Comparison of venography and ultrasound for the diagnosis of asymptomatic deep vein thrombosis in the upper body in children: results of the PARKAA study. Prophylactic Antithrombin Replacement in Kids with ALL treated with Asparaginase.

Abstract:

:Deep vein thrombosis (DVT) in children occurs primarily in the upper body venous system. This prospective diagnostic study compared bilateral venography and ultrasound for detection of DVT in the upper venous system in 66 children with acute lymphoblastic leukemia. Results were interpreted by central blinded adjudication. Deep venous thrombosis occurred in 29% (19/66) patients. While 15/19 DVT were detected by venography (sensitivity 79%), only 7/19 were detected by ultrasound (sensitivity 37%). The 12 DVT detected by venography but not by ultrasound were located in the subclavian vein or more central veins. Three of 4 DVT detected by ultrasound but not by venography were in the jugular vein. We conclude that ultrasound is insensitive for DVT in the central upper venous system but may be more sensitive than venography in the jugular veins. A combination of both venography and ultrasound is required for screening for DVT in the upper venous system.

journal_name

Thromb Haemost

authors

Male C,Chait P,Ginsberg JS,Hanna K,Andrew M,Halton J,Anderson R,McCusker P,Wu J,Abshire T,Cherrick I,Mahoney D,Mitchell L

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

593-8

issue

4

eissn

0340-6245

issn

2567-689X

journal_volume

87

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Alteration of the platelet transcriptome in chronic kidney disease.

    abstract::Bleeding and thrombotic disorders are major complications affecting patients with chronic kidney disease (CKD). Exposure of circulating platelets to uraemic toxins and contact with artificial surfaces during dialysis induce platelet abnormalities and alter the platelet proteome. We hypothesised that these changes may ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-03-0153

    authors: Plé H,Maltais M,Corduan A,Rousseau G,Madore F,Provost P

    更新日期:2012-10-01 00:00:00

  • Recombinant pro-urokinase requires heparin for optimal clot lysis and restoration of blood flow in a canine femoral artery thrombosis model.

    abstract::Heparin is often used as an adjunct to thrombolytic therapy in order to prevent reocclusion of the patent vessels in patients with thrombotic disease. Controversy exists as to whether heparin is required for effective clot lysis with tissue-type plasminogen activator, while in vitro data and small scale clinical trial...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Burke SE,Lubbers NL,Nelson RA,Henkin J

    更新日期:1993-04-01 00:00:00

  • Failure of immunosuppression in a severe haemophilia B patient with specific antibody.

    abstract::Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. T...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Allain JP,Frommel D

    更新日期:1976-08-31 00:00:00

  • Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy.

    abstract::In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure of the retina to revascularise its ischaemic areas. Non-resolving retina ischaemia/hypoxia results in upregulation of pro-angiogenic factors and pathologic neov...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH15-01-0051

    authors: Economopoulou M,Avramovic N,Klotzsche-von Ameln A,Korovina I,Sprott D,Samus M,Gercken B,Troullinaki M,Grossklaus S,Funk RH,Li X,Imhof BA,Orlova VV,Chavakis T

    更新日期:2015-11-25 00:00:00

  • Plasma D-dimer as a marker for postoperative deep venous thrombosis. A study after total hip or knee arthroplasty.

    abstract::Plasma levels of D-dimer have been found useful as a marker of deep venous thrombosis in those patients in whom thrombosis is suspected, but their usefulness in postoperative screening is less clear. We have investigated the relationship of D-dimer to deep venous thrombosis in 90 patients after total hip and knee arth...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Dunn ID,Hui AC,Triffitt PD,Crozier AE,Gregg PJ,Sinclair ME,Armstrong AL,Mitchell VE

    更新日期:1994-11-01 00:00:00

  • Homozygous Pro74-->Arg mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome.

    abstract::Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

    更新日期:2000-07-01 00:00:00

  • Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.

