European Concerted Action on Anticoagulation--comparison of fresh plasma and whole blood multicentre ISI calibrations of CoaguChek Mini and TAS PT-NC whole blood prothrombin time point-of-care monitors.

abstract：:Unfractionated heparin is the most commonly used anticoagulant in ST-elevation myocardial infarction (STEMI) and its effect can be monitored with activated partial thromboplastin time (aPTT). However, the optimal aPTT range during heparin therapy after primary percutaneous coronary intervention (PCI) is yet to be defi...

journal_title：Thrombosis and haemostasis

authors： Kikkert WJ,van Nes SH,Lieve KV,Dangas GD,van Straalen J,Vis M,Baan J Jr,Koch KT,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2013-05-01 00:00:00

abstract：:In 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, alpha-granule release (represented by beta-thromboglobulin [beta TG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug...

journal_title：Thrombosis and haemostasis

authors： Kyrle PA,Westwick J,Scully MF,Kakkar VV,Lewis GP

更新日期：1987-02-03 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:Probands from 15 unrelated families with hereditary protein S deficiency type I, that is having a plasma total protein S concentration fifty percent of normal, were screened for abnormalities in their protein S genes by Southern analysis. Two probands were found to have a deviating DNA pattern with the restriction enz...

journal_title：Thrombosis and haemostasis

authors： Ploos van Amstel HK,Reitsma PH,Hamulyák K,de Die-Smulders CE,Mannucci PM,Bertina RM

更新日期：1989-11-24 00:00:00

abstract：:We have developed a sensitive and quantitative RT-PCR assay for the determination of tissue factor (TF) mRNA levels in human cells. An in vitro synthesized internal standard RNA was used to correct for differences in reverse transcription or amplification of various RNA samples. The PCR products were quantitated by hy...

journal_title：Thrombosis and haemostasis

authors： Pötgens AJ,Lubsen NH,van Altena G,Schoenmakers JG,Ruiter DJ,de Waal RM

更新日期：1994-02-01 00:00:00

abstract：:Multiple clinical trials have proven that thrombolytic therapy is an effective treatment for acute myocardial infarction. Spontaneous intracranial hemorrhage (ICH) occurs in a small percentage of patients as a result of the treatment. The etiology of the ICH is unknown and there is currently no established experimenta...

journal_title：Thrombosis and haemostasis

authors： Paoni NF,Steinmetz HG,Gillett N,Refino CJ,Badillo JM,Bunting S

更新日期：1996-05-01 00:00:00

abstract：:Thrombospondin (TSP), a large glycoprotein present in platelets, and various normal and tumor tissues, has recently been shown to promote cell adhesion and platelet aggregation. Most importantly because TSP has been shown to promote metastasis of melanoma tumor cells to the lung in a murine model (1) and since thrombo...

journal_title：Thrombosis and haemostasis

authors： Tuszynski GP,Smith M,Rothman VL,Capuzzi DM,Joseph RR,Katz J,Besa EC,Treat J,Switalska HI

更新日期：1992-06-01 00:00:00

abstract：:Stress may counteract responses to antiplatelet drug treatment. We investigated if adding clopidogrel to aspirin treatment could attenutate stress-induced platelet activation and myocardial ischemia in patients with coronary artery disease (CAD). Thirty-one male patients with documented CAD-treated with aspirin (75-16...

journal_title：Thrombosis and haemostasis

authors： Perneby C,Wallén NH,Hofman-Bang C,Tornvall P,Ivert T,Li N,Hjemdahl P

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. In studies in vitro, PRAP-1, a Fab-fragment of a polyclonal antibody against human PAI-1, was shown to inhibit PAI-1 activity in rat plasma as well as to stimul...

journal_title：Thrombosis and haemostasis

authors： Abrahamsson T,Nerme V,Strömqvist M,Akerblom B,Legnehed A,Pettersson K,Westin Eriksson A

更新日期：1996-01-01 00:00:00

abstract：:Monitoring of anti-factor Xa activity is often performed during treatment with low-molecular-weight heparins (LMWHs) in pregnancy because the anticoagulant effect may decrease as pregnancy progresses, but assays for anti-factor Xa activity are unavailable in many clinical institutions caring for pregnant women. Heptes...

