Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.

abstract：:The efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused ...

journal_title：Thrombosis and haemostasis

authors： Mojica Muñoz AK,Jamasbi J,Uhland K,Degen H,Münch G,Ungerer M,Brandl R,Megens R,Weber C,Lorenz R,Siess W

更新日期：2017-08-01 00:00:00

abstract：:By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evid...

journal_title：Thrombosis and haemostasis

authors： Hemker HC,Al Dieri R,De Smedt E,Béguin S

更新日期：2006-11-01 00:00:00

abstract：:Per cent aggregation, release and content of adenine nucleotides, and specific radioactivity were evaluated in citrated platelet-rich plasma (PRP) prepared from paired samples of maternal and cord blood. Platelets of newborn infants aggregated normally in response to highdose ADP (20 muM), strong collagen suspensions,...

journal_title：Thrombosis and haemostasis

authors： Corby DG,Zuck TF

更新日期：1976-08-31 00:00:00

abstract：:Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

journal_title：Thrombosis and haemostasis

authors： Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

更新日期：2012-11-01 00:00:00

abstract：:Recent clinical studies have shown that the interruption of platelet function appears to be effective for treatment of coronary occlusive diseases. For this purpose, a Fab fragment of humanized anti-platelet glycoprotein (GP) IIb/IIIa monoclonal antibody (YM 337) that exhibited an in vivo antithrombotic effect without...

journal_title：Thrombosis and haemostasis

authors： Kuwahara M,Sugimoto M,Tsuji S,Miyata S,Nishio K,Kaku S,Suzuki K,Kawasaki T,Yoshioka A

更新日期：1998-07-01 00:00:00

abstract：:Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objec...

journal_title：Thrombosis and haemostasis

authors： Burchall GF,Piva TJ,Ranasinha S,Teede HJ

更新日期：2017-11-01 00:00:00

abstract：:Current thrombolytic strategies have a number of important shortcomings including resistance to recanalization and development of acute reocclusion. The purpose of this study was to investigate whether the lysis of venous thrombi by streptokinase could be enhanced by SR 46349, a novel 5-HT2 receptor antagonist, or clo...

journal_title：Thrombosis and haemostasis

authors： Herbert JM,Bernat A,Sainte-Marie M,Dol F,Rinaldi M

更新日期：1993-03-01 00:00:00

abstract：:Fibrinolytic therapy can result in rapid lysis of deep vein thrombi (DVT), but its use is limited by the failure of many patients to respond and by the increased risk of bleeding complications in comparison with anticoagulant therapy alone. Treatment could be improved by the ability to select patients most likely to r...

journal_title：Thrombosis and haemostasis

authors： Francis CW,Totterman S

更新日期：1995-03-01 00:00:00

abstract：:An international collaborative study involving seven laboratories was undertaken to assess the suitability of a freeze-dried preparation of human plasmin to replace the current International Reference Preparation (IRP) for plasmin. Chromogenic and fibrinolytic assays were used by all participating laboratories to asse...

journal_title：Thrombosis and haemostasis

authors： Gaffney PJ,Mussett MV

更新日期：1983-10-31 00:00:00

abstract：:Inhibition of adenylate cyclase in intact platelets by addition of compounds such as 2', 5' - dideoxyadenosine prevented the inhibition of platelet aggregation by PGE1 but did not affect the responses of platelets to aggregating agents in the absence of PGE1. This confirms that cyclic AMP mediates the effects of PGE1 ...

journal_title：Thrombosis and haemostasis

authors： Haslam RJ,Davidson MM,Fox JE,Lynham JA

更新日期：1978-10-31 00:00:00

abstract：:The novel fast inhibitor to tissue plasminogen activator in plasma has been determined in 20 healthy non-pregnant women, 48 apparently healthy pregnant women and 136 women with risk pregnancies (preeclampsia, suspected fetal growth retardation, thrombosis or previous history of thrombosis, diabetes and others). In hea...

