Patients with essential thrombocythaemia have an increased prevalence of antiphospholipid antibodies which may be associated with thrombosis.

abstract：:In order to assess the value of I.P.G. for the diagnosis of D.V.T. in general practice, an I.P.G. was carried out by a skilled technician in 255 consecutive patients with suspected D.V.T. at home. Ascending venography was carried out in 185 of these patients. In addition, blood for assay of AT III, platelet count, fib...

journal_title：Thrombosis and haemostasis

authors： Peters SH,Jonker JJ,de Boer AC,den Ottolander GJ

更新日期：1982-12-27 00:00:00

abstract：:Given conflicting data on temporal variability in pharmacodynamic platelet responses to clopidogrel, we investigated platelet reactivity on clopidogrel and aspirin for up to six months after elective percutaneous coronary intervention (PCI) with drug-eluting stents. Platelet reactivity was determined in 102 patients b...

journal_title：Thrombosis and haemostasis

authors： Nührenberg TG,Stratz C,Leggewie S,Hochholzer W,Valina CM,Gick M,Kirtane AJ,Stone GW,Neumann FJ,Trenk D

更新日期：2015-11-01 00:00:00

abstract：:Women with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk of thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because of limited trial data. A strategy of risk assessment and heparin prophylaxis was evaluated in pregn...

journal_title：Thrombosis and haemostasis

authors： Bauersachs RM,Dudenhausen J,Faridi A,Fischer T,Fung S,Geisen U,Harenberg J,Herchenhan E,Keller F,Kemkes-Matthes B,Schinzel H,Spannagl M,Thaler CJ,EThIG Investigators.

更新日期：2007-12-01 00:00:00

abstract：:Imaging methods based on time-lapse microscopy are important tools for studying the dynamic events that shape thrombus formation upon vascular injury. However, there is a lack of methods to translate the vast amount of visual data generated in such experiments into quantitative variables describing platelet movements ...

journal_title：Thrombosis and haemostasis

authors： Tunströmer K,Faxälv L,Boknäs N,Lindahl TL

更新日期：2018-09-01 00:00:00

abstract：:In consecutive patients with suspected venous thromboembolism the interobserver variability of the SimpliRED D-dimer test was evaluated by two observers who independently scored one plate, the between assay variation was performed simultaneously by a third independent observer, who assessed a second plate. The biologi...

journal_title：Thrombosis and haemostasis

authors： Turkstra F,van Beek EJ,Büller HR

更新日期：1998-01-01 00:00:00

abstract：:Using an in vitro model of clot lysis, the individual response to a pharmacological concentration of recombinant tissue plasminogen activator (rt-PA) and the influence on this response of the physiological variations of blood parameters known to interfere with the fibrinolytic/thrombolytic process were investigated in...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Scopece S,Gelato AV,Dimonte D,Semeraro N

更新日期：1997-04-01 00:00:00

abstract：:In haemophilia B (HB) (factor IX [FIX] deficiency), F9 genotype largely determines clinical phenotype. Aimed to characterise Argentinian families with HB, this study presents F9 genotype frequencies and their specific FIX inhibitor risk and 10 novel F9 mutations. Ninety-one DNA samples from HB patients and relat...

journal_title：Thrombosis and haemostasis

authors： Radic CP,Rossetti LC,Abelleyro MM,Candela M,Pérez Bianco R,de Tezanos Pinto M,Larripa IB,Goodeve A,De Brasi C

更新日期：2013-01-01 00:00:00

abstract：:We have investigated the intracellular mechanisms involved in microtubular remodelling by thrombin and its possible involvement in platelet aggregation and secretion. Platelet stimulation with thrombin induces a time- and concentration-dependent regulation of the microtubular content, which was found to be maximally e...

journal_title：Thrombosis and haemostasis

authors： Bouaziz A,Amor NB,Woodard GE,Zibidi H,López JJ,Bartegi A,Salido GM,Rosado JA

更新日期：2007-08-01 00:00:00

abstract：:The structural and functional properties of plasma and platelet vWF were studied in 8 patients (5 unrelated families) with vWD demonstrating a mutation at position 611 (R611C or R611H). Following reduction, electrophoresis and immunoblotting with a polyclonal anti-reduced vWF antibody, abnormal proteolysis of vWF was ...

journal_title：Thrombosis and haemostasis

authors： Nishikubo T,Christophe O,Lavergne JM,Obert B,Nonami K,Takahashi Y,Yoshioka A,Meyer D,Girma JP

更新日期：1997-01-01 00:00:00

abstract：:Fibrinogen degradation products formed by the action of purified haemolymph and saliva of a Saturnidae caterpillar of the Lonomia genus were studies by immunoelectrophoresis and polyacrylamide/SDS gel electrophoresis. The pattern of degradation differ form the one described for plasmin, trypsin, brinase, and ochrase. ...

