Tissue plasminogen activator is endocytosed by mannose and galactose receptors of rat liver cells.

abstract：:In 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, alpha-granule release (represented by beta-thromboglobulin [beta TG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug...

journal_title：Thrombosis and haemostasis

authors： Kyrle PA,Westwick J,Scully MF,Kakkar VV,Lewis GP

更新日期：1987-02-03 00:00:00

abstract：:Major orthopedic surgery is known to be associated with potentially serious arterial and venous vascular complications, although uncertainty exists about current event rates. Using electronic databases and investigator contact, we identified randomized and cohort studies reporting overall mortality and fatal vascular ...

journal_title：Thrombosis and haemostasis

authors： Dahl OE,Caprini JA,Colwell CW Jr,Frostick SP,Haas S,Hull RD,Laporte S,Stein PD

更新日期：2005-05-01 00:00:00

abstract：:We evaluated the effect of d-alpha-tocopherol (vitamin E) on the production of prostacyclin (PGI2) by cultured bovine aortic endothelial cells. Vitamin E at physiological doses significantly enhanced the production of PGI2 by aortic endothelial cells when added to the culture simultaneously with histamine, the Ca2+ io...

journal_title：Thrombosis and haemostasis

authors： Kunisaki M,Umeda F,Inoguchi T,Nawata H

更新日期：1992-12-07 00:00:00

abstract：:Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could pl...

journal_title：Thrombosis and haemostasis

authors： Leoncini G,Bruzzese D,Signorello MG,Armani U,Piana A,Ghiglione D,Camicione P

更新日期：2007-02-01 00:00:00

abstract：:Tissue factor (TF) plays a critical role in tumour growth and metastasis, and its enhanced release into plasma in association with cellular microparticles (MPs) has recently been associated with pathological cancer progression. We have previously demonstrated significantly elevated levels of plasma TF antigen as well ...

journal_title：Thrombosis and haemostasis

authors： Haubold K,Rink M,Spath B,Friedrich M,Chun FK,Marx G,Amirkhosravi A,Francis JL,Bokemeyer C,Eifrig B,Langer F

更新日期：2009-06-01 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:In this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be ...

journal_title：Thrombosis and haemostasis

authors： Boyle MD,Lottenberg R

更新日期：1997-01-01 00:00:00

abstract：:We have evaluated the effect of plasminogen activators (t-PA and urokinase) on an experimental model of disseminated intravascular coagulation (DIC) in rabbits by injection of 20 micrograms/kg/h of E. coli lipopolysaccharide during 6 h t-PA (0.2 mg/kg and 0.7 mg/kg), urokinase (3000 U/kg/h) and saline (control) were g...

journal_title：Thrombosis and haemostasis

authors： Paloma MJ,Páramo JA,Rocha E

更新日期：1995-12-01 00:00:00

abstract：:A multicenter study of various types of von Willebrand's disease (vWD) was conducted in order to compare the different electrophoretic techniques used to evaluate von Willebrand factor multimers in plasma. Seven laboratories participated in the blind study of eight plasma samples from two healthy subjects and six vWD ...

journal_title：Thrombosis and haemostasis

authors： Mannucci PM,Abildgaard CF,Gralnick HR,Hill FG,Hoyer LW,Lombardi R,Nilsson IM,Tuddenham E,Meyer D

更新日期：1985-12-17 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:Activation of leukocytes plays an essential role in the mechanism of restenosis. Prior research has focused on monocytes and little is known about the role of neutrophils in this process. Neutrophils are known to contribute to tissue injury through oxygen-derived free radicals that nitrate tyrosine. This study was des...

journal_title：Thrombosis and haemostasis

authors： Inoue T,Kato T,Hikichi Y,Hashimoto S,Hirase T,Morooka T,Imoto Y,Takeda Y,Sendo F,Node K

更新日期：2006-01-01 00:00:00

abstract：:Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been show...

journal_title：Thrombosis and haemostasis

authors： Gray E,Mulloy B,Barrowcliffe TW

更新日期：2008-05-01 00:00:00

abstract：:Tissue factor (thromboplastin or Factor III), a glycoprotein cofactor, is required for Factor VII to express its catalytic activity, thereby initiating the extrinsic as well as intrinsic pathway of blood coagulation. Human brain tissue factor was purified 2,500-fold to 98% homogeneity from 2% Triton X-100 extraction o...