    abstract::Mice with a total deficiency in blood coagulation Factor X (FX) were generated by targeted replacement of an 18-kb fragment of the FX gene, comprising all exons encoding the mature FX protein, with a neo(r) cassette. The genotype distribution among the offspring from heterozygous breeding pairs suggested that FX defic...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Dewerchin M,Liang Z,Moons L,Carmeliet P,Castellino FJ,Collen D,Rosen ED

    更新日期:2000-02-01 00:00:00

  • Effect of local urokinase on arterial occlusion of lower limbs.

    abstract::Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 pati...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Fiessinger JN,Aiach M,Capron L,Devanlay M,Vayssairat M,Juillet Y

    更新日期:1981-06-30 00:00:00

  • Transcriptional regulation of tissue- and urokinase-type plasminogen activator genes by thrombin in human fetal lung fibroblasts.

    abstract::The mechanism of thrombin induction of tissue- and urokinase-type plasminogen activator (t-PA and u-PA) biosynthesis was investigated in cultured human fetal lung fibroblast cells, IMR-90. Northern blot analysis of total RNA from thrombin-treated cells showed marked accumulations of both t-PA and u-PA mRNA during 24 h...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Hayakawa Y,Tazawa S,Ishikawa T,Niiya K,Sakuragawa N

    更新日期:1995-08-01 00:00:00

  • Comparison of specific antibody, D-Phe-Pro-Arg-CH2Cl and aprotinin for prevention of in vitro effects of recombinant tissue-type plasminogen activator on haemostasis parameters.

    abstract::In vitro, concentration-dependent effects of rt-PA on a range of coagulation and fibrinolytic assays in thawed plasma samples were investigated. In absence of a fibrinolytic inhibitor, 2 micrograms rt-PA/ml blood (3.4 micrograms/ml plasma) caused prolongation of clotting time assays and decreases of plasminogen (to 44...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Seifried E,Tanswell P

    更新日期:1987-10-28 00:00:00

  • Once-daily subcutaneous dalteparin, a low molecular weight heparin, for the initial treatment of acute deep vein thrombosis.

    abstract::The aim of the study was to compare the efficacy and safety of once-daily subcutaneous injection of dalteparin, a low molecular weight heparin, with that of intravenous unfractionated heparin in the treatment of deep venous thrombosis (DVT). Patients were included if they had deep venous thrombosis distal to inguinal ...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Fiessinger JN,Lopez-Fernandez M,Gatterer E,Granqvist S,Kher A,Olsson CG,Söderberg K

    更新日期:1996-08-01 00:00:00

  • Intravascular leukocyte migration through platelet thrombi: directing leukocytes to sites of vascular injury.

    abstract::Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular injury. Recent observations of neutrophil extracellular traps (NETs) formation and its mutual reactions with platelet thrombi adds more cl...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH14-08-0662

    authors: Ghasemzadeh M,Hosseini E

    更新日期:2015-06-01 00:00:00

  • Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.

    abstract:BACKGROUND: Anticoagulant therapy has seldom been achieved in randomized trials targeting nonspecific overall sepsis patients. Although the key components to identify the appropriate target in sepsis may be disseminated intravascular coagulation (DIC) and high disease severity, the interaction and relation of these two...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0039-1693740

    authors: Yamakawa K,Gando S,Ogura H,Umemura Y,Kabata D,Shintani A,Shiraishi A,Saitoh D,Fujishima S,Mayumi T,Kushimoto S,Abe T,Shiino Y,Nakada TA,Tarui T,Hifumi T,Otomo Y,Okamoto K,Kotani J,Sakamoto Y,Sasaki J,Shiraishi S

    更新日期:2019-11-01 00:00:00

  • The role of the factor X activation peptide: a deletion mutagenesis approach.

    abstract::To understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed. Two single-chain, variant enzymes were generated in which 41 residues were deleted from the AP: fX (des-137-183) and fX(des-137-183;N191A), which lacks a carbohydrate moiety at Asn191 due to an alanine su...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Rudolph AE,Mullane MP,Porche-Sorbet R,Daust HA,Miletich JP

    更新日期:2002-11-01 00:00:00

  • Human thrombi contain an abundance of active thrombin.

