当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells.

Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells.

Abstract：

:The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a thrombin receptor agonist/activating peptide (TRAP). In this study, Northern blot analysis showed that cultured human vascular smooth muscle cells (HVSMC) express a thrombin receptor transcript. TRAP, in contrast to thrombin was shown to be a weak mitogen for HVSMC. A combination of TRAP and enzymatically-inactivated thrombin (PPACK-thrombin) which provides receptor occupancy, did not potentiate TRAP-induced mitogenesis, indicating that TRAP and PPACK-thrombin do not reproduce the mitogenic effect of enzymatically-active thrombin. Both thrombin and TRAP, induced the expression of c-fos and the PDGF-A gene in a pertussis toxin (PTX)-insensitive manner. Examination of thrombin and TRAP-treated cells by immunofluorescence staining followed by computer assisted image analysis revealed that thrombin and to a lesser extent TRAP induced PDGF-AA protein expression. Antibodies to PDGF-AA partially inhibited thrombin but not TRAP-induced mitogenesis in HVSMC. This study indicates that in addition to the common signalling pathways utilised by thrombin and TRAP, enzymatically-active thrombin activates other signalling pathways and hence TRAP does not mimic fully the biological effect of thrombin on HVSMC.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Kanthou C,Benzakour O,Patel G,Deadman J,Kakkar VV,Lupu F

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1340-7

issue

5

eissn

0340-6245

issn

2567-689X

journal_volume

74

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Localization of tissue thromboplastin in the human brain.

    abstract：:Monospecific antisera against the purified protein component of tissue thromboplastin (apoprotein-III) from human brain have been raised in goats and rabbits. The antisera neutralized tissue thromboplastin prepared from brain, thyroid gland and pulmonary tissue, indicating that apoproteins in the various preparations ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Bjorklid E,Storm-Mathisen J,Storm E,Prydz H

    更新日期：1977-02-28 00:00:00

  • Protective effect of ischaemic preconditioning on ischaemia/reperfusion-induced microvascular obstruction determined by on-line measurements of coronary pressure and blood flow in pigs.

    abstract：:We investigated the protective effect of ischaemic preconditioning (IP) on the maintenance of coronary patency using on-line measurements of coronary pressures and blood flow in a closed-chest reperfused acute myocardial infarction (MI) model in pigs. Catheter-based 90-min occlusion followed by 60-min reperfusion of t...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-03-0165

    authors： Posa A,Pavo N,Hemetsberger R,Csonka C,Csont T,Ferdinandy P,Petrási Z,Varga C,Pavo IJ,Laszlo F Jr,Huber K,Gyöngyösi M

    更新日期：2010-02-01 00:00:00

  • Heparin induced thrombocytopenia: a prospective study.

    abstract：:Thrombocytopenia occurred in 11.6% of 43 patients prospectively randomized to receive either bovine lung or porcine mucosal heparin. Four patients received bovine heparin and developed mild to moderate thrombocytopenia after eight to twelve days which resolved when therapy was stopped in one to six days. One patient r...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Ansell J,Slepchuk N Jr,Kumar R,Lopez A,Southard L,Deykin D

    更新日期：1980-02-29 00:00:00

  • Lymphocyte adhesion to human endothelial cells induces tissue factor expression via a juxtacrine pathway.

    abstract：:To study the effect of lymphocyte adhesion on the procoagulant activity of endothelial cells, we have stimulated HUVECs with interferon-gamma to upregulate adhesion molecules. Subsequent addition of lymphocytes induced the expression of tissue factor (TF) by HUVECs. Both CD4+ and CD8+ T-cells promoted this TF synthesi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Schmid E,Müller TH,Budzinski RM,Pfizenmaier K,Binder K

    更新日期：1995-03-01 00:00:00

  • Khorana score and histotype predicts incidence of early venous thromboembolism in non-Hodgkin lymphomas. A pooled-data analysis of 12 clinical trials of Fondazione Italiana Linfomi (FIL).

