Increased euglobulin fibrinolytic potential in women on oral contraceptives low in oestrogen--levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII, and C1-inactivator.

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:This study examines the relationship between plasma Plasminogen Activator Inhibitor-1 (PAI-1) activity and the PAI-1 4G/5G polymorphism, and their association with the risk of myocardial infarction (MI). Furthermore, this study explores whether a high level of PAI-1 or whether the PAI-1 4G/5G polymorphism synergistica...

journal_title：Thrombosis and haemostasis

authors： Leander K,Wiman B,Hallqvist J,Sten-Linder M,de Faire U,Stockholm Heart Epidemiology Program.

更新日期：2003-06-01 00:00:00

abstract：:The Asian population is thought to have a low risk of venous thromboembolism (VTE), but the epidemiology of VTE in cancer patients remains unclear. The National Health Insurance Research Database of Taiwan was used to find hospitalised patients newly-diagnosed with cancer to determine the incidence of VTE in cancer pa...

journal_title：Thrombosis and haemostasis

authors： Yu YB,Gau JP,Liu CY,Yang MH,Chiang SC,Hsu HC,Hong YC,Hsiao LT,Liu JH,Chiou TJ,Chen PM,Lee TS,Chou LF,Tzeng CH,Chen TJ

更新日期：2012-08-01 00:00:00

abstract：:Although there is considerable variability of platelet reactivity among patients treated with clopidogrel, little is known about inter-individual differences and possible role of proton pump inhibitors (PPIs) after prasugrel. We defined the extent of inter-patient variability, and evaluated the impact of PPI interacti...

journal_title：Thrombosis and haemostasis

authors： Aradi D,Kuliczkowski W,Atar D,Serebruany VL

更新日期：2012-02-01 00:00:00

abstract：:Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

journal_title：Thrombosis and haemostasis

authors： Furlan M,Rupp C,Beck EA,Svendsen L

更新日期：1982-04-30 00:00:00

abstract：:The characterization of mutations in von Willebrand disease provides useful insight into the synthesis, structure, and function of von Willebrand factor. This growing body of information has prompted a reclassification of vWD types that is intended to reflect distinct pathophysiologic mechanisms. Despite this apparent...

journal_title：Thrombosis and haemostasis

authors： Sadler JE,Matsushita T,Dong Z,Tuley EA,Westfield LA

更新日期：1995-07-01 00:00:00

abstract：:An association has been reported between thrombotic events and the use of L-asparaginase (ASP) in children with acute lymphoblastic leukaemia (ALL). The mechanism for thrombosis is likely related to an acquired antithrombin deficiency. Since a primary prophylaxis using antithrombin concentrates may prevent thrombosis,...

journal_title：Thrombosis and haemostasis

authors： Mitchell L,Andrew M,Hanna K,Abshire T,Halton J,Wu J,Anderson R,Cherrick I,Desai S,Mahoney D,McCusker P,Chait P,Abdolell M,de Veber G,Mikulis D

更新日期：2003-08-01 00:00:00

abstract：:Platelet aggregation and adenine nucleotides in platelets have been studied in thirteen patients with myeloproliferative disorders. ADP induced aggregation was abnormal in two patients, but collagen induced aggregation was impaired in 11 patients. The concentrations of ATP and ADP in resting platelets in the patients ...

journal_title：Thrombosis and haemostasis

authors： Nishimura J,Okamoto S,Ibayashi H

更新日期：1979-06-30 00:00:00

abstract：:Analysis of platelet membrane proteins and glycoproteins by SDS polyacrylamide gel electrophoresis was carried out before and after treatment with thrombin. Extended incubation with thrombin (in the presence of EDTA or adenosine, which inhibit aggregation) produced extensive changes in the bands observed. With incuba...

journal_title：Thrombosis and haemostasis

authors： Podolsak B

更新日期：1977-06-30 00:00:00

abstract：:Serine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in ...

journal_title：Thrombosis and haemostasis

authors： Yousef GM,Diamandis EP

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Recombinant hirudin, a pure, specific antithrombin could be more effective than heparin in the treatment of deep vein thrombosis, but its short half-life requires constant intravenous infusion, whereas subcutaneous administration of recombinant hirudin can ensure stable and prolonged plasma levels. The aim o...