journal_title：Thrombosis and haemostasis

authors： Arocha-Piñango CL,Perales J,Carvajal Z

更新日期：1981-06-30 00:00:00

abstract：BACKGROUND: Anticoagulant therapy has seldom been achieved in randomized trials targeting nonspecific overall sepsis patients. Although the key components to identify the appropriate target in sepsis may be disseminated intravascular coagulation (DIC) and high disease severity, the interaction and relation of these two...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Gando S,Ogura H,Umemura Y,Kabata D,Shintani A,Shiraishi A,Saitoh D,Fujishima S,Mayumi T,Kushimoto S,Abe T,Shiino Y,Nakada TA,Tarui T,Hifumi T,Otomo Y,Okamoto K,Kotani J,Sakamoto Y,Sasaki J,Shiraishi S

更新日期：2019-11-01 00:00:00

abstract：:In vitro, concentration-dependent effects of rt-PA on a range of coagulation and fibrinolytic assays in thawed plasma samples were investigated. In absence of a fibrinolytic inhibitor, 2 micrograms rt-PA/ml blood (3.4 micrograms/ml plasma) caused prolongation of clotting time assays and decreases of plasminogen (to 44...

journal_title：Thrombosis and haemostasis

authors： Seifried E,Tanswell P

更新日期：1987-10-28 00:00:00

abstract：:Some correlations between plasma and platelet fatty acids (FA) were evaluated "ex vivo" in 94 normal subjects. The highest relationships between total FA from plasma and platelets were found for 18:1 (r = 0.74) and 18:2 (r = 0.67). Low correlations were obtained for free fatty acids (FFA). The most significant correla...

journal_title：Thrombosis and haemostasis

authors： Vallés J,Aznar J,Santos MT

更新日期：1984-12-29 00:00:00

abstract：:In an international collaborative study three candidate reference and the local APTT reagent have been tested with lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients to determine whether it was possible to standardize APTT heparin monitoring. The APTT responses of patient...

journal_title：Thrombosis and haemostasis

authors： Van der Velde EA,Poller L

更新日期：1995-01-01 00:00:00

abstract：:Clinical observations have shown that heparin has antiinflammatory activities. The effect of heparin on neutrophil chemotaxis was evaluated in vitro in the Boyden Chamber. This method enabled differentiation between the direct effects of heparin on neutrophil migration and locomotion, and its effects on chemotactic fa...

journal_title：Thrombosis and haemostasis

authors： Matzner Y,Marx G,Drexler R,Eldor A

更新日期：1984-10-31 00:00:00

abstract：:A suggestive locus on chromosome 8 could be shown to be associated with familial high factor VIII (FVIII) levels in venous thromboembolism. The ADAMDEC 1 gene is a candidate expressing an ectodomain sheddase. However, the ectodomain of the clearance receptor for FVIII, the low-density lipoprotein receptor-related prot...

journal_title：Thrombosis and haemostasis

authors： Berger M,Moscatelli H,Kulle B,Luxembourg B,Blouin K,Spannagl M,Lindhoff-Last E,Schambeck CM

更新日期：2008-05-01 00:00:00

abstract：:Thrombus formation at an artificial surface in contact with blood is a complex process that encompasses accretion of platelets from flowing blood and fibrin deposition. Platelet adhesion and fibrin formation are intimately intertwined reactions that are triggered by different sets of surface adsorbed plasma proteins. ...

journal_title：Thrombosis and haemostasis

authors： Keuren JF,Wielders SJ,Willems GM,Morra M,Lindhout T

更新日期：2002-04-01 00:00:00

abstract：:Previously, we demonstrated in a rat model of heparin-induced osteoporosis that low molecular weight heparin (LMWH) produces less bone loss than unfractionated heparin, and that only heparin increases osteoclast number and activity. In contrast, both heparin and LMWH were found to decrease osteoblast function to a sim...

journal_title：Thrombosis and haemostasis

authors： Bhandari M,Hirsh J,Weitz JI,Young E,Venner TJ,Shaughnessy SG

更新日期：1998-09-01 00:00:00

abstract：:Mechanisms mediating initial adsorption of coagulation proteins to live cells were investigated. Adsorption kinetics were examined under varying flow conditions using tracer-dilution techniques in perfused spherical monolayers of cells expressing tissue factor. At biologically relevant time and concentration ranges, r...

journal_title：Thrombosis and haemostasis

authors： McGee MP,Teuschler H

更新日期：1999-07-01 00:00:00

abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

journal_title：Thrombosis and haemostasis

authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

更新日期：1999-09-01 00:00:00

abstract：:Interactions between the uPA receptor (uPAR) and various integrins, including alpha(5)beta(1), are known to modulate integrin-dependent cell adhesion, and we have shown that the integrin-associated tetraspanin protein CD82 down-regulates uPAR-dependent plasminogen activation by affecting alpha(5)beta(1) cellular local...

