Liver blood flow as a major determinant of the clearance of recombinant human tissue-type plasminogen activator.

abstract：:Activation of leukocytes plays an essential role in the mechanism of restenosis. Prior research has focused on monocytes and little is known about the role of neutrophils in this process. Neutrophils are known to contribute to tissue injury through oxygen-derived free radicals that nitrate tyrosine. This study was des...

journal_title：Thrombosis and haemostasis

authors： Inoue T,Kato T,Hikichi Y,Hashimoto S,Hirase T,Morooka T,Imoto Y,Takeda Y,Sendo F,Node K

更新日期：2006-01-01 00:00:00

abstract：:This study explores the effects on some hematological parameters of a low-dose aspirin regimen (50 mg/day) versus a conventional aspirin treatment with reported antithrombotic efficacy (324 mg/day), in patients with acute myocardial infarction. Fifteen patients were randomized into 3 equal groups receiving 50 mg or 32...

journal_title：Thrombosis and haemostasis

authors： De Caterina R,Giannessi D,Boem A,Bernini W,Battaglia D,Michelassi C,Dell'Amico F,L'Abbate A,Patrignani P,Patrono C

更新日期：1985-08-30 00:00:00

abstract：:A new method to determine the concentration of free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assa...

journal_title：Thrombosis and haemostasis

authors： Giri TK,Hillarp A,Härdig Y,Zöller B,Dahlbäck B

更新日期：1998-04-01 00:00:00

abstract：:The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothelial cell BH4 is required for ...

journal_title：Thrombosis and haemostasis

authors： McNeill E,Channon KM

更新日期：2012-11-01 00:00:00

abstract：:Plasmin triggers chemotaxis and NF-kappa B- and AP-1-mediated proinflammatory gene expression in human peripheral monocytes (PM). Compared with macrophages and dendritic cells, PM express mainly the peroxisome proliferator-activated receptor (PPAR) gamma and traces of PPAR alpha as detected by semiquantitative RT-PCR ...

journal_title：Thrombosis and haemostasis

authors： Syrovets T,Schüle A,Jendrach M,Büchele B,Simmet T

更新日期：2002-08-01 00:00:00

abstract：:Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could pl...

journal_title：Thrombosis and haemostasis

authors： Leoncini G,Bruzzese D,Signorello MG,Armani U,Piana A,Ghiglione D,Camicione P

更新日期：2007-02-01 00:00:00

abstract：:The stimulated release of von Willebrand factor (vWF) from endothelial cells by secretagogues such as thrombin is associated with the translocation of Weibel-Palade bodies to the cell membrane and the surface expression of P-selectin (also known as GMP 140, PADGEM and CD 62). P-selectin, which is stored in Weibel-Pala...

journal_title：Thrombosis and haemostasis

authors： Collins PW,Macey MG,Cahill MR,Newland AC

更新日期：1993-08-02 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:Primary prevention is the key to managing a significant proportion of the burden of venous thromboembolism (VTE), defined as deep venous thrombosis (DVT) or pulmonary embolism (PE). This is because VTE may lead to sudden death or are often misdiagnosed and therefore treatment is not feasible. Primary prevention usuall...

journal_title：Thrombosis and haemostasis

authors： Granziera S,Cohen AT

更新日期：2015-06-01 00:00:00

abstract：:The effect of the ADP receptor antagonists ATP and adenosine 5'-(beta, gamma-methylene)triphosphate (AMP-PCP), and the ADP-utilizing enzyme systems creatine phosphokinase/creatine phosphate (CPK/CP) and pyruvate kinase/phosphoenol pyruvate (PK/PEP) on platelet deposition onto type I collagen was examined. An in vitro ...

journal_title：Thrombosis and haemostasis

authors： Wagner WR,Hubbell JA

更新日期：1992-04-02 00:00:00

abstract：:Desmopressin acetate administration markedly stimulates release of tissue plasminogen activator (t-PA) from vascular endothelial cells. The mechanism for this effect is unknown. Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA re...

