Potentiating effect of clopidogrel and SR 46349, a novel 5-HT2 antagonist, on streptokinase-induced thrombolysis in the rabbit.

Abstract:

:Current thrombolytic strategies have a number of important shortcomings including resistance to recanalization and development of acute reocclusion. The purpose of this study was to investigate whether the lysis of venous thrombi by streptokinase could be enhanced by SR 46349, a novel 5-HT2 receptor antagonist, or clopidogrel, an analogue of ticlopidine. The activity of these compounds was evaluated by following the lysis of radiolabelled fibrin under a continuous infusion of streptokinase (4,000 IU kg-1 h-1 over 4 h). Streptokinase alone induced 42% thrombolysis when compared to saline. The i.v. co-administration of SR 46349 or clopidogrel (10 mg/kg) enhanced significantly streptokinase-induced thrombolysis. Thrombolysis measured by [125I]-fibrinogen lysis increased to 65 and 59% respectively. This efficacy was achieved without additional prolongation of the template bleeding time observed with streptokinase alone. Thus, the concomitant use of a 5-HT2 receptor antagonist or an anti-ADP agent during streptokinase therapy may facilitate clot lysis.

journal_name

Thromb Haemost

authors

Herbert JM,Bernat A,Sainte-Marie M,Dol F,Rinaldi M

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

268-71

issue

3

eissn

0340-6245

issn

2567-689X

journal_volume

69

pub_type

杂志文章
  • Megakaryocytes in the giant platelet syndrome. A cytochemical and ultrastructural study.

    abstract::When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes als...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kass L,Leichtman DA,Beals TF,Schnitzer B

    更新日期:1977-10-31 00:00:00

  • Recombinant pro-urokinase requires heparin for optimal clot lysis and restoration of blood flow in a canine femoral artery thrombosis model.

    abstract::Heparin is often used as an adjunct to thrombolytic therapy in order to prevent reocclusion of the patent vessels in patients with thrombotic disease. Controversy exists as to whether heparin is required for effective clot lysis with tissue-type plasminogen activator, while in vitro data and small scale clinical trial...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Burke SE,Lubbers NL,Nelson RA,Henkin J

    更新日期:1993-04-01 00:00:00

  • Detection of complement-fixing antiphospholipid antibodies in association with thrombosis.

    abstract::Antiphospholipid antibody (aPL) is a hallmark of antiphospholipid syndrome (APS), characterized by thrombosis and recurrent fetal loss. We developed a novel ELISA system to detect complement-fixing ability of anticardiolipin antibody (aCL), and evaluated its clinical usefulness through studying the prevalence of the a...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Munakata Y,Saito T,Matsuda K,Seino J,Shibata S,Sasaki T

    更新日期:2000-05-01 00:00:00

  • Participation of Hageman factor dependent pathways in human disease states.

    abstract::Abnormalities of Hageman factor dependent pathways have been described in a wide variety of human disease states. Congenital deficiencies of factor XII (Hageman trait) prekallikrein (Fletcher trait) and high molecular weight kininogen (Williams, Fitzgerald and Flaujeac traits) although resulting in profound in vitro c...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Colman RW,Wong PY

    更新日期:1977-12-15 00:00:00

  • The role of CD40 in CD40L- and antibody-mediated platelet activation.

    abstract::Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-12-0774

    authors: Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

    更新日期:2005-06-01 00:00:00

  • Impact of polymorphisms in genes involved in autoimmune disease on inhibitor development in Chinese patients with haemophilia A.

    abstract::One of the most severe and important complication in the treatment of haemophilia A (HA) patients is the formation of inhibitors. The mechanism that leads to factor (F)VIII inhibitor formation is complicated. Both genetic and environmental factors have been mentioned to play decisive roles. Recently, polymorphisms in ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH11-06-0425

    authors: Lu Y,Ding Q,Dai J,Wang H,Wang X

    更新日期:2012-01-01 00:00:00

  • New splicing mutations in the human factor XIIIA gene, each producing multiple mutant transcripts of varying abundance.

