The in vitro inhibitory effect on thrombin by 2,3-diphosphoglycerate.

abstract：:Complement C3 is a novel risk factor for cardiovascular disease (CVD), but the underlying mechanism is currently unknown. We determined the associations of the anaphylatoxin C3a, the activation product of C3, and of C3 itself with estimates of atherosclerosis and CVD. We studied associations of C3a and C3 with carotid...

journal_title：Thrombosis and haemostasis

authors： Hertle E,van Greevenbroek MM,Arts IC,van der Kallen CJ,Geijselaers SL,Feskens EJ,Jansen EH,Schalkwijk CG,Stehouwer CD

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Patients undergoing surgery for cancer are at high risk for venous thromboembolism (VTE). Agents that selectively inhibit thrombin, such as dermatan sulphate, have potential for a favourable benefit-risk ratio in the prevention of this complication. METHODS:Patients scheduled for elective abdominal, thoraci...

journal_title：Thrombosis and haemostasis

authors： Di Carlo V,Agnelli G,Prandoni P,Coccheri S,Gensini GF,Gianese F,Mannucci PM

更新日期：1999-07-01 00:00:00

abstract：:Adjunctive use of phosphodiesterase (PDE) inhibitor can enhance antiplatelet and vasoprotective properties in patients with cardiovascular disease. The aim of this study was to evaluate the impact of PDE5 inhibitor dipyridamole on platelet function in stented patients with high platelet reactivity (HPR) during dual an...

journal_title：Thrombosis and haemostasis

authors： Park Y,Jeong YH,Tantry US,Ahn JH,Kim KH,Koh JS,Park JR,Hwang SJ,Kwak CH,Hwang JY,Gurbel PA

更新日期：2014-12-01 00:00:00

abstract：:Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor V(Leiden) (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns. Pregnant women with known thrombophilia (n=27) were enro...

journal_title：Thrombosis and haemostasis

authors： Hyytiäinen S,Wartiovaara-Kautto U,Ulander VM,Kaaja R,Heikinheimo M,Petäjä J

更新日期：2006-03-01 00:00:00

abstract：:We examined the antithrombotic activity of a novel synthetic inhibitor of factor Xa, YM-60828, in an electrically-induced carotid artery thrombosis model in rats. In the first experiment, the antithrombotic activity of YM-60828 after i.v. infusion was compared with those of heparin, darteparin and argatroban. Test dru...

journal_title：Thrombosis and haemostasis

authors： Kawasaki T,Sato K,Sakai Y,Hirayama F,Koshio H,Taniuchi Y,Matsumoto Y

更新日期：1998-02-01 00:00:00

abstract：:Several studies have highlighted a specific role for membrane cholesterol domains in platelet signalling. Upon adhesion to von Willebrand factor (VWF) or collagen, cholesterol-rich domains (CRDs) accumulate in filopodial extensions and selectively harbour counterpart receptors (GPIb and GPVI) and associated signalling...

journal_title：Thrombosis and haemostasis

authors： van Lier M,Verhoef S,Cauwenberghs S,Heemskerk JW,Akkerman JW,Heijnen HF

更新日期：2008-06-01 00:00:00

abstract：:A randomised, prospective, double-blind trial was performed, to compare the safety and efficacy of a new low-molecular-weight heparin (LMWH) Bemiparin and standard unfractionated heparin (UFH), for the prophylaxis of postoperative venous thromboembolism. 300 patients scheduled to undergo elective hip arthroplasty were...

journal_title：Thrombosis and haemostasis

authors： Kakkar VV,Howes J,Sharma V,Kadziola Z

更新日期：2000-04-01 00:00:00

abstract：:Dabigatran is an oral, reversible thrombin inhibitor that has shown promising results in large clinical trials. Laboratory monitoring is not needed but the effects on common coagulation assays are incompletely known. Dabigatran was added to plasma from healthy subjects in the concentration range 0-1,000 μg/l and analy...

journal_title：Thrombosis and haemostasis

authors： Lindahl TL,Baghaei F,Blixter IF,Gustafsson KM,Stigendal L,Sten-Linder M,Strandberg K,Hillarp A,Expert Group on Coagulation of the External Quality Assurance in Laboratory Medicine in Sweden.