    abstract：:Current data suggests that the risk of venous thromboembolism (VTE) in patients with non-Hodgkin lymphoma (NHL) is comparable to that observed in patients with solid tumours, although more robust confirmatory analyses are required. With that in mind, we investigated the occurrence of VTE in a pooled analysis of 12 "Fo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-11-0895

    authors： Santi RM,Ceccarelli M,Bernocco E,Monagheddu C,Evangelista A,Valeri F,Monaco F,Vitolo U,Cortelazzo S,Cabras MG,Spina M,Baldini L,Boccomini C,Chiappella A,Bari A,Luminari S,Visco C,Calabrese M,Limberti G,Levis A,Con

    更新日期：2017-04-27 00:00:00

  • Platelet behaviour in normal pregnancy, pregnancy complicated by essential hypertension and pregnancy-induced hypertension.

    abstract：:Platelet behaviour was studied throughout pregnancy in a group of women who remained normotensive and a group with essential hypertension (EHT). Women who developed pregnancy-induced hypertension (PIH) were also studied together with a group of non-pregnant female controls. We determined the sensitivity of platelets t...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Morrison R,Crawford J,MacPherson M,Heptinstall S

    更新日期：1985-10-30 00:00:00

  • Benefit-risk profile of non-vitamin K antagonist oral anticoagulants in the management of venous thromboembolism.

    abstract：:The prevention and treatment of venous thromboembolism (VTE) remains a clinical challenge, primarily owing to drawbacks associated with the use of heparins and vitamin K antagonists (VKAs). These and other factors, including a growing elderly population, mean that VTE presents a continuing burden to patients and physi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,meta分析,评审

    doi：10.1160/TH14-06-0484

    authors： Beyer-Westendorf J,Ageno W

    更新日期：2015-02-01 00:00:00

  • The influence of molsidomine and its active metabolite SIN-1 on fibrinolysis and platelet aggregation.

    abstract：:Molsidomine and its active metabolite SIN-1 were examined in humans and animals for platelet suppressant and fibrinolytic activities. Following oral administration of molsidomine at doses of 6 or 15 mg/kg to rabbits, their blood platelets in PRP ex vivo required higher threshold concentrations of ADP, AA and thrombin ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Basista M,Grodzińska L,Swies J

    更新日期：1985-12-17 00:00:00

  • High plasma heparin cofactor II activity protects from restenosis after femoropopliteal stenting.

    abstract：:High heparin cofactor II (HCII) activity has recently been described to protect from coronary instent restenosis, presumably by inactivating thrombin in injured arteries. In this study, we investigated the association of HCII activity and restenosis after femoropopliteal stenting. We studied 63 consecutive patients wi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH04-05-0311

    authors： Schillinger M,Exner M,Sabeti S,Mlekusch W,Amighi J,Handler S,Quehenberger P,Kalifeh N,Wagner O,Minar E

    更新日期：2004-11-01 00:00:00

  • Analysis of the venous thromboembolic risk associated with severe postpartum haemorrhage in the NOHA First cohort.

    abstract：:Severe postpartum haemorrhages (PPH) are responsible for maternal morbidity/mortality. Their complex management sometimes requires haemostatic supplementation, and therapeutic trials on fibrinogen or activated factor VII, which may add to the thrombotic risk, are currently being considered. Furthermore, there is a ris...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Chauleur C,Cochery-Nouvellon E,Mercier E,Aya G,Marès P,Mismetti P,Lissalde-Lavigne G,Gris JC

    更新日期：2008-11-01 00:00:00

  • Biological and thrombolytic properties of proenzyme and active forms of human urokinase--II. Turnover of natural and recombinant urokinase in rabbits and squirrel monkeys.

    abstract：:The turnover of recombinant pro-urokinase (Rec-pro-UK), recombinant urokinase (Rec-UK) and natural urinary urokinase (Nat-UK) was studied in rabbits and in squirrel monkeys (Saimiri sciureus). Following intravenous injection, urokinase activity disappeared rapidly from the blood. The initial disappearance rate could b...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Collen D,De Cock F,Lijnen HR