    abstract::Coagulation factor XIII, a transglutaminase which stabilises blood clots by covalently cross-linking fibrin, is essential for normal haemostasis. FXIII deficiency results in a life-long bleeding disorder with added complications in wound healing and tissue repair. Sequence changes in the human FXIIIA gene, largely mis...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Anwar R,Miloszewski KJ,Markham AF

    更新日期:1998-06-01 00:00:00

  • Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.

    abstract::The mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A total of ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-03-0202

    authors: Berger JS,Becker RC,Kuhn C,Helms MJ,Ortel TL,Williams R

    更新日期:2013-01-01 00:00:00

  • Response variability to aspirin as assessed by the platelet function analyzer (PFA)-100. A systematic review.

    abstract::It was the aim of the present study to perform a systematic review of the published studies that estimated the prevalence of non-responders to aspirin, as assessed by the closure time of PFA-100, a point-of-care device, and to analyse: 1) some major clinical and methodological factors that can influence it and 2) its ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH07-08-0530

    authors: Crescente M,Di Castelnuovo A,Iacoviello L,Vermylen J,Cerletti C,de Gaetano G

    更新日期:2008-01-01 00:00:00

  • Studies of the effects of estradiol, progesterone, cortisol, thrombophlebitis, and typhoid vaccine on synthesis and catabolism of antithrombin III in the dog.

    abstract::Effects of estradiol, progesterone, cortisol, thrombophlebitis and typhoid vaccine on the synthesis and catabolism of antithrombin III (AT) in dogs were studied, using I-125-labeled AT (I-125-AT) as a tracer. Five dogs were used for each study. A single intramuscular injection of 20 mg estradiol caused a 20% decrease ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kobayashi N,Takeda Y

    更新日期:1977-02-28 00:00:00

  • A novel fibrinogen Bbeta chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia.

    abstract::Congenital afibrinogenemia and severe hypofibrinogenemia are severe bleeding disorders characterized by either undetectable or very low levels of fibrinogen in patients' plasma and platelets. A majority of the reported cases are caused by mutations in the fibrinogen Aalpha chain. In this study, we identified a genetic...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH06-01-0020

    authors: Xu X,Wu J,Zhai Z,Zhou R,Wang X,Wang H,Ding K,Sun Z,Ni H

    更新日期:2006-06-01 00:00:00

  • Megakaryocyte gene targeting mediated by restricted expression of recombinase Cre.

    abstract::The availability of mice with tissue-specific expression of recombinase Cre is the limiting step for a successful gene targeting by the Cre-LoxP methodology. This work aimed at generating transgenic mice with restricted expression of recombinase Cre in megakaryocytes and platelets, driven by the promoter of the αIIb g...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH10-06-0378

    authors: Nowakowski A,Alonso-Martín S,Arias-Salgado EG,Fernández D,Vilar M,Ayuso MS,Parrilla R

    更新日期:2011-01-01 00:00:00

  • Characterization of beta2-glycoprotein I binding to phospholipid membranes.

    abstract::The plasma protein beta2-glycoprotein I (beta2-GPI) is a major target of autoantibodies in patients with the antiphospholipid syndrome. To understand the physiological function of beta2-GPI and its potential role in the pathophysiology of the antiphospholipid syndrome, the binding of beta2-GPI to phospholipid membrane...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Harper MF,Hayes PM,Lentz BR,Roubey RA

    更新日期:1998-10-01 00:00:00

  • Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens.

    abstract::Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, ge...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH10-03-0201

    authors: Kelly LA,O'Leary JJ,Seidlova-Wuttke D,Wuttke W,Norris LA

    更新日期:2010-12-01 00:00:00

  • Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore).

