Lack of platelet response to collagen associated with an autoantibody against glycoprotein Ia: a novel cause of acquired qualitative platelet dysfunction.

abstract：:Pharmacological prophylaxis for postoperative venous thromboembolism is generally restricted to the hospital stay. A high incidence of deep vein thrombosis (DVT) and pulmonary embolism presenting after hospital discharge has been reported and thus it has been claimed that pharmacological prophylaxis should be continue...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Ranucci V,Veschi F,Rinonapoli E,Lupattelli L,Nenci GG

更新日期：1995-10-01 00:00:00

abstract：:Ridogrel (6.3 x 10(-6) to 10(-4) M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 x 10(-6) M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within 20 min of incubation of...

journal_title：Thrombosis and haemostasis

authors： Janssens WJ,Cools FJ,Hoskens LA,Van Nueten JM

更新日期：1990-08-13 00:00:00

abstract：:Tissue factor (TF) markedly enhances the ability of factor VIIa (FVIIa) to cleave both macromolecular and small peptidyl substrates. Using soluble mutant TF (sTF) to investigate TF-enhanced FVIIa amidolytic activity in solution, we screened thirty-four commercially available peptidyl-p-nitroanilide substrates and foun...

journal_title：Thrombosis and haemostasis

authors： Neuenschwander PF,Branam DE,Morrissey JH

更新日期：1993-12-20 00:00:00

abstract：:The major plasmin inhibitors namely alpha2-plasmin inhibitor and alpha2-macroglobulin were compared for their effects on lysis of fibrin clot. Plasmin fibrinolytic activity was immediately inhibited by alpha2-plasmin inhibitor, whereas alpha2-macroglobulin inhibited plasmin progressively. Urokinase(plasminogen activat...

journal_title：Thrombosis and haemostasis

authors： Aoki N,Moroi M,Tachiya K

更新日期：1978-02-28 00:00:00

abstract：:A high throughput 384-well plate assay of blood function in 60 microl reactions with the fluorogenic thrombin substrate, boc-VPR-MCA, allowed for real-time monitoring of coagulation under a diverse set of reaction conditions. Using recalcified, citrated whole blood diluted 3-fold with corn trypsin inhibitor (to block ...

journal_title：Thrombosis and haemostasis

authors： Lo K,Diamond SL

更新日期：2004-10-01 00:00:00

abstract：:It was the study objective to evaluate whether chewing a 180 mg loading dose of ticagrelor versus an equal dose of traditional oral administration, enhances inhibition of platelet aggregation 1 hour (h) after administering a ticagrelor loading dose in non-ST elevation myocardial infarction (NSTEMI) patients. Dual anti...

journal_title：Thrombosis and haemostasis

authors： Asher E,Frydman S,Katz M,Regev E,Sabbag A,Mazin I,Abu-Much A,Kukuy A,Mazo A,Erez A,Berkovitch A,Narodistky M,Barbash I,Segev A,Beigel R,Matetzky S

更新日期：2017-04-03 00:00:00

abstract：:Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better the...

journal_title：Thrombosis and haemostasis

authors： Schouten M,van 't Veer C,Roelofs JJ,Gerlitz B,Grinnell BW,Levi M,van der Poll T

更新日期：2011-12-01 00:00:00

abstract：:Following exposure of rats to graded doses of fresh cigarette smoke, the aortic endothelium examined by scanning electron microscopy regularly showed alterations. These essentially consisted of areas of blebbing and microvillus-like projections from the luminal surface, and the presence in the majority of cases, of mi...

journal_title：Thrombosis and haemostasis

authors： Pittilo RM,Mackie IJ,Rowles PM,Machin SJ,Woolf N

更新日期：1982-10-29 00:00:00

abstract：:DX-9065a is an antithrombin III (AT III)-independent and selective inhibitor of activated blood coagulation factor X (FXa). We evaluated the effects of DX-9065a and warfarin on bleeding time and blood loss in rat tail transection model and on blood loss in hydrochloride (HCl)-induced rat gastrointestinal haemorrhage m...

