Distribution of the recombinant coagulation factor 125I-rFVIIa in rats.

abstract：BACKGROUND: Clinical effectiveness of recombinant human soluble thrombomodulin (rhTM) in sepsis or sepsis-induced coagulopathy remains a matter of dispute. Recently, the Sepsis Coagulopathy Asahi Recombinant LEThrombomodulin (SCARLET) trial, the latest multinational multi-centre phase III randomized controlled trial, w...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Murao S,Aihara M

更新日期：2019-01-01 00:00:00

abstract：:We have investigated the intracellular mechanisms involved in microtubular remodelling by thrombin and its possible involvement in platelet aggregation and secretion. Platelet stimulation with thrombin induces a time- and concentration-dependent regulation of the microtubular content, which was found to be maximally e...

journal_title：Thrombosis and haemostasis

authors： Bouaziz A,Amor NB,Woodard GE,Zibidi H,López JJ,Bartegi A,Salido GM,Rosado JA

更新日期：2007-08-01 00:00:00

abstract：:The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a thrombin receptor agonist/activating peptide (TRAP). In this study, Northern blot analysis showed that cultured human vascular smooth muscle cells (HVSMC) expr...

journal_title：Thrombosis and haemostasis

authors： Kanthou C,Benzakour O,Patel G,Deadman J,Kakkar VV,Lupu F

更新日期：1995-11-01 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:Alpha 2-macroglobulin (alpha 2 M) in vitro inhibits numerous proteinases that are generated during inflammatory reactions and therefore, probably plays an important role in diseases such as sepsis. To monitor the state of alpha 2 M in sepsis, we developed novel assays for functional and inactive alpha 2M. Functional a...

journal_title：Thrombosis and haemostasis

authors： Abbink JJ,Nuijens JH,Eerenberg AJ,Huijbregts CC,Strack van Schijndel RJ,Thijs LG,Hack CE

更新日期：1991-01-23 00:00:00

abstract：:Factor Xa (fXa)-inhibitors are as effective and safer than vitamin-K-antagonists (VKA) in the treatment of venous thromboembolism (VTE). We previously classified the severity of clinical presentation and course of all major bleeding events from the EINSTEIN, AMPLIFY and HOKUSAI-VTE trials separately. The current aim w...

journal_title：Thrombosis and haemostasis

authors： Bleker SM,Brekelmans MPA,Eerenberg ES,Cohen AT,Middeldorp S,Raskob G,Büller HR

更新日期：2017-10-01 00:00:00

abstract：:We have investigated the influence of long term oral anticoagulants (OAC) upon the plasma levels of prothrombin fragment 1 + 2 (F1 + 2), of thrombin-antithrombin III complexes (TAT) and of D-Dimer in 20 patients affected by a proximal deep vein thrombosis (DVT) diagnosed by ultrasonic duplex scanning. Patients (63 +/-...

journal_title：Thrombosis and haemostasis

authors： Elias A,Bonfils S,Daoud-Elias M,Gauthier B,Sié P,Boccalon H,Boneu B

更新日期：1993-04-01 00:00:00

abstract：:Mammalian urokinase-type plasminogen activator (uPA) is produced as a stable single polypeptide chain zymogen and requires a distinct proteolytic cleavage to become an active, two-chain enzyme. In contrast, chicken uPA, both native and recombinant, is found predominantly as a two-chain, active enzyme even in the absen...

journal_title：Thrombosis and haemostasis

authors： Aimes RT,Regazzoni K,Quigley JP

更新日期：2003-02-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Cell accumulation is a prerequisite for adipose tissue inflammation. The leukocyte integrin Mac-1 (CD11b/CD18, αMβ2) is a classic adhesion receptor critically regulating inflammatory cell recruitment. Here, we tested the hypothesis that a genetic deficiency and a therapeutic modulation of Mac-1 regulate adipose tissue...

journal_title：Thrombosis and haemostasis

authors： Wolf D,Bukosza N,Engel D,Poggi M,Jehle F,Anto Michel N,Chen YC,Colberg C,Hoppe N,Dufner B,Boon L,Blankenbach H,Hilgendorf I,von Zur Muhlen C,Reinöhl J,Sommer B,Marchini T,Febbraio MA,Weber C,Bode C,Peter K,Lutge