journal_title：Thrombosis and haemostasis

authors： Schiele F,Vuillemenot A,Kramarz P,Kieffer Y,Soria J,Soria C,Camez A,Mirshahi MC,Bassand JP

更新日期：1994-05-01 00:00:00

abstract：:Incubation of platelet-rich plasma (PRP) with ouabain, an inhibitor of sodium/potassium ATPase (Na+/K+ ATPase), induced a significant rise in basal platelet intracellular calcium concentration [( Ca2+]i) when measured using fura 2. Ouabain induced an enhanced aggregation response to low doses of collagen in both PRP a...

journal_title：Thrombosis and haemostasis

authors： Lees AD,Wilson J,Orchard CH,Orchard MA

更新日期：1989-11-24 00:00:00

abstract：:A disintegrin and metalloproteases (ADAMs) are membrane-bound enzymes responsible for the shedding or cleavage of various cell surface molecules, such as adhesion molecules, cytokines/chemokines and growth factors. This shedding can result in the release of soluble proteins that can exert agonistic or antagonistic fun...

journal_title：Thrombosis and haemostasis

authors： van der Vorst EPC,Weber C,Donners MMPC

更新日期：2018-07-01 00:00:00

abstract：:We have recently reported the short-term intraindividual variability of several coagulation factors and inhibitors included in the ARIC study (Chambless et al. Ann Epidemiol 1992; 2:723). In this paper, we reported the intraindividual variability results of additional hemostatic factors. Blood samples were collected f...

journal_title：Thrombosis and haemostasis

authors： Nguyen ND,Ghaddar H,Stinson V,Chambless LE,Wu KK

更新日期：1995-02-01 00:00:00

abstract：:There is little information on the clinical outcome of patients with venous thromboembolism and renal insufficiency. RIETE is an ongoing, prospective registry of consecutive patients with acute, objectively confirmed, symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE). In this analysis we analyzed the t...

journal_title：Thrombosis and haemostasis

authors： Falgá C,Capdevila JA,Soler S,Rabuñal R,Sánchez Muñoz-Torrero JF,Gallego P,Monreal M,RIETE Investigators.

更新日期：2007-10-01 00:00:00

abstract：:Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weight...

journal_title：Thrombosis and haemostasis

authors： Lima MA,Viskov C,Herman F,Gray AL,de Farias EH,Cavalheiro RP,Sassaki GL,Hoppensteadt D,Fareed J,Nader HB

更新日期：2013-03-01 00:00:00

abstract：:Antithrombin (AT) is a serine protease inhibitor that regulates the activity of coagulation proteases of both intrinsic and extrinsic pathways. We identified an AT-deficient patient with a heterozygous Thr90Ser (T90S) mutation who experiences recurrent venous thrombosis. To understand the molecular basis of the clotti...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Villoutreix BO,Biswas I,Ding Q,Wang X,Rezaie AR

更新日期：2020-07-01 00:00:00

abstract：:We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC (50) of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidase...

journal_title：Thrombosis and haemostasis

authors： Wang YX,Zhao L,Nagashima M,Vincelette J,Sukovich D,Li W,Subramanyam B,Yuan S,Emayan K,Islam I,Hrvatin P,Bryant J,Light DR,Vergona R,Morser J,Buckman BO

更新日期：2007-01-01 00:00:00

abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

journal_title：Thrombosis and haemostasis

authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

更新日期：2016-09-27 00:00:00

abstract：:We studied the occurrence of myocardial infarction (MI), ischaemic stroke (IS) and pulmonary embolism (PE) before and after breast cancer hospitalisation compared with cancer-free controls. For this, women with a first breast cancer hospitalisation during 2000-2007 were selected from the PHARMO Record Linkage System, ...

journal_title：Thrombosis and haemostasis

authors： van Herk-Sukel MP,Shantakumar S,Kamphuisen PW,Penning-van Beest FJ,Herings RM

