Kinetic study of the effect of heparin on the amidase activity of trypsin, plasmin and urokinase.

abstract：:In a previous report we found an inverse correlation between pre-operative platelet count (PlC) levels and the risk of post-operative pulmonary embolism in patients undergoing hip surgery. In the present study, we prospectively evaluated the prognostic significance of pre-operative PlC levels on survival in 180 consec...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Fernandez-Llamazares J,Piñol M,Julian JF,Broggi M,Escola D,Abad A

更新日期：1998-05-01 00:00:00

abstract：:D-dimer, a degradation product of fibrin, is being increasingly used as a marker and prognostic factor in various thrombotic diseases. Previous reports have shown that obstructive sleep apnea is associated with platelet activation and hypercoagulability. The aim of the study was to assess the potential role of the pla...

journal_title：Thrombosis and haemostasis

authors： Shitrit D,Peled N,Shitrit AB,Meidan S,Bendayan D,Sahar G,Kramer MR

更新日期：2005-09-01 00:00:00

abstract：:We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC (50) of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidase...

journal_title：Thrombosis and haemostasis

authors： Wang YX,Zhao L,Nagashima M,Vincelette J,Sukovich D,Li W,Subramanyam B,Yuan S,Emayan K,Islam I,Hrvatin P,Bryant J,Light DR,Vergona R,Morser J,Buckman BO

更新日期：2007-01-01 00:00:00

abstract：:Increased plasma plasminogen activator inhibitor-1 (PAI-1) has been implicated in the development of vascular disease. In type 2 diabetes mellitus high PAI-1 levels are associated with increased plasma concentrations of free fatty acids (FFA) and triacylglycerol indicating an association or a causal relationship. To a...

journal_title：Thrombosis and haemostasis

authors： Krebs M,Geiger M,Polak K,Vales A,Schmetterer L,Wagner OF,Waldhäusl W,Binder BR,Roden M

更新日期：2003-09-01 00:00:00

abstract：:Tissue plasminogen activator labeled with radioactive iodine (125I-tPA) was immobilized on vascular prostheses chemically modified with a thin coating of water-insoluble surfactant, tridodecylmethylammonium chloride (TDMAC). Surfactant-treated Dacron, polytetrafluoroethylene (PTFE), silastic, polyethylene and polyuret...

journal_title：Thrombosis and haemostasis

authors： Harvey RA,Kim HC,Pincus J,Trooskin SZ,Wilcox JN,Greco RS

更新日期：1989-02-28 00:00:00

abstract：:We tested the response of the fibrinolytic activity and factor VIII-antigen levels to infusion of DDAVP in healthy volunteers and we studied the influence of propranolol and aspirin on this response. After DDAVP, 0.4 microgram/kg in 10 min i.v., the fibrinolytic activity of redissolved euglobulins rose from 179 to 452...

journal_title：Thrombosis and haemostasis

authors： Brommer EJ,Derkx FH,Barrett-Bergshoeff MM,Schalekamp MA

更新日期：1984-02-28 00:00:00

abstract：:Lysosomal Associated Membrane Protein-2 (LAMP-2) is an inherent component of lysosomal granule membranes in diverse cell types, including platelets. We examined platelets for evidence of LAMP-2 in dense granule membranes as CD63 has previously been shown to be present in both lysosomal and dense granule membranes. Imm...

journal_title：Thrombosis and haemostasis

authors： Israels SJ,McMillan EM,Robertson C,Singhory S,McNicol A

更新日期：1996-04-01 00:00:00

abstract：:Although intravital microscopy models of thrombosis in mice have contributed to dissect the mechanisms of thrombus formation and stability, they have not been well adapted to study long-term evolution of occlusive thrombi. Here, we assessed the suitability of the dorsal skinfold chamber (DSC) for the study of thrombol...

journal_title：Thrombosis and haemostasis

authors： Boulaftali Y,Lamrani L,Rouzaud MC,Loyau S,Jandrot-Perrus M,Bouton MC,Ho-Tin-Noé B