journal_title：Thrombosis and haemostasis

authors： Tanabe K,Morishima Y,Shibutani T,Terada Y,Hara T,Shinohara Y,Aoyagi K,Kunitada S,Kondo T

更新日期：1999-05-01 00:00:00

abstract：:Vitamin K antagonists (VKAs) remain as the most prescribed drug for treatment and prevention of thrombotic disorders in many countries, despite the recent approval of the new oral anticoagulants (NOACs). Although effectiveness and safety of VKAs are tightly associated to maintaining the patient within the internationa...

journal_title：Thrombosis and haemostasis

authors： Jiménez-Varo E,Cañadas-Garre M,Henriques CI,Pinheiro AM,Gutiérrez-Pimentel MJ,Calleja-Hernández MÁ

更新日期：2014-09-02 00:00:00

abstract：:Clots formed from platelet rich plasma were found to be lysed more readily by low concentrations of pro-urokinase (pro-UK) than clots formed from platelet poor plasma. This was not a non-specific effect since the reverse occurred with tissue plasminogen activator. A mechanical explanation due to platelet-mediated clot...

journal_title：Thrombosis and haemostasis

authors： Loza JP,Gurewich V,Johnstone M,Pannell R

更新日期：1994-03-01 00:00:00

abstract：:The aim of this study was to evaluate the thrombolytic activity of two hybrid plasminogen activators (HPAs) in a rabbit jugular vein thrombosis model. In the two HPAs the kringle-2 domain (K2tu-PA) or the finger and the kringle-2 domains (FK2tu-PA) of tissue-type plasminogen activator (t-PA) are linked to the catalyti...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Pascucci C,Colucci M,Nenci GG,Mele A,Bürgi R,Heim J

更新日期：1992-09-07 00:00:00

abstract：:The effect of thrombin on the phosphorylating activity of platelet membranes was compared to that of trypsin. Preincubation of non-32P phosphorylated platelet membranes with or without either of these two enzymes resulted in a considerable loss of membrane protein kinase activity which was most severe when trypsin was...

journal_title：Thrombosis and haemostasis

authors： Steiner M

更新日期：1976-06-30 00:00:00

abstract：:The prevention and treatment of venous thromboembolism (VTE) remains a clinical challenge, primarily owing to drawbacks associated with the use of heparins and vitamin K antagonists (VKAs). These and other factors, including a growing elderly population, mean that VTE presents a continuing burden to patients and physi...

journal_title：Thrombosis and haemostasis

authors： Beyer-Westendorf J,Ageno W

更新日期：2015-02-01 00:00:00

abstract：:This study aimed to evaluate the relationship between anaemia and pulmonary embolism (PE) prognosis. We analysed a cohort of 764 patients with acute PE referred to a single center for diagnosis and management. Patients were divided into groups by quartiles of haemoglobin (Hb): Hb < 11.7 g/dl; Hb 11.7 to 12.9 g/dl; Hb ...

journal_title：Thrombosis and haemostasis

authors： Jiménez D,Escobar C,Martí D,Díaz G,César J,García-Avello A,Sueiro A,Yusen RD

更新日期：2009-07-01 00:00:00

abstract：:Binding of the coagulation protease factor VIIa to its receptor Tissue Factor (TF) induces intracellular signals in several cell types including HaCaT keratinocytes. TF belongs to the cytokine receptor family, but is most likely not alone in transferring the complete TF/FVIIa signal over the plasma membrane. The prote...

journal_title：Thrombosis and haemostasis

authors： Wiiger MT,Prydz H

更新日期：2004-07-01 00:00:00

abstract：:We analyzed the protein C gene (PROC) with the denaturing gradient gel electrophoresis (DGGE) scanning strategy in a series of 129 patients with suspected protein C (PC) deficiency (93 with low plasma PC levels and 36 with borderline level). At least one sequence variation was found in 104 of the 129 patients. Thirty-...

