Heptest-STAT, a new assay for monitoring of low-molecular-weight heparins, is not influenced by pregnancy-related changes of blood plasma.

abstract：:Monocytes play a central role in the inflammatory disease atherosclerosis. CD14+CD16+ monocytes are considered proinflammatory monocytes, as they have an increased capacity to produce proinflammatory cytokines, such as TNF-alpha, and are elevated in various inflammatory diseases. We hypothesized that patients with cor...

journal_title：Thrombosis and haemostasis

authors： Schlitt A,Heine GH,Blankenberg S,Espinola-Klein C,Dopheide JF,Bickel C,Lackner KJ,Iz M,Meyer J,Darius H,Rupprecht HJ

更新日期：2004-08-01 00:00:00

abstract：:Platelet-monocyte aggregates are increasingly being used to quantify platelet activation. The variables that influence platelet-monocyte aggregates have not been well defined. We sought to determine the effect of blood collection, handling and processing techniques on detected levels of platelet-monocyte aggregates us...

journal_title：Thrombosis and haemostasis

authors： Harding SA,Din JN,Sarma J,Jessop A,Weatherall M,Fox KA,Newby DE

更新日期：2007-08-01 00:00:00

abstract：:In order to detect impaired synthesis of blood coagulation factors associated to consumption coagulopathy, a simultaneous evaluation of factor II-related antigen (II rAg) and of antithrombin III (AT III) was carried out in 16 patients affected with severe defibrination. An in vitro preliminary study on plasma and seru...

journal_title：Thrombosis and haemostasis

authors： Sié P,Letrenne E,Caranobe C,Genestal M,Cathala B,Boneu B

更新日期：1982-06-28 00:00:00

abstract：:Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients w...

journal_title：Thrombosis and haemostasis

authors： Pawlitschek F,Keyl C,Zieger B,Budde U,Beyersdorf F,Neumann FJ,Stratz C,Nührenberg TG,Trenk D

更新日期：2018-01-01 00:00:00

abstract：:Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type...

journal_title：Thrombosis and haemostasis

authors： Hardy AT,Palma-Barqueros V,Watson SK,Malcor JD,Eble JA,Gardiner EE,Blanco JE,Guijarro-Campillo R,Delgado JL,Lozano ML,Teruel-Montoya R,Vicente V,Watson SP,Rivera J,Ferrer-Marín F

更新日期：2018-06-01 00:00:00

abstract：:Bernard-Soulier syndrome is a rare congenital platelet disorder that affects a surface membrane adhesion receptor, glycoprotein (GP) Ib-V-IX. Both the genetic defects and the bleeding diatheses associated with the syndrome are heterogeneous due, in part, to the complexity of the involved receptor which consists of fou...

journal_title：Thrombosis and haemostasis

authors： Li C,Pasquale DN,Roth GJ

更新日期：1996-11-01 00:00:00

abstract：:Elucidation of the molecular defects responsible for antithrombin III deficiency is proceeding rapidly. In order that a record is kept of the new and duplicated mutations that are found, we have compiled a database that we plan to update annually. In this, the first report of the database, we list 6 antithrombin III l...

journal_title：Thrombosis and haemostasis

authors： Lane DA,Ireland H,Olds RJ,Thein SL,Perry DJ,Aiach M

更新日期：1991-12-02 00:00:00

abstract：:It is conceivable that the extent and spatio-temperal expression of dozens or even a few hundred genes are significantly altered during the development and progression of atherosclerosis as compared to normal circumstances. Differential gene expression in vascular cells and in blood cells, due to gene-gene and gene-en...

journal_title：Thrombosis and haemostasis

authors： Monajemi H,Arkenbout EK,Pannekoek H

更新日期：2001-07-01 00:00:00

abstract：:Tridegin is a potent inhibitor of factor XIIIa from the leech, Haementeria ghilianii, which inhibits protein cross-linking. It modifies plasmin-mediated fibrin degradation as shown by the absence of D-dimer and approximately halves the time for fibrinolysis. Plasma clots formed in the presence of Tridegin lyse more ra...

journal_title：Thrombosis and haemostasis

authors： Seale L,Finney S,Sawyer RT,Wallis RB

更新日期：1997-05-01 00:00:00

abstract：:Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) wi...