journal_title：Thrombosis and haemostasis

authors： Wiman B,Csemiczky G,Marsk L,Robbe H

更新日期：1984-10-31 00:00:00

abstract：:Laboratory diagnosis of antiphospholipid antibodies is important in patients with clinical features of the antiphospholipid syndrome, such as thrombosis and fetal loss. We have developed a novel method for the detection of antiphospholipid antibodies using flow cytometry. Anionic phospholipids cardiolipin, phosphatidy...

journal_title：Thrombosis and haemostasis

authors： Stewart MW,Etches WS,Russell AS,Percy JS,Johnston CA,Chew CK,Gordon PA

更新日期：1993-10-18 00:00:00

abstract：:The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factor VII (FVII) deficiency. The results of 12 consecutive surgical...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Tjønnfjord GE,Wallensten R,Martinowitz U,Kenet G

更新日期：2005-12-01 00:00:00

abstract：:Parameters of the fibrinolytic system were studied in a primate model where the generation of thrombin was promoted in vivo. The procoagulant stimulus used was a combination of human factor Xa in combination with phosphatidylcholine/phosphatidylserine lipid vesicles (PCPS) as the source of coagulant active phospholipi...

journal_title：Thrombosis and haemostasis

authors： Giles AR,Nesheim ME,Herring SW,Hoogendoorn H,Stump DC,Heldebrant CM

更新日期：1990-06-28 00:00:00

abstract：:In patients with von Willebrand disease (VWD) replacement therapy with factor VIII/von Willebrand (VWF) concentrates is increasingly applied as prophylactic regimen. Since 2000, 82 consecutively enrolled patients with clinically relevant bleeding episodes (spontaneous, peri- or postoperative) were diagnosed with VWD [...

journal_title：Thrombosis and haemostasis

authors： Halimeh S,Krümpel A,Rott H,Bogdanova N,Budde U,Manner D,Faeser B,Mesters R,Nowak-Göttl U

更新日期：2011-04-01 00:00:00

abstract：:The prevention and treatment of venous thromboembolism (VTE) remains a clinical challenge, primarily owing to drawbacks associated with the use of heparins and vitamin K antagonists (VKAs). These and other factors, including a growing elderly population, mean that VTE presents a continuing burden to patients and physi...

journal_title：Thrombosis and haemostasis

authors： Beyer-Westendorf J,Ageno W

更新日期：2015-02-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein however the mechanisms by which Lp(a) promote the atherosclerotic process are not clear. The apolipoprotein(a) portion of Lp(a) shares partial homology with plasminogen, a finding that has stimulated numerous studies. Lp(a) binds to fibrin and the affinity between f...

journal_title：Thrombosis and haemostasis

authors： Harpel PC,Hermann A,Zhang X,Ostfeld I,Borth W

更新日期：1995-07-01 00:00:00

abstract：:Platelet-rich clots are inefficiently lysed by current fibrinolytic agents. Platelets contain a great deal of plasminogen activator inhibitor 1 (PAI-1), the principal endogenous inhibitor of tissue-type plasminogen activator (t-PA). We have tested whether PAI-1 resistant t-PAs would be more effective thrombolytic agen...

journal_title：Thrombosis and haemostasis

authors： Shohet RV,Spitzer S,Madison EL,Bassel-Duby R,Gething MJ,Sambrook JF

更新日期：1994-01-01 00:00:00

abstract：:The aim of this study was to evaluate the thrombolytic activity of two hybrid plasminogen activators (HPAs) in a rabbit jugular vein thrombosis model. In the two HPAs the kringle-2 domain (K2tu-PA) or the finger and the kringle-2 domains (FK2tu-PA) of tissue-type plasminogen activator (t-PA) are linked to the catalyti...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Pascucci C,Colucci M,Nenci GG,Mele A,Bürgi R,Heim J

更新日期：1992-09-07 00:00:00

abstract：:A technique has been developed to monitor the development of thrombin in freshly collected whole blood in the absence of anticoagulants. It is based on the centrifugal separation of the cellular components from subsamples of blood drawn from non-anticoagulated clotting whole blood which are diluted in buffer containin...

