The procoagulant effects of factor V Leiden may be balanced against decreased levels of factor V and do not reflect in vivo thrombin formation in newborns.

abstract：:As an adjunct to a European multicentre prospective study, five quality assessment (QA) exercises, spanning a period of 2.5 years, were undertaken. In these, fifteen laboratories from eight countries each performed ten haemostatic factor assays. The design of the QA exercises allowed the between-duplicate, between-day...

journal_title：Thrombosis and haemostasis

authors： Thompson SG,Calori G,Thomson JM,Haverkate F,Duckert F

更新日期：1991-02-12 00:00:00

abstract：:The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively ac...

journal_title：Thrombosis and haemostasis

authors： Ong SB,Hall AR,Dongworth RK,Kalkhoran S,Pyakurel A,Scorrano L,Hausenloy DJ

更新日期：2015-03-01 00:00:00

abstract：:Local ISI calibration has been proposed to improve INR accuracy and inter-laboratory precision. We evaluated the affect of local PT calibration on INR precision and accuracy using six levels of frozen plasma calibrants prepared and pooled from normal donors and patients stabilized on sodium warfarin (coumarin) based o...

journal_title：Thrombosis and haemostasis

authors： Adcock DM,Johnston M

更新日期：2002-01-01 00:00:00

abstract：:Both the HEPTEST and amidolytic anti factor Xa assays are currently being used for heparin activity detection in plasma from patients receiving standard heparin or low molecular weight heparin (LMWH). In this study we have investigated the influence of recombinant and endogenous Tissue Factor Pathway Inhibitor (TFPI) ...

journal_title：Thrombosis and haemostasis

authors： Kristensen HI,Ostergaard PB,Nordfang O,Abildgaard U,Lindahl AK

更新日期：1992-09-07 00:00:00

abstract：:Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). In this study, we examined how changes in platelet function relate to changes in platelet coun...

journal_title：Thrombosis and haemostasis

authors： Zwifelhofer NMJ,Bercovitz RS,Cole R,Yan K,Simpson PM,Moroi A,Newman PJ,Niebler RA,Scott JP,Stuth EAD,Woods RK,Benson DW,Newman DK

更新日期：2020-01-01 00:00:00

abstract：:We investigated the extent to which fibroblasts isolated from diverse tissues differ in their capacity to modulate inflammation by comparing the global gene expression profiles of cultured human fibroblasts from skin, acute and chronically inflamed synovium, lymph node and tonsil. The responses of these fibroblasts to...

journal_title：Thrombosis and haemostasis

authors： Parsonage G,Falciani F,Burman A,Filer A,Ross E,Bofill M,Martin S,Salmon M,Buckley CD

更新日期：2003-10-01 00:00:00

abstract：:This study examines the relationship between plasma Plasminogen Activator Inhibitor-1 (PAI-1) activity and the PAI-1 4G/5G polymorphism, and their association with the risk of myocardial infarction (MI). Furthermore, this study explores whether a high level of PAI-1 or whether the PAI-1 4G/5G polymorphism synergistica...

journal_title：Thrombosis and haemostasis

authors： Leander K,Wiman B,Hallqvist J,Sten-Linder M,de Faire U,Stockholm Heart Epidemiology Program.

更新日期：2003-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of morbidity and mortality, and the composition of the tumour stroma is a strong predictor of survival in this cancer type. Tissue factor (TF) functions as the trigger of haemostasis together with its ligand coagulation factor VII/VIIa, and TF expression has been found in tumou...

journal_title：Thrombosis and haemostasis

authors： Eriksson O,Asplund A,Hegde G,Edqvist PH,Navani S,Pontén F,Siegbahn A

更新日期：2016-11-30 00:00:00

abstract：:Emicizumab, a bispecific monoclonal antibody, bridges activated factor IX (FIXa) and FX, replacing the function of missing FVIIIa to restore effective hemostasis in persons with hemophilia A (PwHA). Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III H...

journal_title：Thrombosis and haemostasis

authors： Schmitt C,Adamkewicz JI,Xu J,Petry C,Catalani O,Young G,Negrier C,Callaghan MU,Levy GG

