A pilot study of subcutaneous recombinant hirudin (HBW 023) in the treatment of deep vein thrombosis.

abstract：:Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thromboti...

journal_title：Thrombosis and haemostasis

authors： Deroo S,Deatrick KB,Henke PK

更新日期：2010-10-01 00:00:00

abstract：:Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

journal_title：Thrombosis and haemostasis

authors： Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

更新日期：2020-02-01 00:00:00

abstract：:Plasma samples from 35 patients with colorectal cancer, 16 patients with pancreatic cancer and 46 patients with various cancers in the terminal stage were analysed for soluble plasma thrombomodulin with an ELISA method. At time of diagnosis and before primary treatment, the patients with colorectal cancer had normal p...

journal_title：Thrombosis and haemostasis

authors： Lindahl AK,Boffa MC,Abildgaard U

更新日期：1993-02-01 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Niewiarowski S,Rucinski B,Budzynski AZ

更新日期：1979-07-01 00:00:00

abstract：:We investigated changes in both thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels and its functional effect on in vitro fibrinolysis in normal pregnancy. 152 pregnant women and 31 women in the immediate postpartum period were studied, with pregnancy divided into 6 windows at 4 weekly intervals. As TAFI...

journal_title：Thrombosis and haemostasis

authors： Mousa HA,Downey C,Alfirevic Z,Toh CH

更新日期：2004-11-01 00:00:00

abstract：:Disrupting the CD40-CD40L co-stimulatory pathway reduces atherosclerosis and induces a stable atherosclerotic plaque phenotype that is low in inflammation and high in fibrosis. Therefore, inhibition of the CD40-CD40L pathway is an attractive therapeutic target to reduce clinical complications of atherosclerosis. The C...

journal_title：Thrombosis and haemostasis

authors： Lievens D,Eijgelaar WJ,Biessen EA,Daemen MJ,Lutgens E

更新日期：2009-08-01 00:00:00

abstract：:Limited data exist on thrombophilia and the risk of venous thrombosis (VT) during pregnancy and postpartum. The objectives of the present study were to investigate the role of haemostatic risk factors for pregnancy-related VT and their phenotypic expression in deep-vein thrombosis (DVT) and pulmonary embolism (PE). To...

journal_title：Thrombosis and haemostasis

authors： Bergrem A,Dahm AE,Jacobsen AF,Sandvik L,Sandset PM

更新日期：2012-12-01 00:00:00

abstract：:The transforming growth factor-beta (TGFbeta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGFbeta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the...

journal_title：Thrombosis and haemostasis

authors： Brunner G,Blakytny R

更新日期：2004-08-01 00:00:00

abstract：:The role of platelets in regulating vascular homeostasis has expanded beyond mediation of haemostasis and thrombosis. The discovery of platelet RNA and the presence of subpopulations of platelets containing varying amounts of RNA suggest a role for platelet transcripts in vascular function. As the RNA in anucleated pl...

journal_title：Thrombosis and haemostasis

authors： Clancy L,Beaulieu LM,Tanriverdi K,Freedman JE

更新日期：2017-05-03 00:00:00

abstract：:A group of 90 hemophiliacs who had been regularly treated with non virus-inactivated factor VIII or IX concentrates were studied in 1983. At that time 50 patients were HIV-1-antibody positive, 6 additional seroconversions occurred until 1985. 26 of the 50 patients seropositive in 1983 are currently asymptomatic. 4 pat...

journal_title：Thrombosis and haemostasis

authors： Stain C,Pabinger-Fasching I,Guggenberger K,Köller U,Stain M,Hartl H,Heinz F,Mayerhofer S,Kyrle PA,Lechner K

更新日期：1989-06-30 00:00:00

abstract：BACKGROUND:Preliminary evidence suggests that use of antipsychotic drugs is associated with an increased risk of venous thromboembolism. OBJECTIVE:To evaluate the relationship between antipsychotic or antidepressant drug use and venous thromboembolism among adults aged 65 years and older. DESIGN:Retrospective cohort ...

journal_title：Thrombosis and haemostasis

authors： Ray JG,Mamdani MM,Yeo EL

更新日期：2002-08-01 00:00:00

abstract：:The vast majority of thrombin (>95%) is generated after clotting is completed, suggesting that thrombin formation serves purposes beyond coagulation, such as tissue repair after vessel injury. Two types of vascular thrombin binding sites exist: protease-activated receptors (PARs) and thrombomodulin (TM). Their express...

journal_title：Thrombosis and haemostasis

authors： Schrör K,Bretschneider E,Fischer K,Fischer JW,Pape R,Rauch BH,Rosenkranz AC,Weber AA

更新日期：2010-05-01 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical out...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Touloumenidou T,Sakellari I,Batsis I,Mallouri D,Psomopoulos F,Tsagiopoulou M,Koutra M,Yannaki E,Papalexandri A,Taylor P,Nikolousis E,Stamouli M,Holbro A,Baltadakis I,Liga M,Spyridonidis A,Tsirigotis P,Cha

更新日期：2020-04-01 00:00:00

abstract：:This review collects evidence about immune and inflammatory functions of platelets from a clinician's point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Pla...

journal_title：Thrombosis and haemostasis

authors： Duerschmied D,Bode C,Ahrens I

更新日期：2014-10-01 00:00:00

abstract：:The macromolecular composition of the extracellular matrix (ECM) produced by the human microvascular endothelial cell line (HMEC-1) was determined by ELISA and its thrombogenicity was studied in blood perfusion assays. Results were compared with those obtained with the ECM produced by human umbilical vein endothelial ...