更新日期：2011-02-01 00:00:00

abstract：:Edoxaban is an oral direct factor (F)Xa inhibitor in advanced stages of clinical development. The primary objective of the present study was to assess the pharmacodynamics (PD) and safety of enoxaparin 1 mg/kg followed 12 hours (h) post-dose by edoxaban 60 mg, which is the regimen being used in the phase III study of ...

journal_title：Thrombosis and haemostasis

authors： Zahir H,Matsushima N,Halim AB,He L,Zhang G,Lee F,Worland V,Mendell J

更新日期：2012-07-01 00:00:00

abstract：:Human protein S (HPS) has three potential N-linked glycosylation sites at Asn458, 468, 489. To study the role of glycosylation at these sites, PCR mutagenesis was used to abolish the consensus sequence of each N-linked glycosylation site (Asn458-->Gln, Ser460-->Gly; Asn468-->Gln, Thr470-->Gly; Asn489-->Gln, Thr491-->G...

journal_title：Thrombosis and haemostasis

authors： Lu D,Xie RL,Rydzewski A,Long GL

更新日期：1997-06-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) include lupus-type anticoagulant (LA) and antibodies recognizing complexes of anionic phospholipids (e.g. cardiolipin) and proteins (e.g. prothrombin and beta2-glycoprotein I). The presence of APA is associated with an increased risk of both arterial and venous thrombosis. How...

journal_title：Thrombosis and haemostasis

authors： Musiał J,Swadźba J,Jankowski M,Grzywacz M,Bazan-Socha S,Szczeklik A

更新日期：1997-10-01 00:00:00

abstract：:There is much debate over the appropriateness of prescribing prolonged anticoagulation to heterozygous carriers of factor V Leiden suffering a first episode of deep vein thrombosis (DVT). We, thus used meta-analysis to estimate from six eligible studies the summary odds-ratio of recurrent DVT in carriers of factor V L...

journal_title：Thrombosis and haemostasis

authors： Marchetti M,Pistorio A,Barosi G

更新日期：2000-11-01 00:00:00

abstract：:A preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received ...

journal_title：Thrombosis and haemostasis

authors： Parrilla N,Ansell J

更新日期：1982-02-26 00:00:00

abstract：:Fresh retracted clots are known to be poorly lysable by fibrinolytic agents. We have studied whether lysis of retracted clots could be enhanced by bulk transport in comparison to pure diffusion of plasma containing urokinase (400 IU/ml) into the clots. Cylindrical retracted blood clots were occlusively glued by a poly...

journal_title：Thrombosis and haemostasis

authors： Blinc A,Keber D,Lahajnar G,Stegnar M,Zidansek A,Demsar F

更新日期：1992-12-07 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

更新日期：2019-09-01 00:00:00

abstract：:Positively charged macromolecule, polylysine (mol. wt. 15,000; 23,000; 180,000) could induce the platelet aggregation in low concentration but high concentration was required in the case of neutral macromolecule, dextran (mol. wt. 40,000; 250,000; 2,000,000). The larger molecules of polylysine and dextran were more ef...

journal_title：Thrombosis and haemostasis

authors： Taketomi Y,Kuramoto A

更新日期：1978-08-31 00:00:00

abstract：:Antithrombin (AT) is a serine protease inhibitor that regulates the activity of coagulation proteases of both intrinsic and extrinsic pathways. We identified an AT-deficient patient with a heterozygous Thr90Ser (T90S) mutation who experiences recurrent venous thrombosis. To understand the molecular basis of the clotti...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Villoutreix BO,Biswas I,Ding Q,Wang X,Rezaie AR

更新日期：2020-07-01 00:00:00

abstract：:A model has been developed to study the transport of fluid and macromolecules through human arterial umbilical cord endothelial cell monolayers in vitro. Cells were cultured on fibronectin-coated polycarbonate filters and formed within a few days a tight monolayer, with an electrical resistance of 17 +/- 4 Ohm.cm2. Th...

journal_title：Thrombosis and haemostasis

authors： Langeler EG,van Hinsbergh VW

更新日期：1988-10-31 00:00:00

abstract：:An enzyme immuno assay was developed to measure complexes of tissue-type plasminogen activator (t-PA) with C1-inhibitor in order to study the role of C1-inhibitor as an inhibitor of t-PA in plasma. In vitro experiments with melanoma and recombinant t-PA learned that purified C1-inhibitor reacts with both single chain ...

journal_title：Thrombosis and haemostasis

authors： Huisman LG,van Griensven JM,Kluft C

更新日期：1995-03-01 00:00:00

abstract：:In this study, we investigate the influence of three factor VII (FVII) gene polymorphisms on activated FVII levels (FVIIa), and also on the risk of myocardial infarction (MI) in patients with advanced coronary atherosclerotic disease (CAD). The -323A2 allele in the promoter is known to be associated with low FVII leve...

