The effect of monthly ibandronate on bone mineral density and bone turnover markers in patients with haemophilia A and B and increased risk for fracture.

abstract：:Dabigatran is an oral, reversible thrombin inhibitor that has shown promising results in large clinical trials. Laboratory monitoring is not needed but the effects on common coagulation assays are incompletely known. Dabigatran was added to plasma from healthy subjects in the concentration range 0-1,000 μg/l and analy...

journal_title：Thrombosis and haemostasis

authors： Lindahl TL,Baghaei F,Blixter IF,Gustafsson KM,Stigendal L,Sten-Linder M,Strandberg K,Hillarp A,Expert Group on Coagulation of the External Quality Assurance in Laboratory Medicine in Sweden.

更新日期：2011-02-01 00:00:00

abstract：:Thrombus formation at an artificial surface in contact with blood is a complex process that encompasses accretion of platelets from flowing blood and fibrin deposition. Platelet adhesion and fibrin formation are intimately intertwined reactions that are triggered by different sets of surface adsorbed plasma proteins. ...

journal_title：Thrombosis and haemostasis

authors： Keuren JF,Wielders SJ,Willems GM,Morra M,Lindhout T

更新日期：2002-04-01 00:00:00

abstract：:When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes als...

journal_title：Thrombosis and haemostasis

authors： Kass L,Leichtman DA,Beals TF,Schnitzer B

更新日期：1977-10-31 00:00:00

abstract：:Primary prevention is the key to managing a significant proportion of the burden of venous thromboembolism (VTE), defined as deep venous thrombosis (DVT) or pulmonary embolism (PE). This is because VTE may lead to sudden death or are often misdiagnosed and therefore treatment is not feasible. Primary prevention usuall...

journal_title：Thrombosis and haemostasis

authors： Granziera S,Cohen AT

更新日期：2015-06-01 00:00:00

abstract：:The ability of cellular fibronectin, found in the vessel wall in a fibrillar conformation, to regulate platelet functions and trigger thrombus formation remains largely unknown. In this study, we evaluated how parietal cellular fibronectin can modulate platelet responses under flow conditions. A fibrillar network was ...

journal_title：Thrombosis and haemostasis

authors： Maurer E,Schaff M,Receveur N,Bourdon C,Mercier L,Nieswandt B,Dubois C,Jandrot-Perrus M,Goetz JG,Lanza F,Gachet C,Mangin PH

更新日期：2015-11-25 00:00:00

abstract：:To study the reversible complex formation between the plasma protein histidine-rich glycoprotein (HRG) and plasminogen, crossed immunoelectrophoresis of HRG was modified. In the modification, purified plasminogen was introduced into the gel of the first dimension electrophoresis. Two molecular forms of plasminogen, Gl...

journal_title：Thrombosis and haemostasis

authors： Kluft C,Los P

更新日期：1988-12-22 00:00:00

abstract：:Edoxaban is an oral direct factor (F)Xa inhibitor in advanced stages of clinical development. The primary objective of the present study was to assess the pharmacodynamics (PD) and safety of enoxaparin 1 mg/kg followed 12 hours (h) post-dose by edoxaban 60 mg, which is the regimen being used in the phase III study of ...

journal_title：Thrombosis and haemostasis

authors： Zahir H,Matsushima N,Halim AB,He L,Zhang G,Lee F,Worland V,Mendell J

更新日期：2012-07-01 00:00:00

abstract：:The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin intake on circadian rhythm and morning peak of platelet reactivity is not known. It was our objective to evaluate the effect of timing of aspirin intake on circadia...

journal_title：Thrombosis and haemostasis

authors： Bonten TN,Saris A,van Oostrom MJ,Snoep JD,Rosendaal FR,Zwaginga J,Eikenboom J,van der Meer PF,van der Bom JG

更新日期：2014-12-01 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor V(Leiden) (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns. Pregnant women with known thrombophilia (n=27) were enro...

journal_title：Thrombosis and haemostasis

authors： Hyytiäinen S,Wartiovaara-Kautto U,Ulander VM,Kaaja R,Heikinheimo M,Petäjä J

更新日期：2006-03-01 00:00:00

abstract：:A disintegrin and metalloproteases (ADAMs) are membrane-bound enzymes responsible for the shedding or cleavage of various cell surface molecules, such as adhesion molecules, cytokines/chemokines and growth factors. This shedding can result in the release of soluble proteins that can exert agonistic or antagonistic fun...

