A randomised trial of subcutaneous low molecular weight heparin (CY 216) compared with intravenous unfractionated heparin in the treatment of deep vein thrombosis. A collaborative European multicentre study.

abstract：BACKGROUND: Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the r...

journal_title：Thrombosis and haemostasis

authors： Crombag GAJC,Spronk HM,Nelemans P,Schreuder FHBM,Truijman MTB,van Dijk AC,de Rotte AAJ,Liem MI,Daemen MJAP,van der Steen AFW,Mess WH,Nederkoorn PJ,Hendrikse J,van der Lugt A,Wildberger JE,Ten Cate H,van Oostenbrugge RJ,

更新日期：2018-08-01 00:00:00

abstract：:Echolucent carotid plaques are associated with higher risk for future ischemic cerebrovascular events (CVE) than echogenic plaques independent of the degree of stenosis. Elevated markers of thrombin generation are associated with atherosclerotic plaques and are increased in the acute and chronic phases of CVE. The pre...

journal_title：Thrombosis and haemostasis

authors： With Notø AT,Mathiesen EB,Østerud B,Amiral J,Vissac AM,Hansen JB

更新日期：2008-03-01 00:00:00

abstract：:The antithrombotic effect of MCI-9042, (+-)-2-(dimethyl-amino)-1-((o-(m- methoxyphenethyl)phenoxyl]methyl]ethyl hydrogen succinate hydrochloride was investigated in three different experimental thrombosis models in animals. Simultaneous injection of serotonin and collagen into the tail vein in mice induced acute pulmo...

journal_title：Thrombosis and haemostasis

authors： Hara H,Kitajima A,Shimada H,Tamao Y

更新日期：1991-10-01 00:00:00

abstract：:Tissue plasminogen activator labeled with radioactive iodine (125I-tPA) was immobilized on vascular prostheses chemically modified with a thin coating of water-insoluble surfactant, tridodecylmethylammonium chloride (TDMAC). Surfactant-treated Dacron, polytetrafluoroethylene (PTFE), silastic, polyethylene and polyuret...

journal_title：Thrombosis and haemostasis

authors： Harvey RA,Kim HC,Pincus J,Trooskin SZ,Wilcox JN,Greco RS

更新日期：1989-02-28 00:00:00

abstract：:Autoantibodies to the zwitterionic phospholipid (PL), phosphatidylethanolamine (PE) have been described in patients with thrombotic diseases. Recently, we reported that many antiphosphatidylethanolamine antibodies (aPE) are not specific for PE per se, but are directed to plasma proteins which can bind PE, for example,...

journal_title：Thrombosis and haemostasis

authors： Sugi T,Mclntyre JA

更新日期：1996-09-01 00:00:00

abstract：:Carboxypeptidase U (CPU, EC 3.4.17.20) is a recently described basic carboxypeptidase which circulates in plasma as the zymogen procarboxypeptidase U (proCPU). In the current study, we report on the presence of the proCPU/CPU system in different mammalian species--pig, guinea pig, dog, mouse, rabbit, rat and human. Th...

journal_title：Thrombosis and haemostasis

authors： Schatteman KA,Goossens FJ,Scharpé SS,Hendriks DF

更新日期：1999-12-01 00:00:00

abstract：:The surface of the platelet expresses procoagulant phospholipids that bind coagulation factors and contribute to the procoagulant activity of the cell. The evidence, however, also suggests that platelets may possess specific receptors for coagulation Factors V(a) and VIII(a). Examination of a limited set of the availa...

journal_title：Thrombosis and haemostasis

authors： Nesheim ME,Furmaniak-Kazmierczak E,Henin C,Côté G

更新日期：1993-07-01 00:00:00

abstract：:Cystic fibrosis (CF) is characterized by a persistent inflammatory state, which can be secondary to chronic pulmonary infection and may affect vascular endothelium. We measured circulating levels of von Willebrand factor (vWF), tissue-plasminogen activator (t-PA), and P-selectin in 20 CF patients and 20 healthy subjec...