journal_title：Thrombosis and haemostasis

authors： Bozzini C,Girelli D,Bernardi F,Ferraresi P,Olivieri O,Pinotti M,Martinelli N,Manzato F,Friso S,Villa G,Pizzolo F,Beltrame F,Corrocher R

更新日期：2004-09-01 00:00:00

abstract：INTRODUCTION: Bleeds such as intra-ventricular (IVH) and pulmonary haemorrhage (PH) are life-threatening events in extremely low birth weight (ELBW) infants. Serial coagulation monitoring by measuring the international normalized ratio (INR) with small volume samples might facilitate early diagnosis and possibly preven...

journal_title：Thrombosis and haemostasis

authors： Thanhaeuser M,Binder C,Derhaschnig U,Jilma B,Kornsteiner-Krenn M,Huber-Dangl M,Repa A,Kreissl A,Berger A,Haiden N

更新日期：2018-07-01 00:00:00

abstract：:Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outco...

journal_title：Thrombosis and haemostasis

authors： Kim J,Kim YD,Song TJ,Park JH,Lee HS,Nam CM,Nam HS,Heo JH

更新日期：2012-08-01 00:00:00

abstract：:The object was to assess the variability in displayed International Normalised Ratio (INR) between monitors of the same manufacture using whole blood samples from the same subjects. Two brands of monitor, CoaguChek Mini and the TAS PT-NC were tested. 14 instruments of each brand were tested on the same day at the same...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Chauhan N,Shiach C,van den Besselaar AM,Tripodi A,Jespersen J,European Concerted Action on Anticoagulation.

更新日期：2002-12-01 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Piazza G

更新日期：2018-12-01 00:00:00

abstract：:The effect of chronic administration of ethanol to rats in a controlled regimen upon the activities of the coagulation factors II, VII, VIII, IX and X has been studied. No significant differences were found for factor II, IX and X between the ethanol-treated rats and the control group given an isocaloric diet with car...

journal_title：Thrombosis and haemostasis

authors： Morland J,Holm T,Prydz H

更新日期：1976-12-31 00:00:00

abstract：:Heparin and its derivatives have been shown to inhibit angiogenesis and metastasis formation. Accordingly, we investigated the effect of heparin fragments containing 4 to 22 monomers on human melanoma cell proliferation, migration and invasion in vitro as well as on the in vivo metastatic potential in a SCID mouse mod...

journal_title：Thrombosis and haemostasis

authors： Kenessey I,Simon E,Futosi K,Bereczky B,Kiss A,Erdödi F,Gallagher JT,Tímár J,Tóvári J

更新日期：2009-12-01 00:00:00

abstract：:Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma...

journal_title：Thrombosis and haemostasis

authors： Lallukka S,Luukkonen PK,Zhou Y,Isokuortti E,Leivonen M,Juuti A,Hakkarainen A,Orho-Melander M,Lundbom N,Olkkonen VM,Lassila R,Yki-Järvinen H

更新日期：2017-01-26 00:00:00

abstract：:Platelet activation as a result of vascular injury provokes endothelial cells to respond in a manner which limits or reverses the occlusive consequences of platelet accumulation. If the agonistic forces are strong, platelet accumulation is irreversible. In vitro data from our laboratory have repeatedly demonstrated th...

journal_title：Thrombosis and haemostasis

authors： Marcus AJ,Safier LB,Broekman MJ,Islam N,Fliessbach JH,Hajjar KA,Kaminski WE,Jendraschak E,Silverstein RL,von Schacky C

更新日期：1995-07-01 00:00:00

abstract：:In a group of 705 healthy middle-aged men, we have examined the relationship between plasma levels of Factor VII (FVII) c and Factor VII antigen (FVIIag) and two polymorphisms in the FVII gene. One polymorphism alters arginine at position 353 to glutamine (R/Q), and the other is the result of a 10 base pair (bp) inser...

journal_title：Thrombosis and haemostasis

authors： Humphries S,Temple A,Lane A,Green F,Cooper J,Miller G

更新日期：1996-04-01 00:00:00

abstract：:Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by...

journal_title：Thrombosis and haemostasis

authors： Opitz B,Eitel J,Meixenberger K,Suttorp N

更新日期：2009-12-01 00:00:00