journal_title：Thrombosis and haemostasis

authors： Grant MB,Guay C,Lottenberg R

更新日期：1988-04-08 00:00:00

abstract：:Five expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; x3), Biostate (x3) and Humate/Haemate (x3). All laborato...

journal_title：Thrombosis and haemostasis

authors： Favaloro EJ,Bukuya M,Martinelli T,Tzouroutis J,Duncan E,Welldon K,Collecutt M,Aumann H,Thom J,Gilmore G

更新日期：2002-03-01 00:00:00

abstract：:Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic...

journal_title：Thrombosis and haemostasis

authors： Boisramé-Helms J,Delabranche X,Degirmenci SE,Zobairi F,Berger A,Meyer G,Burban M,Mostefai HA,Levy B,Toti F,Meziani F

更新日期：2014-01-01 00:00:00

abstract：:We have devised an improved high pressure liquid chromatographic technique whereby serotonin, nucleosides, cyclic nucleotides, namely cAMP and cGMP, and 5'mono-, 5'di-, and 5'tri-nucleotides can be analyzed. The cyclic nucleotides have been measured in picomolar quantities. All nucleotides can be quantitated in a sing...

journal_title：Thrombosis and haemostasis

authors： D'Souza L,Glueck HI

更新日期：1977-12-15 00:00:00

abstract：:A robust two-way analysis of variance technique was applied to determine simultaneously the effects of method and thromboplastin on prothrombin time. A new approach to outlier detection for two-way analysis of variance was used. Focusing on the underlying error structure improved the uniformity of the grading procedur...

journal_title：Thrombosis and haemostasis

authors： Han Y,Lawson WB,Dodds WJ,Lawrence CE

更新日期：1985-10-30 00:00:00

abstract：OBJECTIVE: Blood monocyte subsets are emerging as biomarkers of cardiovascular inflammation. However, our understanding of human monocyte heterogeneity and their immunophenotypic features under healthy and inflammatory conditions is still evolving. RATIONALE: In this study, we sought to investigate the immunophenome o...

journal_title：Thrombosis and haemostasis

authors： Hoffmann J,Fišer K,Liebetrau C,Staubach N,Kost D,Voss S,Heiden AZ,Dörr O,Lipps C,Nef HM,Möllmann H,Hamm CW,Keller T,Troidl C

更新日期：2020-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1160/TH14-06-0547.]. ...

journal_title：Thrombosis and haemostasis

authors：

更新日期：2017-04-03 00:00:00

abstract：:The blockade of platelet membrane glycoprotein IIb/IIIa by a monoclonal antibody, 7E3, was measured by flow cytometry using a fluorescein isothiocyanate-conjugated disintegrin, FITC-crotavirin, as the probe. After treatment of platelets with 7E3 or 7E3 F(ab')2, there is a good correlation between the inhibition of pla...

journal_title：Thrombosis and haemostasis

authors： Liu CZ,Hur BT,Huang TF

更新日期：1996-10-01 00:00:00

abstract：:Atherosclerosis is at least in part an inflammatory disease. CD14 is an endotoxin receptor that after binding of lipopolysaccharides evokes endothelial activation and secretion of several cytokines. A polymorphism of CD14 has been associated with myocardial infarction. We evaluated the role of the -159 T/C polymorphis...

journal_title：Thrombosis and haemostasis

authors： Agema WR,Wouter Jukema J,de Maat MP,Zwinderman AH,Kastelein JJ,Rabelink TJ,van der Wall EE

更新日期：2004-05-01 00:00:00

abstract：:Following favourable results from a previous study, a large, multicentre, prospective, case-control study was performed to further assess the incidence of bleeding complications after dental extraction in patients taking oral anticoagulant therapy (OAT). Four hundred fifty-one patients being treated with warfarin who ...

journal_title：Thrombosis and haemostasis

authors： Bacci C,Maglione M,Favero L,Perini A,Di Lenarda R,Berengo M,Zanon E

更新日期：2010-11-01 00:00:00

abstract：:In a recent study, we purified and cloned a newly identified bioactive factor that stimulates prostacyclin (PGI2) production by vascular endothelial cells (ECs) using conditioned medium (CM) from cultured human diploid fibroblast cells. The present study was undertaken to clarify whether PSF is expressed in ECs and va...