更新日期：2017-01-26 00:00:00

abstract：:The turnover of recombinant pro-urokinase (Rec-pro-UK), recombinant urokinase (Rec-UK) and natural urinary urokinase (Nat-UK) was studied in rabbits and in squirrel monkeys (Saimiri sciureus). Following intravenous injection, urokinase activity disappeared rapidly from the blood. The initial disappearance rate could b...

journal_title：Thrombosis and haemostasis

authors： Collen D,De Cock F,Lijnen HR

更新日期：1984-08-31 00:00:00

abstract：:Light to moderate drinking is associated with lower risk of coronary heart (CHD) than non-drinkers. We have examined the relationships between total alcohol intake and type of alcoholic beverage and several potential biological mechanisms. We carried out the study in 3158 men aged 60-79 years drawn from general practi...

journal_title：Thrombosis and haemostasis

authors： Wannamethee SG,Lowe GD,Shaper G,Whincup PH,Rumley A,Walker M,Lennon L

更新日期：2003-12-01 00:00:00

abstract：:A study was made of the influence of thrombin on the platelet-aggregating activity of human factor VIII with Ristocetin as cofactor. Purified factor VIII and different amounts of a thrombin-Sepharose 2B complex were mixed and incubated for various periods of time. The factor VIII-related platelet-aggregating activitie...

journal_title：Thrombosis and haemostasis

authors： Vukovich T,Koller E,Doleschel W

更新日期：1979-10-31 00:00:00

abstract：:Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

journal_title：Thrombosis and haemostasis

authors： Agarwal KC,Russo FX,Parks RE Jr

更新日期：1982-10-29 00:00:00

abstract：:An alternative method of uniting small diameter vessels to obtain tissue union while limiting the thrombogenic effect of suture placement at a vessel anastomosis involves the use of a thrombin based fibrin glue as a surgical sealant. This investigation addresses whether the in vitro application of a thrombin based glu...

journal_title：Thrombosis and haemostasis

authors： Dascombe WH,Dumanian G,Hong C,Heil BV,Labadie K,Hessel B,Blombäck B,Johnson PC

更新日期：1997-08-01 00:00:00

abstract：:A nutritionally induced obesity model was used to investigate the modulation of fibrinolytic and gelatinolytic activity during the development of adipose tissue. Five week old male mice were fed a standard fat diet (SFD, 13% kcal as fat) or a high fat diet (HFD, 42% kcal as fat) for up to 15 weeks. The HFD resulted in...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maquoi E,Demeulemeester D,Van Hoef B,Collen D

更新日期：2002-08-01 00:00:00

abstract：:The aim of this study was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. In studies in vitro, PRAP-1, a Fab-fragment of a polyclonal antibody against human PAI-1, was shown to inhibit PAI-1 activity in rat plasma as well as to stimul...

journal_title：Thrombosis and haemostasis

authors： Abrahamsson T,Nerme V,Strömqvist M,Akerblom B,Legnehed A,Pettersson K,Westin Eriksson A

更新日期：1996-01-01 00:00:00

abstract：:Paired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1...

journal_title：Thrombosis and haemostasis

authors： Jones CR,McCabe R,Hamilton CA,Reid JL

更新日期：1985-02-18 00:00:00

abstract：:Pregnancy and delivery have measurable effects on haemostatic and immunological changes. Degradation of fibrinogen induces significant structural and conformational modulation and leads to the progressive loss of antigenic sites present on the parent molecule but also exposes some new sites. These neoantigens may be r...

journal_title：Thrombosis and haemostasis

authors： Kondera-Anasz Z

更新日期：1998-05-01 00:00:00

abstract：:Extrinsic coagulation pathway inhibitor may be an important regulator of haemostasis to prevent thrombosis after tissue damage. The functional activity of this inhibitor was determined using a chromogenic substrate assay, and compared to the activities of antithrombin, heparin cofactor II and protein C during the peri...

journal_title：Thrombosis and haemostasis

authors： Sandset PM,Høgevold HE,Lyberg T,Andersson TR,Abildgaard U

更新日期：1989-11-24 00:00:00

abstract：:The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin intake on circadian rhythm and morning peak of platelet reactivity is not known. It was our objective to evaluate the effect of timing of aspirin intake on circadia...

