Reliability of a single beta-thromboglobulin measurement in a diabetic population: importance of PGE1 in anticoagulant mixture. Damad Study Group.

Abstract:

:During the collection of samples for plasma beta-thromboglobulin (beta-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single beta-TG measurement, blood samples were collected simultaneously from both arms on two separate occasions in 56 diabetic patients selected for a clinical trial. From each arm, blood was taken into two tubes containing an anticoagulant mixture with (tube A) and without (tube B) PGE1. The overall mean value of B-TG in tube B was 1.14 times higher than in tube A (p less than 0.01). The markedly large between-arms variation accounted for the most part of within-subject variation in both tubes and was significantly greater in tube B than in tube A. Based on the difference between B-TG values from both arms, the number of subjects with artificially high B-TG values was significantly higher in tube B than in tube A on each occasion (overall rate: 28% and 14% respectively). Estimate of between-occasions variation showed that B-TG levels were relatively stable for each subject between two occasions in each tube. It is concluded that the use of PGE1 decreases falsely high B-TG levels, but a single measurement of B-TG does not provide a reliable estimate of the true B-TG value in vivo.

journal_name

Thromb Haemost

authors

Scarabin PY,Strain L,Ludlam CA,Jones J,Kohner EM

subject

Has Abstract

pub_date

1987-04-07 00:00:00

pages

201-4

issue

2

eissn

0340-6245

issn

2567-689X

journal_volume

57

pub_type

杂志文章
  • Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migration.

    abstract::Tissue factor (TF) is the primary initiator of the coagulation cascade and is thought to play a key role in the generation of arterial thrombosis. Recent studies have suggested that TF mediates inflammatory processes in the arterial wall and may be an important regulator of intimal hyperplasia. We have employed geneti...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-02-0122

    authors: Pyo RT,Sato Y,Mackman N,Taubman MB

    更新日期:2004-09-01 00:00:00

  • Fatal vascular outcomes following major orthopedic surgery.

    abstract::Major orthopedic surgery is known to be associated with potentially serious arterial and venous vascular complications, although uncertainty exists about current event rates. Using electronic databases and investigator contact, we identified randomized and cohort studies reporting overall mortality and fatal vascular ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-11-0769

    authors: Dahl OE,Caprini JA,Colwell CW Jr,Frostick SP,Haas S,Hull RD,Laporte S,Stein PD

    更新日期:2005-05-01 00:00:00

  • Ultra-low-molecular-weight heparins: precise structural features impacting specific anticoagulant activities.

    abstract::Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weight...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-11-0795

    authors: Lima MA,Viskov C,Herman F,Gray AL,de Farias EH,Cavalheiro RP,Sassaki GL,Hoppensteadt D,Fareed J,Nader HB

    更新日期:2013-03-01 00:00:00

  • Anticoagulation in patients with atrial fibrillation undergoing coronary stent implantation.

    abstract::In patients with atrial fibrillation (AF) undergoing coronary stent implantation, the optimal antithrombotic strategy is unclear. We evaluated whether use of oral anticoagulation (OAC) was associated with any benefit in morbidity or mortality in patients with AF, high risk of thromboembolism (TE) (CHA2DS2-VASC score ≥...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH13-04-0351

    authors: Bernard A,Fauchier L,Pellegrin C,Clementy N,Saint Etienne C,Banerjee A,Naudin D,Angoulvant D

    更新日期:2013-09-01 00:00:00

  • Platelet-derived microparticles and coagulation activation in breast cancer patients.

    abstract::In the mid 1800s Trousseau observed cancer-associated thrombosis, of which the underlying pathogenesis still remains unknown. We performed a prospective study on platelet-derived microparticles (PMP) and their procoagulant potential in breast cancer patients. Fifty-eight breast cancer patients and 13 women with benign...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Toth B,Liebhardt S,Steinig K,Ditsch N,Rank A,Bauerfeind I,Spannagl M,Friese K,Reininger AJ

