Hereditary and acquired thrombophilia in patients with upper extremity deep-vein thrombosis. Results from the MAISTHRO registry.

abstract：:The walls of rabbit mesenteric arterioles and venules (diameter 20 to 40 microns) were punctured with glass micropipets (tip diameter 6 to 8 microns). Thromboembolic reactions resulting from this standardized, small mechanical vessel wall injury could be quantified in vivo with the use of intravital video-microscopy. ...

journal_title：Thrombosis and haemostasis

authors： oude Egbrink MG,Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1988-02-25 00:00:00

abstract：:Platelets contain, besides alpha- and delta-granules, lysosomes which store glycohydrolases able to degrade glycoproteins, glycolipids and glycosaminoglycans. While several studies have shown that alpha- and delta-granule secretion takes place "in vivo" in humans upon platelet activation, no data are available on the ...

journal_title：Thrombosis and haemostasis

authors： Ciferri S,Emiliani C,Guglielmini G,Orlacchio A,Nenci GG,Gresele P

更新日期：2000-01-01 00:00:00

abstract：:Human high molecular weight kininogen (HK), a single chain plasma glycoprotein, serves as a cofactor in the contact system of blood coagulation. After cleavage by human plasma kallikrein, the nonapeptide bradykinin is released. The HK light chain (LC) contains coagulant activity, which requires both the ability to bin...

journal_title：Thrombosis and haemostasis

authors： Kunapuli SP,DeLa Cadena RA,Colman RW

更新日期：1992-04-02 00:00:00

abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

journal_title：Thrombosis and haemostasis

authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

更新日期：2019-03-01 00:00:00

abstract：:Although venous thromboembolism (VTE) is a leading cause of maternal mortality, there is a paucity of real-world clinical data on clinical presentation and management of VTE during pregnancy and postpartum period. Using data from the international RIETE (Registro Informatizado Enfermedad Trombo Embólica) registry, pre...

journal_title：Thrombosis and haemostasis

authors： Elgendy IY,Fogerty A,Blanco-Molina Á,Rosa V,Schellong S,Skride A,Portillo J,Lopez-Miguel P,Monreal M,Weinberg I

更新日期：2020-10-01 00:00:00

abstract：:In an international collaborative study three candidate reference and the local APTT reagent have been tested with lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients to determine whether it was possible to standardize APTT heparin monitoring. The APTT responses of patient...

journal_title：Thrombosis and haemostasis

authors： Van der Velde EA,Poller L

更新日期：1995-01-01 00:00:00

abstract：:Recently, numerous studies have suggested an association between factor XII (FXII) deficiency and recurrent pregnancy losses, and between autoantibodies to FXII and recurrent pregnancy losses. Autoantibodies to FXII rather than FXII deficiency may be a risk factor for recurrent pregnancy losses. To know the pathogenes...

journal_title：Thrombosis and haemostasis

authors： Inomo A,Sugi T,Fujita Y,Matsubayashi H,Izumi S,Mikami M

更新日期：2008-02-01 00:00:00

abstract：:Direct oral anticoagulants may be effective and safe for treatment of venous thromboembolism (VTE) in cancer patients, but they have not been compared with low-molecular-weight heparin (LMWH), the current recommended treatment for these patients. The Hokusai VTE-cancer study is a randomised, open-label, clinical trial...

journal_title：Thrombosis and haemostasis

authors： van Es N,Di Nisio M,Bleker SM,Segers A,Mercuri MF,Schwocho L,Kakkar A,Weitz JI,Beyer-Westendorf J,Boda Z,Carrier M,Chlumsky J,Décousus H,Garcia D,Gibbs H,Kamphuisen PW,Monreal M,Ockelford P,Pabinger I,Verhamme P,G

更新日期：2015-11-25 00:00:00

abstract：:Wound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completi...

journal_title：Thrombosis and haemostasis

authors： Sulniute R,Shen Y,Guo YZ,Fallah M,Ahlskog N,Ny L,Rakhimova O,Broden J,Boija H,Moghaddam A,Li J,Wilczynska M,Ny T