    更新日期：1984-08-31 00:00:00

  • Patients with essential thrombocythaemia have an increased prevalence of antiphospholipid antibodies which may be associated with thrombosis.

    abstract：:A significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life. We performed a retrospective cross sectional study of the prevalence of antiphospholipid antibodies (APA) in 68 ET patients. Compared to 2...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Harrison CN,Donohoe S,Carr P,Dave M,Mackie I,Machin SJ

    更新日期：2002-05-01 00:00:00

  • Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets.

    abstract：:The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

    更新日期：1991-09-02 00:00:00

  • The effects of standard and low molecular weight heparin on bone nodule formation in vitro.

    abstract：:Previously, we demonstrated in a rat model of heparin-induced osteoporosis that low molecular weight heparin (LMWH) produces less bone loss than unfractionated heparin, and that only heparin increases osteoclast number and activity. In contrast, both heparin and LMWH were found to decrease osteoblast function to a sim...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Bhandari M,Hirsh J,Weitz JI,Young E,Venner TJ,Shaughnessy SG

    更新日期：1998-09-01 00:00:00

  • Homozygous Pro74-->Arg mutation in the platelet glycoprotein Ibbeta gene associated with Bernard-Soulier syndrome.

    abstract：:Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

    更新日期：2000-07-01 00:00:00

  • The effects of citrate and extracellular calcium ions on the platelet release reaction induced by adenosine diphosphate and collagen.

    abstract：:The ADP-induced release of 3H-serotonin from human platelets in heparinized platelets rich plasma is markedly stimulated by the addition of sodium citrate. The aggregation and release that is induced by collagen is less affected by citrate. Data is presented that supports the view that the effects of citrate on both A...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Heptinstall S,Taylor PM

    更新日期：1979-08-31 00:00:00

  • Activated Factor X-Based versus Thrombin-Based Antithrombin Testing in Thrombophilia Workup in the DOAC Era.

    abstract：:Antithrombin (AT) activity tests are used for diagnosing hereditary AT deficiency, a main genetic determinant of thrombophilia. They are either based on inhibition of thrombin (FIIa) or activated factor X (FXa). FXa-based assays have been suggested to be preferable to FIIa-based assays due to their higher sensitivity ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-08-0568

    authors： Rühl H,Reda S,Müller J,Oldenburg J,Pötzsch B

    更新日期：2018-02-01 00:00:00

  • Platelet inhibitory drugs: an in vivo method of evaluation in patients.

    abstract：:The measurement of platelet deposition in human thrombi is essential for the evaluation of platelet-inhibitory drugs and prosthetic materials for use in patients. The rate of 111Indium-labelled platelet accumulation on Dacron arterial grafts was measured in 27 patients randomised to take either aspirin and dipyridamol...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Norcott HC,Goldman M,Hawker RJ,Rafiqi EI,Drolc Z,McCollum CN

    更新日期：1982-12-27 00:00:00

  • Can Sequential Coagulation Monitoring Predict Major Haemorrhage in Extremely Low Birth Weight Infants?

    abstract：INTRODUCTION: Bleeds such as intra-ventricular (IVH) and pulmonary haemorrhage (PH) are life-threatening events in extremely low birth weight (ELBW) infants. Serial coagulation monitoring by measuring the international normalized ratio (INR) with small volume samples might facilitate early diagnosis and possibly preven...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1655744

    authors： Thanhaeuser M,Binder C,Derhaschnig U,Jilma B,Kornsteiner-Krenn M,Huber-Dangl M,Repa A,Kreissl A,Berger A,Haiden N

    更新日期：2018-07-01 00:00:00

  • Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.

    abstract：:A suggestive locus on chromosome 8 could be shown to be associated with familial high factor VIII (FVIII) levels in venous thromboembolism. The ADAMDEC 1 gene is a candidate expressing an ectodomain sheddase. However, the ectodomain of the clearance receptor for FVIII, the low-density lipoprotein receptor-related prot...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：10.1160/TH08-01-0059

    authors： Berger M,Moscatelli H,Kulle B,Luxembourg B,Blouin K,Spannagl M,Lindhoff-Last E,Schambeck CM