journal_title：Thrombosis and haemostasis

authors： Furio E,García-Fuster MJ,Redon J,Marques P,Ortega R,Sanz MJ,Piqueras L

更新日期：2018-03-01 00:00:00

abstract：:Heparin is often used as an adjunct to thrombolytic therapy in order to prevent reocclusion of the patent vessels in patients with thrombotic disease. Controversy exists as to whether heparin is required for effective clot lysis with tissue-type plasminogen activator, while in vitro data and small scale clinical trial...

journal_title：Thrombosis and haemostasis

authors： Burke SE,Lubbers NL,Nelson RA,Henkin J

更新日期：1993-04-01 00:00:00

abstract：:We investigated the presence of the gene mutation of factor V, FV R506Q or factor V Leiden, responsible for activated protein C resistance, in DNA samples of 127 probands and 188 relatives from 128 families with antithrombin deficiency. The factor V mutation was identified in 18 families. Nine families were available ...

journal_title：Thrombosis and haemostasis

authors： van Boven HH,Reitsma PH,Rosendaal FR,Bayston TA,Chowdhury V,Bauer KA,Scharrer I,Conard J,Lane DA

更新日期：1996-03-01 00:00:00

abstract：:Staphylokinase (SAK) expresses plasminogen activator (PA) activity by forming a complex with plasmin. The interaction between the plasmin-SAK complex and plasminogen was investigated using synthesized peptides, which were constructed according to the amino acid sequence of the SAK molecule. A synthetic nonadecapeptide...

journal_title：Thrombosis and haemostasis

authors： Okada K,Ueshima S,Matsuno H,Kawao N,Okamoto C,Tanaka M,Matsuo O

更新日期：2007-05-01 00:00:00

abstract：:We evaluated the effect of d-alpha-tocopherol (vitamin E) on the production of prostacyclin (PGI2) by cultured bovine aortic endothelial cells. Vitamin E at physiological doses significantly enhanced the production of PGI2 by aortic endothelial cells when added to the culture simultaneously with histamine, the Ca2+ io...

journal_title：Thrombosis and haemostasis

authors： Kunisaki M,Umeda F,Inoguchi T,Nawata H

更新日期：1992-12-07 00:00:00

abstract：:The increased risk for deep vein thrombosis (DVT) after orthopaedic surgery has been well documented as well as hypercoagulable state during both total hip arthroplasty (THA) and total knee replacement (TKR). To investigate the influence of the surgical procedure [posterolateral (PL) or lateral (L) approach for THA, u...

journal_title：Thrombosis and haemostasis

authors： Fedi S,Gori AM,Falciani M,Cellai AP,Aglietti P,Baldini A,Vena LM,Prisco D,Abbate R,Gensini GF

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND: Factor XI (FXI) deficiency is a rare autosomal bleeding disorder. The rarity of spontaneous bleeding and absence of optimal tools to predict the bleeding risk in FXI-deficient patients hamper the standardization of prophylactic treatment enabling them to undergo major surgeries without blood products. OBJE...

journal_title：Thrombosis and haemostasis

authors： Salomon O,Budnik I,Avishai E,Tamarin I,Bashari D,Dardik R,Livnat T

更新日期：2019-12-01 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:Extensive contact between blood and artificial surfaces causes platelet activation and depletion. The aim of the present study was to test the efficacy of Ro 44-9883, a potent and selective peptidomimetic GPIIb-IIIa antagonist, in preventing platelet loss in guinea pigs undergoing extracorporeal circulation (ECC) with...

journal_title：Thrombosis and haemostasis

authors： Carteaux JP,Steiner B,Roux S

更新日期：1993-11-15 00:00:00

abstract：:The physiologic activation of the plasma kallikrein-kinin system requires the assembly of its constituents on a cell membrane. High- molecular-weight kininogen (HK) and cleaved HK (HKa) both interact with at least three endothelial cell binding proteins: urokinase plasminogen activator receptor (uPAR), globular C1q re...

journal_title：Thrombosis and haemostasis

authors： Pixley RA,Espinola RG,Ghebrehiwet B,Joseph K,Kao A,Bdeir K,Cines DB,Colman RW