    更新日期:2008-10-01 00:00:00

  • A fibrin specific monoclonal antibody which interferes with the fibrinolytic effect of tissue plasminogen activator.

    abstract::Monoclonal antibodies to human fibrin have been prepared from stable hybridomas, obtained by fusion of a mouse myeloma cell line (NS-1) and spleen cells of Balb/c mice immunized with a suspension of human fibrin. One cell line, DG1, producing a monoclonal antibody of the IgG1, kappa subclass, reacted specifically with...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Gargan PE,Ploplis VA,Scheu JD

    更新日期:1988-06-16 00:00:00

  • A FV multiallelic marker detects genetic components of APC resistance contributing to venous thromboembolism in FV Leiden carriers.

    abstract::Activated protein C resistance (APCR) is a major risk factor for venous thromboembolism (VTE). Although the factor V (FV) Leiden mutation accounts for the vast majority of APCR cases, other polymorphisms may contribute to the APCR phenotype. Genetic components of APCR and thrombophilia were investigated by two dinucle...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Mingozzi F,Legnani C,Lunghi B,Scanavini D,Castoldi E,Palareti G,Marchetti G,Bernardi F

    更新日期:2003-06-01 00:00:00

  • Hypofibrinogenaemia with compound heterozygosity for two gamma chain mutations - gamma 82 Ala-->Gly and an intron two GT-->AT splice site mutation.

    abstract::We investigated the molecular basis of hypofibrinogenaemia in a woman with a history of recurrent, pregnancy-associated bleeding, and miscarriage. She had a Clauss fibrinogen of 0.9 mg/ml and SDS PAGE of purified fibrinogen showed a normal pattern of chains. However careful inspection of reverse phase chain separation...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Wyatt J,Brennan SO,May S,George PM

    更新日期:2000-09-01 00:00:00

  • Tissue factor, protease activated receptors and pathologic heart remodelling.

    abstract::Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tiss...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH14-03-0243

    authors: Antoniak S,Sparkenbaugh E,Pawlinski R

    更新日期:2014-11-01 00:00:00

  • Pharmacological modulation of procoagulant microparticles improves haemodynamic dysfunction during septic shock in rats.

    abstract::Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH13-04-0313

    authors: Boisramé-Helms J,Delabranche X,Degirmenci SE,Zobairi F,Berger A,Meyer G,Burban M,Mostefai HA,Levy B,Toti F,Meziani F

    更新日期:2014-01-01 00:00:00

  • Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis.

    abstract::Vessel wall matrix changes occur after injury, although this has not been well studied in the venous system. This study tested the hypothesis that the thrombus dictates the vein wall response and vein wall damage is directly related to the duration of thrombus contact. To determine the injury response over time, rats ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Henke PK,Varma MR,Moaveni DK,Dewyer NA,Moore AJ,Lynch EM,Longo C,Deatrick CB,Kunkel SL,Upchurch GR Jr,Wakefield TW

    更新日期:2007-11-01 00:00:00

  • von Willebrand factor multimer patterns in pregnancy-induced hypertension.

    abstract::Microangiopathy and disseminated platelet aggregation have been reported in thrombotic thrombocytopenic purpura (TTP) and pregnancy-induced hypertension (PIH). Since unusually large von Willebrand factor (vWF) multimers have been implicated in the evolvement of TTP, we analyzed factor VIII/vWF parameters in patients w...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Brenner B,Zwang E,Bronshtein M,Seligsohn U

    更新日期:1989-09-29 00:00:00

  • Failure of dabigatran and rivaroxaban to prevent thromboembolism in antiphospholipid syndrome: a case series of three patients.

    abstract::Direct oral factor inhibitors (DOFIs) are an attractive alternative to vitamin K antagonists (VKA) for the treatment of patients with antiphospholipid syndrome (APS). In the absence of prospective, randomised trial data, reports of therapeutic failures in clinical practice alert clinicians to potential limitations of ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH14-03-0272

    authors: Schaefer JK,McBane RD,Black DF,Williams LN,Moder KG,Wysokinski WE

    更新日期:2014-11-01 00:00:00

  • Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets.