    更新日期：2008-05-01 00:00:00

  • Pharmacological modulation of procoagulant microparticles improves haemodynamic dysfunction during septic shock in rats.

    abstract：:Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH13-04-0313

    authors： Boisramé-Helms J,Delabranche X,Degirmenci SE,Zobairi F,Berger A,Meyer G,Burban M,Mostefai HA,Levy B,Toti F,Meziani F

    更新日期：2014-01-01 00:00:00

  • Enhanced TNF alpha and oxidative stress in patients with heart failure: effect of TNF alpha on platelet O2- production.

    abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-02-0105

    authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

    更新日期：2003-08-01 00:00:00

  • Lack of platelet response to collagen associated with an autoantibody against glycoprotein Ia: a novel cause of acquired qualitative platelet dysfunction.

    abstract：:Platelets from a patient with an acquired hemorrhagic disorder had a severely impaired response to collagen, whereas platelet aggregation to other agonists and coagulations tests were normal. No abnormalities of the patient's platelet membrane glycoproteins (GP) were seen. Treatment of the patient with immunosuppressi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Deckmyn H,Chew SL,Vermylen J

    更新日期：1990-08-13 00:00:00

  • Low Affinity Platelet Factor 4 and High Affinity Platelet Factor 4 - Two Antiheparin Factors Secreted by Human Platelets.

    abstract：: ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1657075

    authors： Niewiarowski S,Rucinski B,Budzynski AZ

    更新日期：1979-07-01 00:00:00

  • Heterogeneity of molecular size of factor VIII/von Willebrand factor in von Willbrand's disease.

    abstract：:Patterns of VIIIR:AG in the plasma and its fractions, cryoprecipitate and cryosupernatant, from various types of von Willebrand's disease (vWd) were observed by SDS 1.5% polyacrylamide gel electrophoresis - cross immunoelectrophoresis (SDS PAGE - CIE). VIIIR:AG in normal cryoprecipitate showed several precipitin peaks...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Mikami S,Takahashi Y,Nishino M,Okubo Y,Fukui H

    更新日期：1981-06-30 00:00:00

  • Immunohistochemical localization of a novel peptide, prostacyclin-stimulating factor (PSF), in human tissues.

    abstract：:In a recent study, we purified and cloned a newly identified bioactive factor that stimulates prostacyclin (PGI2) production by vascular endothelial cells (ECs) using conditioned medium (CM) from cultured human diploid fibroblast cells. The present study was undertaken to clarify whether PSF is expressed in ECs and va...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Masakado M,Umeda F,Takei A,Hashimoto T,Sueishi K,Nawata H

    更新日期：1995-12-01 00:00:00

  • A comparative multi-laboratory assessment of three factor VIII/von Willebrand factor concentrates.

    abstract：:Five expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; x3), Biostate (x3) and Humate/Haemate (x3). All laborato...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Favaloro EJ,Bukuya M,Martinelli T,Tzouroutis J,Duncan E,Welldon K,Collecutt M,Aumann H,Thom J,Gilmore G

    更新日期：2002-03-01 00:00:00

  • Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction.

    abstract：BACKGROUND: Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1660437

    authors： Coelho-Lima J,Mohammed A,Cormack S,Jones S,Das R,Egred M,Panahi P,Ali S,Spyridopoulos I

    更新日期：2018-07-01 00:00:00

  • Tissue plasminogen activator is endocytosed by mannose and galactose receptors of rat liver cells.

    abstract：:Experiments were carried out to characterize the specificity of uptake of tPA in rat liver cells. Endocytosis in liver endothelial cells of the native carbohydrate variants of tissue plasminogen activator (tPA), and tPA inactivated by diisopropyl fluorophosphate was found to be competitive, suggesting that the determi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Smedsrød B,Einarsson M,Pertoft H

    更新日期：1988-06-16 00:00:00

  • Vascular thrombogenicity induced by progressive LDL oxidation: protection by antioxidants.

    abstract：:Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

    更新日期：2003-03-01 00:00:00