Ionomycin-stimulated arachidonic acid release in human platelets: a role for protein kinase C and tyrosine phosphorylation.

abstract：:In 70-80% of cases, pulmonary embolism is the consequence of lower extremity deep vein thrombosis. It has been demonstrated that the most common coagulation defect predisposing to venous thrombosis, resistance to activated protein C (APC), is not associated with an increased risk for pulmonary embolism, but the eviden...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Panzeri D,Mannucci PM

更新日期：1997-03-01 00:00:00

abstract：:Pulmonary embolism (PE) may encompass a wide spectrum of severity. To determine whether clinical findings, D-dimer (DD) concentration, and deep vein thrombosis (DVT) shown by lower-limb venous compression ultrasonography (US) might predict the scintigraphic extent of PE, we studied 104 hemodynamically stable consecuti...

journal_title：Thrombosis and haemostasis

authors： Galle C,Papazyan JP,Miron MJ,Slosman D,Bounameaux H,Perrier A

更新日期：2001-11-01 00:00:00

abstract：:Patients with diabetes display increased platelet activation. Recent data show a markedly increased risk for cardiovascular events already in pre-diabetic individuals with impaired glucose tolerance (IGT). We investigated whether IGT is associated with platelet activation. Blood samples were collected from young lean ...

journal_title：Thrombosis and haemostasis

authors： Schäfer A,Widder J,Eigenthaler M,Bischoff H,Ertl G,Bauersachs J

更新日期：2004-07-01 00:00:00

abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

journal_title：Thrombosis and haemostasis

authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

更新日期：2010-03-01 00:00:00

abstract：:Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tiss...

journal_title：Thrombosis and haemostasis

authors： Antoniak S,Sparkenbaugh E,Pawlinski R

更新日期：2014-11-01 00:00:00

abstract：:The aim of this study was to evaluate the existence of an additive effect between standard heparin and dDAVP in the enhancement of endogenous fibrinolysis. Eight healthy volunteers were studied in a randomized double blind placebo controlled cross-over trial. The volunteers were treated i.v. with dDAVP, 0.4 micrograms...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Levi M,Cosmi B,ten Cate JW,Nenci GG

更新日期：1989-06-30 00:00:00

abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

journal_title：Thrombosis and haemostasis

authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

更新日期：2013-12-01 00:00:00

abstract：:Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could pl...

journal_title：Thrombosis and haemostasis

authors： Leoncini G,Bruzzese D,Signorello MG,Armani U,Piana A,Ghiglione D,Camicione P

更新日期：2007-02-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which have been defined by varying laboratory test systems. Lupus anticoagulants (LA) and anticardiolipin antibodies (ACA) are the two most prominent members of this family of antibodies. LA are detected utilizing various phospholipid (PL) depen...

journal_title：Thrombosis and haemostasis

authors： Triplett DA

更新日期：1995-07-01 00:00:00

abstract：:The simultaneous additon of suboptimal concentrations of factor VIII and intact or plasmin-lysed fibrinogen into mixtures of the vitamin K dependent factors, phospholipids, adsorbed bovine serum (supplier to factor V) and calcium, increased the amount of thrombin which was generated three to twenty times over the sum ...

journal_title：Thrombosis and haemostasis

authors： Triantaphyllopoulos DC,Ryan LT

更新日期：1976-04-30 00:00:00

abstract：:Hemophilia B is a sex-linked recessive bleeding disorder characterized by the presence of either a decreased amount of normal factor IX (FIX) or the presence of a dysfunctional FIX. We have identified a unique mutation in a family with mild hemophilia B. DNA analysis of family members revealed a single base transition...

journal_title：Thrombosis and haemostasis

authors： Lefkowitz JB,Nuss R,Haver T,Jacobson L,Thompson AR,Manco-Johnson M

更新日期：2001-09-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:Mice with a total deficiency in blood coagulation Factor X (FX) were generated by targeted replacement of an 18-kb fragment of the FX gene, comprising all exons encoding the mature FX protein, with a neo(r) cassette. The genotype distribution among the offspring from heterozygous breeding pairs suggested that FX defic...

journal_title：Thrombosis and haemostasis

authors： Dewerchin M,Liang Z,Moons L,Carmeliet P,Castellino FJ,Collen D,Rosen ED

更新日期：2000-02-01 00:00:00

abstract：:The redistribution of platelet glycoproteins (GP) Ib, IIb and IIIa in response to stimulation with human platelet specific alloantibodies, autoantibodies and a quinidine-dependent antibody was investigated using immunofluorescence and a quantitative radioimmunoassay. The platelet GPs carrying the corresponding epitope...

journal_title：Thrombosis and haemostasis

authors： Santoso S,Kiefel V,Mueller-Eckhardt C

更新日期：1987-10-28 00:00:00

abstract：:The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic ris...

journal_title：Thrombosis and haemostasis

authors： Kirkeby A,Torup L,Bochsen L,Kjalke M,Abel K,Theilgaard-Monch K,Johansson PI,Bjørn SE,Gerwien J,Leist M

更新日期：2008-04-01 00:00:00

abstract：:The amino acid sequence of the subunit of human platelet factor 4 has been determined. Human platelet factor 4 consists of identical subunits containing 70 amino acids, each with a molecular weight of 7,756. The molecule contains no methionine, phenylalanine or tryptophan. The proposed amino acid sequence of PF4 is: G...

journal_title：Thrombosis and haemostasis

authors： Morgan FJ,Begg GS,Chesterman CN

更新日期：1980-02-29 00:00:00

abstract：:Outcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y12 receptor inhibitors like prasugrel. While most of the ischaemic risk reduction for prasugrel versus clopidogrel was demonstrated in the early treatment pe...

