Effect of ridogrel on vascular contractions caused by vasoactive substances released during platelet activation.

abstract：:Tissue factor pathway inhibitor (TFPI) plays a crucial role in haemostasis by regulating TF-induced initiation of coagulation. Since it is expressed by endothelial and trophoblastic cells, TFPI is of particular importance at the placental level and might be involved in the occurrence of gestational vascular complicati...

journal_title：Thrombosis and haemostasis

authors： Ittel A,Bretelle F,Gris JC,Chau C,Sébahoun G,Boubli L,Arnoux D

更新日期：2011-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. Even though aPL heterogeneity is quite well established, little is known, if the ability to activate platelets is common to all aPL or depends on antigen specificity. To further...

journal_title：Thrombosis and haemostasis

authors： Hollerbach A,Müller-Calleja N,Ritter S,Häuser F,Canisius A,Orning C,Jurk K,Lackner KJ

更新日期：2019-07-01 00:00:00

abstract：:Platelet membrane glycoproteins (GP) IIb/IIa and rap1b, a 21 kDa GTP binding protein, associate with the triton-insoluble, activation-dependent platelet cytoskeleton with similar rates and divalent cation requirement. To examine the possibility that GPIIb/IIIa was required for rap1b association with the cytoskeleton, ...

journal_title：Thrombosis and haemostasis

authors： White GC 2nd,Fischer TH,Duffy CM

更新日期：1998-04-01 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:Inflammation and thrombosis, two processes influencing each other, are involved in the pathogenesis of cerebrovascular disease. We showed that in patients with acute ischaemic stroke circulating platelets are activated and exhausted. To identify whether activated haemostasis might be cause or effect, we investigated t...

journal_title：Thrombosis and haemostasis

authors： Jurk K,Ritter MA,Schriek C,Van Aken H,Droste DW,Ringelstein EB,Kehrel BE

更新日期：2010-06-01 00:00:00

abstract：:The mechanism of thrombin induction of tissue- and urokinase-type plasminogen activator (t-PA and u-PA) biosynthesis was investigated in cultured human fetal lung fibroblast cells, IMR-90. Northern blot analysis of total RNA from thrombin-treated cells showed marked accumulations of both t-PA and u-PA mRNA during 24 h...

journal_title：Thrombosis and haemostasis

authors： Hayakawa Y,Tazawa S,Ishikawa T,Niiya K,Sakuragawa N

更新日期：1995-08-01 00:00:00

abstract：:Angiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties. In this r...

journal_title：Thrombosis and haemostasis

authors： Degani H,Chetrit-Dadiani M,Bogin L,Furman-Haran E

更新日期：2003-01-01 00:00:00

abstract：:We have tried to offer a unifying hypothesis tying vessel wall narrowing in atherosclerotic plaques to plaque rupture and healing (Fig. 7). This hypothesis is supported by evidence that smooth muscle cells are capable of interacting with a fibrin clot, specifically contracting a fibrin clot, and that inhibition of coa...

journal_title：Thrombosis and haemostasis

authors： Yee KO,Schwartz SM

更新日期：1999-08-01 00:00:00

abstract：:Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys-->Asn). The mass increase of 2177 Da in the new beta chain indicated the attachment of a fully sialylated biantennary oligosaccharide on the new Asn residue; the exp...

journal_title：Thrombosis and haemostasis

authors： Brennan SO,Loreth RM,George PM

更新日期：1998-08-01 00:00:00

abstract：:Severe factor XI (FXI) deficiency is a bleeding disorder generally inherited as an autosomal recessive trait and characterized by haemorrhagic symptoms mainly associated with injury or surgery. So far, more than 150 causative molecular defects have been identified throughout the F11 gene. In the present study, we inve...

journal_title：Thrombosis and haemostasis

authors： Guella I,Soldà G,Spena S,Asselta R,Ghiotto R,Tenchini ML,Castaman G,Duga S

更新日期：2008-03-01 00:00:00

abstract：:Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is requ...

journal_title：Thrombosis and haemostasis

authors： Mühle C,Schulz-Drost S,Khrenov AV,Saenko EL,Klinge J,Schneider H

更新日期：2004-03-01 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Niewiarowski S,Rucinski B,Budzynski AZ

