当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction.

Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction.

Abstract：

:This study explores the effects on some hematological parameters of a low-dose aspirin regimen (50 mg/day) versus a conventional aspirin treatment with reported antithrombotic efficacy (324 mg/day), in patients with acute myocardial infarction. Fifteen patients were randomized into 3 equal groups receiving 50 mg or 324 mg aspirin or placebo, daily for 21 days. Compared with placebo, bleeding time was significantly and similarly prolonged with both aspirin doses (+ 71 +/- 22% and + 69 +/- 20%, mean +/- S.D.). Aspirin 50 mg/day suppressed arachidonate-induced platelet aggregation and secondary phase aggregation after ADP and adrenaline. Collagen aggregation was inhibited by 44 +/- 15%. In no case were differences in the antiplatelet effects of the two doses observed. The effects of 50 mg/day persisted without attenuation during the observation period. Platelet thromboxane B2 generation during arachidonate-induced aggregation was inhibited by 95 +/- 2 and 99 +/- 1% compared to placebo group after 50 and 324 mg/day, respectively (P between doses less than 0.05). No change was observed with any treatment in coagulation time, prothrombin time or plasma thromboplastin time. Thus, in patients with acute myocardial infarction, the antiplatelet effects of aspirin 50 mg/day are stable over time and superimposable on those of 324 mg/day. The antithrombotic efficacy of aspirin 50 mg/day remains to be tested clinically.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

De Caterina R,Giannessi D,Boem A,Bernini W,Battaglia D,Michelassi C,Dell'Amico F,L'Abbate A,Patrignani P,Patrono C

subject

Has Abstract

pub_date

1985-08-30 00:00:00

pages

528-32

issue

2

eissn

0340-6245

issn

2567-689X

journal_volume

54

pub_type

临床试验,杂志文章,随机对照试验

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Effects of alpha2-plasmin inhibitor on fibrin clot lysis. Its comparison with alpha2-macroglobulin.

    abstract：:The major plasmin inhibitors namely alpha2-plasmin inhibitor and alpha2-macroglobulin were compared for their effects on lysis of fibrin clot. Plasmin fibrinolytic activity was immediately inhibited by alpha2-plasmin inhibitor, whereas alpha2-macroglobulin inhibited plasmin progressively. Urokinase(plasminogen activat...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Aoki N,Moroi M,Tachiya K

    更新日期：1978-02-28 00:00:00

  • Further studies on the modulation of blood coagulation by human serum amyloid P component and its acute phase homologue C-reactive protein.

    abstract：:Serum amyloid P component (SAP), and its acute phase homologue C-reactive protein (CRP), prolonged activated partial thromboplastin times (APTT) in cell free plasma when assayed at physiological concentrations in the presence of heparin. SAP also inhibited clot formation initiated through the extrinsic and terminal ph...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Fiedel BA,Ku CS

    更新日期：1986-06-30 00:00:00

  • A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.

    abstract：:We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC (50) of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidase...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Wang YX,Zhao L,Nagashima M,Vincelette J,Sukovich D,Li W,Subramanyam B,Yuan S,Emayan K,Islam I,Hrvatin P,Bryant J,Light DR,Vergona R,Morser J,Buckman BO

    更新日期：2007-01-01 00:00:00

  • Risk Factors for Higher-than-Expected Residual Rivaroxaban Plasma Concentrations in Real-Life Patients.

    abstract：INTRODUCTION:Rivaroxaban (RXA) is a direct oral factor Xa (Xa) antagonist with a short half-life and a fast onset and offset of effect. Before elective surgery, discontinuation is recommended with an interval of at least > 24 hours. In clinical practice, this is, however, not always sufficient to achieve a residual RXA...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1639585

    authors： Kaserer A,Schedler A,Jetter A,Seifert B,Spahn DR,Stein P,Studt JD

    更新日期：2018-05-01 00:00:00

  • Review on the value of graduated elastic compression stockings after deep vein thrombosis.

    abstract：:Graduated elastic compression stockings (GECS) are commonly used in the primary prevention of deep vein thrombosis (DVT); however, their role in preventing recurrent DVT and also post-thrombotic syndrome is less well established. The aim of this review was to investigate the effect of GECS after DVT. A literature sear...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Kakkos SK,Daskalopoulou SS,Daskalopoulos ME,Nicolaides AN,Geroulakos G

