Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. A randomised cross-over trial.

abstract：:Human platelets have unique and reproducible mRNA profiles, with evidence for distinct profiles in haematopoietic stem cell disorders associated with thrombocytosis. Platelet transcript profiling is traditionally studied by microarray analysis, quantitative reverse transcription-PCR or serial analysis of gene expressi...

journal_title：Thrombosis and haemostasis

authors： Gnatenko DV,Zhu W,Bahou WF

更新日期：2008-11-01 00:00:00

abstract：:Tissue factor (TF) plays a pivotal role in thrombus formation and atherogenesis in acute coronary syndrome. Tissue factor pathway inhibitor (TFPI) is a specific physiological inhibitor of TF/FVIIa complex that regulates TF-induced coagulation. Adiponectin (Adp) is an adipocyte-specific adipocytokine with anti-atheroge...

journal_title：Thrombosis and haemostasis

authors： Chen YJ,Zhang LQ,Wang GP,Zeng H,Lü B,Shen XL,Jiang ZP,Chen FP

更新日期：2008-08-01 00:00:00

abstract：:Duplex ultrasound is the first-line diagnostic test for detecting lower limb deep-vein thrombosis (DVT) but it is time consuming, requires patient transport, and cannot be interpreted by most physicians. The accuracy of emergency physician-performed ultrasound (EPPU) for the diagnosis of DVT, when performed at the bed...

journal_title：Thrombosis and haemostasis

authors： Pomero F,Dentali F,Borretta V,Bonzini M,Melchio R,Douketis JD,Fenoglio LM

更新日期：2013-01-01 00:00:00

abstract：:We have established a new analytical method which allows the characterization of von Willebrand factor (vWF) degradation fragments in minute amounts (10 microliters) of plasma, without the need for immunopurification of vWF. Plasma vWF was hydrolysed by S aureus V-8 protease (V-8 protease) and the cleaved fragments se...

journal_title：Thrombosis and haemostasis

authors： Takahashi Y,Kalafatis M,Girma JP,Meyer D

更新日期：1988-12-22 00:00:00

abstract：:The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively ac...

journal_title：Thrombosis and haemostasis

authors： Ong SB,Hall AR,Dongworth RK,Kalkhoran S,Pyakurel A,Scorrano L,Hausenloy DJ

更新日期：2015-03-01 00:00:00

abstract：:Tissue factor (TF) is the blood coagulation initiator, whose cofactor function is required for physiological factor VIIa (FVIIa)-mediated activation of factor X (FX) to FXa. A previous study reported TF on herpes simplex virus type 1 (HSV1), but this explained only part of FVIIa-dependent FXa generation observed on th...

journal_title：Thrombosis and haemostasis

authors： Sutherland MR,Friedman HM,Pryzdial EL

更新日期：2004-11-01 00:00:00

abstract：:Thromboembolic complications have been attributed to the use of radiographic contrast media (CM) during interventional procedures for arterial revascularization. However, due to the low frequency of adverse events, comparisons between different CM have been difficult to perform, although it has been suggested that ion...

journal_title：Thrombosis and haemostasis

authors： Markou CP,Chronos NA,Hanson SR

更新日期：2001-03-01 00:00:00

abstract：:Worldwide, haemophilia is the most common hereditary bleeding disorder. The incidence of haemophilia B, however, is considerably less than haemophilia A and consequently appears to have received less attention in the research literature. This article aims to summarise the available evidence documenting the patient and...

journal_title：Thrombosis and haemostasis

authors： Gater A,Thomson TA,Strandberg-Larsen M

更新日期：2011-09-01 00:00:00

abstract：:We investigated the molecular basis for factor VII (FVII) deficiency in Israel and found that 13 patients were homozygous and 10 heterozygous for a C to T substitution at nucleotide 10648 of the FVII gene. This predicted an Ala244Val change and was associated with decreased FVII activity and antigen level. Of the 36 A...

journal_title：Thrombosis and haemostasis

authors： Tamary H,Fromovich Y,Shalmon L,Reich Z,Dym O,Lanir N,Brenner B,Paz M,Luder AS,Blau O,Korostishevsky M,Zaizov R,Seligsohn U

