Structure and function of the urokinase receptor.

abstract：:Hormone replacement therapy has been associated with venous thromboembolism. Controversy exists regarding the appropriate management of hormone replacement in the perioperative setting and in other situations--such as acute illness--predisposing to acute venous thromboembolism. We performed a case-control study to det...

journal_title：Thrombosis and haemostasis

authors： Hurbanek JG,Jaffer AK,Morra N,Karafa M,Brotman DJ

更新日期：2004-08-01 00:00:00

abstract：:We studied the occurrence of myocardial infarction (MI), ischaemic stroke (IS) and pulmonary embolism (PE) before and after breast cancer hospitalisation compared with cancer-free controls. For this, women with a first breast cancer hospitalisation during 2000-2007 were selected from the PHARMO Record Linkage System, ...

journal_title：Thrombosis and haemostasis

authors： van Herk-Sukel MP,Shantakumar S,Kamphuisen PW,Penning-van Beest FJ,Herings RM

更新日期：2011-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of morbidity and mortality, and the composition of the tumour stroma is a strong predictor of survival in this cancer type. Tissue factor (TF) functions as the trigger of haemostasis together with its ligand coagulation factor VII/VIIa, and TF expression has been found in tumou...

journal_title：Thrombosis and haemostasis

authors： Eriksson O,Asplund A,Hegde G,Edqvist PH,Navani S,Pontén F,Siegbahn A

更新日期：2016-11-30 00:00:00

abstract：:Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncont...

journal_title：Thrombosis and haemostasis

authors： Fender AC,Rauch BH,Geisler T,Schrör K

更新日期：2017-11-01 00:00:00

abstract：:Prothrombin complex concentrates (PCC) are known to carry a risk of thromboembolism. We have chosen to reassess the problem of detecting in vivo signs of activation of the clotting mechanism by assaying fibrinopeptide A (FpA) after PCC administration in hemophilic patients during bleeding episodes. FpA was significant...

journal_title：Thrombosis and haemostasis

authors： Viganó S,Cattaneo M,Gervasoni W,Mannucci PM

更新日期：1980-10-31 00:00:00

abstract：:It has previously been reported that EGF enhances uPA but not tPA in the A431 squamous carcinoma cell line. To determine whether the absence of tPA modulation by EGF reflected steady levels or the action of an anti-activator, we assayed tPA, PAI-1 and tPA/PAI-1 complexes by zymography and immunological assays. Under c...

journal_title：Thrombosis and haemostasis

authors： George F,Pourreau-Schneider N,Arnoux D,Boutière B,Berthois Y,Martin PM,Sampol J

更新日期：1990-11-30 00:00:00

abstract：:Parameters of the fibrinolytic system were studied in a primate model where the generation of thrombin was promoted in vivo. The procoagulant stimulus used was a combination of human factor Xa in combination with phosphatidylcholine/phosphatidylserine lipid vesicles (PCPS) as the source of coagulant active phospholipi...

journal_title：Thrombosis and haemostasis

authors： Giles AR,Nesheim ME,Herring SW,Hoogendoorn H,Stump DC,Heldebrant CM

更新日期：1990-06-28 00:00:00

abstract：:The interdependence of the predictive accuracy of serum osteoprotegerin (OPG) and von Willebrand factor (vWF) levels for long-term cardiovascular outcomes has not been investigated so far. This was a prospective observational cohort study in 361 patients with coronary artery disease undergoing percutaneous coronary in...

journal_title：Thrombosis and haemostasis

authors： Siller-Matula J,Lang IM,Schoergenhofer C,Roest M,Jilma B

更新日期：2017-08-30 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of a fixed dose of recombinant activated factor VII (rFVIIa; NovoSeven) in the home setting for mild to moderately severe joint, muscle; and mucocutaneous bleeding episodes in patients with haemophilia A or B with inhibitors. DESIGN:Multicentre, open-label, single arm, phase...

journal_title：Thrombosis and haemostasis

authors： Key NS,Aledort LM,Beardsley D,Cooper HA,Davignon G,Ewenstein BM,Gilchrist GS,Gill JC,Glader B,Hoots WK,Kisker CT,Lusher JM,Rosenfield CG,Shapiro AD,Smith H,Taft E

更新日期：1998-12-01 00:00:00

abstract：:D-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concerni...