journal_title：Thrombosis and haemostasis

authors： Alhenc-Gelas M,Gandrille S,Aubry ML,Aiach M

更新日期：2000-01-01 00:00:00

abstract：:To assess interobserver variability of venography for screening for postoperative deep venous thrombosis (DVT), we used 185 bilateral ascending contrast venograms (366 lower limbs) which were performed using the long-leg film technique, in the frame of a trial of the efficacy of two low-molecular-weight-heparin fracti...

journal_title：Thrombosis and haemostasis

authors： Couson F,Bounameaux C,Didier D,Geiser D,Meyerovitz MF,Schmitt HE,Schneider PA,Bounameaux H

更新日期：1993-10-18 00:00:00

abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

journal_title：Thrombosis and haemostasis

authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

更新日期：2019-03-01 00:00:00

abstract：:The inhibitory capacity of antithrombin III (AT III) was measured by a quantitative method independent of the velocity of inhibition. When AT III was in excess of thrombin in plasma or in purified system the capacity of inhibitor decreased quantitatively in proportion to the amount of thrombin neutralized. Heparin pre...

journal_title：Thrombosis and haemostasis

authors： Marciniak E

更新日期：1977-08-31 00:00:00

abstract：:The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factor VII (FVII) deficiency. The results of 12 consecutive surgical...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Tjønnfjord GE,Wallensten R,Martinowitz U,Kenet G

更新日期：2005-12-01 00:00:00

abstract：:Prothrombin complex concentrates (PCCs) and fresh-frozen plasma (FFP) have been clinically used for acute warfarin reversal. The recovery of prothrombin time (PT) or international normalised ratio (INR) is often reported as an endpoint, but haemostatic efficacies of PCCs and FFP may not be fully reflected in static cl...

journal_title：Thrombosis and haemostasis

authors： Ogawa S,Szlam F,Ohnishi T,Molinaro RJ,Hosokawa K,Tanaka KA

更新日期：2011-12-01 00:00:00

abstract：:Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weight...

journal_title：Thrombosis and haemostasis

authors： Lima MA,Viskov C,Herman F,Gray AL,de Farias EH,Cavalheiro RP,Sassaki GL,Hoppensteadt D,Fareed J,Nader HB

更新日期：2013-03-01 00:00:00

abstract：:Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic...

journal_title：Thrombosis and haemostasis

authors： Boisramé-Helms J,Delabranche X,Degirmenci SE,Zobairi F,Berger A,Meyer G,Burban M,Mostefai HA,Levy B,Toti F,Meziani F

更新日期：2014-01-01 00:00:00

abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

journal_title：Thrombosis and haemostasis

authors： Kumar R,Béguin S,Hemker HC

更新日期：1995-09-01 00:00:00

abstract：:Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, sugg...

journal_title：Thrombosis and haemostasis

authors： Mao G,Jin J,Kunapuli SP,Rao AK

更新日期：2016-10-28 00:00:00

abstract：:Thrombolytic therapy provides clinical benefit in patients with vascular occlusions, depending upon the organ or limb that is threatened. The impact of therapeutic intervention varies from the quiet alteration of the course of deep vein thrombosis, for which non-life threatening post-phlebitic syndrome can be largely ...

journal_title：Thrombosis and haemostasis

authors： Marder VJ

更新日期：1995-07-01 00:00:00

abstract：:Tissue factor (thromboplastin or Factor III), a glycoprotein cofactor, is required for Factor VII to express its catalytic activity, thereby initiating the extrinsic as well as intrinsic pathway of blood coagulation. Human brain tissue factor was purified 2,500-fold to 98% homogeneity from 2% Triton X-100 extraction o...

journal_title：Thrombosis and haemostasis

authors： Kang S,Niemetz J

更新日期：1988-06-16 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：:Novel strategies for a tailored risk prediction in chronic heart failure (CHF) are crucial to identify patients at very high risk for an improved patient management and to specify treatment regimens. Endothelial progenitor cells (EPCs) are an important endogenous repair mechanism with the ability to counteract endothe...

journal_title：Thrombosis and haemostasis

authors： Koller L,Hohensinner P,Sulzgruber P,Blum S,Maurer G,Wojta J,Hülsmann M,Niessner A

更新日期：2016-08-01 00:00:00