journal_title：Thrombosis and haemostasis

authors： Kang S,Niemetz J

更新日期：1988-06-16 00:00:00

abstract：:Cultured human mesangial cells (HMC) derived from normal kidneys have been shown to synthesize tissue-type plasminogen activator (t-PA) and excess amounts of PA inhibitor type 1 (PAI-1). Conflicting results have been obtained concerning the production of urokinase-type PA (u-PA) and efforts to show PA inhibitor 2 (PAI...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Gesualdo L,Montemurro P,Cavallo LG,Conese M,Mascolo E,Ranieri E,Di Paolo S,Schena FP,Semeraro N

更新日期：1995-12-01 00:00:00

abstract：:The effects of G4120, a cyclic Arg-Gly-Asp (RGD) containing peptide which inhibits fibrinogen binding to the platelet receptor GPIIb/IIIa, on thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) were investigated in a combined arterial and venous thrombosis model in heparinized dogs. The arterial th...

journal_title：Thrombosis and haemostasis

authors： Lu HR,Gold HK,Wu Z,Yasuda T,Pauwels P,Rapold HJ,Napier M,Bunting S,Collen D

更新日期：1992-06-01 00:00:00

abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

journal_title：Thrombosis and haemostasis

authors： Hooper WC,Phillips DJ,Evatt BL

更新日期：1997-05-01 00:00:00

abstract：:Inherited severe hypoplasminogenaemia is a multisystemic disorder leading to deficient extravascular fibrinolysis. As a clinical consequence wound healing capacity of mucous membranes is markedly impaired leading to ligneous conjunctivitis and several other manifestations. Here we report the molecular genetic and clin...

journal_title：Thrombosis and haemostasis

authors： Klammt J,Kobelt L,Aktas D,Durak I,Gokbuget A,Hughes Q,Irkec M,Kurtulus I,Lapi E,Mechoulam H,Mendoza-Londono R,Palumbo JS,Steitzer H,Tabbara KF,Ozbek Z,Pucci N,Sotomayor T,Sturm M,Drogies T,Ziegler M,Schuster V

更新日期：2011-03-01 00:00:00

abstract：:1. Some of the guidelines on the nomenclature for the genotype of bacterial strains can be applied for recommendations on the nomenclature for the description of recombinant mutant fibrinolytic constructs. 2. In view of the usually different size of genomic DNA and corresponding cDNA, it is recommended to employ a dis...

journal_title：Thrombosis and haemostasis

authors： Pannekoek H,Lijnen HR,Loskutoff DJ

更新日期：1990-12-28 00:00:00

abstract：:Our aim was to demonstrate that the sequential use of the Verigene® rapid CYP2C19 test for genetic profiling and the VerifyNowTM bedside test for platelet function measurement in ACS patients may optimise P2Y12 inhibition. "Rapid" (CYP2C19*1/*1 or CYP2C19*17 carriers, n=211) and "slow" metabolisers (CYP2C19*2 carriers...

journal_title：Thrombosis and haemostasis

authors： Collet JP,Kerneis M,Hulot JS,O'Connor SA,Silvain J,Mansencal N,Brugier D,Abtan J,Barthélémy O,Vignalou JB,Payot L,Rousseau H,Vicaut E,Montalescot G,GAMMA Investigators.

更新日期：2016-01-01 00:00:00

abstract：:Constitutive expression of tissue factor (TF) by acute promyelocytic leukemia (APL) cells may contribute to thrombotic complications. In this study we examined the transcriptional mechanisms of all-trans retinoic acid (ATRA)-induced down-regulation of TF in the APL cell line NB4, by analysis of stable clones expressin...

journal_title：Thrombosis and haemostasis

authors： Tenno T,Oberg F,Mackman N,Nilsson K,Siegbahn A

更新日期：2003-11-01 00:00:00

abstract：:Pharmaceutical grade heparins from porcine intestine and bovine lung consist mainly of repeating tri-sulfated units, of the disaccharide →4-α-IdoA2S-1→4-α-GlcNS6S-1→. Heparin preparations from bovine intestine, in contrast, are more heterogeneous. Nuclear magnetic resonance (NMR) and disaccharide analysis after hepari...