    更新日期：2006-10-01 00:00:00

  • The vascular biology of macrophage migration inhibitory factor (MIF). Expression and effects in inflammation, atherogenesis and angiogenesis.

    abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer developme...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH12-11-0831

    authors： Asare Y,Schmitt M,Bernhagen J

    更新日期：2013-03-01 00:00:00

  • Erythropoietin improves signaling through tyrosine phosphorylation in platelets from uremic patients.

    abstract：:Erythropoietin has shown to be effective in the correction of the hemostatic defect present in uremic patients. We have investigated the possible effect of recombinant human erythropoietin (rHuEPO) on the signaling processes occurring in platelets. Platelet suspensions were obtained from hemodialyzed patients before a...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Diaz-Ricart M,Etebanell E,Cases A,López-Pedret J,Castillo R,Ordinas A,Escolar G

    更新日期：1999-10-01 00:00:00

  • A decrease in plasminogen activator inhibitor-1 activity after successful percutaneous transluminal coronary angioplasty is associated with a significantly reduced risk for coronary restenosis.

    abstract：:To determine a possible relation of changes in plasma levels of plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA) to the development of coronary restenosis after successful coronary angioplasty (PTCA), we followed 104 patients with a low grade residual stenosis after PTCA (less than 30%...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Huber K,Jörg M,Probst P,Schuster E,Lang I,Kaindl F,Binder BR

    更新日期：1992-02-03 00:00:00

  • 8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties.

    abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-06-0341

    authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

    更新日期：2010-03-01 00:00:00

  • Proteolytic and immunologic comparison of human and bovine von Willebrand factor.

    abstract：:The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Fragments were analyzed for chain composition, heparin binding, collagen binding, platelet agglutinating activity and recognition by a panel of monoclonal antibodies which reacte...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Bakhshi MR,Kirby EP

    更新日期：1990-06-28 00:00:00

  • A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N, KHRR 296-299 AAAA).

    abstract：:Site directed mutagenesis was used to construct a t-PA variant that contains an additional glycosylation site in the first kringle domain (T103N) combined with a tetra-alanine substitution in the protease domain (KHRR 296-299 AAAA). This combination variant has a plasma clearance rate that is 4.5-fold slower in rats a...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Paoni NF,Keyt BA,Refino CJ,Chow AM,Nguyen HV,Berleau LT,Badillo J,Peña LC,Brady K,Wurm FM

    更新日期：1993-08-02 00:00:00

  • A pilot study of subcutaneous recombinant hirudin (HBW 023) in the treatment of deep vein thrombosis.

    abstract：BACKGROUND:Recombinant hirudin, a pure, specific antithrombin could be more effective than heparin in the treatment of deep vein thrombosis, but its short half-life requires constant intravenous infusion, whereas subcutaneous administration of recombinant hirudin can ensure stable and prolonged plasma levels. The aim o...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章

    doi：

    authors： Schiele F,Vuillemenot A,Kramarz P,Kieffer Y,Soria J,Soria C,Camez A,Mirshahi MC,Bassand JP

    更新日期：1994-05-01 00:00:00

  • Concomitant secretion by A431 cells of tissue plasminogen activator and a specific inhibitor masks EGF modulation of tPA activity.

    abstract：:It has previously been reported that EGF enhances uPA but not tPA in the A431 squamous carcinoma cell line. To determine whether the absence of tPA modulation by EGF reflected steady levels or the action of an anti-activator, we assayed tPA, PAI-1 and tPA/PAI-1 complexes by zymography and immunological assays. Under c...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： George F,Pourreau-Schneider N,Arnoux D,Boutière B,Berthois Y,Martin PM,Sampol J

    更新日期：1990-11-30 00:00:00

  • Marked increase of activated factor VII in uremic patients.

    abstract：:We investigated plasma activated factor VII (FVIIa) levels in uremic patients (nondialysis group: n = 38; dialysis group: n = 36) and healthy controls (n = 32). We also measured the plasma levels of thrombomodulin (an indicator of endothelial cell injury) and tissue factor. Plasma FVIIa showed a marked increase in the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kario K,Matsuo T,Matsuo M,Koide M,Yamada T,Nakamura S,Sakata T,Kato H,Miyata T