journal_title：Thrombosis and haemostasis

authors： Alehagen U,Dahlström U,Lindahl TL

更新日期：2004-12-01 00:00:00

abstract：:Binding of the coagulation protease factor VIIa to its receptor Tissue Factor (TF) induces intracellular signals in several cell types including HaCaT keratinocytes. TF belongs to the cytokine receptor family, but is most likely not alone in transferring the complete TF/FVIIa signal over the plasma membrane. The prote...

journal_title：Thrombosis and haemostasis

authors： Wiiger MT,Prydz H

更新日期：2004-07-01 00:00:00

abstract：:Noninvasive diagnosis of deep vein thrombosis (DVT) is based on ultrasound examination of the leg veins, usually restricted to only compression of the proximal veins (CUS). Patients with negative CUS findings require a second examination or a combination with other tests, which impairs clinical efficiency. In this pro...

journal_title：Thrombosis and haemostasis

authors： Schellong SM,Schwarz T,Halbritter K,Beyer J,Siegert G,Oettler W,Schmidt B,Schroeder HE

更新日期：2003-02-01 00:00:00

abstract：:The blockade of platelet membrane glycoprotein IIb/IIIa by a monoclonal antibody, 7E3, was measured by flow cytometry using a fluorescein isothiocyanate-conjugated disintegrin, FITC-crotavirin, as the probe. After treatment of platelets with 7E3 or 7E3 F(ab')2, there is a good correlation between the inhibition of pla...

journal_title：Thrombosis and haemostasis

authors： Liu CZ,Hur BT,Huang TF

更新日期：1996-10-01 00:00:00

abstract：:Tissue factor (TF), the main initiator of blood coagulation, contributes to the manifestation of disseminated intravascular coagulation following septic shock in meningococcal infection. Since a direct relationship between disease severity and lipopolysaccharide (LPS) concentration in the circulation has been shown, w...

journal_title：Thrombosis and haemostasis

authors： Henriksson CE,Klingenberg O,Ovstebø R,Joø GB,Westvik AB,Kierulf P

更新日期：2005-12-01 00:00:00

abstract：:Hemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children (< 3 years), is mainly related to Shiga toxins (Stx)-producing Escherichia coli (STEC) infections. STEC are confined to the gut resulting in hemorrhagic colitis, whereas Stx are delivered in blood to target kidney and brain, with unc...

journal_title：Thrombosis and haemostasis

authors： Brigotti M,He X,Carnicelli D,Arfilli V,Porcellini E,Galassi E,Tazzari PL,Ricci F,Patfield SA,Testa S,Paglialonga F,Picicco D,Caprioli A,Scavia G,Morabito S,Ardissino G

更新日期：2020-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells. We have studied the production of VEGF by human macrophages in response to lipopolysaccharide (LPS). Macrophages stimulated with LPS expressed VEGF mRNA and protein in concentration- and time-dependent manners. The LPS-induced expression of ...

journal_title：Thrombosis and haemostasis

authors： Itaya H,Imaizumi T,Yoshida H,Koyama M,Suzuki S,Satoh K

更新日期：2001-01-01 00:00:00

abstract：:To evaluate the safety of a beta-Propiolactone/Ultraviolet (BPL/UV), irradiated Factor IX complex preparation we inoculated 8 chimpanzees with 25 units Factor IX/Kilo from a pool of 5 production lots which had been treated in this manner. These lots were derived from approximately 1,000 donors. Animals were followed w...

journal_title：Thrombosis and haemostasis

authors： Prince AM,Stephan W,Brotman B,van den Ende MC

更新日期：1980-12-19 00:00:00

abstract：:Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant...

journal_title：Thrombosis and haemostasis

authors： Freund M,Cazenave JP,Courtney M,Degryse E,Roitsch C,Bernat A,Delebassée D,Defreyn G,Maffrand JP

更新日期：1990-04-12 00:00:00

abstract：:Intraoperative high-dose aprotinin administration has been shown to reduce the intra-and postoperative blood loss in cardiac surgery. The haemostatic effect has been attributed to platelet preserving properties and to inhibition of contact activation reducing thrombotic and fibrinolytic activity during and after cardi...

journal_title：Thrombosis and haemostasis

authors： Spannagl M,Dooijewaard G,Dietrich W,Kluft C

更新日期：1995-05-01 00:00:00

abstract：:Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular injury. Recent observations of neutrophil extracellular traps (NETs) formation and its mutual reactions with platelet thrombi adds more cl...