    abstract::The physiologic activation of the plasma kallikrein-kinin system requires the assembly of its constituents on a cell membrane. High- molecular-weight kininogen (HK) and cleaved HK (HKa) both interact with at least three endothelial cell binding proteins: urokinase plasminogen activator receptor (uPAR), globular C1q re...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH10-09-0591

    authors: Pixley RA,Espinola RG,Ghebrehiwet B,Joseph K,Kao A,Bdeir K,Cines DB,Colman RW

    更新日期:2011-06-01 00:00:00

  • Effectiveness and safety of apixaban versus warfarin in non-valvular atrial fibrillation patients in "real-world" clinical practice. A propensity-matched analysis of 76,940 patients.

    abstract::The ARISTOTLE trial showed a risk reduction of stroke/systemic embolism (SE) and major bleeding in non-valvular atrial fibrillation (NVAF) patients treated with apixaban compared to warfarin. This retrospective study used four large US claims databases (MarketScan, PharMetrics, Optum, and Humana) of NVAF patients newl...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:10.1160/TH17-01-0068

    authors: Li XS,Deitelzweig S,Keshishian A,Hamilton M,Horblyuk R,Gupta K,Luo X,Mardekian J,Friend K,Nadkarni A,Pan X,Lip GYH

    更新日期:2017-06-02 00:00:00

  • Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy.

    abstract::In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure of the retina to revascularise its ischaemic areas. Non-resolving retina ischaemia/hypoxia results in upregulation of pro-angiogenic factors and pathologic neov...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH15-01-0051

    authors: Economopoulou M,Avramovic N,Klotzsche-von Ameln A,Korovina I,Sprott D,Samus M,Gercken B,Troullinaki M,Grossklaus S,Funk RH,Li X,Imhof BA,Orlova VV,Chavakis T

    更新日期:2015-11-25 00:00:00

  • The inhibitory effect of heparin and related glycosaminoglycans on neutrophil chemotaxis.

    abstract::Clinical observations have shown that heparin has antiinflammatory activities. The effect of heparin on neutrophil chemotaxis was evaluated in vitro in the Boyden Chamber. This method enabled differentiation between the direct effects of heparin on neutrophil migration and locomotion, and its effects on chemotactic fa...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Matzner Y,Marx G,Drexler R,Eldor A

    更新日期:1984-10-31 00:00:00

  • Thrombosis in the young: effect of atherosclerotic risk factors on the risk of myocardial infarction associated with prothrombotic factors.

    abstract::Myocardial infarction in the young provides a unique model for the investigation of potential interactions between atherosclerotic and prothrombotic risk factors. Because myocardial infarction reflects atherothrombotic disease, it is important to take into account factors related to atherosclerosis when examining prot...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Siscovick DS,Schwartz SM,Rosendaal FR,Psaty BM

    更新日期:1997-07-01 00:00:00

  • Immunohistochemical localization of a novel peptide, prostacyclin-stimulating factor (PSF), in human tissues.

    abstract::In a recent study, we purified and cloned a newly identified bioactive factor that stimulates prostacyclin (PGI2) production by vascular endothelial cells (ECs) using conditioned medium (CM) from cultured human diploid fibroblast cells. The present study was undertaken to clarify whether PSF is expressed in ECs and va...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Masakado M,Umeda F,Takei A,Hashimoto T,Sueishi K,Nawata H

    更新日期:1995-12-01 00:00:00

  • Homo- and heterogeneous forms of human factor VIII.

    abstract::In order to determine the molecular size of human F VIII as found in fresh plasma and as found in fresh-frozen plasma and in cryoprecipitate and to study the relationship of the factor-related properties, namely F VIII:C, F VIIR:Rcof and F VIIIR:Ag to F VIII, the factor's elution pattern on Sephacryl 1000 was investig...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Vukovich TC

    更新日期:1982-08-24 00:00:00

  • Ionomycin-stimulated arachidonic acid release in human platelets: a role for protein kinase C and tyrosine phosphorylation.

    abstract::Collagen (10-90 micrograms/ml) and ionomycin (1 microM; a calcium ionophore) each evoked rises in intracellular free calcium, protein kinase C activity and arachidonic acid release in human platelets, and as previously demonstrated for collagen, ionomycin (1 microM) stimulated protein tyrosine phosphorylation. However...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Hargreaves PG,Jenner S,Merritt JE,Sage SO,Farndale RW