更新日期：2020-10-21 00:00:00

abstract：:Previously, we demonstrated that in vivo regulation of liver fibrinogen synthesis occurs via the fibrinogen mRNA level. However, the molecular regulatory mechanism of fibrinogen synthesis is still not well understood. Fibrinogen or fibrin degradation products might play an important role in regulating fibrinogen synth...

journal_title：Thrombosis and haemostasis

authors： Princen HM,Moshage HJ,Emeis JJ,de Haard HJ,Nieuwenhuizen W,Yap SH

更新日期：1985-04-22 00:00:00

abstract：:Collagen (10-90 micrograms/ml) and ionomycin (1 microM; a calcium ionophore) each evoked rises in intracellular free calcium, protein kinase C activity and arachidonic acid release in human platelets, and as previously demonstrated for collagen, ionomycin (1 microM) stimulated protein tyrosine phosphorylation. However...

journal_title：Thrombosis and haemostasis

authors： Hargreaves PG,Jenner S,Merritt JE,Sage SO,Farndale RW

更新日期：1996-08-01 00:00:00

abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

journal_title：Thrombosis and haemostasis

authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

更新日期：2016-09-27 00:00:00

abstract：:A model has been developed to study the transport of fluid and macromolecules through human arterial umbilical cord endothelial cell monolayers in vitro. Cells were cultured on fibronectin-coated polycarbonate filters and formed within a few days a tight monolayer, with an electrical resistance of 17 +/- 4 Ohm.cm2. Th...

journal_title：Thrombosis and haemostasis

authors： Langeler EG,van Hinsbergh VW

更新日期：1988-10-31 00:00:00

abstract：:In two randomized double-blind studies perioperative bleeding complications and thromboembolic events were assessed in 189 patients (pts) undergoing elective visceral surgery after subcutaneous administration of a low molecular weight (LMW) heparin fragment (KABI fragment 2165) or unfractionated (UF) heparin. The firs...

journal_title：Thrombosis and haemostasis

authors： Koller M,Schoch U,Buchmann P,Largiadèr F,von Felten A,Frick PG

更新日期：1986-12-15 00:00:00

abstract：:Carbamylation is a non-enzymatic post-translational modification induced upon exposure of free amino groups to urea-derived cyanate leading to irreversible changes of protein charge, structure and function. Levels of carbamylated proteins increase significantly in chronic kidney disease and carbamylated albumin is con...

journal_title：Thrombosis and haemostasis

authors： Binder V,Bergum B,Jaisson S,Gillery P,Scavenius C,Spriet E,Nyhaug AK,Roberts HM,Chapple ILC,Hellvard A,Delaleu N,Mydel P

更新日期：2017-05-03 00:00:00

abstract：:Incubation of platelet-rich plasma (PRP) with ouabain, an inhibitor of sodium/potassium ATPase (Na+/K+ ATPase), induced a significant rise in basal platelet intracellular calcium concentration [( Ca2+]i) when measured using fura 2. Ouabain induced an enhanced aggregation response to low doses of collagen in both PRP a...

journal_title：Thrombosis and haemostasis

authors： Lees AD,Wilson J,Orchard CH,Orchard MA

更新日期：1989-11-24 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00

abstract：:The influence of ionic and non-ionic contrast media (CM) on platelet and leukocyte activation and platelet-leukocyte crosstalk was investigated in hirudinized whole blood. The blood was incubated with and without the ionic CM ioxaglate and the nonionic CM iodixanol at 37 degrees C for 5 min, without or with stirring. ...

journal_title：Thrombosis and haemostasis

authors： Ji Q,Ghaly M,Hjemdahl P,Tornvall P,Li N

更新日期：2005-05-01 00:00:00

abstract：:A method is described for the purification of antiactivator from bovine euglobulin-free serum by means of gelfiltration and ion exchange chromatography. The purified antiactivator has no antifibrinolytic activity. It has a molecular weight of about 115,000 and it appears to be a gamma globulin. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nanninga LB,Guest MM

更新日期：1979-10-31 00:00:00

abstract：:Central venous access devices are often essential for the administration of chemotherapy to patients with malignancy, but its use has been associated with a number of complications, mainly thrombosis. The true incidence of upper extremity deep vein thrombosis (DVT) in this setting is difficult to estimate since there ...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Alastrue A,Rull M,Mira X,Muxart J,Rosell R,Abad A