    abstract::The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

    更新日期:1991-09-02 00:00:00

  • mRNA levels of CD31, CD144, CD146 and von Willebrand factor do not serve as surrogate markers for circulating endothelial cells.

    abstract::Circulating endothelial cells (CEC) are considered a promising marker to determine the extent of vascular damage. However, currently available and validated CEC enumeration assays are laborious, time consuming and costly, which limits their clinical utility. Here, we evaluated the feasibility of quantifying mRNA level...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH09-08-0594

    authors: Strijbos MH,van Krimpen BA,Debets R,Kraan J,Sleijfer S,Gratama JW,Lamers CH

    更新日期:2010-08-01 00:00:00

  • Solvent effects on activity and conformation of plasminogen activator inhibitor-1.

    abstract::We have studied effects of the solvent composition on the activity and the conformation of human plasminogen activator inhibitor-1 (PAI-1) from HT-1080 fibrosarcoma cells. Non-ionic detergents, includine Triton X-100, reduced the inhibitory activity of PAI-1 more than 20-fold at 0 degrees C, but less than 2-fold at 37...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Andreasen PA,Egelund R,Jensen S,Rodenburg KW

    更新日期:1999-03-01 00:00:00

  • Coagulation factor XII regulates inflammatory responses in human lungs.

    abstract::Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH16-12-0904

    authors: Hess R,Wujak L,Hesse C,Sewald K,Jonigk D,Warnecke G,Fieguth HG,de Maat S,Maas C,Bonella F,Preissner KT,Weiss B,Schaefer L,Kuebler WM,Markart P,Wygrecka M

    更新日期:2017-10-05 00:00:00

  • Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia.

    abstract::Homozygous carriers of factor V Leiden have an approximately 80-fold increased risk of venous thrombosis. Also double heterozygous carriers of both the factor V Leiden and the prothrombin gene mutations are at high thrombotic risk. The magnitude of the risk of venous thrombosis in pregnant women with the two severe th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Martinelli I,Legnani C,Bucciarelli P,Grandone E,De Stefano V,Mannucci PM

    更新日期:2001-09-01 00:00:00

  • Organization of the provisional fibronectin matrix: control by products of blood coagulation.

    abstract::Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal module...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Mosher DF

    更新日期:1995-07-01 00:00:00

  • Magnetic resonance imaging of deep vein thrombi correlates with response to thrombolytic therapy.

    abstract::Fibrinolytic therapy can result in rapid lysis of deep vein thrombi (DVT), but its use is limited by the failure of many patients to respond and by the increased risk of bleeding complications in comparison with anticoagulant therapy alone. Treatment could be improved by the ability to select patients most likely to r...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Francis CW,Totterman S

    更新日期:1995-03-01 00:00:00

  • Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity.

    abstract::Plasmin triggers chemotaxis and NF-kappa B- and AP-1-mediated proinflammatory gene expression in human peripheral monocytes (PM). Compared with macrophages and dendritic cells, PM express mainly the peroxisome proliferator-activated receptor (PPAR) gamma and traces of PPAR alpha as detected by semiquantitative RT-PCR ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Syrovets T,Schüle A,Jendrach M,Büchele B,Simmet T

    更新日期:2002-08-01 00:00:00

  • A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells.

    abstract::Vascular smooth muscle cell (VSMC) proliferation occurs in vascular obstructive events such as atherosclerosis and restenosis. We previously showed that Notch receptors are induced in smooth muscle cells during vascular remodeling. Our goal was to determine the mechanisms employed by Notch signaling to regulate prolif...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH06-04-0224

    authors: Havrda MC,Johnson MJ,O'Neill CF,Liaw L

    更新日期:2006-09-01 00:00:00

  • Evaluation of the effect of betapropiolactone/ultraviolet irradiation (BPL/UV) treatment of source plasma on hepatitis transmission by factor IX complex in chimpanzees.

