascular volume may cause haemodilution including blood cell- and plasma-dilution. After plasma-dilution, fibrinogen is the first factor that decreases to critically low concentrations. Fibrin formed in lowered levels is susceptible to fibrinolysis, a natural forerun...

journal_title：Thrombosis and haemostasis

authors： He S,Johnsson H,Zabczyk M,Hultenby K,Wallén H,Blombäck M

更新日期：2014-03-03 00:00:00

abstract：:Congenital factor VII (FVII) deficiency is a rare bleeding disorder caused by mutations in F7 gene with autosomal recessive inheritance. A clinical heterogeneity with poor correlation with FVII:C levels has been described. It was the objective of this study to identify genetic defects and to evaluate their relationshi...

journal_title：Thrombosis and haemostasis

authors： Quintavalle G,Riccardi F,Rivolta GF,Martorana D,Di Perna C,Percesepe A,Tagliaferri A,Ad-Hoc Study Group.

更新日期：2017-08-01 00:00:00

abstract：:Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objec...

journal_title：Thrombosis and haemostasis

authors： Burchall GF,Piva TJ,Ranasinha S,Teede HJ

更新日期：2017-11-01 00:00:00

abstract：:Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by...

journal_title：Thrombosis and haemostasis

authors： Opitz B,Eitel J,Meixenberger K,Suttorp N

更新日期：2009-12-01 00:00:00

abstract：:An association has been reported between thrombotic events and the use of L-asparaginase (ASP) in children with acute lymphoblastic leukaemia (ALL). The mechanism for thrombosis is likely related to an acquired antithrombin deficiency. Since a primary prophylaxis using antithrombin concentrates may prevent thrombosis,...

journal_title：Thrombosis and haemostasis

authors： Mitchell L,Andrew M,Hanna K,Abshire T,Halton J,Wu J,Anderson R,Cherrick I,Desai S,Mahoney D,McCusker P,Chait P,Abdolell M,de Veber G,Mikulis D

更新日期：2003-08-01 00:00:00

abstract：:Factor VIII procoagulant activity (F VIII:C) and factor VIII related antigen (F VIII R: Ag) were investigated in 35 patients with Argentine hemorrhagic fever. Since the results obtained in the three clinical forms of the disease were not significantly different, they were tabulated altogether. F VIII:C was low in earl...

journal_title：Thrombosis and haemostasis

authors： Molinas FC,Maiztegui JI

更新日期：1981-08-28 00:00:00

abstract：:Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence du...

journal_title：Thrombosis and haemostasis

authors： Stroo I,Zeerleder S,Ding C,Luken BM,Roelofs JJTH,de Boer OJ,Meijers JCM,Castellino FJ,van 't Veer C,van der Poll T

更新日期：2017-07-26 00:00:00

abstract：:MicroRNAs are small non-coding RNAs that negatively regulate posttranscriptional gene expression. Several microRNAs have been described to regulate the process of angiogenesis. Previously, we have shown that bone morphogenetic protein 4 (BMP4) increased the pro-angiogenic activity of endothelial cells. In this project...

journal_title：Thrombosis and haemostasis

authors： Esser JS,Saretzki E,Pankratz F,Engert B,Grundmann S,Bode C,Moser M,Zhou Q

更新日期：2017-04-03 00:00:00

abstract：:Most of the knowledge acquired on platelet function and biochemistry has been obtained from platelets prepared from blood anticoagulated with sodium citrate. Using washed platelets from human blood (PNB) to which no anticoagulants were added, we report on responses not observed with platelets prepared from citrate-ant...

journal_title：Thrombosis and haemostasis

authors： Bowry SK,Müller-Berghaus G

更新日期：1986-10-21 00:00:00

abstract：:An international collaborative study involving seven laboratories was undertaken to assess the suitability of a freeze-dried preparation of human plasmin to replace the current International Reference Preparation (IRP) for plasmin. Chromogenic and fibrinolytic assays were used by all participating laboratories to asse...

journal_title：Thrombosis and haemostasis

authors： Gaffney PJ,Mussett MV

更新日期：1983-10-31 00:00:00

abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

journal_title：Thrombosis and haemostasis

authors： Hooper WC,Phillips DJ,Evatt BL

更新日期：1997-05-01 00:00:00

abstract：:There is an increased number of in vitro evidence that angiotensin II (Ang II) may promote thrombosis. However there are no in vivo experiments exploring the effect of Ang II on thrombus formation. In the present study we have investigated the influence of Ang II on venous thrombosis in renovascular hypertensive rats....

journal_title：Thrombosis and haemostasis

authors： Mogielnicki A,Chabielska E,Pawlak R,Szemraj J,Buczko W

更新日期：2005-06-01 00:00:00

abstract：:The esterase activity of highly purified human urokinase on Nalpha-acetylglycl-L-lysine methyl ester is strongly inhibited by 1 X 10(-5) to 1 X 10(-2)M Cu++, Hg++, Ni++, Co++, Fe+++, and Mn++ solutions, whereas Na+, K+, Ca++, and Mg++ are weakly effective. This inhibition is parallel with the inhibition of activation ...

journal_title：Thrombosis and haemostasis

authors： Sumi H,Takada Y,Takada A

更新日期：1978-02-28 00:00:00

abstract：:Enhanced adhesion of sickle erythrocytes to the vascular endothelium and subendothelial matrix is fundamental to the development of vascular occlusion in sickle cell disease. Erythrocyte membrane sulfatide is implicated in the pathogenesis of vasoocclusive crises in sickle cell disease (SCD) patients. Because previous...