更新日期：2011-07-01 00:00:00

abstract：:In patients with atrial fibrillation (AF) undergoing coronary stent implantation, the optimal antithrombotic strategy is unclear. We evaluated whether use of oral anticoagulation (OAC) was associated with any benefit in morbidity or mortality in patients with AF, high risk of thromboembolism (TE) (CHA2DS2-VASC score ≥...

journal_title：Thrombosis and haemostasis

authors： Bernard A,Fauchier L,Pellegrin C,Clementy N,Saint Etienne C,Banerjee A,Naudin D,Angoulvant D

更新日期：2013-09-01 00:00:00

abstract：:Without thromboprophylaxis, knee arthroscopy (KA) carries a low to moderate risk of venous thromboembolism. Over 5 million arthroscopies are performed worldwide yearly. It was our study objective to assess the efficacy and safety of rivaroxaban for thromboprophylaxis after therapeutic KA. Patients undergoing KA in nin...

journal_title：Thrombosis and haemostasis

authors： Camporese G,Bernardi E,Noventa F,Bosco M,Monteleone G,Santoro L,Bortoluzzi C,Freguja S,Nardin M,Marullo M,Zanon G,Mazzola C,Damiani G,Maniscalco P,Imberti D,Lodigiani C,Becattini C,Tonello C,Agnelli G,ERIKA Study Gr

更新日期：2016-08-01 00:00:00

abstract：:Interaction of proteases with cell surface receptors may modulate cell adhesion, migration, invasion, and matrix degradation. Since the plasminogen activator system has been hypothesized to play a role in intimal thickening after various types of vascular injury, we first studied the expression of urokinase receptor (...

journal_title：Thrombosis and haemostasis

authors： Okada SS,Golden MA,Raghunath PN,Tomaszewski JE,David ML,Kuo A,Kariko K,Barnathan ES

更新日期：1998-07-01 00:00:00

abstract：:The molecular basis of Factor V deficiency has been defined in few patients only. We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. This substitution results in the replacement of an arginine (R) by a histidine (H) in amino acid position 2074, lo...

journal_title：Thrombosis and haemostasis

authors： Schrijver I,Houissa-Kastally R,Jones CD,Garcia KC,Zehnder JL

更新日期：2002-02-01 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The fu...

journal_title：Thrombosis and haemostasis

authors： Dangelmaier C,Manne BK,Liverani E,Jin J,Bray P,Kunapuli SP

更新日期：2014-03-03 00:00:00

abstract：:Restenosis following successful percutaneous coronary revascularization continues to represent a major problem limiting the clinical efficacy of this procedure. The underlying mechanisms of restenosis are comprised of a combination of effects from vessel recoil, negative vascular remodeling, thrombus formation and neo...

journal_title：Thrombosis and haemostasis

authors： Rosanio S,Tocchi M,Patterson C,Runge MS

更新日期：1999-09-01 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00

abstract：:Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could pl...

journal_title：Thrombosis and haemostasis

authors： Leoncini G,Bruzzese D,Signorello MG,Armani U,Piana A,Ghiglione D,Camicione P

更新日期：2007-02-01 00:00:00

abstract：:Thrombin-activated human platelets release substance(s) of a proteic nature which induce an increase in the intracellular calcium concentration in polymorphonuclear leukocytes (PMN). Aim of this study was to characterize the platelet released product(s) responsible for PMN stimulation. PMN-stimulating activity was iso...

journal_title：Thrombosis and haemostasis

authors： Piccardoni P,Evangelista V,Piccoli A,de Gaetano G,Walz A,Cerletti C

更新日期：1996-11-01 00:00:00

abstract：:The redistribution of platelet glycoproteins (GP) Ib, IIb and IIIa in response to stimulation with human platelet specific alloantibodies, autoantibodies and a quinidine-dependent antibody was investigated using immunofluorescence and a quantitative radioimmunoassay. The platelet GPs carrying the corresponding epitope...

journal_title：Thrombosis and haemostasis

authors： Santoso S,Kiefel V,Mueller-Eckhardt C

更新日期：1987-10-28 00:00:00