journal_title：Thrombosis and haemostasis

authors： Sibbing D,Aradi D,Jacobshagen C,Gross L,Trenk D,Geisler T,Orban M,Gori T,Hadamitzky M,Merkely B,Kiss RG,Komócsi A,Dézsi CA,Thalmeier A,Löw A,Holdt L,Teupser D,Ince H,Felix SB,Parma R,Malek L,Horstkotte J,Bayla

更新日期：2017-01-05 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:Staphylokinase is a potent highly fibrin-selective thrombolytic agent, but it induces a humoral immune response in most treated patients. Staphylokinase-specific T-lymphocytes can be found in normal healthy individuals, from whom a large panel of staphylokinase-specific T-cells were cloned. The staphylokinase amino ac...

journal_title：Thrombosis and haemostasis

authors： Warmerdam PA,Plaisance S,Vanderlick K,Vandervoort P,Brepoels K,Collen D,De Maeyer M

更新日期：2002-04-01 00:00:00

abstract：:The clinical severity in some patients with haemophilia A appears to be unrelated to the levels of factor (F)VIII activity (FVIII:C), but mechanisms are poorly understood. We have investigated a patient with a FVIII gene mutation at Arg1781 to His (R1781H) presenting with a mild phenotype despite FVIII:C of 0.9 IU/dl....

journal_title：Thrombosis and haemostasis

authors： Yada K,Nogami K,Wakabayashi H,Fay PJ,Shima M

更新日期：2013-06-01 00:00:00

abstract：:Patterns of VIIIR:AG in the plasma and its fractions, cryoprecipitate and cryosupernatant, from various types of von Willebrand's disease (vWd) were observed by SDS 1.5% polyacrylamide gel electrophoresis - cross immunoelectrophoresis (SDS PAGE - CIE). VIIIR:AG in normal cryoprecipitate showed several precipitin peaks...

journal_title：Thrombosis and haemostasis

authors： Mikami S,Takahashi Y,Nishino M,Okubo Y,Fukui H

更新日期：1981-06-30 00:00:00

abstract：:Fourteen patients diagnosed as having thrombotic thrombocytopenia purpura (TTP) were studied. Those who survived have been followed during a 1 to 7 year period. The clinical diagnosis was based on changing neurological findings, thrombocytopenia and evidence of microangiopathic hemolytic anemia. Laboratory tests inclu...

journal_title：Thrombosis and haemostasis

authors： Chediak J,Eldridge J,Bergmann F,Sobel D,Baron J,Maxey B,Telfer MC

更新日期：1988-08-30 00:00:00

abstract：:Autoantibodies to the zwitterionic phospholipid (PL), phosphatidylethanolamine (PE) have been described in patients with thrombotic diseases. Recently, we reported that many antiphosphatidylethanolamine antibodies (aPE) are not specific for PE per se, but are directed to plasma proteins which can bind PE, for example,...

journal_title：Thrombosis and haemostasis

authors： Sugi T,Mclntyre JA

更新日期：1996-09-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:The characterization of mutations in von Willebrand disease provides useful insight into the synthesis, structure, and function of von Willebrand factor. This growing body of information has prompted a reclassification of vWD types that is intended to reflect distinct pathophysiologic mechanisms. Despite this apparent...

journal_title：Thrombosis and haemostasis

authors： Sadler JE,Matsushita T,Dong Z,Tuley EA,Westfield LA

更新日期：1995-07-01 00:00:00

abstract：:Intraoperative high-dose aprotinin administration has been shown to reduce the intra-and postoperative blood loss in cardiac surgery. The haemostatic effect has been attributed to platelet preserving properties and to inhibition of contact activation reducing thrombotic and fibrinolytic activity during and after cardi...

journal_title：Thrombosis and haemostasis

authors： Spannagl M,Dooijewaard G,Dietrich W,Kluft C

更新日期：1995-05-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) activity in blood and blood plasma has been difficult to determine because it is unstable, especially in subjects with high levels of plasminogen activator inhibitor type 1 (PAI-1). We have attempted to stabilize the tPA activity by collecting 9 volumes of blood in 1 volume acidic ci...

journal_title：Thrombosis and haemostasis

authors： Rånby M,Sundell IB,Nilsson TK

更新日期：1989-11-24 00:00:00

abstract：:Haemophilia A and B are X-linked disorders which are due to a reduced activity of coagulation factor VIII or IX, respectively. Female carriers have a wide range of plasma concentration of factor VIII or factor IX, and may in rare cases have an affected phenotype. In order to investigate if this variation is related to...

journal_title：Thrombosis and haemostasis

authors： Orstavik KH,Scheibel E,Ingerslev J,Schwartz M

更新日期：2000-03-01 00:00:00

abstract：:Human endothelial cells isolated from umbilical cords were solubilized in Triton X-100 and examined by crossed immunoelectrophoresis using rabbit antiserum against endothelial cells. Endogenous labelling of the endothelial cell proteins with 14C-mannose followed by crossed immunoelectrophoresis and autoradiography rev...

journal_title：Thrombosis and haemostasis

authors： Børsum T

更新日期：1990-04-12 00:00:00

abstract：:Forty-eight patients with acute proximal deep vein thrombosis (DVT) were randomised to intravenous infusions for 4 to 6 days with melagatran, a novel synthetic low molecular weight thrombin inhibitor, or unfractionated heparin adjusted by the activated partial thromboplastin time (APTT). The aim of the study was to in...

journal_title：Thrombosis and haemostasis

authors： Eriksson H,Eriksson UG,Frison L,Hansson PO,Held P,Holmström M,Hägg A,Jonsson T,Lapidus L,Leijd B,Stockelberg D,Säfwenberg U,Taghavi A,Thorsén M

更新日期：1999-03-01 00:00:00