journal_title：Thrombosis and haemostasis

authors： Zhou Z,Thiagarajan P,Udden M,Lòpez JA,Guchhait P

更新日期：2011-06-01 00:00:00

abstract：:Causative mutations in the factor VIII gene of seven unrelated patients with severe haemophilia A were identified using the mutation screening procedure conformation sensitive gel electrophoresis (1) and characterised by direct sequencing. Female family members of all patients had requested either carrier status deter...

journal_title：Thrombosis and haemostasis

authors： Williams IJ,Abuzenadah A,Winship PR,Preston FE,Dolan G,Wright J,Peake IR,Goodeve AC

更新日期：1998-04-01 00:00:00

abstract：:Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, t...

journal_title：Thrombosis and haemostasis

authors： Nurden AT

更新日期：2011-05-01 00:00:00

abstract：:Research into cancer-associated thrombosis (CAT) entails managing dynamic data that pose an analytical challenge. Thus, methods that assume proportional hazards to investigate prognosis entail a risk of misinterpreting or overlooking key traits or time-varying effects. We examined the AGAMENON registry, which collects...

journal_title：Thrombosis and haemostasis

authors： Carmona-Bayonas A,Jimenez-Fonseca P,Garrido M,Custodio A,Hernandez R,Lacalle A,Cano JM,Aguado G,Martínez de Castro E,Alvarez Manceñido F,Macias I,Visa L,Martín Richard M,Mangas M,Sánchez Cánovas M,Longo F,Iglesias Rey L,

更新日期：2019-11-01 00:00:00

abstract：:MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9-RD is caused by mutations of MYH9 , the gene encoding for non-muscle heavy-chain myosin-9. Wild...

journal_title：Thrombosis and haemostasis

authors： Savoia A,De Rocco D,Panza E,Bozzi V,Scandellari R,Loffredo G,Mumford A,Heller PG,Noris P,De Groot MR,Giani M,Freddi P,Scognamiglio F,Riondino S,Pujol-Moix N,Fabris F,Seri M,Balduini CL,Pecci A

更新日期：2010-04-01 00:00:00

abstract：:Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escal...

journal_title：Thrombosis and haemostasis

authors： Jeong YH,Oh JH,Yoon HJ,Park Y,Suh J,Lee SW,Lee K,Kim JS,Chun WJ,Park YH,Nam CW,Kim JH,Ahn JH,Hwang SJ,Hwang JY,Tantry US,Gurbel P,Shin ES

更新日期：2021-01-05 00:00:00

abstract：:Sulodexide, a highly purified glycosaminoglycan, was investigated for treatment of venous leg ulcers. Patients (n = 235) undergoing local treatment including wound care and compression bandaging, were randomised to receive either sulodexide or matching placebo for three months. Primary study endpoint was complete ulce...

journal_title：Thrombosis and haemostasis

authors： Coccheri S,Scondotto G,Agnelli G,Aloisi D,Palazzini E,Zamboni V,Venous arm of the SUAVIS (Sulodexide Arterial Venous Italian Study) Group.

更新日期：2002-06-01 00:00:00

abstract：:Interactions between endothelial cell adhesion molecules and their beta2 integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G2 kap...

journal_title：Thrombosis and haemostasis

authors： Dupuy E,Herbert JM,Giraudeau V,Quere I,Zini JM,Tobelem G

更新日期：1998-09-01 00:00:00

abstract：:Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact...

journal_title：Thrombosis and haemostasis

authors： Hess R,Wujak L,Hesse C,Sewald K,Jonigk D,Warnecke G,Fieguth HG,de Maat S,Maas C,Bonella F,Preissner KT,Weiss B,Schaefer L,Kuebler WM,Markart P,Wygrecka M

更新日期：2017-10-05 00:00:00

abstract：:Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing medical education (CME) on eAlerts and on thromboproph...

journal_title：Thrombosis and haemostasis

authors： Beeler PE,Kucher N,Blaser J

更新日期：2011-10-01 00:00:00

abstract：:Paired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1...

journal_title：Thrombosis and haemostasis

authors： Jones CR,McCabe R,Hamilton CA,Reid JL

更新日期：1985-02-18 00:00:00

abstract：:Accumulating evidence suggests an immune-modulatory role for platelets (PLT) and PLT-derived microvesicles. In particular, ectosomes, i.e. vesicles budding from PLT surface, have been shown to exert immunosuppressive activities on phagocytes. Here we investigated the effects mediated by PLT-derived ectosomes (PLT-Ecto...

journal_title：Thrombosis and haemostasis

authors： Sadallah S,Amicarella F,Eken C,Iezzi G,Schifferli JA

更新日期：2014-12-01 00:00:00

abstract：:Fibrinolytic therapy can result in rapid lysis of deep vein thrombi (DVT), but its use is limited by the failure of many patients to respond and by the increased risk of bleeding complications in comparison with anticoagulant therapy alone. Treatment could be improved by the ability to select patients most likely to r...

journal_title：Thrombosis and haemostasis

authors： Francis CW,Totterman S

更新日期：1995-03-01 00:00:00

abstract：:The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively ac...

journal_title：Thrombosis and haemostasis

authors： Ong SB,Hall AR,Dongworth RK,Kalkhoran S,Pyakurel A,Scorrano L,Hausenloy DJ

更新日期：2015-03-01 00:00:00

abstract：:Samples taken at various stages of preparation of intermediate purity factor VIII concentrate were assayed for factor VIII coagulant activity (VIII:C), factor VIII coagulant antigen (VIIIC:Ag) and factor VIII related antigen (VIIIR:Ag). The antigen results were used to assess mechanical loss during fractionation as th...

journal_title：Thrombosis and haemostasis

authors： Prowse CV,Griffin B,Pepper DS,Dickson AJ,McQuillan TA,Dickson IH,Foster PR

更新日期：1981-10-01 00:00:00