    更新日期：1995-05-01 00:00:00

  • Interaction of bovine platelets with bovine glomerular basement membrane.

    abstract：:The interaction of bovine platelets with bovine glomerular basement membrane has been studied by aggregometry, transmission and scanning electron microscopy and measurement of [3H] serotonin release. In the absence of added calcium platelets adhere to basement membrane but fail to undergo the release reaction or aggre...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Davis JL,Chandler DK,Riquetti P,Rogers S,Kocan KM,Ownby CL,Hudson BG,Carraway KL

    更新日期：1979-12-21 00:00:00

  • Platelets release their lysosomal content in vivo in humans upon activation.

    abstract：:Platelets contain, besides alpha- and delta-granules, lysosomes which store glycohydrolases able to degrade glycoproteins, glycolipids and glycosaminoglycans. While several studies have shown that alpha- and delta-granule secretion takes place "in vivo" in humans upon platelet activation, no data are available on the ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Ciferri S,Emiliani C,Guglielmini G,Orlacchio A,Nenci GG,Gresele P

    更新日期：2000-01-01 00:00:00

  • Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism.

    abstract：:The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. It was the study objective to evaluate in vivo lipid peroxidation and platelet activation in carriers of the MTHFR 677 C→T polymo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH11-12-0899

    authors： Dragani A,Falco A,Santilli F,Basili S,Rolandi G,Cerasa L,Lattanzio S,Ciabattoni G,Patrono C,Davì G

    更新日期：2012-09-01 00:00:00

  • Involvement of IRAKs and TRAFs in anti-β₂GPI/β₂GPI-induced tissue factor expression in THP-1 cells.

    abstract：:Our previous study has shown that Toll-like receptor 4 (TLR4) and its signalling pathway contribute to anti-β₂-glycoprotein I/β₂-glycoprotein I (anti-β₂GPI/β₂GPI)-induced tissue factor (TF) expression in human acute monocytic leukaemia cell line THP-1 and annexin A2 (ANX2) is involved in this pathway. However, its dow...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH11-04-0229

    authors： Xu G,Wen H,Zhou H,Guo D,Zhou F,Chen D,Xie H,Wang T,Wang H

    更新日期：2011-12-01 00:00:00

  • Differential Effects on Haemostatic Markers by Metformin and the Contraceptive Pill: A Randomized Comparative Trial in PCOS.

    abstract：:Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objec...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-04-0248

    authors： Burchall GF,Piva TJ,Ranasinha S,Teede HJ

    更新日期：2017-11-01 00:00:00

  • Protection of single-chain urokinase-type plasminogen activator (scu-PA) in aprotinin treated cardiac surgical patients undergoing cardiopulmonary bypass.

    abstract：:Intraoperative high-dose aprotinin administration has been shown to reduce the intra-and postoperative blood loss in cardiac surgery. The haemostatic effect has been attributed to platelet preserving properties and to inhibition of contact activation reducing thrombotic and fibrinolytic activity during and after cardi...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Spannagl M,Dooijewaard G,Dietrich W,Kluft C

    更新日期：1995-05-01 00:00:00

  • High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).

    abstract：:The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic ris...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH07-03-0208

    authors： Kirkeby A,Torup L,Bochsen L,Kjalke M,Abel K,Theilgaard-Monch K,Johansson PI,Bjørn SE,Gerwien J,Leist M

    更新日期：2008-04-01 00:00:00

  • The in vitro inhibitory effect on thrombin by 2,3-diphosphoglycerate.

    abstract：:Thrombin incubated with 2,3-diphosphoglycerate (150 nmol 2,3-DPG/1 NIH thrombin unit) lost up to 70% of its clotting activity, whereas the esterase activity remained unchanged. No fibrinopeptide release by thrombin was observed in the presence of 2,3-DPG. The fibrin polymerization was normal. By chromatography on Ambe...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Del Principe D,Strappini PM,Del Vecchio S,Menichelli A,Biancini G,Cosmi EV,Bastianon V,D'Arcangelo C

    更新日期：1981-10-01 00:00:00

  • Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity.