更新日期：1996-09-01 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

journal_title：Thrombosis and haemostasis

authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

更新日期：1980-02-29 00:00:00

abstract：:We previously reported a monoclonal antibody named IF-43 that specifically recognizes thrombin-modified fibrinogen (desAA- and desAABB- fibrin monomer) bound with fibrinogen or other D(1) domain-containing plasmic fragments such as fragments X,Y, and D(1), but not intact fibrinogen or cross-linked fibrin degradation p...

journal_title：Thrombosis and haemostasis

authors： Nakahara K,Kazahaya Y,Shintani Y,Yamazumi K,Eguchi Y,Koga S,Wada H,Matsuda M

更新日期：2003-05-01 00:00:00

abstract：:During the collection of samples for plasma beta-thromboglobulin (beta-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single beta-TG measurement, blood samples were collected simultaneously from both arms on two separate...

journal_title：Thrombosis and haemostasis

authors： Scarabin PY,Strain L,Ludlam CA,Jones J,Kohner EM

更新日期：1987-04-07 00:00:00

abstract：:Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. T...

journal_title：Thrombosis and haemostasis

authors： Allain JP,Frommel D

更新日期：1976-08-31 00:00:00

abstract：:We studied the recovery pattern of platelet malondialdehyde (MDA) formation after a single intake of various doses of aspirin (ASA). In normal subjects, there were striking differences in the recovery pattern between large doses (1,000 or 500 mg) and small doses (100 or 50 mg) of oral ASA. The 2 day lag phase was pres...

journal_title：Thrombosis and haemostasis

authors： Takayama H,Okuma M,Uchino H

更新日期：1982-08-24 00:00:00

abstract：:We developed an ELISA test to measure the binding of plasma von Willebrand factor (vWF) to arterial microfibrils and compared this interaction to the binding of vWF to collagen under the same conditions. We found that vWF binds to microfibrils in a similar manner as it binds to collagen: the binding was independent of...

journal_title：Thrombosis and haemostasis

authors： Fauvel-Lafève F,Legrand YJ

更新日期：1990-08-13 00:00:00

abstract：:We have studied 155 subjects, 48 normals, 36 diabetics without complications, 44 with complications and 27 patients with macroangiopathy. beta-Thromboglobulin (beta-TG) and platelet factor 4 (PF4) are elevated in the patients groups. There is no correlation between the plasma levels of beta-TG and the stages of either...

journal_title：Thrombosis and haemostasis

authors： Fritschi J,Christe M,Lämmle B,Marbet GA,Berger W,Duckert F

更新日期：1984-12-29 00:00:00

abstract：:Recombinant human factor VIIa (rFVIIa; NovoSeven) is a two-chain activated clotting factor that is used in the treatment of haemophilia. The distribution of radioactivity in male and pregnant and non-pregnant female rats has been examined by whole-body autoradiography (WBA) after single intravenous doses of 125I-radio...

journal_title：Thrombosis and haemostasis

authors： Beeby TL,Chasseaud LF,Taylor T,Thomsen MK

更新日期：1993-09-01 00:00:00

abstract：:Heparin therapy was monitored with the activated partial thromboplastin time (APTT) and with chromogenic substrate assays (factor Xa and factor IIa inhibition) in 100 plasma samples from 47 patients. Heparin concentrations were classified as being below, within or above a defined therapeutic range (TR; 0.2-0.55 units ...

journal_title：Thrombosis and haemostasis

authors： Fey MF,Lang M,Furlan M,Beck EA

更新日期：1987-10-28 00:00:00

abstract：:Inflammation and thrombosis, two processes influencing each other, are involved in the pathogenesis of cerebrovascular disease. We showed that in patients with acute ischaemic stroke circulating platelets are activated and exhausted. To identify whether activated haemostasis might be cause or effect, we investigated t...

journal_title：Thrombosis and haemostasis

authors： Jurk K,Ritter MA,Schriek C,Van Aken H,Droste DW,Ringelstein EB,Kehrel BE

更新日期：2010-06-01 00:00:00

abstract：:Platelets from cattle with the Chediak-Higashi syndrome (CHS) have a platelet dense granule deficiency. One hypothesis for the platelet dense granule deficiency is that the granule is simply not formed in CHS megakaryocytes (MK). Alternative hypotheses include that the granule is assembled in CHS MK but a functional a...