journal_title：Thrombosis and haemostasis

authors： van der Vorst EPC,Weber C,Donners MMPC

更新日期：2018-07-01 00:00:00

abstract：:The effects of etamsylate on human platelet aggregation and ATP release as well as on the arachidonate metabolism by the platelet have been studied. Etamsylate enhanced these platelet functions induced by arachidonic acid (AA), thromboxane A2, collagen and calcium ionophore A23187 but not those induced by ADP and epin...

journal_title：Thrombosis and haemostasis

authors： Okuma M,Takayama H,Sugiyama T,Sensaki S,Uchino H

更新日期：1982-12-27 00:00:00

abstract：:A pulmonary embolism model in hamsters was used for the quantitative evaluation of the thrombolytic and pharmacokinetic properties of variants of tissue-type plasminogen activator (t-PA). A 25 microliters 125I-fibrin labeled human plasma clot was made in vitro and injected into the jugular vein of heparinized hamsters...

journal_title：Thrombosis and haemostasis

authors： Collen D,Lijnen HR,Vanlinthout I,Kieckens L,Nelles L,Stassen JM

更新日期：1991-02-12 00:00:00

abstract：:We investigated the presence of the gene mutation of factor V, FV R506Q or factor V Leiden, responsible for activated protein C resistance, in DNA samples of 127 probands and 188 relatives from 128 families with antithrombin deficiency. The factor V mutation was identified in 18 families. Nine families were available ...

journal_title：Thrombosis and haemostasis

authors： van Boven HH,Reitsma PH,Rosendaal FR,Bayston TA,Chowdhury V,Bauer KA,Scharrer I,Conard J,Lane DA

更新日期：1996-03-01 00:00:00

abstract：:In this study, we investigate the influence of three factor VII (FVII) gene polymorphisms on activated FVII levels (FVIIa), and also on the risk of myocardial infarction (MI) in patients with advanced coronary atherosclerotic disease (CAD). The -323A2 allele in the promoter is known to be associated with low FVII leve...

journal_title：Thrombosis and haemostasis

authors： Bozzini C,Girelli D,Bernardi F,Ferraresi P,Olivieri O,Pinotti M,Martinelli N,Manzato F,Friso S,Villa G,Pizzolo F,Beltrame F,Corrocher R

更新日期：2004-09-01 00:00:00

abstract：:Platelet-monocyte aggregates are increasingly being used to quantify platelet activation. The variables that influence platelet-monocyte aggregates have not been well defined. We sought to determine the effect of blood collection, handling and processing techniques on detected levels of platelet-monocyte aggregates us...

journal_title：Thrombosis and haemostasis

authors： Harding SA,Din JN,Sarma J,Jessop A,Weatherall M,Fox KA,Newby DE

更新日期：2007-08-01 00:00:00

abstract：:An algal sulfated galactan has high anticoagulant and antithrombotic activities. Its serpin-dependent anticoagulant action is due to promoting thrombin and factor (F)Xa inhibition by antithrombin and heparin cofactor II. Here, we evaluated the anticoagulant effect of the algal sulfated galactan using serpin-free plasm...

journal_title：Thrombosis and haemostasis

authors： Glauser BF,Rezende RM,Melo FR,Pereira MS,Francischetti IM,Monteiro RQ,Rezaie AR,Mourão PA

更新日期：2009-12-01 00:00:00

abstract：:Platelets are suggested to play a crucial role in cancer progression and the prothrombotic state of cancer patients. Here, we aimed to examine the activation status of platelets in cancer patients and investigate their association with risk of death and occurrence of venous thromboembolism (VTE) in a prospective obser...

journal_title：Thrombosis and haemostasis

authors： Riedl J,Kaider A,Marosi C,Prager GW,Eichelberger B,Assinger A,Pabinger I,Panzer S,Ay C

更新日期：2017-01-05 00:00:00

abstract：:Recombinant human factor VIIa (rFVIIa; NovoSeven) is a two-chain activated clotting factor that is used in the treatment of haemophilia. The distribution of radioactivity in male and pregnant and non-pregnant female rats has been examined by whole-body autoradiography (WBA) after single intravenous doses of 125I-radio...