    abstract::This study assessed the abundance and activity of thrombin in human thrombi. removed at autopsy or during surgery. Arterial and venous thrombus sections showed thrombin activity by in situ zymography, based on conversion of fibrinogen to fibrin. Hirudin or antibodies to thrombin abolished the activity. Thrombin activi...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Mutch NJ,Robbie LA,Booth NA

    更新日期:2001-10-01 00:00:00

  • Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets.

    abstract::We have investigated the intracellular mechanisms involved in microtubular remodelling by thrombin and its possible involvement in platelet aggregation and secretion. Platelet stimulation with thrombin induces a time- and concentration-dependent regulation of the microtubular content, which was found to be maximally e...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Bouaziz A,Amor NB,Woodard GE,Zibidi H,López JJ,Bartegi A,Salido GM,Rosado JA

    更新日期:2007-08-01 00:00:00

  • Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment.

    abstract::Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH16-02-0167

    authors: Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

    更新日期:2016-08-30 00:00:00

  • Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder.

    abstract::MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9-RD is caused by mutations of MYH9 , the gene encoding for non-muscle heavy-chain myosin-9. Wild...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH09-08-0593

    authors: Savoia A,De Rocco D,Panza E,Bozzi V,Scandellari R,Loffredo G,Mumford A,Heller PG,Noris P,De Groot MR,Giani M,Freddi P,Scognamiglio F,Riondino S,Pujol-Moix N,Fabris F,Seri M,Balduini CL,Pecci A

    更新日期:2010-04-01 00:00:00

  • Antiphospholipid Syndrome in Chronic Thromboembolic Pulmonary Hypertension: A Well-Defined Subgroup of Patients.

    abstract::Antiphospholipid syndrome (APS) is an acquired thrombophilia with an uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess the association of APS with the clinical phenotype of CTEPH. We retrospectively reviewed data of CTEPH patients referred to our center. Cli...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0039-1692428

    authors: Jiang X,Du Y,Cheng CY,Denas G,Zhou YP,Wu T,Zhang YX,Han ZY,Pengo V,Jing ZC

    更新日期:2019-09-01 00:00:00

  • Effect of platelet antiserum on the precipitation of soluble fibrin by endotoxin.

    abstract::Rabbits were injected with a platelet antiserum to examine the role of thrombocytopenia of the precipitation of soluble fibrin by endotoxin.dotoxin. Platelet antiserum removed more than 98% of the circulating platelets, and the resulting thrombocytopenia with platelet counts below 10,000 per mul persisted during the e...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Müller-Berghaus G,Kramer W

    更新日期:1976-02-29 00:00:00

  • Quantification of functional and inactivated alpha 2-macroglobulin in sepsis.

    abstract::Alpha 2-macroglobulin (alpha 2 M) in vitro inhibits numerous proteinases that are generated during inflammatory reactions and therefore, probably plays an important role in diseases such as sepsis. To monitor the state of alpha 2 M in sepsis, we developed novel assays for functional and inactive alpha 2M. Functional a...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Abbink JJ,Nuijens JH,Eerenberg AJ,Huijbregts CC,Strack van Schijndel RJ,Thijs LG,Hack CE

    更新日期:1991-01-23 00:00:00

  • Managing Anti-Platelet Therapy in Thrombocytopaenic Patients with Haematological Malignancy: A Multinational Clinical Vignette-Based Experiment.

    abstract::Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676520

    authors: Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

    更新日期:2019-01-01 00:00:00

  • Thrombin generation, a function test of the haemostatic-thrombotic system.

    abstract::By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evid...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Hemker HC,Al Dieri R,De Smedt E,Béguin S

    更新日期:2006-11-01 00:00:00

  • Baboon models of acute arterial thrombosis.

    abstract::In conclusion, we believe that the baboon offers many advantages as an experimental animal to study vascular disease, thrombus formation and dissolution, the effects of mediating variables, and the relative efficacy of therapeutic interventions. Each specific application for testing therapeutic agents may require test...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Hanson SR,Harker LA

    更新日期:1987-10-28 00:00:00

  • The effects of standard and low molecular weight heparin on bone nodule formation in vitro.