    更新日期:1996-08-01 00:00:00

  • Factor II related antigen and antithrombin III levels as indicators of liver failure in consumption coagulopathy.

    abstract::In order to detect impaired synthesis of blood coagulation factors associated to consumption coagulopathy, a simultaneous evaluation of factor II-related antigen (II rAg) and of antithrombin III (AT III) was carried out in 16 patients affected with severe defibrination. An in vitro preliminary study on plasma and seru...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Sié P,Letrenne E,Caranobe C,Genestal M,Cathala B,Boneu B

    更新日期:1982-06-28 00:00:00

  • Intra-operative activation of coagulation--a stimulus to thrombosis mediated by vasopressin?

    abstract::Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic fu...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Grant PJ,Tate GM,Davies JA,Williams NS,Prentice CR

    更新日期:1986-02-28 00:00:00

  • Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.

    abstract::Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domain...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Sarafanov AG,Makogonenko EM,Andersen OM,Mikhailenko IA,Ananyeva NM,Khrenov AV,Shima M,Strickland DK,Saenko EL

    更新日期:2007-12-01 00:00:00

  • Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.

    abstract::Activated protein C (APC)-mediated inactivation of factor VIII (FVIII) correlates with cleavage at either Arg336 and/or Arg562. To elucidate the APC cleavage requirements for inactivation of FVIII, APC cleavage site mutants in FVIII (R336I, R562K and R336I/R562K) were made by site-directed mutagenesis. Analysis of the...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Amano K,Michnick DA,Moussalli M,Kaufman RJ

    更新日期:1998-03-01 00:00:00

  • The role of factor IX in tissue thromboplastin induced coagulation.

    abstract::Tissue thromboplastin apoprotein was partially purified from human brain. The apoprotein was recombined with mixed phospholipids to yield active thromboplastin. The recombined thromboplastin induced proteolytic activation of isolated human factor IX in the presence of factor VII and Ca2+. The clotting times of various...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: van den Besselaar AM,Ram IE,Alderkamp GH,Bertina RM

    更新日期:1982-08-24 00:00:00

  • Characterisation of epitopes on human tissue plasminogen activator recognised by a group of monoclonal antibodies.

    abstract::Seven mouse monoclonal antibodies have been produced against human melanoma tissue plasminogen activator (t-PA). They were specifically bound to 125I t-PA but not 125I urokinase (u-PA) and inhibited t-PA, but not u-PA, activity in plasminogen-rich 125I fibrin wells. Three of the antibodies directly inhibited the amido...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: MacGregor IR,Micklem LR,James K,Pepper DS

    更新日期:1985-02-18 00:00:00

  • A sensitive immunochemical assay for measuring the concentration of the activated protein C-protein C inhibitor complex in plasma: use of a catcher antibody specific for the complexed/cleaved form of the inhibitor.

    abstract::Activated protein C (APC) is a serine proteinase that regulates blood coagulation. In plasma it is inhibited mainly by the protein C inhibitor (PCI). The plasma concentrations of APC-PCI complex is increased in hypercoagulative states such as deep venous thrombosis. Formation of the APC-PCI complex induces a drastic c...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Strandberg K,Kjellberg M,Knebel R,Lilja H,Stenflo J

    更新日期:2001-08-01 00:00:00

  • Prevalence of three common polymorphisms in the A-subunit gene of factor XIII in patients with coronary artery disease.

    abstract::Activated blood coagulation factor XIII has an important role in the final stage of the clotting cascade by the covalent crosslinking of alpha- and gamma-fibrin chains. We have recently shown that a functional polymorphism in exon 2. codon 34 of the FXIII A-subunit gene is protective against myocardial infarction. To ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kohler HP,Futers TS,Grant PJ

    更新日期:1999-04-01 00:00:00