journal_title：Thrombosis and haemostasis

authors： Beeby TL,Chasseaud LF,Taylor T,Thomsen MK

更新日期：1993-09-01 00:00:00

abstract：:Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thromboti...

journal_title：Thrombosis and haemostasis

authors： Deroo S,Deatrick KB,Henke PK

更新日期：2010-10-01 00:00:00

abstract：:Hyperglycemia-induced mitochondrial overproduction of reactive oxygen species leads to the activation of different biochemical pathways involved in endothelial damage of the diabetic retina. Tenilsetam [(+/-)-3-(2-thienyl)-2-piperazinone] is a dicarbonyl scavenger in the millimolar range and a transition metal ion che...

journal_title：Thrombosis and haemostasis

authors： Hoffmann J,Alt A,Lin J,Lochnit G,Schubert U,Schleicher E,Chavakis T,Brownlee M,Van der Woude FJ,Preissner KT,Hammes HP

更新日期：2006-04-01 00:00:00

abstract：:Fibrinogen degradation products formed by the action of purified haemolymph and saliva of a Saturnidae caterpillar of the Lonomia genus were studies by immunoelectrophoresis and polyacrylamide/SDS gel electrophoresis. The pattern of degradation differ form the one described for plasmin, trypsin, brinase, and ochrase. ...

journal_title：Thrombosis and haemostasis

authors： Arocha-Piñango CL,Perales J,Carvajal Z

更新日期：1981-06-30 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:The mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A total of ...

journal_title：Thrombosis and haemostasis

authors： Berger JS,Becker RC,Kuhn C,Helms MJ,Ortel TL,Williams R

更新日期：2013-01-01 00:00:00

abstract：:Collagen (10-90 micrograms/ml) and ionomycin (1 microM; a calcium ionophore) each evoked rises in intracellular free calcium, protein kinase C activity and arachidonic acid release in human platelets, and as previously demonstrated for collagen, ionomycin (1 microM) stimulated protein tyrosine phosphorylation. However...

journal_title：Thrombosis and haemostasis

authors： Hargreaves PG,Jenner S,Merritt JE,Sage SO,Farndale RW

更新日期：1996-08-01 00:00:00

abstract：:Atrial fibrillation (AF) is a common complication of coronary artery bypass grafting (CABG). We sought to determine the diagnostic validity of plasma biomarkers of i) inflammation (marked by interleukin-6 [IL-6] and high-sensitivity C-reactive protein [hs-CRP]), ii) extracellular matrix remodelling (matrix metalloprot...

journal_title：Thrombosis and haemostasis

authors： Kaireviciute D,Blann AD,Balakrishnan B,Lane DA,Patel JV,Uzdavinys G,Norkunas G,Kalinauskas G,Sirvydis V,Aidietis A,Lip GY

更新日期：2010-07-01 00:00:00

abstract：:Activated protein C (APC) is a serine proteinase that regulates blood coagulation. In plasma it is inhibited mainly by the protein C inhibitor (PCI). The plasma concentrations of APC-PCI complex is increased in hypercoagulative states such as deep venous thrombosis. Formation of the APC-PCI complex induces a drastic c...

journal_title：Thrombosis and haemostasis

authors： Strandberg K,Kjellberg M,Knebel R,Lilja H,Stenflo J

更新日期：2001-08-01 00:00:00

abstract：:Thrombopoietin is produced at a constant rate by the liver and kidney and is removed from the circulation upon binding and subsequent uptake via the Tpo receptor, c-Mpl, expressed by platelets and mega-karyocytes. Apart from uptake, this study shows that platelets can also function as a storage pool for Tpo. Upon stim...

journal_title：Thrombosis and haemostasis

authors： Folman CC,Linthorst GE,van Mourik J,van Willigen G,de Jonge E,Levi M,de Haas M,von dem Borne AE

更新日期：2000-06-01 00:00:00

abstract：:von Willebrand disease (VWD) is a quantitative or qualitative defect in von Willebrand factor (VWF) resulting in mucocutaneous bleeding symptoms and hemorrhage following hemostatic challenges, such as trauma or surgery. VWD-specific therapy, DDAVP (1-desamino-8-D-arginine vasopressin) and VWF concentrates, is necessar...

journal_title：Thrombosis and haemostasis

authors： Seaman CD,Ragni MV

更新日期：2020-08-01 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00