更新日期：1979-07-01 00:00:00

abstract：:Platelet adhesion and aggregation at the sites of vascular injury are key events for thrombosis and haemostasis. It has been well demonstrated that interaction between glycoprotein (GP) Ibα and von Willebrand factor (VWF) initiates platelet adhesion and contributes to platelet aggregation, particularly at high shear. ...

journal_title：Thrombosis and haemostasis

authors： Lei X,Reheman A,Hou Y,Zhou H,Wang Y,Marshall AH,Liang C,Dai X,Li BX,Vanhoorelbeke K,Ni H

更新日期：2014-02-01 00:00:00

abstract：:Elucidation of the molecular defects responsible for antithrombin III deficiency is proceeding rapidly. In order that a record is kept of the new and duplicated mutations that are found, we have compiled a database that we plan to update annually. In this, the first report of the database, we list 6 antithrombin III l...

journal_title：Thrombosis and haemostasis

authors： Lane DA,Ireland H,Olds RJ,Thein SL,Perry DJ,Aiach M

更新日期：1991-12-02 00:00:00

abstract：:Aspirin prevents thrombotic events by inhibiting platelet cyclooxygenase-1 (COX-1), thus reducing thromboxane A2 formation and platelet aggregation. The C50T polymorphism of COX-1 is associated with an impaired inhibition of both thromboxane production and in-vitro platelet aggregation by aspirin. We studied whether t...

journal_title：Thrombosis and haemostasis

authors： Clappers N,van Oijen MG,Sundaresan S,Brouwer MA,Te Morsche RH,Keuper W,Peters WH,Drenth JP,Verheugt FW

更新日期：2008-07-01 00:00:00

abstract：:Laboratory diagnosis of antiphospholipid antibodies is important in patients with clinical features of the antiphospholipid syndrome, such as thrombosis and fetal loss. We have developed a novel method for the detection of antiphospholipid antibodies using flow cytometry. Anionic phospholipids cardiolipin, phosphatidy...

journal_title：Thrombosis and haemostasis

authors： Stewart MW,Etches WS,Russell AS,Percy JS,Johnston CA,Chew CK,Gordon PA

更新日期：1993-10-18 00:00:00

abstract：:Tissue factor (TF) is the blood coagulation initiator, whose cofactor function is required for physiological factor VIIa (FVIIa)-mediated activation of factor X (FX) to FXa. A previous study reported TF on herpes simplex virus type 1 (HSV1), but this explained only part of FVIIa-dependent FXa generation observed on th...

journal_title：Thrombosis and haemostasis

authors： Sutherland MR,Friedman HM,Pryzdial EL

更新日期：2004-11-01 00:00:00

abstract：:Direct oral factor inhibitors (DOFIs) are an attractive alternative to vitamin K antagonists (VKA) for the treatment of patients with antiphospholipid syndrome (APS). In the absence of prospective, randomised trial data, reports of therapeutic failures in clinical practice alert clinicians to potential limitations of ...

journal_title：Thrombosis and haemostasis

authors： Schaefer JK,McBane RD,Black DF,Williams LN,Moder KG,Wysokinski WE

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:It is known that the fibrinolysis inhibitors in the human placenta are proteins which, in vitro, block urokinase plasminogen activation and are for this reason called urokinase inhibitors. In the present study it was found, for the first time, that a slow-molecular urokinase inhibitor also occurs in the human placenta...

journal_title：Thrombosis and haemostasis

authors： Uszynski M

更新日期：1980-02-29 00:00:00

abstract：:The clinical benefits of unfractionated heparin (UFH) and low molecular weight heparin (LMWH) have been shown in many trials. However, the mode of action of heparin has not been fully elucidated. Thus, we wanted to study the effects of UFH and LMWH in vivo by measuring coagulation activation markers in blood obtained ...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Wolz M,Nieszpaur-Los M,Schneider B,Lechner K,Eichler HG,Kyrle PA