更新日期：2011-06-01 00:00:00

abstract：:Several studies have highlighted a specific role for membrane cholesterol domains in platelet signalling. Upon adhesion to von Willebrand factor (VWF) or collagen, cholesterol-rich domains (CRDs) accumulate in filopodial extensions and selectively harbour counterpart receptors (GPIb and GPVI) and associated signalling...

journal_title：Thrombosis and haemostasis

authors： van Lier M,Verhoef S,Cauwenberghs S,Heemskerk JW,Akkerman JW,Heijnen HF

更新日期：2008-06-01 00:00:00

abstract：:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy v...

journal_title：Thrombosis and haemostasis

authors： Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CR

更新日期：1989-04-25 00:00:00

abstract：:Vitamin K-dependent proteins are currently purified from pooled human plasma or produced in mammalian cell culture systems by recombinant DNA technology. Transgenic animals may provide an additional expression system for the production of these therapeutic proteins. Mice have been used to test hybrid genes which direc...

journal_title：Thrombosis and haemostasis

authors： Luboń H,Paleyanda RK

更新日期：1997-07-01 00:00:00

abstract：:Multiple clinical trials have proven that thrombolytic therapy is an effective treatment for acute myocardial infarction. Spontaneous intracranial hemorrhage (ICH) occurs in a small percentage of patients as a result of the treatment. The etiology of the ICH is unknown and there is currently no established experimenta...

journal_title：Thrombosis and haemostasis

authors： Paoni NF,Steinmetz HG,Gillett N,Refino CJ,Badillo JM,Bunting S

更新日期：1996-05-01 00:00:00

abstract：:Deep vein thrombosis (DVT) in children occurs primarily in the upper body venous system. This prospective diagnostic study compared bilateral venography and ultrasound for detection of DVT in the upper venous system in 66 children with acute lymphoblastic leukemia. Results were interpreted by central blinded adjudicat...

journal_title：Thrombosis and haemostasis

authors： Male C,Chait P,Ginsberg JS,Hanna K,Andrew M,Halton J,Anderson R,McCusker P,Wu J,Abshire T,Cherrick I,Mahoney D,Mitchell L

更新日期：2002-04-01 00:00:00

abstract：:Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by...

journal_title：Thrombosis and haemostasis

authors： Opitz B,Eitel J,Meixenberger K,Suttorp N

更新日期：2009-12-01 00:00:00

abstract：:The liver can be injured and its functions altered by activation of the coagulation and inflammatory processes in sepsis. The objective of the present study was to investigate the pattern of protease- activated receptors (PARs) over time in a model of acute liver injury induced by lipopolysaccharide (LPS); and whether...

journal_title：Thrombosis and haemostasis

authors： Jesmin S,Gando S,Zaedi S,Sakuraya F

更新日期：2006-12-01 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:Omega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis. We investigated the effects of n-3 FAs on procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis. Eleven of the 23 included patients had received 5.1 g n-3 FA daily for 6 months (group I) whereas 12 ...

journal_title：Thrombosis and haemostasis

authors： Seljeflot I,Johansen O,Arnesen H,Eggesbø JB,Westvik AB,Kierulf P

更新日期：1999-04-01 00:00:00

abstract：:East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit ...

journal_title：Thrombosis and haemostasis

authors： Kim HK,Tantry US,Smith SC Jr,Jeong MH,Park SJ,Kim MH,Lim DS,Shin ES,Park DW,Huo Y,Chen SL,Bo Z,Goto S,Kimura T,Yasuda S,Chen WJ,Chan M,Aradi D,Geisler T,Gorog DA,Sibbing D,Lip GYH,Angiolillo DJ,Gurbel PA,J

更新日期：2020-11-10 00:00:00

abstract：:The platelet integrin alpha(IIb)beta(3) mediates the final step of platelet aggregation that requires pre-activation through an inside-out signal initiated by agonists. Experiments conducted under static conditions using platelet-rich plasma show that platelet activation and adhesion activity of alpha(IIb)beta(3) are ...

journal_title：Thrombosis and haemostasis

authors： Ball C,Vijayan KV,Nguyen T,Anthony K,Bray PF,Essex DW,Dong JF

更新日期：2008-11-01 00:00:00