Thrombolytic activity of two chimeric recombinant plasminogen activators (FK2tu-PA and K2tu-PA) in rabbits.

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:Recombinant factor VIIa (rFVIIa: NovoSeven; Novo Nordisk) has proven efficacy in the treatment of haemophilic patients with inhibitors. This prospective, double-blind study compared rFVIIa (35 vs. 90 microg/kg) in the initiation and maintenance of haemostasis during and after elective surgery. Patients with inhibitors...

journal_title：Thrombosis and haemostasis

authors： Shapiro AD,Gilchrist GS,Hoots WK,Cooper HA,Gastineau DA

更新日期：1998-11-01 00:00:00

abstract：:Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithro...

journal_title：Thrombosis and haemostasis

authors： Peng S,Xue G,Gong L,Fang C,Chen J,Yuan C,Chen Z,Yao L,Furie B,Huang M

更新日期：2017-06-28 00:00:00

abstract：:Although there is considerable variability of platelet reactivity among patients treated with clopidogrel, little is known about inter-individual differences and possible role of proton pump inhibitors (PPIs) after prasugrel. We defined the extent of inter-patient variability, and evaluated the impact of PPI interacti...

journal_title：Thrombosis and haemostasis

authors： Aradi D,Kuliczkowski W,Atar D,Serebruany VL

更新日期：2012-02-01 00:00:00

abstract：:The antithrombotic effect of MCI-9042, (+-)-2-(dimethyl-amino)-1-((o-(m- methoxyphenethyl)phenoxyl]methyl]ethyl hydrogen succinate hydrochloride was investigated in three different experimental thrombosis models in animals. Simultaneous injection of serotonin and collagen into the tail vein in mice induced acute pulmo...

journal_title：Thrombosis and haemostasis

authors： Hara H,Kitajima A,Shimada H,Tamao Y

更新日期：1991-10-01 00:00:00

abstract：:Despite years of research and efforts to translate stroke research to clinical therapy, ischaemic stroke remains a major cause of death, disability, and diminished quality of life. Primary and secondary preventive measures combined with improved quality of care have made significant progress. However, no novel drug fo...

journal_title：Thrombosis and haemostasis

authors： Mosnier LO,Zlokovic BV,Griffin JH

更新日期：2014-11-01 00:00:00

abstract：:We examined the effect of a synthetic thrombin inhibitor, MCI-9038, on two experimental animal models of disseminated intravascular coagulation (DIC). In a model that DIC induced by the intravenous infusion of thrombin, MCI-9038 suppressed the decrease of platelet count by about 50% at a dose of 0.2 micrograms/kg/min ...

journal_title：Thrombosis and haemostasis

authors： Hara H,Tamao Y,Kikumoto R,Okamoto S

更新日期：1987-04-07 00:00:00

abstract：:The effect of negatively-charged polymers, used in some artificial devices, on plasma clotting and kinin systems was studied in vitro using polyelectrolyte complexes. Contact activation was observed as an immediate, transient and surface-dependent phenomenon. After incubation of the plasma with the polymer a small dec...

journal_title：Thrombosis and haemostasis

authors： Boffa MC,Dreyer B,Pusineri C

更新日期：1984-02-28 00:00:00

abstract：:An amidrazonophenylalanine derivative, LB30057, inhibits the catalytic activity of thrombin potently by interaction with the active site of thrombin, and has high water solubility. In the present study, we evaluated the effect of LB30057 on the biological activities of thrombin at various tissues, and determined wheth...

journal_title：Thrombosis and haemostasis

authors： Kang KT,Jung BI,Bae ON,Lee MY,Chung SM,Lee JY,Lee SK,Kim IC,Chung JH

更新日期：2003-01-01 00:00:00

abstract：:The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factor VII (FVII) deficiency. The results of 12 consecutive surgical...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Tjønnfjord GE,Wallensten R,Martinowitz U,Kenet G

更新日期：2005-12-01 00:00:00

abstract：:The aim of this observational cohort study was to specify the risk of the vitamin K antagonist (VKA) phenprocoumon during first trimester of pregnancy, in particular to estimate the risk of birth defects and spontaneous fetal loss. Four hundred eight pregnancies with phenprocoumon exposure were compared to 1,642 pregn...