journal_title：Thrombosis and haemostasis

authors： Dempfle CE,Zharkowa U,Elmas E,Ahmad-Nejad P,Neumaier M,Borggrefe M

更新日期：2009-11-01 00:00:00

abstract：:Platelet adhesion and aggregation at the sites of vascular injury are key events for thrombosis and haemostasis. It has been well demonstrated that interaction between glycoprotein (GP) Ibα and von Willebrand factor (VWF) initiates platelet adhesion and contributes to platelet aggregation, particularly at high shear. ...

journal_title：Thrombosis and haemostasis

authors： Lei X,Reheman A,Hou Y,Zhou H,Wang Y,Marshall AH,Liang C,Dai X,Li BX,Vanhoorelbeke K,Ni H

更新日期：2014-02-01 00:00:00

abstract：:The platelet integrin alpha(IIb)beta(3) mediates the final step of platelet aggregation that requires pre-activation through an inside-out signal initiated by agonists. Experiments conducted under static conditions using platelet-rich plasma show that platelet activation and adhesion activity of alpha(IIb)beta(3) are ...

journal_title：Thrombosis and haemostasis

authors： Ball C,Vijayan KV,Nguyen T,Anthony K,Bray PF,Essex DW,Dong JF

更新日期：2008-11-01 00:00:00

abstract：:In a previous report we found an inverse correlation between pre-operative platelet count (PlC) levels and the risk of post-operative pulmonary embolism in patients undergoing hip surgery. In the present study, we prospectively evaluated the prognostic significance of pre-operative PlC levels on survival in 180 consec...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Fernandez-Llamazares J,Piñol M,Julian JF,Broggi M,Escola D,Abad A

更新日期：1998-05-01 00:00:00

abstract：:Tissue factor (TF) is the blood coagulation initiator, whose cofactor function is required for physiological factor VIIa (FVIIa)-mediated activation of factor X (FX) to FXa. A previous study reported TF on herpes simplex virus type 1 (HSV1), but this explained only part of FVIIa-dependent FXa generation observed on th...

journal_title：Thrombosis and haemostasis

authors： Sutherland MR,Friedman HM,Pryzdial EL

更新日期：2004-11-01 00:00:00

abstract：:Amniotic fluid inhibited the fibrinolytic, amidolytic and esterolytic activity of urokinase. Kinetic studies with AGLMe demonstrated non-competitive inhibition. A major part of the inhibitory activity could be separated from alpha 1-antitrypsin by ion-exchange chromatography on DEAE-Sephadex A-50. Plasminogen activato...

journal_title：Thrombosis and haemostasis

authors： Walker JE,Campbell DM,Ogston D

更新日期：1980-08-29 00:00:00

abstract：:An analysis was made of 346 cases of disseminated intravascular coagulation (DIC) diagnosed by utilizing a combination of laboratory tests which reflect the pathophysiology of the syndrome. The goals of the study were three fold: 1) to compare our clinical disease categories with those of other investigators, 2) to re...

journal_title：Thrombosis and haemostasis

authors： Spero JA,Lewis JH,Hasiba U

更新日期：1980-02-29 00:00:00

abstract：:Over the last few years methods have been developed to assess appearance of thrombin during blood clotting in a clinical setting. This can be achieved either by measurement of the specific thrombin markers or by analysis of the thrombin generation kinetics. Thrombin markers rise following coronary occlusion and, surpr...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A

更新日期：1995-07-01 00:00:00

abstract：:Although it is recognized that glycoprotein (GP) IIb-IIIa complexes are deficient in platelets in Glanzmann's thrombasthenia, little is known of the origin of the defect. We have examined the megakaryocytes in a bone marrow aspirate obtained from a thrombasthenia patient during surgery. Analysis of platelet proteins b...

journal_title：Thrombosis and haemostasis

authors： Hourdillé P,Fialon P,Belloc F,Namur M,Boisseau MR,Nurden AT

更新日期：1986-08-20 00:00:00

abstract：:In a recent study, we purified and cloned a newly identified bioactive factor that stimulates prostacyclin (PGI2) production by vascular endothelial cells (ECs) using conditioned medium (CM) from cultured human diploid fibroblast cells. The present study was undertaken to clarify whether PSF is expressed in ECs and va...