journal_title：Thrombosis and haemostasis

authors： Bass R,Ellis V

更新日期：2009-05-01 00:00:00

abstract：:Long-term evidence supports a clustering of cardiovascular events in the early morning and smaller mechanistic studies in aspirin-treated patients have shown increased platelet reactivity at the end of the dosing interval. Comparative pharmacodynamic analyses for different adenosine diphosphate (ADP) receptor inhibito...

journal_title：Thrombosis and haemostasis

authors： Freynhofer MK,Hein-Rothweiler R,Haller PM,Aradi D,Dézsi DA,Gross L,Orban M,Trenk D,Geisler T,Huczek Z,Toth-Gayor GG,Massberg S,Huber K,Sibbing D

更新日期：2019-04-01 00:00:00

abstract：:A congenitally abnormal fibrinogen was isolated from blood of a young man with deep-vein thrombosis. Two other affected members of his family had three episodes of severe arterial thrombosis. The fibrinogen showed a delayed clotting by thrombin, but a normal clotting by Arvin, Reptilase, and prothrombin-staphylocoagul...

journal_title：Thrombosis and haemostasis

authors： Haverkate F,Koopman J,Kluft C,D'Angelo A,Cattaneo M,Mannucci PM

更新日期：1986-02-28 00:00:00

abstract：:Plaque rupture underlies most myocardial infarctions. Plaques vulnerable to rupture have thin fibrous caps, an excess of macrophages over vascular smooth muscle cells, large lipid cores, and depletion of collagen and other matrix proteins form the cap and lipid core. Production of matrix metalloproteinases from macrop...

journal_title：Thrombosis and haemostasis

authors： Newby AC,George SJ,Ismail Y,Johnson JL,Sala-Newby GB,Thomas AC

更新日期：2009-06-01 00:00:00

abstract：:The effect of supernatant from phorbol myristate acetate (PMA) stimulated human polymorphonuclear granulocytes (PMN) on human factor VII was studied in vitro. The supernatant caused a rapid loss in factor VII coagulant activity by the action of human leukocyte elastase (HLE) and cathepsin G in the supernatant, as demo...

journal_title：Thrombosis and haemostasis

authors： Anderssen T,Halvorsen H,Bajaj SP,Osterud B

更新日期：1993-09-01 00:00:00

abstract：:The leech protein hirudin is a potent inhibitor of thrombin, but clinical use of recombinant hirudin is restricted by haemorrhagic risks, and complicated by hirudin's rapid clearance from the circulation. We previously employed albumin fusion to slow hirudin variant 3 (HV3) clearance. In this study, we hypothesized th...

journal_title：Thrombosis and haemostasis

authors： Sheffield WP,Eltringham-Smith LJ,Gataiance S,Bhakta V

更新日期：2009-05-01 00:00:00

abstract：:Antiphospholipid antibody (aPL) is a hallmark of antiphospholipid syndrome (APS), characterized by thrombosis and recurrent fetal loss. We developed a novel ELISA system to detect complement-fixing ability of anticardiolipin antibody (aCL), and evaluated its clinical usefulness through studying the prevalence of the a...

journal_title：Thrombosis and haemostasis

authors： Munakata Y,Saito T,Matsuda K,Seino J,Shibata S,Sasaki T

更新日期：2000-05-01 00:00:00

abstract：:The alphaIIbeta3 receptor (GPIIb/IIIa) is the only platelet-specific integrin receptor and the most abundant adhesion/aggregation receptor on the surface of human platelets. Since mice are increasingly being used as models of human disease, we analyzed the structure and function of murine platelet alphaIIbeta3, utiliz...

journal_title：Thrombosis and haemostasis

authors： Smyth SS,Tsakiris DA,Scudder LE,Coller BS

更新日期：2000-12-01 00:00:00

abstract：:A synthetic hirudin55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models of experimental thrombosis in mice and rats. Intravenous injection caused dose-related inhibition of thrombin and anticoagulation in rat blood samples, protection from thromboembolism in mice and inhibition of st...

journal_title：Thrombosis and haemostasis

authors： Broersma RJ,Kutcher LW,Heminger EF,Krstenansky JL,Marshall FN

更新日期：1991-04-08 00:00:00

abstract：:The blockade of platelet membrane glycoprotein IIb/IIIa by a monoclonal antibody, 7E3, was measured by flow cytometry using a fluorescein isothiocyanate-conjugated disintegrin, FITC-crotavirin, as the probe. After treatment of platelets with 7E3 or 7E3 F(ab')2, there is a good correlation between the inhibition of pla...

journal_title：Thrombosis and haemostasis

authors： Liu CZ,Hur BT,Huang TF

更新日期：1996-10-01 00:00:00