journal_title：Thrombosis and haemostasis

authors： Ghasemzadeh M,Hosseini E

更新日期：2015-06-01 00:00:00

abstract：:Tissue factor-factor VIIa catalysed activation of factor IX is inhibited by the complex of tissue factor pathway inhibitor (TFPI) and factor Xa. At present, no information is available as to what extent the kinetics of complex formation between TFPI and factor Xa during factor X activation contribute to the overall ra...

journal_title：Thrombosis and haemostasis

authors： Lindhout T,Franssen J,Willems G

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND: Accurate diagnosis of symptomatic low von Willebrand factor (VWF) remains a major challenge in von Willebrand disease (VWD). However, present tests do not adequately take into account flow forces that, at very high shear rates, reveal a weakness in the VWF-platelet glycoprotein glycoprotein Ib bond in norma...

journal_title：Thrombosis and haemostasis

authors： Grabowski EF,Van Cott EM,Bornikova L,Boyle DC,Silva RL

更新日期：2020-05-01 00:00:00

abstract：:Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (...

journal_title：Thrombosis and haemostasis

authors： Braunersreuther V,Montecucco F,Pelli G,Galan K,Proudfoot AE,Belin A,Vuilleumier N,Burger F,Lenglet S,Caffa I,Soncini D,Nencioni A,Vallée JP,Mach F

更新日期：2013-10-01 00:00:00

abstract：:Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escal...

journal_title：Thrombosis and haemostasis

authors： Jeong YH,Oh JH,Yoon HJ,Park Y,Suh J,Lee SW,Lee K,Kim JS,Chun WJ,Park YH,Nam CW,Kim JH,Ahn JH,Hwang SJ,Hwang JY,Tantry US,Gurbel P,Shin ES

更新日期：2021-01-05 00:00:00

abstract：:An alternative method of uniting small diameter vessels to obtain tissue union while limiting the thrombogenic effect of suture placement at a vessel anastomosis involves the use of a thrombin based fibrin glue as a surgical sealant. This investigation addresses whether the in vitro application of a thrombin based glu...

journal_title：Thrombosis and haemostasis

authors： Dascombe WH,Dumanian G,Hong C,Heil BV,Labadie K,Hessel B,Blombäck B,Johnson PC

更新日期：1997-08-01 00:00:00

abstract：:Wound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completi...

journal_title：Thrombosis and haemostasis

authors： Sulniute R,Shen Y,Guo YZ,Fallah M,Ahlskog N,Ny L,Rakhimova O,Broden J,Boija H,Moghaddam A,Li J,Wilczynska M,Ny T

更新日期：2016-05-02 00:00:00

abstract：:We performed a DNA analysis on a patient with severe type I factor VII deficiency by the polymerase chain reaction amplification and a direct DNA sequencing method. The proband was a 66-year-old Japanese woman who had recurrent episodes of excessive bleeding after dental extraction. The functional and antigenic levels...

journal_title：Thrombosis and haemostasis

authors： Ozawa T,Niiya K,Higuchi W,Sakuragawa N

更新日期：1997-09-01 00:00:00

abstract：:It is conceivable that the extent and spatio-temperal expression of dozens or even a few hundred genes are significantly altered during the development and progression of atherosclerosis as compared to normal circumstances. Differential gene expression in vascular cells and in blood cells, due to gene-gene and gene-en...

journal_title：Thrombosis and haemostasis

authors： Monajemi H,Arkenbout EK,Pannekoek H

更新日期：2001-07-01 00:00:00

abstract：:Thirty-one non-hemophilic patients with acquired antibodies to factor VIII were entered into a prospective, randomized, multi-institutional trial to determine the safety and efficacy of prednisone (P), cyclophosphamide (C), or the combination in the treatment of this disorder. Patients were eligible if they had antibo...

journal_title：Thrombosis and haemostasis

authors： Green D,Rademaker AW,Briët E

更新日期：1993-11-15 00:00:00

abstract：:Proteins in the plasma membrane anchor the cell within its microenvironment and sense changes occurring outside the cell. The anchoring interactions are cell type-specific and may involve adjacent cells or extracellular matrix proteins (ECMPs). In development, wound healing, and in various forms of pathology, includin...

journal_title：Thrombosis and haemostasis

authors： Gonias SL,Wu L,Salicioni AM

更新日期：2004-06-01 00:00:00