Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus.

abstract：:The aim of the present study was to analyse differences in the protein expression profile between platelets from aspirin (ASA)-resistant patients and ASA-sensitive patients. We analysed platelets from 51 clinically stable coronary ischaemic patients taking ASA (100 mg/day) divided into ASA-resistant (n=25) and ASA-sen...

journal_title：Thrombosis and haemostasis

authors： Mateos-Cáceres PJ,Macaya C,Azcona L,Modrego J,Mahillo E,Bernardo E,Fernandez-Ortiz A,López-Farré AJ

更新日期：2010-01-01 00:00:00

abstract：:The effects on platelet function of a 5-day course of Ticlopidine (Tcl) have been studied in two groups of volunteers receiving different dosage schedules. Tcl had a relatively greater inhibitory effect on aggregation induced by ADP than by other agonists, and a greater effect, in contrast to that of an ADP receptor a...

journal_title：Thrombosis and haemostasis

authors： Hardisty RM,Powling MJ,Nokes TJ

更新日期：1990-08-13 00:00:00

abstract：:Genetic determinants of venous thromboembolism (VTE) in the African-American population are poorly characterised. It was recently shown that fibrinogen gamma gene (FGG) polymorphisms 10034C>T and 9340T>C influence VTE risk in the Caucasian population. In the African-American population these polymorphisms are common, ...

journal_title：Thrombosis and haemostasis

authors： Uitte de Willige S,Pyle ME,Vos HL,de Visser MC,Lally C,Dowling NF,Hooper WC,Bertina RM,Austin H

更新日期：2009-06-01 00:00:00

abstract：:Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) wi...

journal_title：Thrombosis and haemostasis

authors： Furio E,García-Fuster MJ,Redon J,Marques P,Ortega R,Sanz MJ,Piqueras L

更新日期：2018-03-01 00:00:00

abstract：:Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges ...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Schwameis M,Gilbert JC,Schörgenhofer C,Jilma B

更新日期：2018-06-01 00:00:00

abstract：:In trauma patients, resuscitation treatment of intravascular volume may cause haemodilution including blood cell- and plasma-dilution. After plasma-dilution, fibrinogen is the first factor that decreases to critically low concentrations. Fibrin formed in lowered levels is susceptible to fibrinolysis, a natural forerun...

journal_title：Thrombosis and haemostasis

authors： He S,Johnsson H,Zabczyk M,Hultenby K,Wallén H,Blombäck M

更新日期：2014-03-03 00:00:00

abstract：:The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

journal_title：Thrombosis and haemostasis

authors： Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

更新日期：1991-09-02 00:00:00

abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

journal_title：Thrombosis and haemostasis

authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

更新日期：2003-08-01 00:00:00

abstract：:Unstimulated human platelets from normal volunteers adhere to sulfatides (galactosylceramide-I3-sulfate) as single cells but do not adhere appreciably to other lipids including gangliosides, neutral glycolipids, phospholipids or cholesterol-3-SO4. Platelet adhesion to sulfatide is saturable and dose-dependent, reaches...

journal_title：Thrombosis and haemostasis

authors： Data RE,Williams SB,Roberts DD,Gralnick HR

更新日期：1991-05-06 00:00:00

abstract：:The effect of aspirin on LPS-incubation of whole blood was investigated. Aspirin induced a concentration dependent increase (2.5-5-fold at 5 mM aspirin) in LPS-induced appearance of TNF-alpha and fibrinopeptide A (FPA) in plasma, despite the concomitant increase in the inhibitory cytokine IL-100. Aspirin substantially...

journal_title：Thrombosis and haemostasis

authors： Osnes LT,Haug KB,Joø GB,Westvik AB,Ovstebø R,Kierulf P

更新日期：2000-06-01 00:00:00

abstract：:Inherited thrombophilic states are associated with an increased risk for deep vein thrombosis (DVT), but whether they are also risk factors for superficial vein thrombosis (SVT) is uncertain. We assessed the risk conferred by inherited thrombophilic states in patients with a first episode of SVT in whom the coexistenc...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Taioli E,De Stefano V,Chiusolo P,Mannucci PM

更新日期：1999-10-01 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:The cellular phospholipid, lysophosphatidic acid (LPA), released by activated platelets and fibroblasts or, at high levels, from ovarian and cervical carcinomas is a powerful serum mitogen that may modulate several signaling pathways in endothelial cells (EC). Hence, LPA could function in a paracrine manner during EC-...

journal_title：Thrombosis and haemostasis

authors： Palmetshofer A,Robson SC,Nehls V

更新日期：1999-11-01 00:00:00

abstract：:Platelet aggregation and adenine nucleotides in platelets have been studied in thirteen patients with myeloproliferative disorders. ADP induced aggregation was abnormal in two patients, but collagen induced aggregation was impaired in 11 patients. The concentrations of ATP and ADP in resting platelets in the patients ...

journal_title：Thrombosis and haemostasis

authors： Nishimura J,Okamoto S,Ibayashi H

更新日期：1979-06-30 00:00:00

abstract：:Heparin-coating improves the biocompatibility of blood contacting artificial surfaces. This led us to investigate the impact of heparin-coating (Carmeda AB, Stockholm) of polymetylmetacrylate on the expression of monocyte tissue factor procoagulant activity (TF-PCA) by surface adhesion. Also, the anticoagulant effect ...

journal_title：Thrombosis and haemostasis

authors： Barstad RM,Hamers MJ,Møller AS,Sakariassen KS

更新日期：1998-02-01 00:00:00

abstract：:Anticoagulant control facilities are being overwhelmed by requests for monitoring and large numbers of patients are not therefore receiving treatment. Procedures designed for point-of-care testing have therefore been developed, the most popular being the CoaguChek. The need for external quality assessment (EQA) of mon...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Poller L,van den Besselaar AM,van der Meer FJ,Palareti G,Tripodi A,Shiach C,Keown M,Ibrahim S