更新日期：1994-12-01 00:00:00

abstract：:The development of venous thromboembolism (VTE), which includes deep-vein thrombosis and pulmonary embolism, may be associated with inherited or acquired risk factors that can be measured in plasma or DNA testing. The main inherited thrombophilias include the plasma deficiencies of the natural anticoagulants antithrom...

journal_title：Thrombosis and haemostasis

authors： Franchini M,Martinelli I,Mannucci PM

更新日期：2016-01-01 00:00:00

abstract：:Prolonged immobilization and advanced age are considered to be important risk factors for venous thromboembolism (VTE). Nevertheless, the need for VTE prophylaxis in long-term bedridden patients is not known. To assess whether very prolonged immobilization (i.e. over three months) carries an increased risk for clinica...

journal_title：Thrombosis and haemostasis

authors： Gatt ME,Paltiel O,Bursztyn M

更新日期：2004-03-01 00:00:00

abstract：:We studied the occurrence of myocardial infarction (MI), ischaemic stroke (IS) and pulmonary embolism (PE) before and after breast cancer hospitalisation compared with cancer-free controls. For this, women with a first breast cancer hospitalisation during 2000-2007 were selected from the PHARMO Record Linkage System, ...

journal_title：Thrombosis and haemostasis

authors： van Herk-Sukel MP,Shantakumar S,Kamphuisen PW,Penning-van Beest FJ,Herings RM

更新日期：2011-07-01 00:00:00

abstract：:von Willebrand disease (VWD) is a quantitative or qualitative defect in von Willebrand factor (VWF) resulting in mucocutaneous bleeding symptoms and hemorrhage following hemostatic challenges, such as trauma or surgery. VWD-specific therapy, DDAVP (1-desamino-8-D-arginine vasopressin) and VWF concentrates, is necessar...

journal_title：Thrombosis and haemostasis

authors： Seaman CD,Ragni MV

更新日期：2020-08-01 00:00:00

abstract：:Although associated with adverse outcomes in other cardiopulmonary diseases, limited evidence exists on the prognostic value of anaemia in patients with acute pulmonary embolism (PE). We sought to examine the associations between anaemia and mortality and length of hospital stay in patients with PE. We evaluated 14,27...

journal_title：Thrombosis and haemostasis

authors： Donzé J,Labarère J,Méan M,Jiménez D,Aujesky D

更新日期：2011-08-01 00:00:00

abstract：:Local ISI calibration has been proposed to improve INR accuracy and inter-laboratory precision. We evaluated the affect of local PT calibration on INR precision and accuracy using six levels of frozen plasma calibrants prepared and pooled from normal donors and patients stabilized on sodium warfarin (coumarin) based o...

journal_title：Thrombosis and haemostasis

authors： Adcock DM,Johnston M

更新日期：2002-01-01 00:00:00

abstract：:Atherosclerosis and its clinical manifestations (i.e. myocardial infarction, stroke) are major causes of mortality and morbidity in Western countries. Endothelial dysfunction is considered the first step in the cascade leading up to coronary events. Increasing evidence suggests that direct inhibition of thromboxane A2...

journal_title：Thrombosis and haemostasis

authors： Giannarelli C,Zafar MU,Badimon JJ

更新日期：2010-11-01 00:00:00

abstract：:Vitamin K-dependent protein S is a cofactor to the anticoagulant serine protease activated protein C (APC) in the proteolytic inactivation of the procoagulant, activated factor V (FVa) and factor VIII (FVIIIa). In the FVa degradation, protein S selectively accelerates the cleavage at Arg306, having no effect on the Ar...

journal_title：Thrombosis and haemostasis

authors： Evenäs P,García de Frutos P,Nicolaes GA,Dahlbäck B

更新日期：2000-08-01 00:00:00

abstract：:Thrombotic complications are frequently associated with atherosclerosis. Lysophosphatidylcholine (LPC), a component accumulated in oxidatively modified LDL (ox-LDL), is known to play a crucial role in the initiation and progression of atherosclerotic vascular lesions. Since a vascular anticoagulant, tissue factor path...

journal_title：Thrombosis and haemostasis

authors： Sato N,Kokame K,Miyata T,Kato H

更新日期：1998-01-01 00:00:00