    abstract::To evaluate the safety of a beta-Propiolactone/Ultraviolet (BPL/UV), irradiated Factor IX complex preparation we inoculated 8 chimpanzees with 25 units Factor IX/Kilo from a pool of 5 production lots which had been treated in this manner. These lots were derived from approximately 1,000 donors. Animals were followed w...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Prince AM,Stephan W,Brotman B,van den Ende MC

    更新日期:1980-12-19 00:00:00

  • The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes.

    abstract::Lysosomal Associated Membrane Protein-2 (LAMP-2) is an inherent component of lysosomal granule membranes in diverse cell types, including platelets. We examined platelets for evidence of LAMP-2 in dense granule membranes as CD63 has previously been shown to be present in both lysosomal and dense granule membranes. Imm...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Israels SJ,McMillan EM,Robertson C,Singhory S,McNicol A

    更新日期:1996-04-01 00:00:00

  • Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites.

    abstract::Platelet activation may contribute to the increased risk of thrombotic complications in patients with antiphospholipid antibodies (aPL). The increased urinary excretion of 11-dehydro-thromboxane B2 (11-DH-TXB2) reported in patients with lupus anticoagulant (LA) and/or anticardiolipin antibodies (aCL) reflects in vivo ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Forastiero R,Martinuzzo M,Carreras LO,Maclouf J

    更新日期:1998-01-01 00:00:00

  • Blood collection in strong acidic citrate anticoagulant used in a study of dietary influence on basal tPA activity.

    abstract::Tissue plasminogen activator (tPA) activity in blood and blood plasma has been difficult to determine because it is unstable, especially in subjects with high levels of plasminogen activator inhibitor type 1 (PAI-1). We have attempted to stabilize the tPA activity by collecting 9 volumes of blood in 1 volume acidic ci...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Rånby M,Sundell IB,Nilsson TK

    更新日期:1989-11-24 00:00:00

  • Extracellular fibrinogen binding protein, Efb, from Staphylococcus aureus binds to platelets and inhibits platelet aggregation.

    abstract::S. aureus produces and secretes a protein, extracellular fibrinogen binding protein (Efb), which contributes to virulence in wound infection. We have shown here that Efb is a potent inhibitor of platelet aggregation. Efb can bind specifically to platelets by two mechanisms; 1) to fibrinogen naturally bound to the surf...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH03-05-0287

    authors: Shannon O,Flock JI

    更新日期:2004-04-01 00:00:00

  • A mutation in the protein S pseudogene is linked to protein S deficiency in a thrombophilic family.

    abstract::Probands from 15 unrelated families with hereditary protein S deficiency type I, that is having a plasma total protein S concentration fifty percent of normal, were screened for abnormalities in their protein S genes by Southern analysis. Two probands were found to have a deviating DNA pattern with the restriction enz...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Ploos van Amstel HK,Reitsma PH,Hamulyák K,de Die-Smulders CE,Mannucci PM,Bertina RM

    更新日期:1989-11-24 00:00:00

  • The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer.

    abstract::The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years w...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH13-08-0632

    authors: Baranyai Z,Krzystanek M,Jósa V,Dede K,Agoston E,Szász AM,Sinkó D,Szarvas V,Salamon F,Eklund AC,Szállási Z,Jakab F

    更新日期:2014-03-03 00:00:00

  • The organomercurial 4-aminophenylmercuric acetate, independent of matrix metalloproteinases, induces dose-dependent activation/inhibition of platelet aggregation.

    abstract::Matrix metalloproteinases (MMPs) play an important role in many biological and pathological processes including tissue remodeling, wound healing, inflammation, atherosclerosis, and cancer. Numerous publications have supported the concept that activated MMP-2 enhances agonist-induced platelet aggregation and activated ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-08-0541

    authors: Rosenfeldt MT,Valentino M,Labruzzo S,Scudder L,Pavlaki M,Cao J,Vacirca J,Bahou WF,Zucker S

    更新日期:2005-02-01 00:00:00