journal_title：Thrombosis and haemostasis

authors： Meyers K,Seachord C

更新日期：1990-10-22 00:00:00

abstract：:Antithrombin (AT) is a native plasma protein that acts as the main inhibitor of enzymes generated by the coagulation cascade. In extreme thrombotic conditions, consumption of plasma AT can make treatment with AT-associated heparin therapies less effective. Supplementation with recombinant human AT (rhAT) has shown pro...

journal_title：Thrombosis and haemostasis

authors： Berry LR,Thong B,Chan AK

更新日期：2009-08-01 00:00:00

abstract：:Over the last few years methods have been developed to assess appearance of thrombin during blood clotting in a clinical setting. This can be achieved either by measurement of the specific thrombin markers or by analysis of the thrombin generation kinetics. Thrombin markers rise following coronary occlusion and, surpr...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A

更新日期：1995-07-01 00:00:00

abstract：:We aimed to determine the association between autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) and prevalent cardiovascular (CV) disease (CVD) as well as markers of CV risk in the general population. Cross-sectional data were obtained from 6649 subjects (age 52.6 ± 10.7 years, 47.4 % male) of the population...

journal_title：Thrombosis and haemostasis

authors： Antiochos P,Marques-Vidal P,Virzi J,Pagano S,Satta N,Bastardot F,Hartley O,Montecucco F,Mach F,Waeber G,Vollenweider P,Vuilleumier N

更新日期：2016-09-27 00:00:00

abstract：:One of the most severe and important complication in the treatment of haemophilia A (HA) patients is the formation of inhibitors. The mechanism that leads to factor (F)VIII inhibitor formation is complicated. Both genetic and environmental factors have been mentioned to play decisive roles. Recently, polymorphisms in ...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Ding Q,Dai J,Wang H,Wang X

更新日期：2012-01-01 00:00:00

abstract：:We tested the response of the fibrinolytic activity and factor VIII-antigen levels to infusion of DDAVP in healthy volunteers and we studied the influence of propranolol and aspirin on this response. After DDAVP, 0.4 microgram/kg in 10 min i.v., the fibrinolytic activity of redissolved euglobulins rose from 179 to 452...

journal_title：Thrombosis and haemostasis

authors： Brommer EJ,Derkx FH,Barrett-Bergshoeff MM,Schalekamp MA

更新日期：1984-02-28 00:00:00

abstract：:Following favourable results from a previous study, a large, multicentre, prospective, case-control study was performed to further assess the incidence of bleeding complications after dental extraction in patients taking oral anticoagulant therapy (OAT). Four hundred fifty-one patients being treated with warfarin who ...

journal_title：Thrombosis and haemostasis

authors： Bacci C,Maglione M,Favero L,Perini A,Di Lenarda R,Berengo M,Zanon E

更新日期：2010-11-01 00:00:00

abstract：:We compared the Ivy bleeding time method and two alternatives of the Simplate II method (incisions in horizontal and vertical direction) with each other, with regard to the sensitivity, the specificity, the costs and the burden for the patient. In the aspirin study an aspirin-induced bleeding defect was used. Seventy-...

journal_title：Thrombosis and haemostasis

authors： Srámek R,Srámek A,Koster T,Briët E,Rosendaal FR

更新日期：1992-05-04 00:00:00

abstract：:A procedure for using citrated fresh plasmas for International Sensitivity Index (ISI) calibration of two types of whole blood point-of-care test (POCT) prothrombin time (PT) monitor systems has been assessed in a multicentre study. The CoaguChek Mini and TAS PT-NC systems gave higher ISI with whole blood samples than...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Chauhan N,van den Besselaar AM,Tripodi A,Shiach C,Jespersen J,European Concerted Action on Anticoagulation Steering Group Members.

更新日期：2002-05-01 00:00:00

abstract：:The effect of additional treatments combined with conventional therapy on pregnancy outcomes was examined in high-risk primary antiphospholipid syndrome (PAPS) patients to identify the most effective treatment strategy. The study's inclusion criteria were (1) positivity to lupus anticoagulant alone or associated with ...

journal_title：Thrombosis and haemostasis

authors： Ruffatti A,Tonello M,Hoxha A,Sciascia S,Cuadrado MJ,Latino JO,Udry S,Reshetnyak T,Costedoat-Chalumeau N,Morel N,Marozio L,Tincani A,Andreoli L,Haladyj E,Meroni PL,Gerosa M,Alijotas-Reig J,Tenti S,Mayer-Pickel K,Simc

更新日期：2018-04-01 00:00:00