journal_title：Thrombosis and haemostasis

authors： Kessels H,Béguin S,Andree H,Hemker HC

更新日期：1994-07-01 00:00:00

abstract：:The effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were ...

journal_title：Thrombosis and haemostasis

authors： Davies T,Fieldhouse G,McNicol GP

更新日期：1976-04-30 00:00:00

abstract：BACKGROUND: Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors...

journal_title：Thrombosis and haemostasis

authors： Coelho-Lima J,Mohammed A,Cormack S,Jones S,Das R,Egred M,Panahi P,Ali S,Spyridopoulos I

更新日期：2018-07-01 00:00:00

abstract：:Interactions between proteins and heparin(-like) structures involve electrostatic forces and structural features. Based on charge distributions in the linear sequence of protein C inhibitor (PCI), two positively charged regions of PCI were proposed as possible candidates for this interaction. The first region, the A+ ...

journal_title：Thrombosis and haemostasis

authors： Elisen MG,Maseland MH,Church FC,Bouma BN,Meijers JC

更新日期：1996-05-01 00:00:00

abstract：:Using an in vitro model of clot lysis, the individual response to a pharmacological concentration of recombinant tissue plasminogen activator (rt-PA) and the influence on this response of the physiological variations of blood parameters known to interfere with the fibrinolytic/thrombolytic process were investigated in...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Scopece S,Gelato AV,Dimonte D,Semeraro N

更新日期：1997-04-01 00:00:00

abstract：:It was found that the effect of heparin on the amidase activity of urokinase (E C 3.4.21.31), plasmin (E C 3.4.21.7) and trypsin (E C 3.4.21.4) depended on the substrate used. No effect of heparin on the amidase activity of urokinase and trypsin was observed when Pyro Glu-Gly-Arg-p-nitroanilide (S-2444) and alpha-N-ac...

journal_title：Thrombosis and haemostasis

authors： Yomtova VM,Stambolieva NA,Blagoev BM

更新日期：1983-06-28 00:00:00

abstract：:Herpes simplex virus (HSV) infection is histopathologically associated with vascular injury, fibrinoid necrosis and inflammatory cell infiltrates. We have previously shown in vitro that HSV infection of human umbilical vein endothelial cells (HUVEC) promotes a procoagulant phenotype manifest by the induction of tissue...

journal_title：Thrombosis and haemostasis

authors： Bok RA,Jacob HS,Balla J,Juckett M,Stella T,Shatos MA,Vercellotti GM

更新日期：1993-03-01 00:00:00

abstract：:In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go...

journal_title：Thrombosis and haemostasis

authors： Montes R,Puy C,Molina E,Hermida J

更新日期：2012-05-01 00:00:00

abstract：:Obesity and non-insulin dependent diabetes are associated with a decrease in fibrinolysis, which is mediated by the plasminogen system. The purpose of the current study was to investigate the role of the plasminogen system in the reduced body weight of the plasminogen deficient (Plg-/-) mice. In this study we have fou...

journal_title：Thrombosis and haemostasis

authors： Hoover-Plow J,Ellis J,Yuen L

更新日期：2002-06-01 00:00:00

abstract：:We previously reported that antithrombin (AT) reduced ischemia/reperfusion (I/R)-induced liver injury in rats by increasing endothelial production of prostacyclin (PGI2). However, the mechanism(s) underlying this phenomenon remains to be fully elucidated. We also demonstrated that activation of capsaicin-sensitive sen...

journal_title：Thrombosis and haemostasis

authors： Harada N,Okajima K,Yuksel M,Isobe H

更新日期：2005-01-01 00:00:00

abstract：:Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better the...

journal_title：Thrombosis and haemostasis

authors： Schouten M,van 't Veer C,Roelofs JJ,Gerlitz B,Grinnell BW,Levi M,van der Poll T

更新日期：2011-12-01 00:00:00