    abstract::Previously, we demonstrated in a rat model of heparin-induced osteoporosis that low molecular weight heparin (LMWH) produces less bone loss than unfractionated heparin, and that only heparin increases osteoclast number and activity. In contrast, both heparin and LMWH were found to decrease osteoblast function to a sim...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Bhandari M,Hirsh J,Weitz JI,Young E,Venner TJ,Shaughnessy SG

    更新日期:1998-09-01 00:00:00

  • A Disintegrin and Metalloproteases (ADAMs) in Cardiovascular, Metabolic and Inflammatory Diseases: Aspects for Theranostic Approaches.

    abstract::A disintegrin and metalloproteases (ADAMs) are membrane-bound enzymes responsible for the shedding or cleavage of various cell surface molecules, such as adhesion molecules, cytokines/chemokines and growth factors. This shedding can result in the release of soluble proteins that can exert agonistic or antagonistic fun...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1660479

    authors: van der Vorst EPC,Weber C,Donners MMPC

    更新日期:2018-07-01 00:00:00

  • Influence of metoprolol treatment on sympatho-adrenal activation of fibrinolysis.

    abstract::The effects of mental stress (a colour word conflict test, CWT) and adrenaline infusions (0.1 and 0.4 nmol kg-1 min-1) on t-PA activity, t-PA antigen, PAI-1 activity and PAI-1 antigen were studied in 18 healthy male volunteers. Furthermore, the effects of metoprolol (200 mg/day during 1 week) or placebo (double-blind ...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章

    doi:

    authors: Larsson PT,Wiman B,Olsson G,Angelin B,Hjemdahl P

    更新日期:1990-06-28 00:00:00

  • Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity.

    abstract::Inherited severe hypoplasminogenaemia is a multisystemic disorder leading to deficient extravascular fibrinolysis. As a clinical consequence wound healing capacity of mucous membranes is markedly impaired leading to ligneous conjunctivitis and several other manifestations. Here we report the molecular genetic and clin...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH10-04-0216

    authors: Klammt J,Kobelt L,Aktas D,Durak I,Gokbuget A,Hughes Q,Irkec M,Kurtulus I,Lapi E,Mechoulam H,Mendoza-Londono R,Palumbo JS,Steitzer H,Tabbara KF,Ozbek Z,Pucci N,Sotomayor T,Sturm M,Drogies T,Ziegler M,Schuster V

    更新日期:2011-03-01 00:00:00

  • Edoxaban for treatment of venous thromboembolism in patients with cancer. Rationale and design of the Hokusai VTE-cancer study.

    abstract::Direct oral anticoagulants may be effective and safe for treatment of venous thromboembolism (VTE) in cancer patients, but they have not been compared with low-molecular-weight heparin (LMWH), the current recommended treatment for these patients. The Hokusai VTE-cancer study is a randomised, open-label, clinical trial...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1160/TH15-06-0452

    authors: van Es N,Di Nisio M,Bleker SM,Segers A,Mercuri MF,Schwocho L,Kakkar A,Weitz JI,Beyer-Westendorf J,Boda Z,Carrier M,Chlumsky J,Décousus H,Garcia D,Gibbs H,Kamphuisen PW,Monreal M,Ockelford P,Pabinger I,Verhamme P,G

    更新日期:2015-11-25 00:00:00

  • Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors.

    abstract:OBJECTIVE:To assess the safety and efficacy of a fixed dose of recombinant activated factor VII (rFVIIa; NovoSeven) in the home setting for mild to moderately severe joint, muscle; and mucocutaneous bleeding episodes in patients with haemophilia A or B with inhibitors. DESIGN:Multicentre, open-label, single arm, phase...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Key NS,Aledort LM,Beardsley D,Cooper HA,Davignon G,Ewenstein BM,Gilchrist GS,Gill JC,Glader B,Hoots WK,Kisker CT,Lusher JM,Rosenfield CG,Shapiro AD,Smith H,Taft E

    更新日期:1998-12-01 00:00:00