更新日期：2016-05-02 00:00:00

abstract：:The binding of the urokinase plasminogen activator (uPA) to its receptor (uPAR) regulates cell adhesion, surface proteolysis, chemotaxis and cell extravasation in a number of experimental systems. Recent evidences have suggested that uPAR can by itself mediate chemotaxis of human monocytes and cause profound changes i...

journal_title：Thrombosis and haemostasis

authors： Mondino A,Resnati M,Blasi F

更新日期：1999-09-01 00:00:00

abstract：:Cell accumulation is a prerequisite for adipose tissue inflammation. The leukocyte integrin Mac-1 (CD11b/CD18, αMβ2) is a classic adhesion receptor critically regulating inflammatory cell recruitment. Here, we tested the hypothesis that a genetic deficiency and a therapeutic modulation of Mac-1 regulate adipose tissue...

journal_title：Thrombosis and haemostasis

authors： Wolf D,Bukosza N,Engel D,Poggi M,Jehle F,Anto Michel N,Chen YC,Colberg C,Hoppe N,Dufner B,Boon L,Blankenbach H,Hilgendorf I,von Zur Muhlen C,Reinöhl J,Sommer B,Marchini T,Febbraio MA,Weber C,Bode C,Peter K,Lutge

更新日期：2017-01-26 00:00:00

abstract：:We performed a prospective study in 86 consecutive patients with central vein catheter-related deep venous thrombosis (DVT) of the upper extremity, to evaluate the prevalence of pulmonary embolism (PE), and to identify clinical variables that would increase the likelihood of developing PE in an individual patient. Sin...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Raventos A,Lerma R,Ruiz J,Lafoz E,Alastrue A,Llamazares JF

更新日期：1994-10-01 00:00:00

abstract：:Among the nine ellagitannins, rugosin E was the most potent platelet aggregating agent with an EC50 of 1.5 +/- 0.1 microM in rabbit platelets and 3.2 +/- 0.1 microM in human platelets. The aggregations caused by rugosin E and ADP were inhibited by EGTA, PGE1, mepacrine, sodium nitroprusside and neomycin, but not by in...

journal_title：Thrombosis and haemostasis

authors： Teng CM,Kang YF,Chang YL,Ko FN,Yang SC,Hsu FL

更新日期：1997-03-01 00:00:00

abstract：:Coagulation factor XIII, a transglutaminase which stabilises blood clots by covalently cross-linking fibrin, is essential for normal haemostasis. FXIII deficiency results in a life-long bleeding disorder with added complications in wound healing and tissue repair. Sequence changes in the human FXIIIA gene, largely mis...

journal_title：Thrombosis and haemostasis

authors： Anwar R,Miloszewski KJ,Markham AF

更新日期：1998-06-01 00:00:00

abstract：:Platelets are not only centrally involved in haemostasis, but also in antimicrobial defence and inflammation. Since evaluation of platelet physiology in the particular patient group of preterm and term neonatal infants is highly restricted for ethical reasons, there are hardly any data available in healthy and much le...

journal_title：Thrombosis and haemostasis

authors： Andres O,Schulze H,Speer CP

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. In studies in vitro, PRAP-1, a Fab-fragment of a polyclonal antibody against human PAI-1, was shown to inhibit PAI-1 activity in rat plasma as well as to stimul...

journal_title：Thrombosis and haemostasis

authors： Abrahamsson T,Nerme V,Strömqvist M,Akerblom B,Legnehed A,Pettersson K,Westin Eriksson A

更新日期：1996-01-01 00:00:00

abstract：:Early treatment of disseminated intravascular coagulation (DIC) is recommended but global coagulation tests used in authorized DIC criteria are not sensitive for diagnosis of early-phase DIC. We examined the plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC) and D-dimer in p...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Wada H,Okamoto K,Iba T,Uchiyama T,Eguchi Y,Kawasugi K,Koga S,Mayumi T,Koike K,Gando S

更新日期：2006-02-01 00:00:00

abstract：:Central venous access devices are often essential for the administration of chemotherapy to patients with malignancy, but its use has been associated with a number of complications, mainly thrombosis. The true incidence of upper extremity deep vein thrombosis (DVT) in this setting is difficult to estimate since there ...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Alastrue A,Rull M,Mira X,Muxart J,Rosell R,Abad A

更新日期：1996-02-01 00:00:00

abstract：:Platelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners' platelets were much more sensitive to inhibition by prost...