更新日期：2012-05-01 00:00:00

abstract：:Pharmaceutical grade heparins from porcine intestine and bovine lung consist mainly of repeating tri-sulfated units, of the disaccharide →4-α-IdoA2S-1→4-α-GlcNS6S-1→. Heparin preparations from bovine intestine, in contrast, are more heterogeneous. Nuclear magnetic resonance (NMR) and disaccharide analysis after hepari...

journal_title：Thrombosis and haemostasis

authors： Tovar AM,Capillé NV,Santos GR,Vairo BC,Oliveira SN,Fonseca RJ,Mourão PA

更新日期：2012-05-01 00:00:00

abstract：STUDY OBJECTIVE:Cytokines increase endothelial tissue factor (TF) and tissue plasminogen activator inhibitor type-1 (PAI-1) expression in vitro. Tissue factor interacts with factor VII to facilitate thrombosis and PAI-1 inhibits fibrinolysis by endogenous plasminogen activators. Because cytokine release is increased in...

journal_title：Thrombosis and haemostasis

authors： Green J,Doughty L,Kaplan SS,Sasser H,Carcillo JA

更新日期：2002-02-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical out...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Touloumenidou T,Sakellari I,Batsis I,Mallouri D,Psomopoulos F,Tsagiopoulou M,Koutra M,Yannaki E,Papalexandri A,Taylor P,Nikolousis E,Stamouli M,Holbro A,Baltadakis I,Liga M,Spyridonidis A,Tsirigotis P,Cha

更新日期：2020-04-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:Previous studies have demonstrated that cell-permeable cytoplasmic tail (CT) alpha(II)beta peptides can modulate the activation of alpha(IIb)b(3). As alpha(V) CT contains an alpha(II)beta homologous region, a series of cell-permeable alpha(V) and alpha(IIb) peptides were generated to determine if alpha(V) CT can modul...

journal_title：Thrombosis and haemostasis

authors： Haas TA

更新日期：2008-01-01 00:00:00

abstract：:Platelet-rich plasma was obtained 24 hr after the race ended from athletes who ran in the London marathon. The platelets were only marginally less sensitive to adrenaline than were those of non-runners using conventional aggregation tests. However, the runners' platelets were much more sensitive to inhibition by prost...

journal_title：Thrombosis and haemostasis

authors： Dix CJ,Hassall DG,Bruckdorfer KR

更新日期：1984-07-29 00:00:00

abstract：:Angiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties. In this r...

journal_title：Thrombosis and haemostasis

authors： Degani H,Chetrit-Dadiani M,Bogin L,Furman-Haran E

更新日期：2003-01-01 00:00:00

abstract：:Using an in vitro model of clot lysis, the individual response to a pharmacological concentration of recombinant tissue plasminogen activator (rt-PA) and the influence on this response of the physiological variations of blood parameters known to interfere with the fibrinolytic/thrombolytic process were investigated in...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Scopece S,Gelato AV,Dimonte D,Semeraro N

更新日期：1997-04-01 00:00:00

abstract：:The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort s...

journal_title：Thrombosis and haemostasis

authors： Lin JN,Chen HJ,Lin MC,Lai CH,Lin HH,Yang CH,Kao CH

更新日期：2016-01-01 00:00:00

abstract：:Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma. Although the substance has a better effect/side-effect profile, especially with regard to teratogenicity and neurotoxicity, the rate of therapy-induced thrombosis seems comparable to thali...

journal_title：Thrombosis and haemostasis

authors： Gieseler F

更新日期：2008-06-01 00:00:00

abstract：:The incidence of newly diagnosed malignancy is increased in patients with unexplained venous thromboembolism during the first year after a thromboembolic event in comparison to controls (odds ratio, 3.9-36). Extensive screening with computed tomography, endoscopy and tumor markers can identify most of these undetected...

journal_title：Thrombosis and haemostasis

authors： Prins MH,Hettiarachchi RJ,Lensing AW,Hirsh J

更新日期：1997-07-01 00:00:00

abstract：:The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a thrombin receptor agonist/activating peptide (TRAP). In this study, Northern blot analysis showed that cultured human vascular smooth muscle cells (HVSMC) expr...