journal_title：Thrombosis and haemostasis

authors： Tovar AM,Capillé NV,Santos GR,Vairo BC,Oliveira SN,Fonseca RJ,Mourão PA

更新日期：2012-05-01 00:00:00

abstract：:Nitric oxide (NO) is a signaling molecule of major importance modulating not only the function of the vascular wall but also that of blood cells, such as platelets and leukocytes. The synthesis of NO in the circulation has been attributed mainly to the vascular endothelium. Red blood cells (RBC) have been demonstrated...

journal_title：Thrombosis and haemostasis

authors： Kleinbongard P,Keymel S,Kelm M

更新日期：2007-11-01 00:00:00

abstract：:The antithrombotic effect of MCI-9042, (+-)-2-(dimethyl-amino)-1-((o-(m- methoxyphenethyl)phenoxyl]methyl]ethyl hydrogen succinate hydrochloride was investigated in three different experimental thrombosis models in animals. Simultaneous injection of serotonin and collagen into the tail vein in mice induced acute pulmo...

journal_title：Thrombosis and haemostasis

authors： Hara H,Kitajima A,Shimada H,Tamao Y

更新日期：1991-10-01 00:00:00

abstract：:Tamoxifen is a known anti-cancer drug and established estrogen receptor modulator. Few clinical studies have earlier implicated the drug in thrombotic complications attributable to lower anti-thrombin and protein S levels in plasma. However, action of tamoxifen on platelet signalling machinery has not been elucidated ...

journal_title：Thrombosis and haemostasis

authors： Nayak MK,Singh SK,Roy A,Prakash V,Kumar A,Dash D

更新日期：2011-10-01 00:00:00

abstract：:Standard pharmacokinetic (PK) assessments are demanding for persons with hemophilia A, requiring a 72hr washout and 5-11 timed blood samples. A no-washout, single-clinic visit, sparse sampling population PK (PPK) protocol is an attractive alternative. Here, we compared PK parameters obtained with a traditional washout...

journal_title：Thrombosis and haemostasis

authors： Blanchette V,Zunino L,Grassmann V,Barnes C,Carcao M,Curtain J,Jackson SC,Khoo L,Komrska V,Lillicrap D,Morfini M,Romanova G,Stephens D,Zapotocka E,Rand ML,Blatny J

更新日期：2021-01-27 00:00:00

abstract：:In this study, the clot accumulation properties of liposome-coupled plasminogen were compared to those of free (non-liposomal) plasminogen in an in vitro, closed-loop, flow-system. After introduction of a clot into the closed system, double-radiolabelled plasminogen-liposomes were administered and the accumulation of ...

journal_title：Thrombosis and haemostasis

authors： Heeremans JL,Prevost R,Feitsma H,Kluft C,Crommelin DJ

更新日期：1998-01-01 00:00:00

abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

journal_title：Thrombosis and haemostasis

authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

更新日期：2008-01-01 00:00:00

abstract：:A group of 90 hemophiliacs who had been regularly treated with non virus-inactivated factor VIII or IX concentrates were studied in 1983. At that time 50 patients were HIV-1-antibody positive, 6 additional seroconversions occurred until 1985. 26 of the 50 patients seropositive in 1983 are currently asymptomatic. 4 pat...

journal_title：Thrombosis and haemostasis

authors： Stain C,Pabinger-Fasching I,Guggenberger K,Köller U,Stain M,Hartl H,Heinz F,Mayerhofer S,Kyrle PA,Lechner K

更新日期：1989-06-30 00:00:00

abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

journal_title：Thrombosis and haemostasis

authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

更新日期：2016-09-27 00:00:00

abstract：:Hemorrhagic diathesis and widespread microthrombosis are common in heatstroke. To assess the early stages of coagulopathy in heatstroke, thrombin-antithrombin III (TAT), fibrin monomers, plasmin-alpha 2-antiplasmin (PAP), plasminogen and D-Dimer were measured in 16 heatstroke patients (means +/- SE rectal temperature ...

journal_title：Thrombosis and haemostasis

authors： Bouchama A,Bridey F,Hammami MM,Lacombe C,al-Shail E,al-Ohali Y,Combe F,al-Sedairy S,de Prost D

更新日期：1996-12-01 00:00:00