journal_title：Thrombosis and haemostasis

authors： Dix CJ,Hassall DG,Bruckdorfer KR

更新日期：1984-07-29 00:00:00

abstract：:An experimental model incorporating cultured endothelial cells (EC) was used to study the "factor VIII bypassing" activity of prothrombin complex concentrates (PCC), a property exploited in the treatment of hemophiliacs with alloantibodies to factor VIII. Two PCC preparations were ineffective as stimuli of tissue fact...

journal_title：Thrombosis and haemostasis

authors： Teitel JM

更新日期：1991-11-01 00:00:00

abstract：:Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

journal_title：Thrombosis and haemostasis

authors： Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

更新日期：2000-07-01 00:00:00

abstract：:Megakaryocyte (MK)-derived miRNAs have been detected in platelets. Here, we analysed the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that might be altered with their target mRNAs in type 2 diabetes mellitus (DM2). MiRNAs were isolated from leukocyte-depleted platelets and plasma sample...

journal_title：Thrombosis and haemostasis

authors： Fejes Z,Póliska S,Czimmerer Z,Káplár M,Penyige A,Gál Szabó G,Beke Debreceni I,Kunapuli SP,Kappelmayer J,Nagy B Jr

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND: Clinical effectiveness of recombinant human soluble thrombomodulin (rhTM) in sepsis or sepsis-induced coagulopathy remains a matter of dispute. Recently, the Sepsis Coagulopathy Asahi Recombinant LEThrombomodulin (SCARLET) trial, the latest multinational multi-centre phase III randomized controlled trial, w...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Murao S,Aihara M

更新日期：2019-01-01 00:00:00

abstract：:In a preliminary study, we have demonstrated that tissue factor (TF) is immunohistochemically stained in monocytes from patients with disseminated intravascular coagulation (DIC) but not from healthy volunteers, and that leukocytes from DIC patients induce enhanced activated factor X (FXa) generation in the presence o...

journal_title：Thrombosis and haemostasis

authors： Sase T,Wada H,Nishioka J,Abe Y,Gabazza EC,Shiku H,Suzuki K,Nakamura S,Nobori T

更新日期：2003-04-01 00:00:00

abstract：:Plasma levels of D-dimer have been found useful as a marker of deep venous thrombosis in those patients in whom thrombosis is suspected, but their usefulness in postoperative screening is less clear. We have investigated the relationship of D-dimer to deep venous thrombosis in 90 patients after total hip and knee arth...

journal_title：Thrombosis and haemostasis

authors： Dunn ID,Hui AC,Triffitt PD,Crozier AE,Gregg PJ,Sinclair ME,Armstrong AL,Mitchell VE

更新日期：1994-11-01 00:00:00

abstract：:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy v...

journal_title：Thrombosis and haemostasis

authors： Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CR

更新日期：1989-04-25 00:00:00

abstract：:Accumulating evidence suggests an immune-modulatory role for platelets (PLT) and PLT-derived microvesicles. In particular, ectosomes, i.e. vesicles budding from PLT surface, have been shown to exert immunosuppressive activities on phagocytes. Here we investigated the effects mediated by PLT-derived ectosomes (PLT-Ecto...

journal_title：Thrombosis and haemostasis

authors： Sadallah S,Amicarella F,Eken C,Iezzi G,Schifferli JA

更新日期：2014-12-01 00:00:00

abstract：:Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

journal_title：Thrombosis and haemostasis

authors： Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

更新日期：2004-12-01 00:00:00

abstract：:Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems. It can be supposed that PMPs can contribute to the development o...

journal_title：Thrombosis and haemostasis

authors： Sinauridze EI,Kireev DA,Popenko NY,Pichugin AV,Panteleev MA,Krymskaya OV,Ataullakhanov FI

更新日期：2007-03-01 00:00:00

abstract：:The standard treatment of deep vein thrombosis is given by continuous intravenous infusion of unfractionated heparin. This entails hospitalisation, nursing care, immobility and repeated laboratory tests (e.g. activated partial thromboplastin time [APTT], platelet count). In addition approximately 10% of patients suffe...

journal_title：Thrombosis and haemostasis

authors：

更新日期：1991-03-04 00:00:00