journal_title：Thrombosis and haemostasis

authors： Kanthou C,Benzakour O,Patel G,Deadman J,Kakkar VV,Lupu F

更新日期：1995-11-01 00:00:00

abstract：:Antiphospholipid antibodies are a risk factor for venous and arterial thrombosis and may contribute to the development of atherosclerosis.The aim of this study was to investigate whether antibodies to human beta2-glycoprotein 1 (beta2GP1), as a model of antiphospholipid antibodies, modify the phenotype of atherosclero...

journal_title：Thrombosis and haemostasis

authors： Dunoyer-Geindre S,Kwak BR,Pelli G,Roth I,Satta N,Fish RJ,Reber G,Mach F,Kruithof EK,de Moerloose P

更新日期：2007-01-01 00:00:00

abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

journal_title：Thrombosis and haemostasis

authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

更新日期：1999-09-01 00:00:00

abstract：:Atrial fibrillation (AF) is a common complication of coronary artery bypass grafting (CABG). We sought to determine the diagnostic validity of plasma biomarkers of i) inflammation (marked by interleukin-6 [IL-6] and high-sensitivity C-reactive protein [hs-CRP]), ii) extracellular matrix remodelling (matrix metalloprot...

journal_title：Thrombosis and haemostasis

authors： Kaireviciute D,Blann AD,Balakrishnan B,Lane DA,Patel JV,Uzdavinys G,Norkunas G,Kalinauskas G,Sirvydis V,Aidietis A,Lip GY

更新日期：2010-07-01 00:00:00

abstract：:Monitoring of anti-factor Xa activity is often performed during treatment with low-molecular-weight heparins (LMWHs) in pregnancy because the anticoagulant effect may decrease as pregnancy progresses, but assays for anti-factor Xa activity are unavailable in many clinical institutions caring for pregnant women. Heptes...

journal_title：Thrombosis and haemostasis

authors： Dempfle CE,Zharkowa U,Elmas E,Ahmad-Nejad P,Neumaier M,Borggrefe M

更新日期：2009-11-01 00:00:00

abstract：:Recombinant human factor VIIa (rFVIIa; NovoSeven) is a two-chain activated clotting factor that is used in the treatment of haemophilia. The distribution of radioactivity in male and pregnant and non-pregnant female rats has been examined by whole-body autoradiography (WBA) after single intravenous doses of 125I-radio...

journal_title：Thrombosis and haemostasis

authors： Beeby TL,Chasseaud LF,Taylor T,Thomsen MK

更新日期：1993-09-01 00:00:00

abstract：:Mechanisms mediating initial adsorption of coagulation proteins to live cells were investigated. Adsorption kinetics were examined under varying flow conditions using tracer-dilution techniques in perfused spherical monolayers of cells expressing tissue factor. At biologically relevant time and concentration ranges, r...

journal_title：Thrombosis and haemostasis

authors： McGee MP,Teuschler H

更新日期：1999-07-01 00:00:00

abstract：:Few data are available on thrombophilic risk factors and progression of atherosclerotic peripheral arterial disease (PAD). Thrombophilic alterations can be an aggravating factor when arterial stenoses are present. In a cross-sectional study, we evaluated the presence of the thrombophilic factors fibrinogen, homocystei...

journal_title：Thrombosis and haemostasis

authors： Sartori M,Favaretto E,Legnani C,Cini M,Conti E,Amato A,Palareti G

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA2DS2-VASc score is largely validated and recommended by most guidelines. The GARFIELD-AF Stroke score has been proposed as an alternative risk score. METHODS: We analyzed warfarin-treated patients fro...

journal_title：Thrombosis and haemostasis

authors： Proietti M,Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Lip GYH

更新日期：2020-12-09 00:00:00

abstract：:Antiphospholipid antibody (aPL) is a hallmark of antiphospholipid syndrome (APS), characterized by thrombosis and recurrent fetal loss. We developed a novel ELISA system to detect complement-fixing ability of anticardiolipin antibody (aCL), and evaluated its clinical usefulness through studying the prevalence of the a...

journal_title：Thrombosis and haemostasis

authors： Munakata Y,Saito T,Matsuda K,Seino J,Shibata S,Sasaki T

更新日期：2000-05-01 00:00:00

abstract：:The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and ...

journal_title：Thrombosis and haemostasis

authors： Nagamine Y,Medcalf RL,Muñoz-Cánoves P

更新日期：2005-04-01 00:00:00