journal_title：Thrombosis and haemostasis

authors： Hüttel E,Padberg S,Meister R,Beck E,Schaefer C

更新日期：2017-05-03 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00

abstract：:The effects of mental stress (a colour word conflict test, CWT) and adrenaline infusions (0.1 and 0.4 nmol kg-1 min-1) on t-PA activity, t-PA antigen, PAI-1 activity and PAI-1 antigen were studied in 18 healthy male volunteers. Furthermore, the effects of metoprolol (200 mg/day during 1 week) or placebo (double-blind ...

journal_title：Thrombosis and haemostasis

authors： Larsson PT,Wiman B,Olsson G,Angelin B,Hjemdahl P

更新日期：1990-06-28 00:00:00

abstract：:To study the effect of lymphocyte adhesion on the procoagulant activity of endothelial cells, we have stimulated HUVECs with interferon-gamma to upregulate adhesion molecules. Subsequent addition of lymphocytes induced the expression of tissue factor (TF) by HUVECs. Both CD4+ and CD8+ T-cells promoted this TF synthesi...

journal_title：Thrombosis and haemostasis

authors： Schmid E,Müller TH,Budzinski RM,Pfizenmaier K,Binder K

更新日期：1995-03-01 00:00:00

abstract：:Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domain...

journal_title：Thrombosis and haemostasis

authors： Sarafanov AG,Makogonenko EM,Andersen OM,Mikhailenko IA,Ananyeva NM,Khrenov AV,Shima M,Strickland DK,Saenko EL

更新日期：2007-12-01 00:00:00

abstract：:Following favourable results from a previous study, a large, multicentre, prospective, case-control study was performed to further assess the incidence of bleeding complications after dental extraction in patients taking oral anticoagulant therapy (OAT). Four hundred fifty-one patients being treated with warfarin who ...

journal_title：Thrombosis and haemostasis

authors： Bacci C,Maglione M,Favero L,Perini A,Di Lenarda R,Berengo M,Zanon E

更新日期：2010-11-01 00:00:00

abstract：:Few data are available on thrombophilic risk factors and progression of atherosclerotic peripheral arterial disease (PAD). Thrombophilic alterations can be an aggravating factor when arterial stenoses are present. In a cross-sectional study, we evaluated the presence of the thrombophilic factors fibrinogen, homocystei...

journal_title：Thrombosis and haemostasis

authors： Sartori M,Favaretto E,Legnani C,Cini M,Conti E,Amato A,Palareti G

更新日期：2010-07-01 00:00:00

abstract：:Vitamin K antagonists (VKAs) remain as the most prescribed drug for treatment and prevention of thrombotic disorders in many countries, despite the recent approval of the new oral anticoagulants (NOACs). Although effectiveness and safety of VKAs are tightly associated to maintaining the patient within the internationa...

journal_title：Thrombosis and haemostasis

authors： Jiménez-Varo E,Cañadas-Garre M,Henriques CI,Pinheiro AM,Gutiérrez-Pimentel MJ,Calleja-Hernández MÁ

更新日期：2014-09-02 00:00:00

abstract：:The clinical impact of in-stent thrombosis is high because it is associated with high mortality and 20 % of the patients suffer a recurrent event within the two following years. The aim of this study was to characterise the morphologic and proteomic profile of in-stent thrombi (IST) in comparison to thrombi developed ...

journal_title：Thrombosis and haemostasis

authors： Cubedo J,Blasco A,Padro T,Ramaiola I,Juan-Babot O,Goicolea J,Fernández-Díaz JA,Oteo JF,Badimon L

更新日期：2017-08-30 00:00:00

abstract：:The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years w...

journal_title：Thrombosis and haemostasis

authors： Baranyai Z,Krzystanek M,Jósa V,Dede K,Agoston E,Szász AM,Sinkó D,Szarvas V,Salamon F,Eklund AC,Szállási Z,Jakab F