    abstract：:Inherited severe hypoplasminogenaemia is a multisystemic disorder leading to deficient extravascular fibrinolysis. As a clinical consequence wound healing capacity of mucous membranes is markedly impaired leading to ligneous conjunctivitis and several other manifestations. Here we report the molecular genetic and clin...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH10-04-0216

    authors： Klammt J,Kobelt L,Aktas D,Durak I,Gokbuget A,Hughes Q,Irkec M,Kurtulus I,Lapi E,Mechoulam H,Mendoza-Londono R,Palumbo JS,Steitzer H,Tabbara KF,Ozbek Z,Pucci N,Sotomayor T,Sturm M,Drogies T,Ziegler M,Schuster V

    更新日期：2011-03-01 00:00:00

  • Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1.

    abstract：:Platelets and coagulation are involved in bacterial colonisation of the host. Streptocococcus pneumoniae (pneumococcus) are important etiologic agents of respiratory tract infections in humans. The formation of pneumococci-platelet associations may facilitate haematogenous dissemination of pneumococci by providing an ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-01-0049

    authors： Niemann S,Kehrel BE,Heilmann C,Rennemeier C,Peters G,Hammerschmidt S

    更新日期：2009-10-01 00:00:00

  • Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.

    abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-06-0433

    authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

    更新日期：2017-12-01 00:00:00

  • Collaborative study on assays of activated FIX (FIXa). On behalf of the factor VIII and factor IX subcommittee of the ISTH. International Society on Thrombosis and Haemostasis.

    abstract：:A collaborative study has been organised by NIBSC to examine the performance of FIXa assays between laboratories, and to investigate the need for a standard. Ampoules of 3 materials, one monocomponent concentrate (coded C) and 2 different preparations of purified human FIXa (one proposed reference preparation, coded A...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Gray E,Walker D,Heath A,Barrowcliffe TW

    更新日期：1996-12-01 00:00:00

  • Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting.

    abstract：:Today, direct oral anticoagulants (DOAC) are widely used alternatives to Vitamin-K antagonists (VKA). Women of reproductive age may become pregnant during anticoagulation and, while VKA carry an embryotoxic potential, the risk of DOAC embryopathy is unknown. As a result, some patients elect to terminate pregnancy for ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-04-0305

    authors： Beyer-Westendorf J,Michalski F,Tittl L,Middeldorp S,Cohen H,Abdul Kadir R,Arachchillage DJ,Arya R,Ay C,Marten S

    更新日期：2016-09-27 00:00:00

  • Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury.

    abstract：:Antithrombin (AT) is a protein of the serpin superfamily involved in regulation of the proteolytic activity of the serine proteases of the coagulation system. AT is known to exhibit anti-inflammatory and cardioprotective properties when it binds to heparan sulfate proteoglycans (HSPGs) on vascular cells. AMP-activated...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH14-04-0360

    authors： Ma Y,Wang J,Gao J,Yang H,Wang Y,Manithody C,Li J,Rezaie AR

    更新日期：2015-02-01 00:00:00

  • Thrombolysis with an Escherichia coli-produced recombinant plasminogen activator (BM 06.022) in the rabbit model of jugular vein thrombosis.

    abstract：:The recombinant plasminogen activator BM 06.022 consists of the kringle 2 and the protease domains of human t-PA and is unglycosylated because of the expression in Escherichia coli. The thrombolytic and pharmacokinetic properties as well as the hemostasis effects of BM 06.022 were investigated in the rabbit model of j...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Martin U,Fischer S,Kohnert U,Opitz U,Rudolph R,Sponer G,Stern A,Strein K

    更新日期：1991-05-06 00:00:00

  • The effects of long-term using once-a-month injectable contraceptive norethisterone enanthate/estradiol valerate on coagulation in the Chinese.

    abstract：:Sixty-four Chinese women were studied for the effects of injecting once-a-month contraceptive norethisterone enanthate/estradiol valerate between 2 to 4 1/2 years on certain coagulation and fibrinolytic parameters, and 59 women not receiving any steroidal contraception were controls. In both groups there was no signif...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Meng YX,Jiang HY,Lu FY

    更新日期：1990-12-28 00:00:00