journal_title：Thrombosis and haemostasis

authors： Bonten TN,Saris A,van Oostrom MJ,Snoep JD,Rosendaal FR,Zwaginga J,Eikenboom J,van der Meer PF,van der Bom JG

更新日期：2014-12-01 00:00:00

abstract：:An assay system for protein C (PC) activity and PC-inhibitor in plasma was developed. The assay was based on: (1) binding of PC to wells of a microtiter plate coated with a murine monoclonal anti-PC antibody (C3) that did not interfere with the activity or activation of PC; (2) activation of immobilized PC with Protac...

journal_title：Thrombosis and haemostasis

authors： Geiger M,White TM,Griffin JH

更新日期：1989-02-28 00:00:00

abstract：:Red cell distribution width (RDW) has been shown to be an independent predictor of mortality in patients with coronary artery disease and in patients with heart failure. The current study evaluated the prognostic utility of RDW in patients undergoing percutaneous coronary intervention (PCI). We evaluated 859 patients ...

journal_title：Thrombosis and haemostasis

authors： Poludasu S,Marmur JD,Weedon J,Khan W,Cavusoglu E

更新日期：2009-09-01 00:00:00

abstract：:Proteins in the plasma membrane anchor the cell within its microenvironment and sense changes occurring outside the cell. The anchoring interactions are cell type-specific and may involve adjacent cells or extracellular matrix proteins (ECMPs). In development, wound healing, and in various forms of pathology, includin...

journal_title：Thrombosis and haemostasis

authors： Gonias SL,Wu L,Salicioni AM

更新日期：2004-06-01 00:00:00

abstract：:Thrombus formation is recognized pathologically in the affected arteries and is supposed to play a major role in the pathogenesis of Takayasu's arteritis; however, hemostatic conditions in this disorder have not been elucidated fully. We determined plasma levels of molecular markers for platelet activity (platelet fac...

journal_title：Thrombosis and haemostasis

authors： Akazawa H,Ikeda U,Yamamoto K,Kuroda T,Shimada K

更新日期：1996-05-01 00:00:00

abstract：:A possible role of the plasminogen/plasmin or fibrinolytic system in several biological processes has been implied from correlations between fibrinolytic activity and (patho)physiological phenomena. However, such indirect evidence does not allow to definitively establish the biological relevance of this system. Two re...

journal_title：Thrombosis and haemostasis

authors： Carmeliet P,Collen D

更新日期：1995-07-01 00:00:00

abstract：:In haemophilia B (HB) (factor IX [FIX] deficiency), F9 genotype largely determines clinical phenotype. Aimed to characterise Argentinian families with HB, this study presents F9 genotype frequencies and their specific FIX inhibitor risk and 10 novel F9 mutations. Ninety-one DNA samples from HB patients and relat...

journal_title：Thrombosis and haemostasis

authors： Radic CP,Rossetti LC,Abelleyro MM,Candela M,Pérez Bianco R,de Tezanos Pinto M,Larripa IB,Goodeve A,De Brasi C

更新日期：2013-01-01 00:00:00

abstract：:Thrombotic complications are frequently associated with atherosclerosis. Lysophosphatidylcholine (LPC), a component accumulated in oxidatively modified LDL (ox-LDL), is known to play a crucial role in the initiation and progression of atherosclerotic vascular lesions. Since a vascular anticoagulant, tissue factor path...

journal_title：Thrombosis and haemostasis

authors： Sato N,Kokame K,Miyata T,Kato H

更新日期：1998-01-01 00:00:00

abstract：:We have investigated the role of two vasoactive substances, nitric oxide (NO)and endothelin (ET), in the pathophysiology of disseminated intravascular coagulation (DIC), using two types of DIC models. Experimental DIC was induced by sustained infusion of 0.1, 1, 10, or 50 mg/kg lipopolysaccharide (LPS), or 3.75 U/kg t...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Okudaira M,Yoshida T,Ontachi Y,Yamazaki M,Morishita E,Miyamoto K,Nakao S

更新日期：2002-10-01 00:00:00