A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system.

abstract：:Treatment with the direct thrombin inhibitor argatroban (ARG) is often followed by vitamin K-antagonist treatment (VKA). Phenprocoumon (PC) and acenocoumarol (AC) are frequently used in Europe. The standard monitoring test for VKA, pro-thrombin time (PT), is prolonged by direct thrombin inhibitors. Therefore the Inter...

journal_title：Thrombosis and haemostasis

authors： Harder S,Graff J,Klinkhardt U,von Hentig N,Walenga JM,Watanabe H,Osakabe M,Breddin HK

更新日期：2004-06-01 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:Previous studies on recombinant human soluble thrombomodulin (rsTM) from Chinese hamster ovary cells revealed that rsTM was expressed as two proteins that differed functionally in vitro due to the presence (rsTM beta) or absence (rsTM alpha) of chondroitin-4-sulfate. The current study evaluates the in vivo behavior of...

journal_title：Thrombosis and haemostasis

authors： Nawa K,Itani T,Ono M,Sakano K,Marumoto Y,Iwamoto M

更新日期：1992-03-02 00:00:00

abstract：:High heparin cofactor II (HCII) activity has recently been described to protect from coronary instent restenosis, presumably by inactivating thrombin in injured arteries. In this study, we investigated the association of HCII activity and restenosis after femoropopliteal stenting. We studied 63 consecutive patients wi...

journal_title：Thrombosis and haemostasis

authors： Schillinger M,Exner M,Sabeti S,Mlekusch W,Amighi J,Handler S,Quehenberger P,Kalifeh N,Wagner O,Minar E

更新日期：2004-11-01 00:00:00

abstract：:In a previous report we found an inverse correlation between pre-operative platelet count (PlC) levels and the risk of post-operative pulmonary embolism in patients undergoing hip surgery. In the present study, we prospectively evaluated the prognostic significance of pre-operative PlC levels on survival in 180 consec...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Fernandez-Llamazares J,Piñol M,Julian JF,Broggi M,Escola D,Abad A

更新日期：1998-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of morbidity and mortality, and the composition of the tumour stroma is a strong predictor of survival in this cancer type. Tissue factor (TF) functions as the trigger of haemostasis together with its ligand coagulation factor VII/VIIa, and TF expression has been found in tumou...

journal_title：Thrombosis and haemostasis

authors： Eriksson O,Asplund A,Hegde G,Edqvist PH,Navani S,Pontén F,Siegbahn A

更新日期：2016-11-30 00:00:00

abstract：:Severe type I plasminogen deficiency is the underlying cause of ligneous conjunctivitis, a rare disease characterized by wood-like pseudomembranes developing on the ocular and extraocular mucosa. Two unrelated female patients with ligneous conjunctivitis and moderate hypoplasminogenemia are described. Being of fertile...

journal_title：Thrombosis and haemostasis

authors： Teresa Sartori M,Saggiorato G,Pellati D,Casonato A,Spiezia L,Pontara E,Gavasso S,Girolami A

更新日期：2003-07-01 00:00:00

abstract：:Platelet aggregation and thromboxane A2 have been implicated in the pathogenesis of several forms of vascular disease. The aim of this study was to determine the effect of a wide range of adrenoceptor antagonists on platelet aggregation, and thromboxane A2 production, from normal human platelet rich plasma in vitro. L...

journal_title：Thrombosis and haemostasis

authors： Greer IA,Walker JJ,McLaren M,Calder AA,Forbes CD

更新日期：1985-08-30 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. It was the study objective to evaluate in vivo lipid peroxidation and platelet activation in carriers of the MTHFR 677 C→T polymo...

journal_title：Thrombosis and haemostasis

authors： Dragani A,Falco A,Santilli F,Basili S,Rolandi G,Cerasa L,Lattanzio S,Ciabattoni G,Patrono C,Davì G

更新日期：2012-09-01 00:00:00

abstract：:Edoxaban is an oral direct factor (F)Xa inhibitor in advanced stages of clinical development. The primary objective of the present study was to assess the pharmacodynamics (PD) and safety of enoxaparin 1 mg/kg followed 12 hours (h) post-dose by edoxaban 60 mg, which is the regimen being used in the phase III study of ...

journal_title：Thrombosis and haemostasis

authors： Zahir H,Matsushima N,Halim AB,He L,Zhang G,Lee F,Worland V,Mendell J

更新日期：2012-07-01 00:00:00

abstract：:Accurate and precise measurement of plasma D-dimer levels is important in the diagnosis and management of venous thromboembolism. Considerable variability in D-dimer results obtained using different methods has, however, been reported in multicentre studies. This study explored in two separate multicentre exercises th...

journal_title：Thrombosis and haemostasis

authors： Jennings I,Woods TA,Kitchen DP,Kitchen S,Walker ID

更新日期：2007-11-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:Haemophilia A and B have been associated with increased prevalence of low bone mineral density (BMD). However, no study has so far evaluated the effects of anti-osteoporotic therapy on BMD in haemophilia.The primary endpoint of this prospective study was to estimate the effect of 12-month therapy of oral ibandronate 1...

journal_title：Thrombosis and haemostasis

authors： Anagnostis P,Vyzantiadis TA,Charizopoulou M,Adamidou F,Karras S,Goulis DG,Karagiannis A,Garipidou V,Vakalopoulou S

更新日期：2013-08-01 00:00:00

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:Women with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk of thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because of limited trial data. A strategy of risk assessment and heparin prophylaxis was evaluated in pregn...

journal_title：Thrombosis and haemostasis

authors： Bauersachs RM,Dudenhausen J,Faridi A,Fischer T,Fung S,Geisen U,Harenberg J,Herchenhan E,Keller F,Kemkes-Matthes B,Schinzel H,Spannagl M,Thaler CJ,EThIG Investigators.