journal_title：Thrombosis and haemostasis

authors： Masakado M,Umeda F,Takei A,Hashimoto T,Sueishi K,Nawata H

更新日期：1995-12-01 00:00:00

abstract：:To investigate the inhibitory mechanism of tissue factor pathway inhibitor (TFPI), an attempt was made to examine the inhibitory activity of TFPI toward the factor VIIa-truncated tissue factor (TF1-219) complex, which lacks its transmembrane and cytoplasmic domains. Factor VIIa-TF1-219 activity was significantly inhib...

journal_title：Thrombosis and haemostasis

authors： Kazama Y

更新日期：1997-03-01 00:00:00

abstract：:Bleeding and thrombotic disorders are major complications affecting patients with chronic kidney disease (CKD). Exposure of circulating platelets to uraemic toxins and contact with artificial surfaces during dialysis induce platelet abnormalities and alter the platelet proteome. We hypothesised that these changes may ...

journal_title：Thrombosis and haemostasis

authors： Plé H,Maltais M,Corduan A,Rousseau G,Madore F,Provost P

更新日期：2012-10-01 00:00:00

abstract：:Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma...

journal_title：Thrombosis and haemostasis

authors： Lallukka S,Luukkonen PK,Zhou Y,Isokuortti E,Leivonen M,Juuti A,Hakkarainen A,Orho-Melander M,Lundbom N,Olkkonen VM,Lassila R,Yki-Järvinen H

更新日期：2017-01-26 00:00:00

abstract：:Incubation of platelet-rich plasma (PRP) with ouabain, an inhibitor of sodium/potassium ATPase (Na+/K+ ATPase), induced a significant rise in basal platelet intracellular calcium concentration [( Ca2+]i) when measured using fura 2. Ouabain induced an enhanced aggregation response to low doses of collagen in both PRP a...

journal_title：Thrombosis and haemostasis

authors： Lees AD,Wilson J,Orchard CH,Orchard MA

更新日期：1989-11-24 00:00:00

abstract：:The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years w...

journal_title：Thrombosis and haemostasis

authors： Baranyai Z,Krzystanek M,Jósa V,Dede K,Agoston E,Szász AM,Sinkó D,Szarvas V,Salamon F,Eklund AC,Szállási Z,Jakab F

更新日期：2014-03-03 00:00:00

abstract：:Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PA Ag). Since the concentration of t-PA Ag depends on both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated th...

journal_title：Thrombosis and haemostasis

authors： Aillaud MF,Pignol F,Alessi MC,Harle JR,Escande M,Mongin M,Juhan-Vague I

更新日期：1986-06-30 00:00:00

abstract：:Anticoagulant control facilities are being overwhelmed by requests for monitoring and large numbers of patients are not therefore receiving treatment. Procedures designed for point-of-care testing have therefore been developed, the most popular being the CoaguChek. The need for external quality assessment (EQA) of mon...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Poller L,van den Besselaar AM,van der Meer FJ,Palareti G,Tripodi A,Shiach C,Keown M,Ibrahim S

更新日期：2010-05-01 00:00:00

abstract：:An algal sulfated galactan has high anticoagulant and antithrombotic activities. Its serpin-dependent anticoagulant action is due to promoting thrombin and factor (F)Xa inhibition by antithrombin and heparin cofactor II. Here, we evaluated the anticoagulant effect of the algal sulfated galactan using serpin-free plasm...

journal_title：Thrombosis and haemostasis

authors： Glauser BF,Rezende RM,Melo FR,Pereira MS,Francischetti IM,Monteiro RQ,Rezaie AR,Mourão PA

更新日期：2009-12-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical out...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Touloumenidou T,Sakellari I,Batsis I,Mallouri D,Psomopoulos F,Tsagiopoulou M,Koutra M,Yannaki E,Papalexandri A,Taylor P,Nikolousis E,Stamouli M,Holbro A,Baltadakis I,Liga M,Spyridonidis A,Tsirigotis P,Cha

更新日期：2020-04-01 00:00:00