The effects of metal ions on esterase activities of urokinase.

abstract：:Heparin therapy was monitored with the activated partial thromboplastin time (APTT) and with chromogenic substrate assays (factor Xa and factor IIa inhibition) in 100 plasma samples from 47 patients. Heparin concentrations were classified as being below, within or above a defined therapeutic range (TR; 0.2-0.55 units ...

journal_title：Thrombosis and haemostasis

authors： Fey MF,Lang M,Furlan M,Beck EA

更新日期：1987-10-28 00:00:00

abstract：:Obesity and non-insulin dependent diabetes are associated with a decrease in fibrinolysis, which is mediated by the plasminogen system. The purpose of the current study was to investigate the role of the plasminogen system in the reduced body weight of the plasminogen deficient (Plg-/-) mice. In this study we have fou...

journal_title：Thrombosis and haemostasis

authors： Hoover-Plow J,Ellis J,Yuen L

更新日期：2002-06-01 00:00:00

abstract：:Activated protein C (APC)-mediated inactivation of factor VIII (FVIII) correlates with cleavage at either Arg336 and/or Arg562. To elucidate the APC cleavage requirements for inactivation of FVIII, APC cleavage site mutants in FVIII (R336I, R562K and R336I/R562K) were made by site-directed mutagenesis. Analysis of the...

journal_title：Thrombosis and haemostasis

authors： Amano K,Michnick DA,Moussalli M,Kaufman RJ

更新日期：1998-03-01 00:00:00

abstract：:Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems. It can be supposed that PMPs can contribute to the development o...

journal_title：Thrombosis and haemostasis

authors： Sinauridze EI,Kireev DA,Popenko NY,Pichugin AV,Panteleev MA,Krymskaya OV,Ataullakhanov FI

更新日期：2007-03-01 00:00:00

abstract：:An analysis was made of 346 cases of disseminated intravascular coagulation (DIC) diagnosed by utilizing a combination of laboratory tests which reflect the pathophysiology of the syndrome. The goals of the study were three fold: 1) to compare our clinical disease categories with those of other investigators, 2) to re...

journal_title：Thrombosis and haemostasis

authors： Spero JA,Lewis JH,Hasiba U

更新日期：1980-02-29 00:00:00

abstract：:Treatment of bleeding in patients with Glanzmann's thrombasthenia (GT) can be hampered by iso-antibodies against the αIIbβ3 integrin, which cause rapid clearance of transfused donor platelets. Type 1 GT patients with a total absence of αIIbβ3 from the platelet surface are known to be susceptible to form such isoantibo...

journal_title：Thrombosis and haemostasis

authors： Wihadmadyatami H,Röder L,Berghöfer H,Bein G,Heidinger K,Sachs UJ,Santoso S

更新日期：2016-08-01 00:00:00

abstract：:Bacterial pneumonia, the most common cause of sepsis, is associated with activation of coagulation. Factor XI (FXI), the key component of the intrinsic pathway, can be activated via factor XII (FXII), part of the contact system, or via thrombin. To determine whether intrinsic coagulation is involved in host defence du...

journal_title：Thrombosis and haemostasis

authors： Stroo I,Zeerleder S,Ding C,Luken BM,Roelofs JJTH,de Boer OJ,Meijers JCM,Castellino FJ,van 't Veer C,van der Poll T

更新日期：2017-07-26 00:00:00

abstract：:It is conceivable that the extent and spatio-temperal expression of dozens or even a few hundred genes are significantly altered during the development and progression of atherosclerosis as compared to normal circumstances. Differential gene expression in vascular cells and in blood cells, due to gene-gene and gene-en...

journal_title：Thrombosis and haemostasis

authors： Monajemi H,Arkenbout EK,Pannekoek H

更新日期：2001-07-01 00:00:00

abstract：:A four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophi...

journal_title：Thrombosis and haemostasis

authors： Coppola A,Franchini M,Tagliaferri A

更新日期：2009-04-01 00:00:00

abstract：:Using gain-of-function factor IX (FIX) for replacement therapy for haemophilia B (HB) is an attractive strategy. We previously reported a high-activity FIX, FIX-Triple (FIX-V86A/E277A/R338A) as a good substitute for FIX-WT (wild-type) in protein replacement therapy, gene therapy, and cell therapy. Here we generated a ...