journal_title：Thrombosis and haemostasis

authors： Romano M,Collura M,Lapichino L,Pardo F,Falco A,Chiesa PL,Caimi G,Davì G

更新日期：2001-12-01 00:00:00

abstract：:Clopidogrel is a recently introduced platelet ADP receptor antagonist, belonging to the thienopyridine derivatives, like its analogue ticlopidine. Its potential advantage is to be safer than ticlopidine. At 75 mg/od clopidogrel significantly inhibits platelet aggregation in ambulatory patients with symptomatic atheros...

journal_title：Thrombosis and haemostasis

authors： David JL,Limet R

更新日期：1999-11-01 00:00:00

abstract：:Interactions between proteins and heparin(-like) structures involve electrostatic forces and structural features. Based on charge distributions in the linear sequence of protein C inhibitor (PCI), two positively charged regions of PCI were proposed as possible candidates for this interaction. The first region, the A+ ...

journal_title：Thrombosis and haemostasis

authors： Elisen MG,Maseland MH,Church FC,Bouma BN,Meijers JC

更新日期：1996-05-01 00:00:00

abstract：:The influence of ionic and non-ionic contrast media (CM) on platelet and leukocyte activation and platelet-leukocyte crosstalk was investigated in hirudinized whole blood. The blood was incubated with and without the ionic CM ioxaglate and the nonionic CM iodixanol at 37 degrees C for 5 min, without or with stirring. ...

journal_title：Thrombosis and haemostasis

authors： Ji Q,Ghaly M,Hjemdahl P,Tornvall P,Li N

更新日期：2005-05-01 00:00:00

abstract：:MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9-RD is caused by mutations of MYH9 , the gene encoding for non-muscle heavy-chain myosin-9. Wild...

journal_title：Thrombosis and haemostasis

authors： Savoia A,De Rocco D,Panza E,Bozzi V,Scandellari R,Loffredo G,Mumford A,Heller PG,Noris P,De Groot MR,Giani M,Freddi P,Scognamiglio F,Riondino S,Pujol-Moix N,Fabris F,Seri M,Balduini CL,Pecci A

更新日期：2010-04-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Biosynthesis of the adhesive glycoprotein von Willebrand factor (vWf) by endothelial cells results in constitutive secretion of small multimers and storage of the largest multimers in rod-shaped granules called Weibel-Palade bodies. This pattern is reproduced by expression of pro-vWf in heterologous cells with a regul...

journal_title：Thrombosis and haemostasis

authors： Journet AM,Saffaripour S,Wagner DD

更新日期：1993-12-20 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the if vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topic...

journal_title：Thrombosis and haemostasis

authors： Mussoni L,Sironi L,Tedeschi L,Calvio AM,Colli S,Tremoli E

更新日期：2001-11-01 00:00:00

abstract：:Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

journal_title：Thrombosis and haemostasis

authors： Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

更新日期：2019-01-01 00:00:00

abstract：:The aim was to investigate the perioperative risk of ischaemic and bleeding events in patients with coronary stents undergoing cardiac and non-cardiac surgery and how these outcomes are affected by the perioperative use of oral antiplatelet therapy. This was a multicentre, retrospective, observational study conducted ...

journal_title：Thrombosis and haemostasis

authors： Rossini R,Musumeci G,Capodanno D,Lettieri C,Limbruno U,Tarantini G,Russo N,Calabria P,Romano M,Inashvili A,Sirbu V,Guagliumi G,Valsecchi O,Senni M,Gavazzi A,Angiolillo DJ

更新日期：2015-02-01 00:00:00

abstract：:Tissue thromboplastin apoprotein was partially purified from human brain. The apoprotein was recombined with mixed phospholipids to yield active thromboplastin. The recombined thromboplastin induced proteolytic activation of isolated human factor IX in the presence of factor VII and Ca2+. The clotting times of various...