更新日期：2007-12-01 00:00:00

abstract：:Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphism...

journal_title：Thrombosis and haemostasis

authors： Pomp ER,Doggen CJ,Vos HL,Reitsma PH,Rosendaal FR

更新日期：2009-01-01 00:00:00

abstract：:Platelet behaviour was studied throughout pregnancy in a group of women who remained normotensive and a group with essential hypertension (EHT). Women who developed pregnancy-induced hypertension (PIH) were also studied together with a group of non-pregnant female controls. We determined the sensitivity of platelets t...

journal_title：Thrombosis and haemostasis

authors： Morrison R,Crawford J,MacPherson M,Heptinstall S

更新日期：1985-10-30 00:00:00

abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

journal_title：Thrombosis and haemostasis

authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

更新日期：2019-03-01 00:00:00

abstract：:Activated protein C resistance is in almost all cases caused by the factor V Leiden mutation (FV:R506Q). Due to the high prevalence and clinical significance of the mutation reliable methods suited for processing large sets of samples are in demand. We here present the oligonucleotide ligation assay (OLA) with lanthan...

journal_title：Thrombosis and haemostasis

authors： Chakravarty A,Hansen TS,Hørder M,Kristensen SR

更新日期：1997-10-01 00:00:00

abstract：:Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced "FVa activity augmentation" as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (r...

journal_title：Thrombosis and haemostasis

authors： Bhat V,von Drygalski A,Gale AJ,Griffin JH,Mosnier LO

更新日期：2016-03-01 00:00:00

abstract：:Underlying disorders of the coagulation system such as inhibitor deficiencies or decreased fibrinolysis are common in patients suffering from venous thrombosis. They may lead to the necessity of a lifelong prophylaxis. Prompt diagnosis is obviously to the patients benefit. We investigated 22 patients suffering from ve...

journal_title：Thrombosis and haemostasis

authors： Reiter W,Ehrensberger H,Steinbrückner B,Keller F

更新日期：1995-08-01 00:00:00

abstract：:Coagulation factor XIII, a transglutaminase which stabilises blood clots by covalently cross-linking fibrin, is essential for normal haemostasis. FXIII deficiency results in a life-long bleeding disorder with added complications in wound healing and tissue repair. Sequence changes in the human FXIIIA gene, largely mis...

journal_title：Thrombosis and haemostasis

authors： Anwar R,Miloszewski KJ,Markham AF

更新日期：1998-06-01 00:00:00

abstract：:Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, ge...

journal_title：Thrombosis and haemostasis

authors： Kelly LA,O'Leary JJ,Seidlova-Wuttke D,Wuttke W,Norris LA

更新日期：2010-12-01 00:00:00

abstract：:This study was performed to assess the prevalence of deep vein thrombosis (DVT) in consecutive obstetric patients with clinical symptoms of DVT, using impedance plethysmography (IPG) as the diagnostic method and to establish the safety of withholding anticoagulant therapy in patients with a repeatedly normal IPG. In a...

journal_title：Thrombosis and haemostasis

authors： de Boer K,Büller HR,ten Cate JW,Levi M

更新日期：1992-01-23 00:00:00

abstract：:Proteins in the plasma membrane anchor the cell within its microenvironment and sense changes occurring outside the cell. The anchoring interactions are cell type-specific and may involve adjacent cells or extracellular matrix proteins (ECMPs). In development, wound healing, and in various forms of pathology, includin...

journal_title：Thrombosis and haemostasis

authors： Gonias SL,Wu L,Salicioni AM

更新日期：2004-06-01 00:00:00

abstract：:The behavior of direct fibrinolytic (non-plasmin) proteinase activity and plasminogen-activator activity in the lung and spleen was investigated in rats after a single intravenous injection of bacterial endotoxin, and the influence of thrombin inhibitors on the effects of the endotoxin was assessed. The non-plasmin fi...

journal_title：Thrombosis and haemostasis

authors： Okamoto U,Nagamatsu Y,Horie N,Yamamoto J,Sasaki K

更新日期：1985-06-24 00:00:00

abstract：:The vast clinical research programme for the direct, oral factor Xa inhibitor rivaroxaban has generated a wealth of data since the first rivaroxaban approval in 2008 for the prevention of venous thromboembolism (VTE) in patients undergoing elective hip or knee replacement surgery. While rivaroxaban is widely used acro...

journal_title：Thrombosis and haemostasis

authors： Cappato R,Welsh R

更新日期：2016-09-28 00:00:00

abstract：:Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed t...

journal_title：Thrombosis and haemostasis

authors： Wang J,Albertson CM,Zheng H,Fink LM,Herbert JM,Hauer-Jensen M

更新日期：2002-01-01 00:00:00

abstract：:Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by...

journal_title：Thrombosis and haemostasis

authors： Opitz B,Eitel J,Meixenberger K,Suttorp N

更新日期：2009-12-01 00:00:00