journal_title：Thrombosis and haemostasis

authors： Bonnefoy A,Harsfalvi J,Pfliegler G,Fauvel-Lafève F,Legrand C

更新日期：2001-03-01 00:00:00

abstract：:Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, ge...

journal_title：Thrombosis and haemostasis

authors： Kelly LA,O'Leary JJ,Seidlova-Wuttke D,Wuttke W,Norris LA

更新日期：2010-12-01 00:00:00

abstract：:Positively charged macromolecule, polylysine (mol. wt. 15,000; 23,000; 180,000) could induce the platelet aggregation in low concentration but high concentration was required in the case of neutral macromolecule, dextran (mol. wt. 40,000; 250,000; 2,000,000). The larger molecules of polylysine and dextran were more ef...

journal_title：Thrombosis and haemostasis

authors： Taketomi Y,Kuramoto A

更新日期：1978-08-31 00:00:00

abstract：:Haemorrhagic metalloproteinases from Bothrops jararaca and other venoms degrade vessel-wall and plasma proteins involved in platelet plug and fibrin clot formation. These enzymes also cause proteolytic digestion of fibrinogen which has been suggested to cause defective platelet function. Fibrinogen degradation by jara...

journal_title：Thrombosis and haemostasis

authors： Kamiguti AS,Slupsky JR,Zuzel M,Hay CR

更新日期：1994-08-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:Sixteen Danish unrelated thrombophilic families with plasma protein S deficiency of type 1 (or III) are currently under investigation in our laboratory for defects in the protein S alpha gene. The present paper describes a part of this work, which deals with the identification and phenotypical presentation of two uniq...

journal_title：Thrombosis and haemostasis

authors： Andersen BD,Lind B,Philips M,Hansen AB,Ingerslev J,Thorsen S

更新日期：1996-08-01 00:00:00

abstract：:The effect of additional treatments combined with conventional therapy on pregnancy outcomes was examined in high-risk primary antiphospholipid syndrome (PAPS) patients to identify the most effective treatment strategy. The study's inclusion criteria were (1) positivity to lupus anticoagulant alone or associated with ...

journal_title：Thrombosis and haemostasis

authors： Ruffatti A,Tonello M,Hoxha A,Sciascia S,Cuadrado MJ,Latino JO,Udry S,Reshetnyak T,Costedoat-Chalumeau N,Morel N,Marozio L,Tincani A,Andreoli L,Haladyj E,Meroni PL,Gerosa M,Alijotas-Reig J,Tenti S,Mayer-Pickel K,Simc

更新日期：2018-04-01 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:We studied a murine monoclonal antibody (211 A6) to von Willebrand factor (vWF) with a view to investigating structure-relationship of plasma vWF. The specificity of this antibody has been substantiated by ELISA tests and indirect immunofluorescence. It reacts with purified vWF, normal plasma but not with plasma or pl...

journal_title：Thrombosis and haemostasis

authors： Jorieux S,de Romeuf C,Samor B,Goudemand M,Mazurier C

更新日期：1987-06-03 00:00:00

abstract：:An assay system for protein C (PC) activity and PC-inhibitor in plasma was developed. The assay was based on: (1) binding of PC to wells of a microtiter plate coated with a murine monoclonal anti-PC antibody (C3) that did not interfere with the activity or activation of PC; (2) activation of immobilized PC with Protac...

journal_title：Thrombosis and haemostasis

authors： Geiger M,White TM,Griffin JH

更新日期：1989-02-28 00:00:00

abstract：:We have devised an improved high pressure liquid chromatographic technique whereby serotonin, nucleosides, cyclic nucleotides, namely cAMP and cGMP, and 5'mono-, 5'di-, and 5'tri-nucleotides can be analyzed. The cyclic nucleotides have been measured in picomolar quantities. All nucleotides can be quantitated in a sing...

journal_title：Thrombosis and haemostasis

authors： D'Souza L,Glueck HI

更新日期：1977-12-15 00:00:00

abstract：:The contribution of the various components of the contact system in the generation of factor XIIa (FXIIa) and of kallikrein (KRN) on an electronegative surface and the release of the generated enzymes to the bulk phase was examined in mixtures of normal human plasma and plasmas congenitally deficient in these componen...

journal_title：Thrombosis and haemostasis

authors： Mitropoulos KA

更新日期：1999-09-01 00:00:00

abstract：:In a preliminary study, we have demonstrated that tissue factor (TF) is immunohistochemically stained in monocytes from patients with disseminated intravascular coagulation (DIC) but not from healthy volunteers, and that leukocytes from DIC patients induce enhanced activated factor X (FXa) generation in the presence o...

journal_title：Thrombosis and haemostasis

authors： Sase T,Wada H,Nishioka J,Abe Y,Gabazza EC,Shiku H,Suzuki K,Nakamura S,Nobori T

更新日期：2003-04-01 00:00:00

abstract：:This study aims to establish the relative effectiveness and safety of low molecular weight heparin in elderly patients with venous thrombosis in order to find an alternative to oral anticoagulant therapy with less bleeding complications in the long-term treatment of deep venous thrombosis (DVT). One hundred consecutiv...

journal_title：Thrombosis and haemostasis

authors： Veiga F,Escribá A,Maluenda MP,López Rubio M,Margalet I,Lezana A,Gallego J,Ribera JM

更新日期：2000-10-01 00:00:00

abstract：:Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithro...

journal_title：Thrombosis and haemostasis

authors： Peng S,Xue G,Gong L,Fang C,Chen J,Yuan C,Chen Z,Yao L,Furie B,Huang M

更新日期：2017-06-28 00:00:00