Organization of the provisional fibronectin matrix: control by products of blood coagulation.

Abstract:

:Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal modules and occurs at specialized cell surface sites. Cellular display of assembly sites is labile and requires that cells be under tension and have functional beta 1 integrins. Lysophosphatidic acid (LPA) an intermediate for de novo lipid biosynthesis and a product of platelet activation, is a powerful serum modulator of fibronectin assembly.

journal_name

Thromb Haemost

authors

Mosher DF

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

529-33

issue

1

eissn

0340-6245

issn

2567-689X

journal_volume

74

pub_type

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