journal_title：Thrombosis and haemostasis

authors： van den Besselaar AM,Ram IE,Alderkamp GH,Bertina RM

更新日期：1982-08-24 00:00:00

abstract：:Platelet adhesion and aggregation at the sites of vascular injury are key events for thrombosis and haemostasis. It has been well demonstrated that interaction between glycoprotein (GP) Ibα and von Willebrand factor (VWF) initiates platelet adhesion and contributes to platelet aggregation, particularly at high shear. ...

journal_title：Thrombosis and haemostasis

authors： Lei X,Reheman A,Hou Y,Zhou H,Wang Y,Marshall AH,Liang C,Dai X,Li BX,Vanhoorelbeke K,Ni H

更新日期：2014-02-01 00:00:00

abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

journal_title：Thrombosis and haemostasis

authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

更新日期：2013-04-01 00:00:00

abstract：:In a preliminary study, we have demonstrated that tissue factor (TF) is immunohistochemically stained in monocytes from patients with disseminated intravascular coagulation (DIC) but not from healthy volunteers, and that leukocytes from DIC patients induce enhanced activated factor X (FXa) generation in the presence o...

journal_title：Thrombosis and haemostasis

authors： Sase T,Wada H,Nishioka J,Abe Y,Gabazza EC,Shiku H,Suzuki K,Nakamura S,Nobori T

更新日期：2003-04-01 00:00:00

abstract：:Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges ...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Schwameis M,Gilbert JC,Schörgenhofer C,Jilma B

更新日期：2018-06-01 00:00:00

abstract：:Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients w...

journal_title：Thrombosis and haemostasis

authors： Pawlitschek F,Keyl C,Zieger B,Budde U,Beyersdorf F,Neumann FJ,Stratz C,Nührenberg TG,Trenk D

更新日期：2018-01-01 00:00:00

abstract：:Interactions between endothelial cell adhesion molecules and their beta2 integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G2 kap...

journal_title：Thrombosis and haemostasis

authors： Dupuy E,Herbert JM,Giraudeau V,Quere I,Zini JM,Tobelem G

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:Compared with Caucasian patients, East Asian patients have the unique risk-benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was to compare pharmacodynamic profile in East Asian patients with acute coronary syndromes (ACS) treated with prasugrel standard-dose vs. de-escal...

journal_title：Thrombosis and haemostasis

authors： Jeong YH,Oh JH,Yoon HJ,Park Y,Suh J,Lee SW,Lee K,Kim JS,Chun WJ,Park YH,Nam CW,Kim JH,Ahn JH,Hwang SJ,Hwang JY,Tantry US,Gurbel P,Shin ES

更新日期：2021-01-05 00:00:00

abstract：:Rabbits were injected with a platelet antiserum to examine the role of thrombocytopenia of the precipitation of soluble fibrin by endotoxin.dotoxin. Platelet antiserum removed more than 98% of the circulating platelets, and the resulting thrombocytopenia with platelet counts below 10,000 per mul persisted during the e...

journal_title：Thrombosis and haemostasis

authors： Müller-Berghaus G,Kramer W

更新日期：1976-02-29 00:00:00

abstract：:The influence of the sympathetic nervous system on platelet functions in vivo is still controversial. The aims of our study were to compare the response to various sympathetic stimuli in normal subjects and in patients with essential hypertension (HT) or peripheral vascular disease (PVD) and to evaluate any correlatio...

journal_title：Thrombosis and haemostasis

authors： Catalano M,Russo U,Belletti S,Colombo F,Belloni A,del Rosso G,Lombardi F,Libretti A

更新日期：1990-06-28 00:00:00

abstract：:Venous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute to significant long-term sequelae. The PREVAPIX-ALL study is an open-label ...

journal_title：Thrombosis and haemostasis

authors： O'Brien SH,Li D,Mitchell LG,Hess T,Zee P,Yee DL,Newburger JW,Sung L,Rodriguez V

更新日期：2019-05-01 00:00:00