journal_title：Thrombosis and haemostasis

authors： Kao CY,Yang SJ,Tao MH,Jeng YM,Yu IS,Lin SW

更新日期：2013-08-01 00:00:00

abstract：:Patients with diabetes display increased platelet activation. Recent data show a markedly increased risk for cardiovascular events already in pre-diabetic individuals with impaired glucose tolerance (IGT). We investigated whether IGT is associated with platelet activation. Blood samples were collected from young lean ...

journal_title：Thrombosis and haemostasis

authors： Schäfer A,Widder J,Eigenthaler M,Bischoff H,Ertl G,Bauersachs J

更新日期：2004-07-01 00:00:00

abstract：:Interactions between endothelial cell adhesion molecules and their beta2 integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G2 kap...

journal_title：Thrombosis and haemostasis

authors： Dupuy E,Herbert JM,Giraudeau V,Quere I,Zini JM,Tobelem G

更新日期：1998-09-01 00:00:00

abstract：:An abnormal fibrinogen was discovered in the plasma of a clinically asymptomatic woman. This fibrinogen variant was analyzed by high resolution two-dimensional gel electrophoresis and its molecular abnormality established consisting in a slight decrease in molecular mass of the B beta-chains. Analysis of fibrin reveal...

journal_title：Thrombosis and haemostasis

authors： Meyer M,Schellenberg I,Vogel G,Bischoff I

更新日期：1988-04-08 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an acquired thrombophilia with an uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess the association of APS with the clinical phenotype of CTEPH. We retrospectively reviewed data of CTEPH patients referred to our center. Cli...

journal_title：Thrombosis and haemostasis

authors： Jiang X,Du Y,Cheng CY,Denas G,Zhou YP,Wu T,Zhang YX,Han ZY,Pengo V,Jing ZC

更新日期：2019-09-01 00:00:00

abstract：:Thrombomodulin (TM), a marker of endothelial cell damage, has been localized to the placental syncytiotrophoblast. A prospective cohort study of twenty-five pregnant women who were admitted with a clinical diagnosis of placental abruption was undertaken. Abruption was confirmed after delivery in eight cases (Group 1)....

journal_title：Thrombosis and haemostasis

authors： Magriples U,Chan DW,Bruzek D,Copel JA,Hsu CD

更新日期：1999-01-01 00:00:00

abstract：:A new method to determine the concentration of free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assa...

journal_title：Thrombosis and haemostasis

authors： Giri TK,Hillarp A,Härdig Y,Zöller B,Dahlbäck B

更新日期：1998-04-01 00:00:00

abstract：:Proteins in the plasma membrane anchor the cell within its microenvironment and sense changes occurring outside the cell. The anchoring interactions are cell type-specific and may involve adjacent cells or extracellular matrix proteins (ECMPs). In development, wound healing, and in various forms of pathology, includin...

journal_title：Thrombosis and haemostasis

authors： Gonias SL,Wu L,Salicioni AM

更新日期：2004-06-01 00:00:00

abstract：:Current data suggests that the risk of venous thromboembolism (VTE) in patients with non-Hodgkin lymphoma (NHL) is comparable to that observed in patients with solid tumours, although more robust confirmatory analyses are required. With that in mind, we investigated the occurrence of VTE in a pooled analysis of 12 "Fo...

journal_title：Thrombosis and haemostasis

authors： Santi RM,Ceccarelli M,Bernocco E,Monagheddu C,Evangelista A,Valeri F,Monaco F,Vitolo U,Cortelazzo S,Cabras MG,Spina M,Baldini L,Boccomini C,Chiappella A,Bari A,Luminari S,Visco C,Calabrese M,Limberti G,Levis A,Con

更新日期：2017-04-27 00:00:00

abstract：:Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

journal_title：Thrombosis and haemostasis

authors： Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

更新日期：2020-02-01 00:00:00

abstract：:Subcutaneous heparin is the treatment of choice for women requiring anticoagulant therapy during pregnancy. However, heparin therapy presents a management problem at delivery because of its potential to cause a persistent anticoagulant effect and thus increase the risk of bleeding. In order to avoid therapeutic compli...