更新日期：2014-03-03 00:00:00

abstract：:The effects of etamsylate on human platelet aggregation and ATP release as well as on the arachidonate metabolism by the platelet have been studied. Etamsylate enhanced these platelet functions induced by arachidonic acid (AA), thromboxane A2, collagen and calcium ionophore A23187 but not those induced by ADP and epin...

journal_title：Thrombosis and haemostasis

authors： Okuma M,Takayama H,Sugiyama T,Sensaki S,Uchino H

更新日期：1982-12-27 00:00:00

abstract：:Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a p...

journal_title：Thrombosis and haemostasis

authors： Galli M,Ageno W,Squizzato A,Dentali F,Manfredi E,Steidl L,Venco A

更新日期：2005-07-01 00:00:00

abstract：:Hemophilia B is a sex-linked recessive bleeding disorder characterized by the presence of either a decreased amount of normal factor IX (FIX) or the presence of a dysfunctional FIX. We have identified a unique mutation in a family with mild hemophilia B. DNA analysis of family members revealed a single base transition...

journal_title：Thrombosis and haemostasis

authors： Lefkowitz JB,Nuss R,Haver T,Jacobson L,Thompson AR,Manco-Johnson M

更新日期：2001-09-01 00:00:00

abstract：:The platelet integrin alpha(IIb)beta(3) mediates the final step of platelet aggregation that requires pre-activation through an inside-out signal initiated by agonists. Experiments conducted under static conditions using platelet-rich plasma show that platelet activation and adhesion activity of alpha(IIb)beta(3) are ...

journal_title：Thrombosis and haemostasis

authors： Ball C,Vijayan KV,Nguyen T,Anthony K,Bray PF,Essex DW,Dong JF

更新日期：2008-11-01 00:00:00

abstract：:Hemin is a heme oxygenase-1 (HO-1) inducer which provides endogenous carbon monoxide known for playing roles in cell proliferation, inflammation or aggregation process. The objective of the current study was to examine the effect of prophylactic treatment with hemin in a thrombosis vascular model. Three groups of Wist...

journal_title：Thrombosis and haemostasis

authors： Desbuards N,Rochefort GY,Schlecht D,Machet MC,Halimi JM,Eder V,Hyvelin JM,Antier D

更新日期：2007-09-01 00:00:00

abstract：:Central venous access devices are often essential for the administration of chemotherapy to patients with malignancy, but its use has been associated with a number of complications, mainly thrombosis. The true incidence of upper extremity deep vein thrombosis (DVT) in this setting is difficult to estimate since there ...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Alastrue A,Rull M,Mira X,Muxart J,Rosell R,Abad A

更新日期：1996-02-01 00:00:00

abstract：:Over the last few years methods have been developed to assess appearance of thrombin during blood clotting in a clinical setting. This can be achieved either by measurement of the specific thrombin markers or by analysis of the thrombin generation kinetics. Thrombin markers rise following coronary occlusion and, surpr...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A

更新日期：1995-07-01 00:00:00

abstract：:In patients with myeloproliferative disorders (MPD) a group of related diseases of the bone marrow stem cell and recurrent haemorrhagic and/or thrombotic complications, the production of aggregating prostaglandins (PGs) may be normal or slightly reduced, while PGI2 production is normal. However, MPD platelet sensitivi...

journal_title：Thrombosis and haemostasis

authors： Cortelazzo S,Galli M,Castagna D,Viero P,de Gaetano G,Barbui T

更新日期：1988-02-25 00:00:00

abstract：:Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncont...

journal_title：Thrombosis and haemostasis

authors： Fender AC,Rauch BH,Geisler T,Schrör K

更新日期：2017-11-01 00:00:00

abstract：:Several members of a family from Scranton, Pennsylvania were identified to have normal levels of prothrombin antigen while their prothrombin clotting activity was approximately 50% of normal. There has been no previous history of bleeding or other clinical manifestations in this family. The genomic DNA from the proban...

journal_title：Thrombosis and haemostasis

authors： Sun WY,Smirnow D,Jenkins ML,Degen SJ

更新日期：2001-04-01 00:00:00