journal_title：Thrombosis and haemostasis

authors： Masakado M,Umeda F,Takei A,Hashimoto T,Sueishi K,Nawata H

更新日期：1995-12-01 00:00:00

abstract：:The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Fragments were analyzed for chain composition, heparin binding, collagen binding, platelet agglutinating activity and recognition by a panel of monoclonal antibodies which reacte...

journal_title：Thrombosis and haemostasis

authors： Bakhshi MR,Kirby EP

更新日期：1990-06-28 00:00:00

abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

journal_title：Thrombosis and haemostasis

authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

更新日期：2013-12-01 00:00:00

abstract：:We report for the first time that saliva of the hard tick and Lyme disease vector, Ixodes scapularis, is a potent inhibitor of angiogenesis. Saliva (< or = 1:500 dilutions) or salivary gland (0.1-0.5 pairs/assay) dose-dependently inhibits microvascular endothelial cell (MVEC) proliferation. Inhibition was also detecte...

journal_title：Thrombosis and haemostasis

authors： Francischetti IM,Mather TN,Ribeiro JM

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Elevated von Willebrand factor (vWF) is a risk factor in the development of acute myocardial infarction. The importance of vWF and factor VII:C in the pathogenesis of cerebrovascular disease (CVD) is poorly defined. METHODS AND RESULTS:We studied 208 cases of stroke whose pathological type was defined by cr...

journal_title：Thrombosis and haemostasis

authors： Catto AJ,Carter AM,Barrett JH,Bamford J,Rice PJ,Grant PJ

更新日期：1997-06-01 00:00:00

abstract：:Tissue factor (thromboplastin or Factor III), a glycoprotein cofactor, is required for Factor VII to express its catalytic activity, thereby initiating the extrinsic as well as intrinsic pathway of blood coagulation. Human brain tissue factor was purified 2,500-fold to 98% homogeneity from 2% Triton X-100 extraction o...

journal_title：Thrombosis and haemostasis

authors： Kang S,Niemetz J

更新日期：1988-06-16 00:00:00

abstract：:The mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A total of ...

journal_title：Thrombosis and haemostasis

authors： Berger JS,Becker RC,Kuhn C,Helms MJ,Ortel TL,Williams R

更新日期：2013-01-01 00:00:00

abstract：:Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases,...

journal_title：Thrombosis and haemostasis

authors： Sakai H,Goto S,Kim JY,Aoki N,Abe S,Ichikawa N,Yoshida M,Nagaoka Y,Handa S

更新日期：2000-08-01 00:00:00

abstract：:alpha-Granule protein storage is important for producing platelets with normal haemostatic function. The low to undetectable levels of several megakaryocyte-synthesized alpha-granule proteins in normal plasma suggest megakaryocytes are important to sequester these proteins in vivo. alpha-Granule protein storage in vit...

journal_title：Thrombosis and haemostasis

authors： Veljkovic DK,Cramer EM,Alimardani G,Fichelson S,Massé JM,Hayward CP

更新日期：2003-11-01 00:00:00

abstract：:Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic fu...

journal_title：Thrombosis and haemostasis

authors： Grant PJ,Tate GM,Davies JA,Williams NS,Prentice CR

更新日期：1986-02-28 00:00:00

abstract：:Normal adults have very few circulating endothelial cells (CECs) in their blood, but increased levels have been shown in association with conditions associated with endothelial damage such as myocardial infarction and stroke. As atrial fibrillation (AF) is associated with a hypercoagulable state and abnormalities of p...

journal_title：Thrombosis and haemostasis

authors： Freestone B,Lip GY,Chong AY,Nadar S,Lee KW,Blann AD

更新日期：2005-10-01 00:00:00

abstract：:The structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IVA and lipid X, as well as monophosphoryl lipid A and ac...

journal_title：Thrombosis and haemostasis

authors： Moldow CF,Bach RR,Staskus K,Rick PD

更新日期：1993-10-18 00:00:00