journal_title：Thrombosis and haemostasis

authors： Anderson DR,Ginsberg JS,Burrows R,Brill-Edwards P

更新日期：1991-03-04 00:00:00

abstract：:The binding properties of purified bovine fibrinogen to bovine aortic endothelial cells have been examined in a tissue culture system. Endothelial cells bound 125I-fibrinogen in a calcium dependent fashion. Removal of calcium by EDTA instantaneously detached most of the cell-associated fibrinogen. Binding of fibrinoge...

journal_title：Thrombosis and haemostasis

authors： Delvos U,Preissner KT,Müller-Berghaus G

更新日期：1985-02-18 00:00:00

abstract：OBJECTIVE:To look for an association between venous thromboembolism (VTE) and antiphospholipid antibodies (aPL) in patients without Systemic Lupus Erythematosus (SLE) when implementing, beside conventional assays, new tests for aPL screening directed towards purified proteic targets. METHODS:We conducted a cross-secti...

journal_title：Thrombosis and haemostasis

authors： Pasquier E,Amiral J,de Saint Martin L,Mottier D

更新日期：2001-08-01 00:00:00

abstract：:MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9-RD is caused by mutations of MYH9 , the gene encoding for non-muscle heavy-chain myosin-9. Wild...

journal_title：Thrombosis and haemostasis

authors： Savoia A,De Rocco D,Panza E,Bozzi V,Scandellari R,Loffredo G,Mumford A,Heller PG,Noris P,De Groot MR,Giani M,Freddi P,Scognamiglio F,Riondino S,Pujol-Moix N,Fabris F,Seri M,Balduini CL,Pecci A

更新日期：2010-04-01 00:00:00

abstract：:Platelets are critically involved in atherosclerosis and acute thrombosis. The platelet phenotype shows a wide variability documented by the inherited difference of platelet reactivity, platelet volume and count and function of platelet surface receptors. Several candidate genes have been put into focus and investigat...

journal_title：Thrombosis and haemostasis

authors： Geisler T,Schaeffeler E,Gawaz M,Schwab M

更新日期：2013-11-01 00:00:00

abstract：:Recently we prepared sulfated, low-molecular-weight lignins (LMWLs) to mimic the biological activities of heparin and heparan sulfate. Chemo-enzymatically prepared sulfated LMWLs represent a library of diverse non-sugar, aromatic molecules with structures radically different from the heparins, and have been found to p...

journal_title：Thrombosis and haemostasis

authors： Henry BL,Abdel Aziz M,Zhou Q,Desai UR

更新日期：2010-03-01 00:00:00

abstract：:Vitamin K-dependent protein S is a cofactor to the anticoagulant serine protease activated protein C (APC) in the proteolytic inactivation of the procoagulant, activated factor V (FVa) and factor VIII (FVIIIa). In the FVa degradation, protein S selectively accelerates the cleavage at Arg306, having no effect on the Ar...

journal_title：Thrombosis and haemostasis

authors： Evenäs P,García de Frutos P,Nicolaes GA,Dahlbäck B

更新日期：2000-08-01 00:00:00

abstract：:Tecarfarin is a novel vitamin K antagonist that is metabolised by carboxyl estererase, thereby eliminating the variability associated with cytochrome-mediated metabolism. EmbraceAC was designed to compare the quality of anticoagulation with tecarfarin and warfarin as determined by time in therapeutic range (TTR). In t...

journal_title：Thrombosis and haemostasis

authors： Whitlock RP,Fordyce CB,Midei MG,Ellis D,Garcia D,Weitz JI,Canafax DM,Albrecht D,Milner PG

更新日期：2016-08-01 00:00:00

abstract：:In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go...

journal_title：Thrombosis and haemostasis

authors： Montes R,Puy C,Molina E,Hermida J

更新日期：2012-05-01 00:00:00

abstract：:The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and ...

journal_title：Thrombosis and haemostasis

authors： Nagamine Y,Medcalf RL,Muñoz-Cánoves P

更新日期：2005-04-01 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00