更新日期：2010-05-01 00:00:00

abstract：:We tested the response of the fibrinolytic activity and factor VIII-antigen levels to infusion of DDAVP in healthy volunteers and we studied the influence of propranolol and aspirin on this response. After DDAVP, 0.4 microgram/kg in 10 min i.v., the fibrinolytic activity of redissolved euglobulins rose from 179 to 452...

journal_title：Thrombosis and haemostasis

authors： Brommer EJ,Derkx FH,Barrett-Bergshoeff MM,Schalekamp MA

更新日期：1984-02-28 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection is associated with peptic ulcer disease and gastric cancer. The eradication of H. pylori is of special interest in patients with congenital bleeding disorders, for whom treatment of gastrointestinal hemorrhage with factor concentrates is costly. The prevalence of H. pylori var...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Rehnberg AS,Hein M,Hegedus O,Lindmarker P,Hellström PM

更新日期：2003-04-01 00:00:00

abstract：:Major orthopedic surgery is known to be associated with potentially serious arterial and venous vascular complications, although uncertainty exists about current event rates. Using electronic databases and investigator contact, we identified randomized and cohort studies reporting overall mortality and fatal vascular ...

journal_title：Thrombosis and haemostasis

authors： Dahl OE,Caprini JA,Colwell CW Jr,Frostick SP,Haas S,Hull RD,Laporte S,Stein PD

更新日期：2005-05-01 00:00:00

abstract：:Thrombomodulin (TM) is an endothelial glycoprotein that functions as a thrombin cofactor in the activation of protein C. Recent evidence has revealed that TM has unique effects on cellular proliferation, adhesion, and inflammation. We examined TM expression in the arterial remodeling process with different shear condi...

journal_title：Thrombosis and haemostasis

authors： Li YH,Hsieh CY,Wang DL,Chung HC,Liu SL,Chao TH,Shi GY,Wu HL

更新日期：2007-04-01 00:00:00

abstract：:The structural and functional properties of plasma and platelet vWF were studied in 8 patients (5 unrelated families) with vWD demonstrating a mutation at position 611 (R611C or R611H). Following reduction, electrophoresis and immunoblotting with a polyclonal anti-reduced vWF antibody, abnormal proteolysis of vWF was ...

journal_title：Thrombosis and haemostasis

authors： Nishikubo T,Christophe O,Lavergne JM,Obert B,Nonami K,Takahashi Y,Yoshioka A,Meyer D,Girma JP

更新日期：1997-01-01 00:00:00

abstract：:Isolated rat hepatocytes possess per cell 4,500 high-affinity binding sites for thrombin with a Kd of 30-40 pM, and 2.8 X 10(5) low-affinity sites with a Kd of 30 nM. These binding sites are highly specific for thrombin. Half-maximal binding of 125I-labelled thrombin is achieved after 3 min at 37 degrees C and 7 min a...

journal_title：Thrombosis and haemostasis

authors： Weyer B,Petersen TE,Sonne O

更新日期：1988-12-22 00:00:00

abstract：:Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant...

journal_title：Thrombosis and haemostasis

authors： Freund M,Cazenave JP,Courtney M,Degryse E,Roitsch C,Bernat A,Delebassée D,Defreyn G,Maffrand JP

更新日期：1990-04-12 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) acts as both a nuclear protein that regulates gene expression, as well as a pro-inflammatory alarmin that is released from necrotic or activated cells. Recently, HMGB1-expression in human atherosclerotic plaques was identified. Therapeutic blockade of HMGB1 reduced the development of ...

journal_title：Thrombosis and haemostasis

authors： Ahrens I,Chen YC,Topcic D,Bode M,Haenel D,Hagemeyer CE,Seeba H,Duerschmied D,Bassler N,Jandeleit-Dahm KA,Sweet MJ,Agrotis A,Bobik A,Peter K

更新日期：2015-11-01 00:00:00

abstract：:The effects of etamsylate on human platelet aggregation and ATP release as well as on the arachidonate metabolism by the platelet have been studied. Etamsylate enhanced these platelet functions induced by arachidonic acid (AA), thromboxane A2, collagen and calcium ionophore A23187 but not those induced by ADP and epin...

journal_title：Thrombosis and haemostasis

authors： Okuma M,Takayama H,Sugiyama T,Sensaki S,Uchino H

更新日期：1982-12-27 00:00:00

abstract：:Mice with a total deficiency in blood coagulation Factor X (FX) were generated by targeted replacement of an 18-kb fragment of the FX gene, comprising all exons encoding the mature FX protein, with a neo(r) cassette. The genotype distribution among the offspring from heterozygous breeding pairs suggested that FX defic...

journal_title：Thrombosis and haemostasis

authors： Dewerchin M,Liang Z,Moons L,Carmeliet P,Castellino FJ,Collen D,Rosen ED

更新日期：2000-02-01 00:00:00

abstract：:The influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confi...

journal_title：Thrombosis and haemostasis

authors： de Boer A,Kluft C,Kroon JM,Kasper FJ,Schoemaker HC,Pruis J,Breimer DD,Soons PA,Emeis JJ,Cohen AF

更新日期：1992-01-23 00:00:00

abstract：:The binding of the urokinase plasminogen activator (uPA) to its receptor (uPAR) regulates cell adhesion, surface proteolysis, chemotaxis and cell extravasation in a number of experimental systems. Recent evidences have suggested that uPAR can by itself mediate chemotaxis of human monocytes and cause profound changes i...

journal_title：Thrombosis and haemostasis

authors： Mondino A,Resnati M,Blasi F

更新日期：1999-09-01 00:00:00