更新日期：1996-02-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) include lupus-type anticoagulant (LA) and antibodies recognizing complexes of anionic phospholipids (e.g. cardiolipin) and proteins (e.g. prothrombin and beta2-glycoprotein I). The presence of APA is associated with an increased risk of both arterial and venous thrombosis. How...

journal_title：Thrombosis and haemostasis

authors： Musiał J,Swadźba J,Jankowski M,Grzywacz M,Bazan-Socha S,Szczeklik A

更新日期：1997-10-01 00:00:00

abstract：:Congenital afibrinogenemia and severe hypofibrinogenemia are severe bleeding disorders characterized by either undetectable or very low levels of fibrinogen in patients' plasma and platelets. A majority of the reported cases are caused by mutations in the fibrinogen Aalpha chain. In this study, we identified a genetic...

journal_title：Thrombosis and haemostasis

authors： Xu X,Wu J,Zhai Z,Zhou R,Wang X,Wang H,Ding K,Sun Z,Ni H

更新日期：2006-06-01 00:00:00

abstract：:The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic ris...

journal_title：Thrombosis and haemostasis

authors： Kirkeby A,Torup L,Bochsen L,Kjalke M,Abel K,Theilgaard-Monch K,Johansson PI,Bjørn SE,Gerwien J,Leist M

更新日期：2008-04-01 00:00:00

abstract：:The structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IVA and lipid X, as well as monophosphoryl lipid A and ac...

journal_title：Thrombosis and haemostasis

authors： Moldow CF,Bach RR,Staskus K,Rick PD

更新日期：1993-10-18 00:00:00

abstract：:Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containi...

journal_title：Thrombosis and haemostasis

authors： Kemmeren JM,Algra A,Meijers JC,Bouma BN,Grobbee DE

更新日期：2002-02-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a central concern in the intensive care unit (ICU). However, little is known about both current practices for VTE prevention in the ICU and the risk for VTE in persons with severe sepsis and septic shock. XPRESS was a randomized, double-blind, placebo-controlled trial of prophylactic he...

journal_title：Thrombosis and haemostasis

authors： Shorr AF,Williams MD

更新日期：2009-01-01 00:00:00

abstract：:Staphylokinase is a potent highly fibrin-selective thrombolytic agent, but it induces a humoral immune response in most treated patients. Staphylokinase-specific T-lymphocytes can be found in normal healthy individuals, from whom a large panel of staphylokinase-specific T-cells were cloned. The staphylokinase amino ac...

journal_title：Thrombosis and haemostasis

authors： Warmerdam PA,Plaisance S,Vanderlick K,Vandervoort P,Brepoels K,Collen D,De Maeyer M

更新日期：2002-04-01 00:00:00

abstract：:Previous studies have reported that the platelets of healthy term neonates have either diminished or normal reactivity compared to the platelets of adults. To circumvent the methodologic problems of previous studies, we used a whole blood flow cytometric method to study neonatal platelet reactivity to thrombin, a comb...

journal_title：Thrombosis and haemostasis

authors： Rajasekhar D,Kestin AS,Bednarek FJ,Ellis PA,Barnard MR,Michelson AD

更新日期：1994-12-01 00:00:00

abstract：:The generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen...

journal_title：Thrombosis and haemostasis

authors： Koppensteiner R,Speiser W,Minar E,Ahmadi R,Ehringer H

更新日期：1990-10-22 00:00:00

abstract：:Given conflicting data on temporal variability in pharmacodynamic platelet responses to clopidogrel, we investigated platelet reactivity on clopidogrel and aspirin for up to six months after elective percutaneous coronary intervention (PCI) with drug-eluting stents. Platelet reactivity was determined in 102 patients b...

journal_title：Thrombosis and haemostasis

authors： Nührenberg TG,Stratz C,Leggewie S,Hochholzer W,Valina CM,Gick M,Kirtane AJ,Stone GW,Neumann FJ,Trenk D

更新日期：2015-11-01 00:00:00